BacMap

Definition	Bacillus subtilis subsp. subtilis str. 168 chromosome, complete genome.
Accession	NC_000964
Length	4,215,606

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The map label for this gene is fabG

Identifier: 255767385

GI number: 255767385

Start: 1759655

End: 1760383

Strand: Direct

Name: fabG

Synonym: BSU16870

Alternate gene names: 255767385

Gene position: 1759655-1760383 (Clockwise)

Preceding gene: 255767384

Following gene: 16078751

Centisome position: 41.74

GC content: 49.11

Gene sequence:

>729_bases
ATGAACAAAACAGCACTAATCACCGGAGCAAGCGGCGGCATTGGCAAAAGCATCAGCGAAACCCTTGCAGCTAGAGGATA
CAATCTGCTGCTGCATTACAATACAAATCAAAACGCGGCAGCGGAGCTTGCTGAAAAACTAAGTCAGATGTTTGGCGTAA
ATGCGGAGATATTACAAGCTGACCTGTCCGCGCAAGATGGAGCAGATAAGCTGACAAGTTCAATTGTTCAGCCGATTGAT
GCGATTGTTTTAAACAGCGGACGAAGCCATTTTGGGCTGATTACGGATGTAGATAACGCAACGGTCCAGGAAATGGTTCA
GCTTCATGTGGCGAGTCCGTATATGCTGACGAGAAACCTTCTGCCAGGCATGATTCGGAATAAATCGGGAGCGATTGTGG
CTGTCAGCTCGATTTGGGGAGAGACTGGAGCATCCTGTGAAGTGTTGTACAGCATGGCAAAAGGAGCTCAGCATTCATTT
GTAAAAGGATTGGCTAAGGAGCTGGCGCCAAGCGGAATCAGAGTAAACGCCGTAGCGCCGGGTGCAGTTGATACAAATAT
GATGAATCAATTTACCCCGGCTGAAAAAGAAGAGATCGCTGATGAGATTCCGATCGGCCGGCTGGCCCGGCCGCAAGAAA
TTGCGGATGCAACAGCTTTTCTCCTGTCTGAAAAAGCGTCATATATCACCGGCCAAATTCTGTCGGTGAATGGCGGCTGG
CACTGCTGA

Upstream 100 bases:

>100_bases
CGCTGCAGACAGACTGACTGTCTGCAAGGTTGTTCCTAAATCATAAACAAAACATCCCTCCAGTGTGAGGGGTGTTTTTC
TGCGGAAAGAAGGAAAGAGG

Downstream 100 bases:

>100_bases
TCCGAAAATATTCGGTGTATAGTTTCTTTTGCGAAGGACACAATAATCTTGTAACTTCACATGAAATGGAGGAAACAAGC
ATGTCAGTATTAGAAAACTG

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELAEKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPID
AIVLNSGRSHFGLITDVDNATVQEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF
VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADATAFLLSEKASYITGQILSVNGGW
HC

Sequences:

>Translated_242_residues
MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELAEKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPID
AIVLNSGRSHFGLITDVDNATVQEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF
VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADATAFLLSEKASYITGQILSVNGGW
HC
>Mature_242_residues
MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELAEKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPID
AIVLNSGRSHFGLITDVDNATVQEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF
VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADATAFLLSEKASYITGQILSVNGGW
HC

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

Homologues:

