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The map label for this gene is gltC

Identifier: 255767435

GI number: 255767435

Start: 2014779

End: 2015681

Strand: Direct

Name: gltC

Synonym: BSU18460

Alternate gene names: 255767435

Gene position: 2014779-2015681 (Clockwise)

Preceding gene: 16078904

Following gene: 16078912

Centisome position: 47.79

GC content: 42.75

Gene sequence:

>903_bases
ATGGAGCTGCGCCAACTGCGTTATTTTATGGAGGTGGCTGAAAGAGAACACGTTTCAGAAGCCGCTGATCATTTGCATGT
GGCCCAATCAGCAATCAGCAGACAAATTGCCAATCTTGAAGAAGAATTAAATGTGACCTTATTTGAGCGTGAAGGGAGAA
ATATCAAACTCACGCCAATCGGAAAAGAATTTTTAATTCATGTGAAAACGGCGATGAAAGCCATTGATTATGCGAAAGAG
CAAATTGATGAGTATCTTGACCCGCATCGCGGAACGGTAAAGATCGGCTTTCCTACAAGCCTCGCCAGCCAGCTTTTGCC
GACTGTCATTTCAGCGTTTAAAGAAGAATATCCGCACGTCGAATTTTTGCTGCGCCAAGGCTCCTATAAGTTTCTGATTG
AAGCTGTCAGAAACCGCGATATTGATCTGGCCTTATTAGGGCCGGTGCCGACGAATTTCTCTGACATAACGGGAAAAATA
TTATTTACTGAAAAAATTTACGCGCTTGTTCCATTAAATCATCCGCTTGCTAAACAAAAAACGGTTCATTTAATCGATTT
GCGCAACGACCAATTTGTATTGTTCCCGGAAGGATTTGTACTTAGAGAGATGGCAATCGATACTTGCAAACAAGCAGGCT
TTGCTCCTCTCGTTTCCACGGAGGGTGAGGATTTGGATGCGATCAAAGGGTTAGTGTCCGCAGGAATGGGCGTTACCCTT
CTGCCTGAAAGTACTTTTGCTGAAACAACACCTCGTTTTACTGTGAAAATTCCAATTGAGTTCCCTCAAGTAAAACGGAC
TGTCGGAATCATTAAACCGAAAAATAGAGAGCTTGCGCCTTCCGCGAATGATTTTTATGAGTTTGTCATTCAATTTTTCT
CTAAGCTGGAGCAGTATCAATAA

Upstream 100 bases:

>100_bases
TAACAACTCTATAATCATTGTAGGTTTTCAAAACGATATAAACAATATATAATTTAGATCAAAAGAATCTCAAAATGAGA
TAGATGGATGTGAGACAAAC

Downstream 100 bases:

>100_bases
AAAAAATGAACCCGAGCTTCTATATAGAAGCTTCGGGTTTTTTTCTGCAAATTAATTTACAGGTAAAGAAAAATCCACAT
GGCAAACAAATGCTTCTTGA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELNVTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKE
QIDEYLDPHRGTVKIGFPTSLASQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI
LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLVSTEGEDLDAIKGLVSAGMGVTL
LPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNRELAPSANDFYEFVIQFFSKLEQYQ

Sequences:

>Translated_300_residues
MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELNVTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKE
QIDEYLDPHRGTVKIGFPTSLASQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI
LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLVSTEGEDLDAIKGLVSAGMGVTL
LPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNRELAPSANDFYEFVIQFFSKLEQYQ
>Mature_300_residues
MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELNVTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKE
QIDEYLDPHRGTVKIGFPTSLASQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI
LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLVSTEGEDLDAIKGLVSAGMGVTL
LPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNRELAPSANDFYEFVIQFFSKLEQYQ

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1790399, Length=272, Percent_Identity=28.3088235294118, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787879, Length=288, Percent_Identity=29.5138888888889, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI157672245, Length=287, Percent_Identity=28.5714285714286, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787530, Length=243, Percent_Identity=30.0411522633745, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI145693105, Length=299, Percent_Identity=28.7625418060201, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1790208, Length=252, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI2367136, Length=247, Percent_Identity=27.9352226720648, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788297, Length=313, Percent_Identity=26.1980830670927, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1788748, Length=293, Percent_Identity=22.8668941979522, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788296, Length=243, Percent_Identity=26.3374485596708, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788887, Length=302, Percent_Identity=27.4834437086093, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787806, Length=253, Percent_Identity=26.4822134387352, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787601, Length=248, Percent_Identity=26.2096774193548, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788481, Length=289, Percent_Identity=23.5294117647059, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081904, Length=205, Percent_Identity=27.3170731707317, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790262, Length=242, Percent_Identity=23.1404958677686, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI48994962, Length=176, Percent_Identity=26.7045454545455, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788626, Length=242, Percent_Identity=25.6198347107438, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI87082132, Length=248, Percent_Identity=25, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786401, Length=151, Percent_Identity=31.1258278145695, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787949, Length=170, Percent_Identity=27.6470588235294, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789204, Length=299, Percent_Identity=23.4113712374582, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLTC_BACSU (P20668)

Other databases:

- EMBL:   M28509
- EMBL:   AL009126
- EMBL:   AF006720
- PIR:   A69635
- RefSeq:   NP_389728.2
- ProteinModelPortal:   P20668
- SMR:   P20668
- IntAct:   P20668
- EnsemblBacteria:   EBBACT00000001217
- GeneID:   940104
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU18460
- NMPDR:   fig|224308.1.peg.1850
- GenoList:   BSU18460
- GeneTree:   EBGT00070000031895
- HOGENOM:   HBG685425
- ProtClustDB:   CLSK873227
- BioCyc:   BSUB:BSU18460-MONOMER
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00039

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate

EC number: NA

Molecular weight: Translated: 34048; Mature: 34048

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELNVTLFEREGRNIKLTPI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEC
GKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLASQLLPTVISAFKEEYPHV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHH
EFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKILFTEKIYALVPLNHPLAKQK
HHHHHCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHCEEEEEEEEEEEEEECCCCCCCCC
TVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLVSTEGEDLDAIKGLVSAGMGVTL
EEEEEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHCCCCEEE
LPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNRELAPSANDFYEFVIQFFSKLEQYQ
CCCCHHHCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELNVTLFEREGRNIKLTPI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEC
GKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLASQLLPTVISAFKEEYPHV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHH
EFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKILFTEKIYALVPLNHPLAKQK
HHHHHCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHCEEEEEEEEEEEEEECCCCCCCCC
TVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLVSTEGEDLDAIKGLVSAGMGVTL
EEEEEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHCCCCEEE
LPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNRELAPSANDFYEFVIQFFSKLEQYQ
CCCCHHHCCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377