Click here to switch to the map view.

The map label for this gene is nuoN [H]

Identifier: 239618417

GI number: 239618417

Start: 2187279

End: 2188724

Strand: Reverse

Name: nuoN [H]

Synonym: Kole_2057

Alternate gene names: 239618417

Gene position: 2188724-2187279 (Counterclockwise)

Preceding gene: 239618418

Following gene: 239618416

Centisome position: 95.07

GC content: 40.46

Gene sequence:

>1446_bases
ATGAACCCGGTTTGGTTGATTGCTGTTCCTCTTTCGTTAGCTTTCCTTGGGATATTTTCCGGTAACATATCAAGAATCCT
TTTATGGATTGCCGCAATTTCAAACAGTATCATCAGTATAAAGATTGCTACGATATCAGGCACCACAAGCTTTGTAATAG
GTGGGTGGAAACCACCTTTTGGTATAAATCTTGTGGTAGATGATGGAACAAAATTGATAGTTGTCGCGGTTAACATTATC
TTTCTACTGGCATTATTAGCAACTTCAACTGAAAAACTGAAATCATCTTTAAAGCTTTCAGTTGTCTATATGCTTTCTCT
CGCCGCTTTGAACGGGATCGTATTGACCGGTGATCTTTTTAACCTCTTTGTGTTTTTAGAGATCGCTTCCATTTCCGCCT
ACATCATCGCTGCAAGTTCACAACGCAATGAAAGCAAATTCGCAGCGTTTAAATACCTCATTATTGGTTCTGTTGGTTCC
GCTTTATATCTTCTTGGAACATCTATGCTTTACGCAACCTACGGAACTCTAAACATGGCAGACATTTCTCAACACATGAA
GACAGGCATGATACATCCCAATGTTTTAACCGTTGTCAGTCTCCTTTATCTTTTTGGACTTGGAGTGGAAGCAAAATTAT
TCCCTCTCAACGGCTGGGTTCCAGATGTGTACTCTTACGCTTCACAAAGGGCAACTACCATTCTGGCGACAGCTTTTCCG
GTTGTCATGATTTTTGCCTTCTCAAGGATCTTTGTAACTGTTATAGGTTTTGGAGAGGTTCAAAGTTTGATAATAATTCT
TGGGTTGCTCACGGTGGTAATTGGCGAAGTCATTGCATTTAGCCAGAAAAAATTAAAAAGAATGCTCGCTTATTCGAGTA
TAGCTCAGGCAGGGCTCGCACTTCTGCTGATCGGGATTGGAACTGAAAGTTCGATGACAGGCGCTTTCATGCTGTTGATA
AACAACTCGATTTCCAAATTGATCCTCTTCTCCATAGCTGGATATATAATCTCTACAATTTCCGATGACTCTTTTGAAAA
GGTAGCGGCTTTCGCAAGTAAATCCCGAATCTCAGCTTTGTTGTTCACAGCAGGAGCGCTCTCTGTAATCGGAATGCCCC
TGTTTTTTGGATTCAGAGCTAAATTGCTGATAATCGAATCGACCATAAGCTATAACCTCTGGGTACCAGTCGTTTTCCTT
GTAACCGCTTTAATAGAAGCTGTTTATTATTTTAGATGGATTTTCAACATCTATCGACCAGATACCGCCGATAGTATACA
CAAAAAATTGCCAGTAAGAACGCTGATAGCAGGTTCGATACTCGTTGTCATGATAATTATTCTAGGAATAGCTTCACAAG
GAGCTTTTGAAGTATTTGAAAAAGCTGGAACAGCCATACTCGATAGCTTATCCTATGCTTCTACGGTTCTTCTGGGAGGG
ATTTGA

Upstream 100 bases:

>100_bases
TGATTGGCGTTGGGATCACCGCTCTTGCACTTTCTTTGATCATAAAAATACACAGAACATACGGTTCTGTCGATCTGGAT
GAAATAAGGGGGAATGTCAA

Downstream 100 bases:

>100_bases
ATGAGTTTAACCGTTCTCCTGACAATTAGTTTGATATCAGCACCGATTCTATACCTTCTGGCAAAAGTAAACAAAAACTT
CGCATATACGGTTTATGCGT

Product: NADH/Ubiquinone/plastoquinone (complex I)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MNPVWLIAVPLSLAFLGIFSGNISRILLWIAAISNSIISIKIATISGTTSFVIGGWKPPFGINLVVDDGTKLIVVAVNII
FLLALLATSTEKLKSSLKLSVVYMLSLAALNGIVLTGDLFNLFVFLEIASISAYIIAASSQRNESKFAAFKYLIIGSVGS
ALYLLGTSMLYATYGTLNMADISQHMKTGMIHPNVLTVVSLLYLFGLGVEAKLFPLNGWVPDVYSYASQRATTILATAFP
VVMIFAFSRIFVTVIGFGEVQSLIIILGLLTVVIGEVIAFSQKKLKRMLAYSSIAQAGLALLLIGIGTESSMTGAFMLLI
NNSISKLILFSIAGYIISTISDDSFEKVAAFASKSRISALLFTAGALSVIGMPLFFGFRAKLLIIESTISYNLWVPVVFL
VTALIEAVYYFRWIFNIYRPDTADSIHKKLPVRTLIAGSILVVMIIILGIASQGAFEVFEKAGTAILDSLSYASTVLLGG
I

