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The map label for this gene is argD

Identifier: 255767253

GI number: 255767253

Start: 1198099

End: 1199256

Strand: Direct

Name: argD

Synonym: BSU11220

Alternate gene names: 255767253

Gene position: 1198099-1199256 (Clockwise)

Preceding gene: 16078186

Following gene: 255767254

Centisome position: 28.42

GC content: 49.57

Gene sequence:

>1158_bases
ATGAGCAGCTTGTTTCAAACCTACGGCCGTTGGGATATTGACATCAAAAAAGCAAAGGGAACGTACGTTGAGGATCAAAA
CGGCAAAACGTACCTTGATTTCATTCAGGGGATTGCGGTATCAAATCTAGGACACTGCCATGAAGCGGTGACAGAGGCAG
TCAAAAAACAGCTTGACAGCGTATGGCACGTATCCAACCTGTTTCAAAACAGTCTCCAAGAGCAAGCGGCGCAGAAGCTG
GCAGCGCATAGTGCGGGAGATCTTGTCTTTTTCTGCAACAGCGGCGCGGAGGCGAATGAAGGTGCGATAAAGCTTGCCAG
AAAAGCAACTGGAAAAACAAAAATCATCACTTTTCTTCAGTCGTTCCATGGCCGCACGTATGCAGGGATGGCTGCGACCG
GACAGGATAAAATCAAAACAGGCTTCGGCCCGATGCTTGGAGGCTTTCACTACCTGCCATACAATGATCCTTCTGCTTTT
AAAGCTCTTGGGGAGGAAGGCGATATTGCCGCGGTGATGCTTGAAACAGTGCAGGGAGAAGGAGGAGTCAATCCGGCGAG
TGCTGAATTTTTATCAGCCGTACAGTCGTTTTGCAAGGAAAAGCAAGCCCTTCTCATTATTGATGAAATCCAGACCGGCA
TCGGACGGACGGGAAAAGGCTTCGCATATGAGCACTTCGGACTCTCACCGGATATCATCACAGTCGCCAAAGGATTGGGA
AACGGCTTTCCGGTCGGCGCTGTCATCGGAAAGAAACAGCTTGGAGAAGCGTTTACCCCTGGTTCTCACGGAACGACTTT
CGGAGGAAACATGCTGGCGATGGCTGCTGTGAATGCCACATTGCAAATTGTATTCCAGCCTGACTTTTTGCAAGAGGCTG
CTGACAAAGGGGCGTTTTTAAAAGAACAGCTTGAGGCAGAGCTAAAGAGCCCTTTTGTTAAACAAATCCGAGGTAAAGGA
TTAATGCTTGGAATTGAGTGTGATGGCCCGGTTGCTGACATTATTGCTGAATTGCAGACATTAGGCTTGCTTGTATTGCC
GGCCGGCCCGAACGTGATTCGGCTGCTGCCGCCGCTCACCGTGACTAAGGATGAAATAGCAGAAGCCGTCAGCAAGCTGA
AACAGGCAATCGCTCATCATTCCGCTGTAAACCAGTGA

Upstream 100 bases:

>100_bases
ATCAGGTGTCTGAAGTCATGATCGTAAACGGTAAAGGATCATTCTTCGCAGAACAAACCTTTCAAGGGACAAAAATTGTC
AAAGCAAAGGAGGCTGTTTC

Downstream 100 bases:

>100_bases
TTTTTTTTCGATATAAAGGCATAAAAATTCATTTTTATAATTAATTATTCATCAAGAGGTGGGCTGTTAGATGGAAGGTT
ATTTAGTGTTAGAAGATGGG

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLGHCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKL
AAHSAGDLVFFCNSGAEANEGAIKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF
KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTGKGFAYEHFGLSPDIITVAKGLG
NGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAAVNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKG
LMLGIECDGPVADIIAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ

Sequences:

>Translated_385_residues
MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLGHCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKL
AAHSAGDLVFFCNSGAEANEGAIKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF
KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTGKGFAYEHFGLSPDIITVAKGLG
NGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAAVNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKG
LMLGIECDGPVADIIAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ
>Mature_384_residues
SSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLGHCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLA
AHSAGDLVFFCNSGAEANEGAIKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAFK
ALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTGKGFAYEHFGLSPDIITVAKGLGN
GFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAAVNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGL
MLGIECDGPVADIIAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=386, Percent_Identity=33.6787564766839, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI284507298, Length=299, Percent_Identity=36.1204013377926, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI13994255, Length=436, Percent_Identity=29.8165137614679, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI37574042, Length=407, Percent_Identity=28.992628992629, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI24119277, Length=403, Percent_Identity=28.287841191067, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI226442705, Length=407, Percent_Identity=28.009828009828, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI226442709, Length=377, Percent_Identity=28.1167108753316, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI188536080, Length=417, Percent_Identity=23.9808153477218, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI38679950, Length=417, Percent_Identity=23.9808153477218, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI38679946, Length=417, Percent_Identity=23.9808153477218, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1789759, Length=373, Percent_Identity=41.2868632707775, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI1788044, Length=374, Percent_Identity=39.3048128342246, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1789016, Length=394, Percent_Identity=35.5329949238579, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI145693181, Length=375, Percent_Identity=36.5333333333333, Blast_Score=207, Evalue=9e-55,
Organism=Escherichia coli, GI1787560, Length=398, Percent_Identity=36.1809045226131, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1786991, Length=403, Percent_Identity=30.0248138957816, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786349, Length=297, Percent_Identity=32.996632996633, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI25144271, Length=390, Percent_Identity=31.025641025641, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI32564660, Length=428, Percent_Identity=29.6728971962617, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI25144274, Length=382, Percent_Identity=28.5340314136126, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71992977, Length=413, Percent_Identity=29.7820823244552, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI71981843, Length=152, Percent_Identity=30.2631578947368, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17541228, Length=433, Percent_Identity=22.6327944572748, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71992985, Length=109, Percent_Identity=35.7798165137615, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324432, Length=393, Percent_Identity=37.9134860050891, Blast_Score=246, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6323470, Length=401, Percent_Identity=33.9152119700748, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6324386, Length=333, Percent_Identity=26.7267267267267, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321456, Length=429, Percent_Identity=26.3403263403263, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21357415, Length=383, Percent_Identity=30.5483028720627, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI161085790, Length=414, Percent_Identity=28.9855072463768, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI28574759, Length=411, Percent_Identity=29.683698296837, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI21356575, Length=418, Percent_Identity=29.4258373205742, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI281366494, Length=300, Percent_Identity=29, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667139, Length=300, Percent_Identity=29, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667143, Length=300, Percent_Identity=29, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ARGD_BACSU (P36839)

Other databases:

- EMBL:   Z26919
- EMBL:   AL009126
- PIR:   I40375
- RefSeq:   NP_389004.2
- ProteinModelPortal:   P36839
- SMR:   P36839
- EnsemblBacteria:   EBBACT00000001711
- GeneID:   939357
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU11220
- NMPDR:   fig|224308.1.peg.1123
- GenoList:   BSU11220
- GeneTree:   EBGT00070000031861
- HOGENOM:   HBG725944
- ProtClustDB:   PRK02936
- BioCyc:   BSUB:BSU11220-MONOMER
- BRENDA:   2.6.1.11
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 40978; Mature: 40847

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 122-122 BINDING 125-125 BINDING 265-265 BINDING 266-266

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLGHCHEAVTEAVKKQLDS
CCCHHHHHCCCCEEEEECCCCEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGAIKLARKATGKTKIITFLQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHH
SFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAFKALGEEGDIAAVMLETVQGE
HHCCCEEECCCCCCCHHHHCCCCHHHCCEEECCCCCCHHHHHCCCCCCCHHHHHHHHCCC
GGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTGKGFAYEHFGLSPDIITVAKGLG
CCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCCCEECCCCCCCCHHHHHHHCC
NGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAAVNATLQIVFQPDFLQEAADKGAFL
CCCCHHHHHCHHHHCCCCCCCCCCCCCCCCHHHHHHHCEEEEEEECCHHHHHHHHCCHHH
KEQLEAELKSPFVKQIRGKGLMLGIECDGPVADIIAELQTLGLLVLPAGPNVIRLLPPLT
HHHHHHHHHCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCEEEECCCCCEEEECCCCC
VTKDEIAEAVSKLKQAIAHHSAVNQ
CCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLGHCHEAVTEAVKKQLDS
CCHHHHHCCCCEEEEECCCCEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGAIKLARKATGKTKIITFLQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHH
SFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAFKALGEEGDIAAVMLETVQGE
HHCCCEEECCCCCCCHHHHCCCCHHHCCEEECCCCCCHHHHHCCCCCCCHHHHHHHHCCC
GGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTGKGFAYEHFGLSPDIITVAKGLG
CCCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCCCCEECCCCCCCCHHHHHHHCC
NGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAAVNATLQIVFQPDFLQEAADKGAFL
CCCCHHHHHCHHHHCCCCCCCCCCCCCCCCHHHHHHHCEEEEEEECCHHHHHHHHCCHHH
KEQLEAELKSPFVKQIRGKGLMLGIECDGPVADIIAELQTLGLLVLPAGPNVIRLLPPLT
HHHHHHHHHCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCEEEECCCCCEEEECCCCC
VTKDEIAEAVSKLKQAIAHHSAVNQ
CCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8025667; 9384377