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The map label for this gene is accB

Identifier: 16079491

GI number: 16079491

Start: 2531718

End: 2532197

Strand: Reverse

Name: accB

Synonym: BSU24350

Alternate gene names: 16079491

Gene position: 2532197-2531718 (Counterclockwise)

Preceding gene: 255767544

Following gene: 255767543

Centisome position: 60.07

GC content: 44.38

Gene sequence:

>480_bases
ATGTTAAATATCAAAGAAATCCACGAGCTGATTAAAGCAATTGACGAGTCTACAATTGACGAATTCGTATATGAAAATGA
AGGTGTATCCTTAAAACTGAAAAAACACGAAGCAGGCACGGTTCAAGTCATGCAGCAGGCACCGGCAGCACCTGTACAAG
CACAGGCTCCGCAGGCAGTTCAGCCGCAAGCGCAGCAAGCAGCGGCACCTGCCCAAGAAGCACCAAAGCAAGATGAGAAT
CTGCATAAAATCACTTCACCAATGGTAGGAACATTTTATGCTTCTTCATCACCGGAAGCTGGCCCGTATGTAACAGCCGG
TTCAAAAGTAAATGAAAACACAGTTGTCTGCATTGTAGAAGCGATGAAGCTTTTCAACGAAATCGAAGCAGAAGTGAAAG
GCGAAATCGTTGAAGTATTAGTAGAAAACGGCCAGCTGGTCGAATACGGACAACCTCTATTTCTTGTAAAAGCGGAGTAA

Upstream 100 bases:

>100_bases
AGAGTTGAATTCAAAAGTCCGCTCCTGTAAGATGAACATAGTATGTACTTTTAGTAGTAACCTATAAAAAAAGAAATTTC
ATACATAGGAGTGCGATTGA

Downstream 100 bases:

>100_bases
GGAGACTGAACATGATTAAAAAGCTATTGATCGCCAACAGAGGAGAAATTGCTGTCAGAATCATCAGAGCCTGCAGAGAG
CTCGGAATTGAGACTGTCGC

Product: acetyl-CoA carboxylase biotin carboxyl carrier protein subunit

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVMQQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDEN
LHKITSPMVGTFYASSSPEAGPYVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE

Sequences:

>Translated_159_residues
MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVMQQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDEN
LHKITSPMVGTFYASSSPEAGPYVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE
>Mature_159_residues
MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVMQQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDEN
LHKITSPMVGTFYASSSPEAGPYVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain

Homologues:

Organism=Escherichia coli, GI1789653, Length=158, Percent_Identity=40.5063291139241, Blast_Score=109, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BCCP_BACSU (P49786)

Other databases:

- EMBL:   U36245
- EMBL:   D84432
- EMBL:   AL009126
- EMBL:   U35252
- PIR:   H69580
- RefSeq:   NP_390315.1
- ProteinModelPortal:   P49786
- SMR:   P49786
- EnsemblBacteria:   EBBACT00000000656
- GeneID:   938587
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU24350
- NMPDR:   fig|224308.1.peg.2439
- GenoList:   BSU24350
- GeneTree:   EBGT00050000001206
- HOGENOM:   HBG745267
- OMA:   PIMVEAS
- ProtClustDB:   PRK06302
- BioCyc:   BSUB:BSU24350-MONOMER
- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053
- PRINTS:   PR01071
- TIGRFAMs:   TIGR00531

Pfam domain/function: PF00364 Biotin_lipoyl; SSF51230 Hybrid_motif

EC number: NA

Molecular weight: Translated: 17229; Mature: 17229

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: PS00188 BIOTIN; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVMQQAPAAPVQAQAPQAV
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCCC
QPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGPYVTAGSKVNENTVVCIVE
CCCHHHHCCCHHHCCCCCCHHHHHHCCHHEEEECCCCCCCCCEEEECCCCCCCCEEHHHH
AMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECC
>Mature Secondary Structure
MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVMQQAPAAPVQAQAPQAV
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCCC
QPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGPYVTAGSKVNENTVVCIVE
CCCHHHHCCCHHHCCCCCCHHHHHHCCHHEEEECCCCCCCCCEEEECCCCCCCCEEHHHH
AMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377