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The map label for this gene is pgcA

Identifier: 255767219

GI number: 255767219

Start: 1006774

End: 1008519

Strand: Direct

Name: pgcA

Synonym: BSU09310

Alternate gene names: 255767219

Gene position: 1006774-1008519 (Clockwise)

Preceding gene: 255767218

Following gene: 16077997

Centisome position: 23.88

GC content: 45.99

Gene sequence:

>1746_bases
ATGACTTGGAGAAAGAGCTATGAACGCTGGAAACAGACAGAACATTTAGATCTGGAATTAAAAGAGCGCCTTATTGAATT
AGAGGGAGATGAACAGGCCCTTGAGGACTGTTTCTATAAAGACCTTGAATTCGGTACCGGCGGAATGCGCGGGGAAATCG
GCGCCGGGACAAATCGGATGAATATTTACACTGTGCGCAAAGCATCGGCCGGGTTTGCGGCATACATCTCGAAGCAAGGT
GAGGAAGCGAAAAAACGGGGCGTTGTCATTGCTTATGATTCCCGCCATAAGTCTCCGGAGTTCGCGATGGAAGCGGCAAA
AACACTTGCGACACAAGGCATCCAAACATACGTGTTTGATGAGCTTCGCCCGACGCCAGAGCTGTCATTCGCTGTTAGAC
AGCTGAACGCTTATGGTGGAATTGTGGTAACGGCAAGCCATAACCCGCCTGAATATAACGGCTACAAAGTATACGGGGAT
GATGGCGGCCAGCTGCCTCCAAAGGAAGCGGACATCGTCATTGAGCAGGTAAACGCGATTGAAAATGAGCTGACGATCAC
AGTGGACGAAGAAAATAAGTTAAAAGAAAAAGGCTTAATCAAAATCATCGGTGAAGATATTGATAAAGTTTATACAGAAA
AACTGACGTCCATTTCTGTACATCCTGAATTATCGGAAGAAGTAGATGTAAAGGTTGTTTTCACACCGCTGCATGGAACT
GCAAATAAACCGGTCAGACGCGGTCTTGAAGCACTCGGCTACAAAAATGTAACGGTTGTCAAAGAACAGGAACTGCCGGA
TTCAAACTTCTCCACTGTTACATCGCCGAACCCGGAAGAGCATGCGGCATTCGAATATGCCATTAAGCTTGGGGAGGAGC
AGAATGCAGATATTCTCATCGCGACAGATCCTGATGCTGACCGCCTCGGCATCGCGGTGAAAAACGATCAAGGCAAATAT
ACAGTGCTGACAGGAAACCAAACCGGAGCGTTGCTGCTTCATTACCTGCTTTCTGAAAAGAAAAAACAAGGCATCCTGCC
TGATAACGGTGTTGTTCTCAAAACGATCGTCACAAGCGAAATCGGCCGTGCTGTAGCTTCTTCATTCGGCCTTGATACGA
TTGATACGCTGACAGGCTTTAAGTTTATCGGTGAAAAGATTAAGGAATACGAAGCATCAGGCCAGTATACCTTCCAATTC
GGTTATGAAGAGAGCTACGGTTATTTAATCGGGGATTTTGCCCGCGATAAGGACGCCATTCAGGCTGCGCTTTTGGCAGT
TGAAGTTTGCGCGTTCTATAAAAAACAGGGAATGTCATTGTATGAGGCGCTCATCAATCTCTTTAACGAATATGGTTTTT
ATCGTGAAGGGCTGAAATCCCTGACGCTGAAAGGCAAACAAGGAGCAGAGCAAATTGAAGCGATTCTTGCTTCCTTCAGA
CAAAATCCGCCGCAGAAAATGGCGGGCAAACAGGTTGTCACAGCAGAAGATTACGCTGTAAGCAAACGGACGCTTCTGAC
TGAAAGCAAAGAAGAAGCCATCGACTTGCCAAAATCAAATGTATTGAAATACTTCCTGGAAGACGGGTCTTGGTTCTGTC
TCCGTCCTTCTGGAACTGAGCCGAAGGTTAAATTTTATTTCGCCGTAAAAGGGTCATCTTTGGAAGACAGTGAAAAGCGA
CTTGCCGTCCTTTCTGAAGATGTAATGAAGACGGTGGATGAAATTGTTGAGTCAACAGCAAAATAA

Upstream 100 bases:

>100_bases
CTTTTTACGTGCCGAAAGGGGGAGATCTCAGGTTATCAAGTGACAGAGGCACCCGCTTCATATAAAATAATGGCATAAGC
TGATACATAGGAGGACGAAT

Downstream 100 bases:

>100_bases
TTCAAGTATGAGCTGGGTCATTGTAAATGATCCGGCTTTTTCTTTTTCTCATCCAAAAGTCTGAAAGAAAATCATCCTAC
AAGTGAAGCAATGAAATACA

Product: alpha-phosphoglucomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEFGTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQG
EEAKKRGVVIAYDSRHKSPEFAMEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD
DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSISVHPELSEEVDVKVVFTPLHGT
ANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSPNPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKY
TVLTGNQTGALLLHYLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEASGQYTFQF
GYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNEYGFYREGLKSLTLKGKQGAEQIEAILASFR
QNPPQKMAGKQVVTAEDYAVSKRTLLTESKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKR
LAVLSEDVMKTVDEIVESTAK

Sequences:

