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The map label for this gene is yhaU

Identifier: 255767226

GI number: 255767226

Start: 1059203

End: 1060420

Strand: Reverse

Name: yhaU

Synonym: BSU09850

Alternate gene names: 255767226

Gene position: 1060420-1059203 (Counterclockwise)

Preceding gene: 16078050

Following gene: 16078046

Centisome position: 25.15

GC content: 46.55

Gene sequence:

>1218_bases
ATGGACCATCTTGTATTTGAAGTCGGAACTGCACTTGTGCTTGTGGCAATCGCCAGTGTGATCGCCAATAAAATTAAATT
TTCGATTATTCCGTTTCTGATTGTGCTGGGAATGCTTGTTGGACCGCACGCGCCGAAAATGGGGATTATTGATCTAACAT
TTATTCAAAGCAGTGAAATCATCGAGTTTTTCGGGCGAATGGGCGTACTGTTCCTCCTCTTCTATCTCGGACTCGAATTC
TCTGTCGGGAAGTTAATCAAATCAGGAAAATCAATCGCGGTCGGCGGGACGATTTATATTTTGATTAACTTCAGCCTCGG
ACTGCTTTACGGGTTTATCACCGGATTTTCCTTTCTGGAAGTCCTCATCCTCGCAGGCGTCATCACAATCTCGTCAAGTG
CGATTGTCGCAAAAGTGCTCGTTGATTTAAAAAGAACCGCCAACCCGGAAACCGAATTGATTCTCGGCATCATCATGTTT
GAAGATATTTTCCTTGCCGTATATCTGTCCGTTGTTTCCGGCCTTATACTAGGTGATGCGACATCCGTAGGGAGTGCACT
CTTGTCCATTTTGATCGCCTTCGGTTATATGCTGCTGTTTTTTATCGCAGCAAGAAAACTCCCGCCGCTGTTGAACAAAC
TGTTGGACATTCGCTCAAACGAAGTGTTTATTATCGTCATTTTCGCAGCACTCTTTTTTATCGCCGGTTTTTCAGAGACG
ATTCATGTAGCAGAAGCAATCGGCGCGCTGCTGCTCGGTTTGGTCTTTTCAGAAACAGAGCATTCCGATAGGATTGAACA
CCTCGTTGTTCCGTTTCGCGACTTCTTCGGTGCGATGTTCTTTTTCAGCTTCGGCCTCAGCATCGATCCGTTTTCGCTTG
GTGAAGCGGTTTGGCTTGCGTTGGGTGCAGTGATTTTGACCATTCTGGGAAATTTTATCGCCGGAATGGTGGCAGGACGA
CGCGCAGGGCTTTCTCATAAGGCTTCATCGAATATCGGGCTGACGATCGTATCGCGGGGAGAATTTTCGATTATCGTTGC
GAATCTCGGGATAGCCGGCGGACTGTCGGCCACATTAAAGCCGTTTGCCGCATTATATGTCCTCATTCTGGCGATTTTGG
GACCGCTTGTCACAAAGGAATCAAAACGAATTTACCGCTTGCTGAACAAGGTATTTAAATGGAAGCCTGAGGTTCAGCCC
GCAAAAAAACAGGGATAA

Upstream 100 bases:

>100_bases
GATTATTGAAGAAAATGACACCCTTGTCCTCTCAGGTGAGAGAAAGCATCTGAAGAAACTGATTCACGATTTTCTTTCTG
GAGAGGGCGTGTGAGCCCCG

Downstream 100 bases:

>100_bases
AAAAAGCAGCACTGTAATCAGTGCTGCTTTGTCGTTTTTTCAAAAATCTGCTCTAAATATTTGATTTTTTCGTCCGTGTA
GTGCTCGAAGCGCTCATTGT

Product: transporter involved in K+ efflux

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHAPKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEF
SVGKLIKSGKSIAVGGTIYILINFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF
EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIRSNEVFIIVIFAALFFIAGFSET
IHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFFGAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGR
RAGLSHKASSNIGLTIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVFKWKPEVQP
AKKQG

Sequences:

>Translated_405_residues
MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHAPKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEF
SVGKLIKSGKSIAVGGTIYILINFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF
EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIRSNEVFIIVIFAALFFIAGFSET
IHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFFGAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGR
RAGLSHKASSNIGLTIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVFKWKPEVQP
AKKQG
>Mature_405_residues
MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHAPKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEF
SVGKLIKSGKSIAVGGTIYILINFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF
EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIRSNEVFIIVIFAALFFIAGFSET
IHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFFGAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGR
RAGLSHKASSNIGLTIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVFKWKPEVQP
AKKQG

Specific function: Potassium/proton antiporter that mediates the efflux of potassium ions from the cell. Potassium antiport activity requires the presence of khtT. Has higher activity at alkaline pH. Can also mediate rubidium/proton antiport. Has no permeability for sodium

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family

Homologues:

Organism=Homo sapiens, GI157388921, Length=302, Percent_Identity=28.1456953642384, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786685, Length=354, Percent_Identity=26.5536723163842, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786232, Length=267, Percent_Identity=25.4681647940075, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YHAU_BACSU (O07536)

Other databases:

- EMBL:   Y14080
- EMBL:   AL009126
- PIR:   G69819
- RefSeq:   NP_388866.2
- EnsemblBacteria:   EBBACT00000002399
- GeneID:   939761
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU09850
- NMPDR:   fig|224308.1.peg.985
- GenoList:   BSU09850
- GeneTree:   EBGT00050000001156
- HOGENOM:   HBG457478
- ProtClustDB:   CLSK886982
- BioCyc:   BSUB:BSU09850-MONOMER
- InterPro:   IPR006153

Pfam domain/function: PF00999 Na_H_Exchanger

EC number: NA

Molecular weight: Translated: 43638; Mature: 43638

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd5295d4)-; HASH(0xdea0fcc)-; HASH(0xc9120ec)-; HASH(0xcef33ac)-; HASH(0xdc08018)-; HASH(0xd4f41e4)-; HASH(0xb30a528)-; HASH(0xd8e8b90)-; HASH(0xcb0127c)-; HASH(0xd83c450)-; HASH(0xe04e84c)-; HASH(0xda71c70)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHAPKMGIIDLTFIQSSEI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHH
IEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILINFSLGLLYGFITGFSFLE
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHHH
VLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMFEDIFLAVYLSVVSGLILGDA
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
TSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIRSNEVFIIVIFAALFFIAGFSET
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHCCHHH
IHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFFGAMFFFSFGLSIDPFSLGEAVWLA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LGAVILTILGNFIAGMVAGRRAGLSHKASSNIGLTIVSRGEFSIIVANLGIAGGLSATLK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEEEECCCCCCCHHHHH
PFAALYVLILAILGPLVTKESKRIYRLLNKVFKWKPEVQPAKKQG
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCH
>Mature Secondary Structure
MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHAPKMGIIDLTFIQSSEI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHH
IEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILINFSLGLLYGFITGFSFLE
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHHH
VLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMFEDIFLAVYLSVVSGLILGDA
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
TSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIRSNEVFIIVIFAALFFIAGFSET
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHCCHHH
IHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFFGAMFFFSFGLSIDPFSLGEAVWLA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LGAVILTILGNFIAGMVAGRRAGLSHKASSNIGLTIVSRGEFSIIVANLGIAGGLSATLK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEEEECCCCCCCHHHHH
PFAALYVLILAILGPLVTKESKRIYRLLNKVFKWKPEVQPAKKQG
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377