Organism=Homo sapiens, GI32483357, Length=244, Percent_Identity=32.7868852459016, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=29.1666666666667, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI15277342, Length=246, Percent_Identity=27.6422764227642, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=29.7959183673469, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI66933014, Length=203, Percent_Identity=27.5862068965517, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI5031737, Length=243, Percent_Identity=28.8065843621399, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI20149619, Length=194, Percent_Identity=29.8969072164948, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI19923817, Length=247, Percent_Identity=25.9109311740891, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI59889578, Length=197, Percent_Identity=29.4416243654822, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI7705855, Length=195, Percent_Identity=27.6923076923077, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI126723750, Length=247, Percent_Identity=25.9109311740891, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI226371731, Length=194, Percent_Identity=26.8041237113402, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI7706318, Length=193, Percent_Identity=30.5699481865285, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI33667109, Length=190, Percent_Identity=30, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4503301, Length=204, Percent_Identity=27.4509803921569, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI10190704, Length=261, Percent_Identity=26.0536398467433, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI210032110, Length=187, Percent_Identity=25.668449197861, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI7657478, Length=191, Percent_Identity=27.7486910994764, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=33.8842975206612, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI87082100, Length=248, Percent_Identity=35.8870967741936, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=35.0806451612903, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI87082160, Length=244, Percent_Identity=27.8688524590164, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787905, Length=241, Percent_Identity=32.3651452282158, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1788459, Length=244, Percent_Identity=30.7377049180328, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1789378, Length=246, Percent_Identity=27.6422764227642, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1790717, Length=243, Percent_Identity=27.5720164609054, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI2367365, Length=240, Percent_Identity=26.25, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1786812, Length=173, Percent_Identity=31.7919075144509, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=27.027027027027, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789208, Length=244, Percent_Identity=27.0491803278689, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1786701, Length=236, Percent_Identity=25, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787891, Length=248, Percent_Identity=24.5967741935484, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=35.3413654618474, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=34.6774193548387, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17560676, Length=246, Percent_Identity=29.2682926829268, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=29.7959183673469, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=31.1740890688259, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562908, Length=273, Percent_Identity=31.8681318681319, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=266, Percent_Identity=31.5789473684211, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562910, Length=258, Percent_Identity=31.3953488372093, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17561402, Length=247, Percent_Identity=29.1497975708502, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=29.9595141700405, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=30.9160305343511, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=31.9548872180451, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17536651, Length=255, Percent_Identity=27.4509803921569, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560332, Length=264, Percent_Identity=30.6818181818182, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=31.1787072243346, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17538480, Length=259, Percent_Identity=30.1158301158301, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=271, Percent_Identity=29.520295202952, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=260, Percent_Identity=29.6153846153846, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=266, Percent_Identity=30.0751879699248, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=29.6992481203008, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=260, Percent_Identity=29.6153846153846, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17508651, Length=247, Percent_Identity=25.5060728744939, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=248, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=266, Percent_Identity=29.6992481203008, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=254, Percent_Identity=27.5590551181102, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=27.1317829457364, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561272, Length=121, Percent_Identity=32.2314049586777, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=241, Percent_Identity=26.5560165975104, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=28.6259541984733, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=241, Percent_Identity=26.5560165975104, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=264, Percent_Identity=25.7575757575758, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=193, Percent_Identity=27.4611398963731, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=248, Percent_Identity=26.6129032258064, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323882, Length=245, Percent_Identity=28.9795918367347, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320089, Length=213, Percent_Identity=25.8215962441315, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI23397609, Length=247, Percent_Identity=34.8178137651822, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21355319, Length=243, Percent_Identity=31.6872427983539, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=29.8387096774194, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24643142, Length=244, Percent_Identity=32.7868852459016, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21357041, Length=249, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24644339, Length=252, Percent_Identity=29.7619047619048, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24644337, Length=178, Percent_Identity=36.5168539325843, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24640442, Length=197, Percent_Identity=28.4263959390863, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24584748, Length=249, Percent_Identity=28.5140562248996, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161076933, Length=249, Percent_Identity=28.5140562248996, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24584744, Length=247, Percent_Identity=27.9352226720648, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28574402, Length=247, Percent_Identity=27.9352226720648, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24649181, Length=190, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21358495, Length=203, Percent_Identity=26.6009852216749, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YMFI_BACSU (O31767)

Other databases:

- EMBL:   AL009126
- RefSeq:   NP_389569.2
- HSSP:   P50162
- ProteinModelPortal:   O31767
- SMR:   O31767
- EnsemblBacteria:   EBBACT00000003253
- GeneID:   939588
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU16870
- NMPDR:   fig|224308.1.peg.1690
- GenoList:   BSU16870
- GeneTree:   EBGT00070000031724
- HOGENOM:   HBG750976
- ProtClustDB:   PRK05565
- BioCyc:   BSUB:BSU16870-MONOMER
- GO:   GO:0005488
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR19410
- PRINTS:   PR00081
- PRINTS:   PR00080

Pfam domain/function: PF00106 adh_short

EC number: 1.1.1.100

Molecular weight: Translated: 25541; Mature: 25541

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00061 ADH_SHORT

Important sites: ACT_SITE 150-150 BINDING 137-137

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELAEKLSQMFGVNAEILQA
CCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHH
DLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATVQEMVQLHVASPYMLTRNL
HCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHH
LPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSFVKGLAKELAPSGIRVNAVAP
HHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECC
GAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADATAFLLSEKASYITGQILSVNGGW
CCCCHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCCC
HC
CC
>Mature Secondary Structure
MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELAEKLSQMFGVNAEILQA
CCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHH
DLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATVQEMVQLHVASPYMLTRNL
HCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHH
LPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSFVKGLAKELAPSGIRVNAVAP
HHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECC
GAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADATAFLLSEKASYITGQILSVNGGW
CCCCHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEECCCC
HC
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377