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The map label for this gene is accC

Identifier: 255767543

GI number: 255767543

Start: 2530354

End: 2531706

Strand: Reverse

Name: accC

Synonym: BSU24340

Alternate gene names: 255767543

Gene position: 2531706-2530354 (Counterclockwise)

Preceding gene: 16079491

Following gene: 255767542

Centisome position: 60.06

GC content: 45.31

Gene sequence:

>1353_bases
ATGATTAAAAAGCTATTGATCGCCAACAGAGGAGAAATTGCTGTCAGAATCATCAGAGCCTGCAGAGAGCTCGGAATTGA
GACTGTCGCTGTTTATTCAGAAGCTGATAAAGATGCCCTTCATGTTCAAATGGCCGATGAAGCTTTTTGTATCGGACCGA
AAGCATCAAAAGACAGCTATTTAAACGTTACAAATATTGTGAGTGTTGCAAAGCTGACTGGCACGGACGCCATTCATCCG
GGATACGGATTTTTAGCTGAAAATGCTGATTTCGCTGAATTATGTGAAGAAGTGAATGTCACGTTTGTCGGCCCGAGCGC
TGACGCCATTTCAAAAATGGGAACAAAAGACGTTGCGCGGGAAACGATGAAACAGGCCGGCGTGCCAATCGTACCGGGTT
CACAGGGAATTATAGAAAATGTGGAAGAAGCGGTTTCGCTTGCTAATGAAATTGGGTATCCTGTAATTATAAAAGCCACC
GCAGGCGGAGGCGGAAAAGGAATTAGGGTTGCCCGCACTGAAGAGGAACTGATTAATGGCATTAAGATTACACAGCAGGA
AGCGGCAACTGCATTTGGGAATCCAGGTGTATACATCGAAAAATACATAGAAGATTTTCGCCACGTTGAGATCCAAGTGC
TTGCTGATAACTACGGAAATACGATCCATTTGGGCGAACGCGACTGCTCGATCCAAAGACGCCTGCAAAAGCTTTTGGAA
GAATCACCATCTCCTGCCCTTGATTCAGAAATCAGGGAGCAAATGGGAGATGCAGCGGTAAAGGCTGCCAAAGCGGTTGG
CTATACAGGTGCTGGAACAGTTGAATTTATCTATGACTACAATGAACAGCGCTATTACTTCATGGAAATGAACACGAGAA
TCCAGGTGGAGCACCCAGTCACAGAAATGGTGACGGGAACTGACCTGATCAAGGAACAAATCAAAGTGGCTTCAGGAATG
GAACTGAGCCTCAAGCAAGAAGATGTTGAATTTGAAGGCTGGGCCATCGAATGCCGAATCAACGCAGAAAACCCAAGCAA
AAATTTCATGCCGTCACCTGGTGAAATTAAAATGTACCTGCCTCCTGGCGGTCTTGGTGTCCGTGTCGATTCAGCTGCGT
ACCCTGGCTATTCCATCCCACCGTACTATGACAGCATGATTGCAAAGGTAATCACATACGGAAAAACGAGAGATGAAGCG
ATTGCCCGCATGAAGCGCGCATTGAGCGAATTCGTCATCGAAGGCATTGAGACAACAATCCCTTTCCATTTAAAACTGCT
TGAACACGAAACATTTGTGAGCGGAGAGTTTAATACGAAATTTTTAGAAACATATGATGTAATGGGCTCATAA

Upstream 100 bases:

>100_bases
AAGTGAAAGGCGAAATCGTTGAAGTATTAGTAGAAAACGGCCAGCTGGTCGAATACGGACAACCTCTATTTCTTGTAAAA
GCGGAGTAAGGAGACTGAAC

Downstream 100 bases:

>100_bases
TTTTTACGGAGGTGAATTGAATGAAAGACAACAGCTTGCTTAAAATGGATCACGAAGATACGCATTTGGGTAAGGTTGAG
ATTGCACCGGAGGTCATTGA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 1; ACC 1

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQMADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHP
GYGFLAENADFAELCEEVNVTFVGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT
AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNYGNTIHLGERDCSIQRRLQKLLE
ESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEFIYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGM
ELSLKQEDVEFEGWAIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVITYGKTRDEA
IARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS

Sequences:

>Translated_450_residues
MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQMADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHP
GYGFLAENADFAELCEEVNVTFVGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT
AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNYGNTIHLGERDCSIQRRLQKLLE
ESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEFIYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGM
ELSLKQEDVEFEGWAIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVITYGKTRDEA
IARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS
>Mature_450_residues
MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQMADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHP
GYGFLAENADFAELCEEVNVTFVGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT
AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNYGNTIHLGERDCSIQRRLQKLLE
ESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEFIYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGM
ELSLKQEDVEFEGWAIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVITYGKTRDEA
IARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain

Homologues:

