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The map label for this gene is sdhA

Identifier: 255767656

GI number: 255767656

Start: 2906335

End: 2908095

Strand: Reverse

Name: sdhA

Synonym: BSU28440

Alternate gene names: 255767656

Gene position: 2908095-2906335 (Counterclockwise)

Preceding gene: 16079897

Following gene: 16079895

Centisome position: 68.98

GC content: 48.5

Gene sequence:

>1761_bases
ATGAGTCAATCAAGCATTATCGTAGTCGGCGGGGGTCTTGCCGGCCTCATGGCGACAATTAAAGCAGCGGAATCAGGAAT
GGCGGTTAAATTGTTTTCCATCGTTCCTGTCAAACGTTCTCATTCAGTTTGTGCGCAAGGCGGCATAAACGGAGCGGTCA
ATACAAAAGGGGAAGGTGACTCTCCGTGGGAACATTTTGATGACACGGTATACGGGGGAGACTTTCTTGCCAACCAGCCG
CCGGTCAAGGCGATGTGTGAAGCGGCGCCTTCGATCATCCACTTATTAGACCGGATGGGCGTCATGTTTAACCGGACGCC
TGAAGGCCTGCTTGATTTCCGCCGATTCGGGGGTACACAGCACCACAGAACTGCTTATGCTGGTGCGACGACGGGACAGC
AGCTGCTTTACGCACTGGACGAGCAAGTGCGCAGATACGAAGTTGCGGGTCTGGTCACAAAATACGAAGGCTGGGAATTC
CTTGGCGCTGTTTTAGATGATGACAGAACCTGCCGCGGAATTGTTGCACAAAACCTGACAAACATGCAAATTGAATCCTT
CCGTTCAGACGCTGTCATTATGGCGACGGGCGGACCGGGAATCATCTTTGGAAAATCAACGAACTCCATGATTAATACAG
GATCTGCTGCGTCAATCGTTTATCAGCAGGGAGCGTATTATGCAAACGGAGAATTCATTCAAATCCACCCGACAGCCATA
CCGGGCGATGACAAACTAAGACTGATGAGTGAATCAGCGCGTGGTGAAGGCGGGCGCGTGTGGACATATAAAGACGGCAA
ACCATGGTATTTCCTGGAGGAAAAATATCCGGCATACGGAAACCTGGTGCCGCGTGATATTGCGACACGCGAAATATTTG
ATGTGTGTGTGAACCAGAAGCTCGGTATTAACGGTGAAAACATGGTATATCTCGATCTGTCTCATAAAGATCCGAAAGAG
CTTGATATTAAGCTTGGCGGCATCATTGAGATTTATGAGAAATTCATGGGAGACGACCCGCGTAAGCTTCCAATGAAAAT
CTTCCCGGCGGTCCATTATTCTATGGGCGGTTTATGGGTGGATTACGATCAAATGACAAATATCCCTGGACTGTTTGCGG
CTGGGGAATGTGATTATTCTATGCACGGCGGCAACCGCTTGGGAGCGAACTCCCTGCTGTCTGCGATTTACGGAGGCATG
GTGGCCGGTCCGAATGCGGTGAAATATGTAAACGGCTTAGAATCTTCAGCGGAAGACATGTCTTCATCTTTATTCGACGC
TCACGTTAAGAAAGAAGAAGAAAAATGGGCTGATATTATGAGTATGGACGGAACCGAAAATGCCTATGTTCTTCACAAAG
AGCTCGGTGAGTGGATGACGGCGAACGTAACGGTTGTCCGCCATAATGACAAGCTTTTGAAAACGGATGACAAAATTCAG
GAGTTAATGGAGCGCTTCAAAAAGATCAACATCAATGACACGACAAAATGGAGCAACCAGGGAGCGATGTTCACACGCCA
GTTCTCGAACATGCTTCAGCTTGCGAGGGTGATTACCCTTGGCGCATACAACCGTAATGAAAGCCGGGGCGCCCATTATA
AACCGGATTATCCTGAACGTAATGATGATGAATGGCTCAAAACAACAATGGCTAAACATGTAAGCCCGTATGAAGCGCCG
GAATTTGAGTATCAGGATGTCGATGTATCACTGATAACGCCTCGGAAACGGGATTACTCGAAGAAGAAGGTGGCGAAATA
A

Upstream 100 bases:

>100_bases
CGTTACGCTGATTATTTTTGTTGCACTGTCATACGTAGGCTTAAAAGCGATTTTTGCATTTGTTTAAGAGTACTAGATTA
CTAGAGGGAGAGGGGCTATC

Downstream 100 bases:

>100_bases
TCATGAGTGAACAAAAAACCATACGATTTATTATCACACGTCAAGATACAGCTGACAGCACGCCTTATGATGAAGAATTT
GAGATTCCATACCGCCCGAA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVCAQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQP
PVKAMCEAAPSIIHLLDRMGVMFNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF
LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAASIVYQQGAYYANGEFIQIHPTAI
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKE
LDIKLGGIIEIYEKFMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGM
VAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYVLHKELGEWMTANVTVVRHNDKLLKTDDKIQ
ELMERFKKININDTTKWSNQGAMFTRQFSNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAP
EFEYQDVDVSLITPRKRDYSKKKVAK

Sequences:

>Translated_586_residues
MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVCAQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQP
PVKAMCEAAPSIIHLLDRMGVMFNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF
LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAASIVYQQGAYYANGEFIQIHPTAI
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKE
LDIKLGGIIEIYEKFMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGM
VAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYVLHKELGEWMTANVTVVRHNDKLLKTDDKIQ
ELMERFKKININDTTKWSNQGAMFTRQFSNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAP
EFEYQDVDVSLITPRKRDYSKKKVAK
>Mature_585_residues
SQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVCAQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPP
VKAMCEAAPSIIHLLDRMGVMFNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEFL
GAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAASIVYQQGAYYANGEFIQIHPTAIP
GDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKEL
DIKLGGIIEIYEKFMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGMV
AGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYVLHKELGEWMTANVTVVRHNDKLLKTDDKIQE
LMERFKKININDTTKWSNQGAMFTRQFSNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPE
FEYQDVDVSLITPRKRDYSKKKVAK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily

Homologues:

Organism=Homo sapiens, GI156416003, Length=581, Percent_Identity=29.9483648881239, Blast_Score=221, Evalue=2e-57,
Organism=Escherichia coli, GI1790597, Length=570, Percent_Identity=33.5087719298246, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1786942, Length=552, Percent_Identity=31.3405797101449, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1788928, Length=552, Percent_Identity=28.4420289855072, Blast_Score=182, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17505833, Length=542, Percent_Identity=31.3653136531365, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17550100, Length=547, Percent_Identity=31.0786106032907, Blast_Score=223, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6322701, Length=551, Percent_Identity=32.486388384755, Blast_Score=234, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6322416, Length=568, Percent_Identity=30.4577464788732, Blast_Score=220, Evalue=4e-58,
Organism=Drosophila melanogaster, GI17137288, Length=538, Percent_Identity=31.9702602230483, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24655642, Length=538, Percent_Identity=31.9702602230483, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24655647, Length=538, Percent_Identity=31.9702602230483, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24663005, Length=605, Percent_Identity=29.5867768595041, Blast_Score=216, Evalue=4e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHSA_BACSU (P08065)

Other databases:

- EMBL:   M13470
- EMBL:   Z75208
- EMBL:   AL009126
- PIR:   A27763
- RefSeq:   NP_390722.2
- ProteinModelPortal:   P08065
- SMR:   P08065
- EnsemblBacteria:   EBBACT00000000782
- GeneID:   937600
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU28440
- NMPDR:   fig|224308.1.peg.2847
- GenoList:   BSU28440
- GeneTree:   EBGT00050000000837
- HOGENOM:   HBG293998
- ProtClustDB:   PRK08641
- BioCyc:   BSUB:BSU28440-MONOMER
- BRENDA:   1.3.99.1
- GO:   GO:0006810
- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280
- Gene3D:   G3DSA:1.20.58.100
- PANTHER:   PTHR11632:SF4
- PRINTS:   PR00368
- TIGRFAMs:   TIGR01811

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C; SSF46977 Succ_DH_flav_C

EC number: =1.3.99.1

Molecular weight: Translated: 65153; Mature: 65021

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: ACT_SITE 285-285 BINDING 236-236 BINDING 250-250 BINDING 352-352 BINDING 376-376 BINDING 386-386

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVCAQGGINGAVNTKGEGD
CCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCC
SPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVMFNRTPEGLLDFRRFGGTQ
CCHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHCCCCC
HHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEFLGAVLDDDRTCRGIVAQNLT
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCHHHHHHHCCCC
NMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAASIVYQQGAYYANGEFIQIHPTAI
CHHHHHCCCCEEEEEECCCEEEEECCCCCCCCCCCCEEEEEECCCEEECCCEEEEECCCC
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQK
CCCCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCC
LGINGENMVYLDLSHKDPKELDIKLGGIIEIYEKFMGDDPRKLPMKIFPAVHYSMGGLWV
CCCCCCCEEEEEECCCCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEE
DYDQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGMVAGPNAVKYVNGLESSAEDM
EHHHHCCCCCEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
SSSLFDAHVKKEEEKWADIMSMDGTENAYVLHKELGEWMTANVTVVRHNDKLLKTDDKIQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHCCCEECEEEEEEECCCEECCCHHHH
ELMERFKKININDTTKWSNQGAMFTRQFSNMLQLARVITLGAYNRNESRGAHYKPDYPER
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NDDEWLKTTMAKHVSPYEAPEFEYQDVDVSLITPRKRDYSKKKVAK
CCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHCCC
>Mature Secondary Structure 
SQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVCAQGGINGAVNTKGEGD
CCCCEEEECCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCC
SPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVMFNRTPEGLLDFRRFGGTQ
CCHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHCCCCC
HHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEFLGAVLDDDRTCRGIVAQNLT
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCHHHHHHHCCCC
NMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAASIVYQQGAYYANGEFIQIHPTAI
CHHHHHCCCCEEEEEECCCEEEEECCCCCCCCCCCCEEEEEECCCEEECCCEEEEECCCC
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQK
CCCCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCC
LGINGENMVYLDLSHKDPKELDIKLGGIIEIYEKFMGDDPRKLPMKIFPAVHYSMGGLWV
CCCCCCCEEEEEECCCCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEE
DYDQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGMVAGPNAVKYVNGLESSAEDM
EHHHHCCCCCEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
SSSLFDAHVKKEEEKWADIMSMDGTENAYVLHKELGEWMTANVTVVRHNDKLLKTDDKIQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHCCCEECEEEEEEECCCEECCCHHHH
ELMERFKKININDTTKWSNQGAMFTRQFSNMLQLARVITLGAYNRNESRGAHYKPDYPER
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NDDEWLKTTMAKHVSPYEAPEFEYQDVDVSLITPRKRDYSKKKVAK
CCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212