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The map label for this gene is dnaX [H]

Identifier: 239618378

GI number: 239618378

Start: 2148272

End: 2149783

Strand: Direct

Name: dnaX [H]

Synonym: Kole_2018

Alternate gene names: 239618378

Gene position: 2148272-2149783 (Clockwise)

Preceding gene: 239618377

Following gene: 239618379

Centisome position: 93.32

GC content: 39.48

Gene sequence:

>1512_bases
GTGATTTTTATGGCTGAAGTTCTTTATAGAAAATACAGACCGAAAAAGTTCGAAGAAATAGTTGGTCAGGATCAAGTAAA
GATTGTACTAAAAAAAGCGATTGAGAATCAGAGTATCGCTCATGCTTATATCTTTTTTGGTCCGAGGGGTACAGGGAAAA
CAACCACTGCGAGAATCCTTGCGAAGGCTCTCAACTGTCTTTCACATGACGATAAACCTTGTGGAAAATGTGAATCCTGC
ATTGCTGTAGACAATAATTCCCACATGGACGTTATCGAGATCGATGCGGCTTCGTATAGAGGTATCGATGAAATTCGAAA
GATCAGGGACGCAGCGTCTTATAGACCCACCATGGGACATTACAAAGTTTACATCGTGGATGAATTTCACATGCTTACAA
GGGAAGCTTTCAATGCCCTGCTCAAGACTCTGGAAGAACCGCCAGAACACATTGTGTTTATCTTGGCTACGACAAATCTT
GAGAAGGTTCCCGAAACGATTCTTTCAAGGTGTCAGGTGTTTACTTTCAAACCTCTTTCAGAGGGTCAGATAGTAGAATA
TCTTCAGAGGATCCTGAAAGAAGAAAAGAAAACATATACTGTTGAAGCGCTCAAAATCATCGCGAAAGCGGCAAAAGGTG
GTATGCGAGACGCTGTTAATCTTTTGGAACGTGCTCTTGTGTTTGGCGAGAAGATAGAAGAAGATAATGTTAAAAACATT
CTGGGAATTCTACCTGAAGAATATCTCAAAAGTTATCTTGTCGCAATTCTTAATGGAGATAGTGATGAAATCATTGCGTT
GTCTGAGAATATTGAGCGTCTTGGATATTCTCATGACTCGGTAATTCGGCAATCTATCGAGCTTACAAAAGATATGATTA
GCAGGCGCGAACTTGAATTTGAACGCGGTGTGAAACTCATAGAAAAGCTATGGGAAGTAAATAGAGAAATGAGATATTCA
GAAAACAAAAAACTCACTTTTGAGGTTCTTAGTTTAACCACCCTGGCCGCTATGAATGTCCCCTCAGTTTCTGTTGAACC
CGCTAAAGCAGTGAATGCGGTTGTAAAAGAAGAGGTTAAGAAAAGTAATGAAGAAAAAGAGGTGGAGCCCATTACGACTG
ACATAGATGTTTCGAAGAAATCTGAAAAAGTCGATAGTAAATTCAAAGAATTTTTTGAAACTATCTATGAAGAAGGACAT
GTGCTGATCTGGGTTCTCTTGAACCTTGCCACAATTAAAGAGGAAGATGATGTCTTTGCTTTATCTTTTGCTCTCAACGA
TCTTTTTGCCCGGGAACTGGCAAAAGAACATATTGAAACGATTTCCGAATTGATGAAGATGCGACTGGGAAAACCAGCGA
AGATAAACGACAATGATATTGTAGAATCGAGTGACATATTGAAAAAACTGAATCCAGATGAAAAGGCGTACGTGAAAAGA
ATTCTGACACTCTTTGAGGGTCTTGATGCAAAGGATGTAAAAATTGAAATAGAGGAGGAGGGTAATGGCTAA

Upstream 100 bases:

>100_bases
GCGGGGGAAGTTAGTTAATAATTTCACAAATAACTGGAAAGGGGAACTTTACGAAGATATCGGACAATTTCGCGGCAATT
TGGTATAATTTTGAGGGTTG

Downstream 100 bases:

>100_bases
GAAATTCAGAGGACTTGGCGGAAGAAATTTTGGTGGTTCCTCAAAAAAGGCTGGAAACATCTCTGAACTCTTAAAGCAAG
CTCAAAAAGCTCAGGAAGAG

Product: DNA polymerase III, subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MIFMAEVLYRKYRPKKFEEIVGQDQVKIVLKKAIENQSIAHAYIFFGPRGTGKTTTARILAKALNCLSHDDKPCGKCESC
IAVDNNSHMDVIEIDAASYRGIDEIRKIRDAASYRPTMGHYKVYIVDEFHMLTREAFNALLKTLEEPPEHIVFILATTNL
EKVPETILSRCQVFTFKPLSEGQIVEYLQRILKEEKKTYTVEALKIIAKAAKGGMRDAVNLLERALVFGEKIEEDNVKNI
LGILPEEYLKSYLVAILNGDSDEIIALSENIERLGYSHDSVIRQSIELTKDMISRRELEFERGVKLIEKLWEVNREMRYS
ENKKLTFEVLSLTTLAAMNVPSVSVEPAKAVNAVVKEEVKKSNEEKEVEPITTDIDVSKKSEKVDSKFKEFFETIYEEGH
VLIWVLLNLATIKEEDDVFALSFALNDLFARELAKEHIETISELMKMRLGKPAKINDNDIVESSDILKKLNPDEKAYVKR
ILTLFEGLDAKDVKIEIEEEGNG

