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The map label for this gene is ctaO

Identifier: 255767274

GI number: 255767274

Start: 1279514

End: 1280503

Strand: Reverse

Name: ctaO

Synonym: BSU12080

Alternate gene names: 255767274

Gene position: 1280503-1279514 (Counterclockwise)

Preceding gene: 16078274

Following gene: 16078272

Centisome position: 30.38

GC content: 45.56

Gene sequence:

>990_bases
ATGCAGTTTTGGGGGAGGCGTCTATTTTTGGAGAATACAAGAGATTCTGCAGCCATATCTGAAACAAAATACATAAAAGC
TTCGAACCGGGTAACCATTTACGATTTTATCAAACTTGCAAAGCCGGGCATTATCATATCAAACTCGATAGCAGCCTTCG
GCGGGTTTTGGATCGCGTTTGCAAGCGCAGAAAAAACGTTAACCGGCTTGGCTTTTTTGATGACAATGGTAACAGCAATG
TTGGGAACCGCGTTTGTGATGGCTTCCGGCACTGTCTATAACAACTATTTTGATCGGCATATGGACGCAAAAATGGCACG
AACTCGCAGCAGGGCCTCGGTCACAGGGAAAATGCCGCCAGCCATGATCTTAACATATGGCTCTGTTTTAGGAATCGCAG
GTCTTGCCATGCTTTATTCCCTCAATCCATTAACGGCCTTTCTCGGACTGGCCGCCTTTATTTTTTATGCGATCATCTAT
ACGGTATGGGTGAAACGAACGTCTGTGTGGAGCACATTTGTCGGGAGCTTCCCAGGAGCTGCGCCGCCATTGATGGGGTA
TTGTGCCGTAACCGGTGACTTCAGTATGACAGCAGTGCTGTTGTACACGATTATGTTTCTGTGGCAGCCGCCGCATTTTT
GGGCGATTGGGATAAGACGCAAAGAGGAATATCGCGCTGCTGGCGTTCCGCTCTTGCCAGTAGTCAAAGGCAATCATGTA
ACAAAAATAAAAATGATGCAATATATTGCCGTCCTGGTGCCGGTCACGCTATTATTTCCTTTCTCTCTCGGCACCGGCCA
TATAAGCCCATTTTATTTCTTAGCCGCCTTGGTTCTCGGAGGCATATGGATCAAAAAAAGCATCAAAGGATTCAAAACAG
ACGATGACGTGAAGTGGGCAAAGGATATGTTTGTCTACTCGCTTATTTATTTTTGCTTGCTGTTCTTCATCATGATGATC
GATTCATTTATGATGTTTCTGATCAGATGA

Upstream 100 bases:

>100_bases
CAGTCCAGCTCCCCATTTTTTTGTTTTAAAAATGACAATATCATGACAAATATGGGAAATAATTGTGATTCTGTCCCCCT
CTTGTTACGATAACAAAAGC

Downstream 100 bases:

>100_bases
TGCAAAAAGAGCCACACATTAATGTGACTCTTTTTTGTTTGGAAAAACAGCATCTAATAGAAATGTCATGGCAAAAAACA
CAACCATGCAAATCAAAAAT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase 1; Heme O synthase 1 [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGIIISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAM
LGTAFVMASGTVYNNYFDRHMDAKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY
TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGIRRKEEYRAAGVPLLPVVKGNHV
TKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAALVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMI
DSFMMFLIR

Sequences:

>Translated_329_residues
MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGIIISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAM
LGTAFVMASGTVYNNYFDRHMDAKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY
TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGIRRKEEYRAAGVPLLPVVKGNHV
TKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAALVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMI
DSFMMFLIR
>Mature_329_residues
MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGIIISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAM
LGTAFVMASGTVYNNYFDRHMDAKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY
TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGIRRKEEYRAAGVPLLPVVKGNHV
TKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAALVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMI
DSFMMFLIR

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=235, Percent_Identity=30.2127659574468, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1786631, Length=288, Percent_Identity=40.9722222222222, Blast_Score=212, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71998235, Length=234, Percent_Identity=29.9145299145299, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6325085, Length=219, Percent_Identity=27.3972602739726, Blast_Score=89, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19921064, Length=291, Percent_Identity=29.8969072164948, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 36842; Mature: 36842

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGIIISNSIAAFGGFWIAF
CCCCCCCCEEECCCCCHHHHHHHEEECCCCEEHHHHHHHCCCCEEEECCHHHHHHHHHHH
ASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMDAKMARTRSRASVTGKMPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
AMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIYTVWVKRTSVWSTFVGSFPGA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
APPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGIRRKEEYRAAGVPLLPVVKGNHV
CCCHHHHEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCEEEEECCCCC
TKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAALVLGGIWIKKSIKGFKTDDDVKWA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
KDMFVYSLIYFCLLFFIMMIDSFMMFLIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGIIISNSIAAFGGFWIAF
CCCCCCCCEEECCCCCHHHHHHHEEECCCCEEHHHHHHHCCCCEEEECCHHHHHHHHHHH
ASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMDAKMARTRSRASVTGKMPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
AMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIYTVWVKRTSVWSTFVGSFPGA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
APPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGIRRKEEYRAAGVPLLPVVKGNHV
CCCHHHHEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCEEEEECCCCC
TKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAALVLGGIWIKKSIKGFKTDDDVKWA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
KDMFVYSLIYFCLLFFIMMIDSFMMFLIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 10675592 [H]