Sequences:

>Translated_481_residues
MNPVWLIAVPLSLAFLGIFSGNISRILLWIAAISNSIISIKIATISGTTSFVIGGWKPPFGINLVVDDGTKLIVVAVNII
FLLALLATSTEKLKSSLKLSVVYMLSLAALNGIVLTGDLFNLFVFLEIASISAYIIAASSQRNESKFAAFKYLIIGSVGS
ALYLLGTSMLYATYGTLNMADISQHMKTGMIHPNVLTVVSLLYLFGLGVEAKLFPLNGWVPDVYSYASQRATTILATAFP
VVMIFAFSRIFVTVIGFGEVQSLIIILGLLTVVIGEVIAFSQKKLKRMLAYSSIAQAGLALLLIGIGTESSMTGAFMLLI
NNSISKLILFSIAGYIISTISDDSFEKVAAFASKSRISALLFTAGALSVIGMPLFFGFRAKLLIIESTISYNLWVPVVFL
VTALIEAVYYFRWIFNIYRPDTADSIHKKLPVRTLIAGSILVVMIIILGIASQGAFEVFEKAGTAILDSLSYASTVLLGG
I
>Mature_481_residues
MNPVWLIAVPLSLAFLGIFSGNISRILLWIAAISNSIISIKIATISGTTSFVIGGWKPPFGINLVVDDGTKLIVVAVNII
FLLALLATSTEKLKSSLKLSVVYMLSLAALNGIVLTGDLFNLFVFLEIASISAYIIAASSQRNESKFAAFKYLIIGSVGS
ALYLLGTSMLYATYGTLNMADISQHMKTGMIHPNVLTVVSLLYLFGLGVEAKLFPLNGWVPDVYSYASQRATTILATAFP
VVMIFAFSRIFVTVIGFGEVQSLIIILGLLTVVIGEVIAFSQKKLKRMLAYSSIAQAGLALLLIGIGTESSMTGAFMLLI
NNSISKLILFSIAGYIISTISDDSFEKVAAFASKSRISALLFTAGALSVIGMPLFFGFRAKLLIIESTISYNLWVPVVFL
VTALIEAVYYFRWIFNIYRPDTADSIHKKLPVRTLIAGSILVVMIIILGIASQGAFEVFEKAGTAILDSLSYASTVLLGG
I

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=255, Percent_Identity=25.0980392156863, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788831, Length=290, Percent_Identity=27.2413793103448, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI145693160, Length=369, Percent_Identity=28.1842818428184, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788827, Length=299, Percent_Identity=24.0802675585284, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1788829, Length=355, Percent_Identity=21.6901408450704, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788613, Length=336, Percent_Identity=24.4047619047619, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI2367154, Length=289, Percent_Identity=24.2214532871972, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1788614, Length=400, Percent_Identity=24, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 51737; Mature: 51737

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPVWLIAVPLSLAFLGIFSGNISRILLWIAAISNSIISIKIATISGTTSFVIGGWKPPF
CCCEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEEECCCCEEEEECCCCCC
GINLVVDDGTKLIVVAVNIIFLLALLATSTEKLKSSLKLSVVYMLSLAALNGIVLTGDLF
CEEEEEECCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEECHHH
NLFVFLEIASISAYIIAASSQRNESKFAAFKYLIIGSVGSALYLLGTSMLYATYGTLNMA
HHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
DISQHMKTGMIHPNVLTVVSLLYLFGLGVEAKLFPLNGWVPDVYSYASQRATTILATAFP
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
VVMIFAFSRIFVTVIGFGEVQSLIIILGLLTVVIGEVIAFSQKKLKRMLAYSSIAQAGLA
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLIGIGTESSMTGAFMLLINNSISKLILFSIAGYIISTISDDSFEKVAAFASKSRISAL
EEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LFTAGALSVIGMPLFFGFRAKLLIIESTISYNLWVPVVFLVTALIEAVYYFRWIFNIYRP
HHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DTADSIHKKLPVRTLIAGSILVVMIIILGIASQGAFEVFEKAGTAILDSLSYASTVLLGG
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHHHCC
I
C
>Mature Secondary Structure
MNPVWLIAVPLSLAFLGIFSGNISRILLWIAAISNSIISIKIATISGTTSFVIGGWKPPF
CCCEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEEECCCCEEEEECCCCCC
GINLVVDDGTKLIVVAVNIIFLLALLATSTEKLKSSLKLSVVYMLSLAALNGIVLTGDLF
CEEEEEECCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEECHHH
NLFVFLEIASISAYIIAASSQRNESKFAAFKYLIIGSVGSALYLLGTSMLYATYGTLNMA
HHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
DISQHMKTGMIHPNVLTVVSLLYLFGLGVEAKLFPLNGWVPDVYSYASQRATTILATAFP
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
VVMIFAFSRIFVTVIGFGEVQSLIIILGLLTVVIGEVIAFSQKKLKRMLAYSSIAQAGLA
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLIGIGTESSMTGAFMLLINNSISKLILFSIAGYIISTISDDSFEKVAAFASKSRISAL
EEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LFTAGALSVIGMPLFFGFRAKLLIIESTISYNLWVPVVFLVTALIEAVYYFRWIFNIYRP
HHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DTADSIHKKLPVRTLIAGSILVVMIIILGIASQGAFEVFEKAGTAILDSLSYASTVLLGG
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHHHCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA