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The map label for this gene is gltR

Identifier: 255767615

GI number: 255767615

Start: 2725837

End: 2726727

Strand: Direct

Name: gltR

Synonym: BSU26670

Alternate gene names: 255767615

Gene position: 2725837-2726727 (Clockwise)

Preceding gene: 16079716

Following gene: 16079733

Centisome position: 64.66

GC content: 39.96

Gene sequence:

>891_bases
ATGAATATTCAGTTGTTACAGGTTTTTCTCACTACTGCTCGTGAAGGCAGTATTTCCAAGGCTGCTCTGACTTTAAATTA
TGCACAATCGAATGTAACGAATAAGATACAACAACTAGAAAACGATTTACAGACAAAATTATTCTATCGTCATAGTCGAG
GAATCACACTTACTCCCCCAGGGCAAATTCTTGTTTCTTACTCAGAGAAAATTCTACATACTATTGAAGAAGCTAGAGCA
GCCATGGGCGAATCATCCGCGCCTTCTGGGCCACTGCGTATAGGATCAATGGAAACAACAGCTGCAGTTTGGCTTCCTCA
ACTCCTTGCACATTATAATAACCTCTATCCAAATGTTGATTTGAACCTAGTAACCGGCCCTACGGAACAACAAATACAAG
CAGTTTTACATTATGAGTTAAACGGCGCTTTTATTTCAGGGCCTATTGAACACCCTGATTTAGTTCAAGAAAAGGTATTG
GATGAAGAGATGGTTCTTGTTACAAGTGCTTCACACCCTGTGATTTCTTCCATTCAGGATGTTCAAACACAAACAATGCT
TGTATTCCGTAAAGGATGCTCATACAGAGCAAAGCTCAATCATATCCTGCAAGAAGAAGGTTTATTACCTATAAAATTAA
TGGAATTTGGCATACTTGAAGCGATCATTGGCTGTGTAAGCGCCGGCTTGGGGATTTCACTGCTGCCTCGTTCAATCATT
GCTTCGCATGAAAAAGAAGGCCGCATCCGCAGCCACACTATCTCTGACAAATATTCTTTTGTATCAACTATGTTTATAAG
GCGGAAAGACACTTTAATTACCCCTGCTTTATCTGCTTTTTTAACGCATATGAGGGATCATTTTCAGATAAAGAGGCCAG
ATCAATCGTAA

Upstream 100 bases:

>100_bases
TTCTTCTAAGCTTTAGTTTACATGAAGCTCTGCTATCATATATAATTCAAAATTAAGATGGAAGACATCTCAAAATCAGA
TATCAACTATGGAGGACTAG

Downstream 100 bases:

>100_bases
ATAAATGGATGGAAGGCATGCTTCGCCTCAAAATACCCCTGATCAGTTGTCTGATATAAAAATATAGGCGCATCTCAATG
TTTGTATAGAGCAAAAAAGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQTKLFYRHSRGITLTPPGQILVSYSEKILHTIEEARA
AMGESSAPSGPLRIGSMETTAAVWLPQLLAHYNNLYPNVDLNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVL
DEEMVLVTSASHPVISSIQDVQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGILEAIIGCVSAGLGISLLPRSII
ASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPALSAFLTHMRDHFQIKRPDQS

Sequences:

>Translated_296_residues
MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQTKLFYRHSRGITLTPPGQILVSYSEKILHTIEEARA
AMGESSAPSGPLRIGSMETTAAVWLPQLLAHYNNLYPNVDLNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVL
DEEMVLVTSASHPVISSIQDVQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGILEAIIGCVSAGLGISLLPRSII
ASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPALSAFLTHMRDHFQIKRPDQS
>Mature_296_residues
MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQTKLFYRHSRGITLTPPGQILVSYSEKILHTIEEARA
AMGESSAPSGPLRIGSMETTAAVWLPQLLAHYNNLYPNVDLNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVL
DEEMVLVTSASHPVISSIQDVQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGILEAIIGCVSAGLGISLLPRSII
ASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPALSAFLTHMRDHFQIKRPDQS

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1787806, Length=281, Percent_Identity=32.3843416370107, Blast_Score=175, Evalue=2e-45,
Organism=Escherichia coli, GI1790262, Length=278, Percent_Identity=26.978417266187, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI157672245, Length=281, Percent_Identity=24.9110320284698, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1788481, Length=288, Percent_Identity=25, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082132, Length=295, Percent_Identity=25.4237288135593, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI145693105, Length=282, Percent_Identity=26.241134751773, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787601, Length=294, Percent_Identity=24.4897959183673, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787879, Length=295, Percent_Identity=25.4237288135593, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788748, Length=297, Percent_Identity=25.5892255892256, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1790399, Length=243, Percent_Identity=25.1028806584362, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1788296, Length=244, Percent_Identity=27.0491803278689, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790208, Length=297, Percent_Identity=24.2424242424242, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI2367136, Length=248, Percent_Identity=26.6129032258064, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787530, Length=281, Percent_Identity=21.7081850533808, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788887, Length=295, Percent_Identity=22.7118644067797, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789639, Length=125, Percent_Identity=32.8, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI48994962, Length=120, Percent_Identity=35, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789173, Length=259, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788297, Length=242, Percent_Identity=23.9669421487603, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786448, Length=121, Percent_Identity=31.404958677686, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789506, Length=210, Percent_Identity=24.7619047619048, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): GLTR_BACSU (P94501)

Other databases:

- EMBL:   U79494
- EMBL:   U93876
- EMBL:   AL009126
- PIR:   C69635
- RefSeq:   NP_390544.2
- ProteinModelPortal:   P94501
- SMR:   P94501
- EnsemblBacteria:   EBBACT00000003549
- GeneID:   938189
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU26670
- NMPDR:   fig|224308.1.peg.2669
- GenoList:   BSU26670
- GeneTree:   EBGT00070000031761
- HOGENOM:   HBG685425
- PhylomeDB:   P94501
- ProtClustDB:   CLSK2551038
- BioCyc:   BSUB:BSU26670-MONOMER
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate

EC number: NA

Molecular weight: Translated: 32956; Mature: 32956

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQTKLFYRHSRGITLTPP
CCHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
GQILVSYSEKILHTIEEARAAMGESSAPSGPLRIGSMETTAAVWLPQLLAHYNNLYPNVD
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCC
LNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVLDEEMVLVTSASHPVISSIQD
EEEEECCCHHHHHHHHHEEECCEEEECCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHH
VQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGILEAIIGCVSAGLGISLLPRSII
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPALSAFLTHMRDHFQIKRPDQS
HCCCCCCCCHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCEECCCCCC
>Mature Secondary Structure
MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQTKLFYRHSRGITLTPP
CCHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
GQILVSYSEKILHTIEEARAAMGESSAPSGPLRIGSMETTAAVWLPQLLAHYNNLYPNVD
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCC
LNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVLDEEMVLVTSASHPVISSIQD
EEEEECCCHHHHHHHHHEEECCEEEECCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHH
VQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGILEAIIGCVSAGLGISLLPRSII
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPALSAFLTHMRDHFQIKRPDQS
HCCCCCCCCHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377