>Translated_581_residues
MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEFGTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQG
EEAKKRGVVIAYDSRHKSPEFAMEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD
DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSISVHPELSEEVDVKVVFTPLHGT
ANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSPNPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKY
TVLTGNQTGALLLHYLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEASGQYTFQF
GYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNEYGFYREGLKSLTLKGKQGAEQIEAILASFR
QNPPQKMAGKQVVTAEDYAVSKRTLLTESKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKR
LAVLSEDVMKTVDEIVESTAK
>Mature_580_residues
TWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEFGTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGE
EAKKRGVVIAYDSRHKSPEFAMEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGDD
GGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSISVHPELSEEVDVKVVFTPLHGTA
NKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSPNPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYT
VLTGNQTGALLLHYLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEASGQYTFQFG
YEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNEYGFYREGLKSLTLKGKQGAEQIEAILASFRQ
NPPQKMAGKQVVTAEDYAVSKRTLLTESKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRL
AVLSEDVMKTVDEIVESTAK

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family

Homologues:

Organism=Homo sapiens, GI63055049, Length=563, Percent_Identity=33.7477797513321, Blast_Score=295, Evalue=1e-79,
Organism=Homo sapiens, GI31377548, Length=599, Percent_Identity=30.550918196995, Blast_Score=263, Evalue=3e-70,
Organism=Escherichia coli, GI1786904, Length=531, Percent_Identity=25.6120527306968, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788361, Length=359, Percent_Identity=27.2980501392758, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71993870, Length=566, Percent_Identity=30.565371024735, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI71993878, Length=277, Percent_Identity=31.7689530685921, Blast_Score=136, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323934, Length=578, Percent_Identity=30.6228373702422, Blast_Score=226, Evalue=1e-59,
Organism=Drosophila melanogaster, GI20129809, Length=592, Percent_Identity=29.3918918918919, Blast_Score=242, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24651977, Length=481, Percent_Identity=30.7692307692308, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24653722, Length=590, Percent_Identity=27.2881355932203, Blast_Score=211, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PGCA_BACSU (P18159)

Other databases:

- EMBL:   AJ784890
- EMBL:   Y14079
- EMBL:   AL009126
- EMBL:   M34393
- PIR:   C69835
- RefSeq:   NP_388812.2
- ProteinModelPortal:   P18159
- SMR:   P18159
- EnsemblBacteria:   EBBACT00000001184
- GeneID:   936247
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU09310
- GenoList:   BSU09310
- GeneTree:   EBGT00070000032110
- HOGENOM:   HBG571743
- ProtClustDB:   CLSK872931
- BioCyc:   BSUB:BSU09310-MONOMER
- BRENDA:   5.4.2.2
- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841
- Gene3D:   G3DSA:3.40.120.10
- PRINTS:   PR00509

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV; SSF53738 A-D-PHexomutase_a/b/a-I/II/III

EC number: =5.4.2.2

Molecular weight: Translated: 64664; Mature: 64533

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00710 PGM_PMM

Important sites: ACT_SITE 146-146

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEFGTGGMRGEIGAGTNRM
CCCHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
NIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFAMEAAKTLATQGIQTYVFD
EEEEEEECCCCHHHHHHHCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHH
ELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGDDGGQLPPKEADIVIEQVNAI
HCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHC
ENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSISVHPELSEEVDVKVVFTPLHGT
CCCEEEEECCCHHHHHCCHHEEHHHHHHHHHHHHHHEEEECCCCCCCCCEEEEEEECCCC
ANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSPNPEEHAAFEYAIKLGEEQNADILI
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEE
ATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLHYLLSEKKKQGILPDNGVVLKTIVTSE
EECCCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHH
IGRAVASSFGLDTIDTLTGFKFIGEKIKEYEASGQYTFQFGYEESYGYLIGDFARDKDAI
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECHHCCHHHH
QAALLAVEVCAFYKKQGMSLYEALINLFNEYGFYREGLKSLTLKGKQGAEQIEAILASFR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
QNPPQKMAGKQVVTAEDYAVSKRTLLTESKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTE
CCCCHHHCCCEEEEECCHHHHHHHHHCCCHHHHHCCCHHHHHHHHCCCCCEEEECCCCCC
PKVKFYFAVKGSSLEDSEKRLAVLSEDVMKTVDEIVESTAK
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEFGTGGMRGEIGAGTNRM
CCHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
NIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFAMEAAKTLATQGIQTYVFD
EEEEEEECCCCHHHHHHHCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHH
ELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGDDGGQLPPKEADIVIEQVNAI
HCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHC
ENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSISVHPELSEEVDVKVVFTPLHGT
CCCEEEEECCCHHHHHCCHHEEHHHHHHHHHHHHHHEEEECCCCCCCCCEEEEEEECCCC
ANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSPNPEEHAAFEYAIKLGEEQNADILI
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEE
ATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLHYLLSEKKKQGILPDNGVVLKTIVTSE
EECCCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHH
IGRAVASSFGLDTIDTLTGFKFIGEKIKEYEASGQYTFQFGYEESYGYLIGDFARDKDAI
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECHHCCHHHH
QAALLAVEVCAFYKKQGMSLYEALINLFNEYGFYREGLKSLTLKGKQGAEQIEAILASFR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
QNPPQKMAGKQVVTAEDYAVSKRTLLTESKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTE
CCCCHHHCCCEEEEECCHHHHHHHHHCCCHHHHHCCCHHHHHHHHCCCCCEEEECCCCCC
PKVKFYFAVKGSSLEDSEKRLAVLSEDVMKTVDEIVESTAK
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799