Organism=Homo sapiens, GI189095269, Length=441, Percent_Identity=51.2471655328798, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI295821183, Length=441, Percent_Identity=51.2471655328798, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI65506442, Length=441, Percent_Identity=51.2471655328798, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI116805327, Length=445, Percent_Identity=46.9662921348315, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=47.2035794183445, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=47.2035794183445, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=47.2035794183445, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI38679971, Length=509, Percent_Identity=32.4165029469548, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=32.4165029469548, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=32.4165029469548, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=32.4165029469548, Blast_Score=259, Evalue=5e-69,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=32.4165029469548, Blast_Score=259, Evalue=5e-69,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=31.9607843137255, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI18105007, Length=191, Percent_Identity=25.6544502617801, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=56.0810810810811, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1786216, Length=247, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17567343, Length=441, Percent_Identity=46.2585034013605, Blast_Score=413, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71987519, Length=445, Percent_Identity=46.5168539325843, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17562816, Length=451, Percent_Identity=44.1241685144124, Blast_Score=390, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71997168, Length=505, Percent_Identity=31.2871287128713, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71997163, Length=505, Percent_Identity=31.2871287128713, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI133931226, Length=492, Percent_Identity=29.2682926829268, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI193204318, Length=417, Percent_Identity=23.7410071942446, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=45.6375838926174, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=44.3946188340807, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=46.0850111856823, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=32.3643410852713, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6323863, Length=491, Percent_Identity=31.3645621181263, Blast_Score=238, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24651757, Length=449, Percent_Identity=45.6570155902004, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=46.9933184855234, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=46.9933184855234, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=46.9933184855234, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=46.9933184855234, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=46.9933184855234, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=46.9933184855234, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=46.9933184855234, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=46.9933184855234, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=46.9933184855234, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=46.9933184855234, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24651759, Length=411, Percent_Identity=44.5255474452555, Blast_Score=387, Evalue=1e-107,
Organism=Drosophila melanogaster, GI161076409, Length=504, Percent_Identity=33.7301587301587, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24586458, Length=504, Percent_Identity=33.7301587301587, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI161076407, Length=504, Percent_Identity=33.7301587301587, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24586460, Length=504, Percent_Identity=33.7301587301587, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI45555749, Length=331, Percent_Identity=21.4501510574018, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24642586, Length=331, Percent_Identity=21.4501510574018, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACCC1_BACSU (P49787)

Other databases:

- EMBL:   U36245
- EMBL:   D84432
- EMBL:   AL009126
- PIR:   A69581
- RefSeq:   NP_390314.2
- ProteinModelPortal:   P49787
- SMR:   P49787
- EnsemblBacteria:   EBBACT00000003702
- GeneID:   938588
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU24340
- NMPDR:   fig|224308.1.peg.2438
- GenoList:   BSU24340
- GeneTree:   EBGT00050000001329
- HOGENOM:   HBG535236
- PhylomeDB:   P49787
- ProtClustDB:   PRK08591
- BioCyc:   BSUB:BSU24340-MONOMER
- BRENDA:   6.3.4.14
- BRENDA:   6.4.1.2
- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.20
- SMART:   SM00878
- TIGRFAMs:   TIGR00514

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2; SSF52440 PreATP-grasp-like; SSF51246 Rudmnt_hyb_motif

EC number: =6.3.4.14; =6.4.1.2

Molecular weight: Translated: 49453; Mature: 49453

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS50975 ATP_GRASP; PS50979 BC; PS00866 CPSASE_1; PS00867 CPSASE_2

Important sites: ACT_SITE 293-293 BINDING 116-116 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQMADEAFCIGPKASKDSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEECCCCCCCCC
LNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTFVGPSADAISKMGTKDVAR
EEHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHCCEEEECCCHHHHHHCCCHHHHH
ETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKATAGGGGKGIRVARTEEELING
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECHHHHHCC
IKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNYGNTIHLGERDCSIQRRLQKLLE
CEEEHHHHHHHCCCCCHHHHHHHHHHHCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEFIYDYNEQRYYFMEMNTRIQVEHPV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCEEEEECCH
TEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGWAIECRINAENPSKNFMPSPGEIKMYL
HHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEE
PPGGLGVRVDSAAYPGYSIPPYYDSMIAKVITYGKTRDEAIARMKRALSEFVIEGIETTI
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
PFHLKLLEHETFVSGEFNTKFLETYDVMGS
CEEEEEEECCEEECCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQMADEAFCIGPKASKDSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEECCCCCCCCC
LNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTFVGPSADAISKMGTKDVAR
EEHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHCCEEEECCCHHHHHHCCCHHHHH
ETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKATAGGGGKGIRVARTEEELING
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECHHHHHCC
IKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNYGNTIHLGERDCSIQRRLQKLLE
CEEEHHHHHHHCCCCCHHHHHHHHHHHCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEFIYDYNEQRYYFMEMNTRIQVEHPV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCEEEEECCH
TEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGWAIECRINAENPSKNFMPSPGEIKMYL
HHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEE
PPGGLGVRVDSAAYPGYSIPPYYDSMIAKVITYGKTRDEAIARMKRALSEFVIEGIETTI
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
PFHLKLLEHETFVSGEFNTKFLETYDVMGS
CEEEEEEECCEEECCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377