Sequences:

>Translated_503_residues
MIFMAEVLYRKYRPKKFEEIVGQDQVKIVLKKAIENQSIAHAYIFFGPRGTGKTTTARILAKALNCLSHDDKPCGKCESC
IAVDNNSHMDVIEIDAASYRGIDEIRKIRDAASYRPTMGHYKVYIVDEFHMLTREAFNALLKTLEEPPEHIVFILATTNL
EKVPETILSRCQVFTFKPLSEGQIVEYLQRILKEEKKTYTVEALKIIAKAAKGGMRDAVNLLERALVFGEKIEEDNVKNI
LGILPEEYLKSYLVAILNGDSDEIIALSENIERLGYSHDSVIRQSIELTKDMISRRELEFERGVKLIEKLWEVNREMRYS
ENKKLTFEVLSLTTLAAMNVPSVSVEPAKAVNAVVKEEVKKSNEEKEVEPITTDIDVSKKSEKVDSKFKEFFETIYEEGH
VLIWVLLNLATIKEEDDVFALSFALNDLFARELAKEHIETISELMKMRLGKPAKINDNDIVESSDILKKLNPDEKAYVKR
ILTLFEGLDAKDVKIEIEEEGNG
>Mature_503_residues
MIFMAEVLYRKYRPKKFEEIVGQDQVKIVLKKAIENQSIAHAYIFFGPRGTGKTTTARILAKALNCLSHDDKPCGKCESC
IAVDNNSHMDVIEIDAASYRGIDEIRKIRDAASYRPTMGHYKVYIVDEFHMLTREAFNALLKTLEEPPEHIVFILATTNL
EKVPETILSRCQVFTFKPLSEGQIVEYLQRILKEEKKTYTVEALKIIAKAAKGGMRDAVNLLERALVFGEKIEEDNVKNI
LGILPEEYLKSYLVAILNGDSDEIIALSENIERLGYSHDSVIRQSIELTKDMISRRELEFERGVKLIEKLWEVNREMRYS
ENKKLTFEVLSLTTLAAMNVPSVSVEPAKAVNAVVKEEVKKSNEEKEVEPITTDIDVSKKSEKVDSKFKEFFETIYEEGH
VLIWVLLNLATIKEEDDVFALSFALNDLFARELAKEHIETISELMKMRLGKPAKINDNDIVESSDILKKLNPDEKAYVKR
ILTLFEGLDAKDVKIEIEEEGNG

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=340, Percent_Identity=27.0588235294118, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI31881687, Length=340, Percent_Identity=27.0588235294118, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI31563534, Length=295, Percent_Identity=30.1694915254237, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI6677723, Length=253, Percent_Identity=30.8300395256917, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI194306571, Length=253, Percent_Identity=30.8300395256917, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI194306567, Length=253, Percent_Identity=30.8300395256917, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI194306569, Length=173, Percent_Identity=32.9479768786127, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI28882049, Length=292, Percent_Identity=25.6849315068493, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786676, Length=355, Percent_Identity=37.7464788732394, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1787119, Length=230, Percent_Identity=27.8260869565217, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71986063, Length=284, Percent_Identity=29.9295774647887, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17554730, Length=273, Percent_Identity=28.9377289377289, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17541988, Length=309, Percent_Identity=27.831715210356, Blast_Score=102, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324039, Length=257, Percent_Identity=30.7392996108949, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322528, Length=292, Percent_Identity=27.7397260273973, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324478, Length=290, Percent_Identity=28.6206896551724, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19921076, Length=305, Percent_Identity=27.8688524590164, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17647857, Length=284, Percent_Identity=32.0422535211268, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI18859927, Length=340, Percent_Identity=25, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 57390; Mature: 57390

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFMAEVLYRKYRPKKFEEIVGQDQVKIVLKKAIENQSIAHAYIFFGPRGTGKTTTARIL
CEEHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHH
AKALNCLSHDDKPCGKCESCIAVDNNSHMDVIEIDAASYRGIDEIRKIRDAASYRPTMGH
HHHHHHHCCCCCCCCCCCCEEEECCCCCCEEEEECCHHCCCHHHHHHHHHHHCCCCCCCC
YKVYIVDEFHMLTREAFNALLKTLEEPPEHIVFILATTNLEKVPETILSRCQVFTFKPLS
EEEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHCCEEEECCCC
EGQIVEYLQRILKEEKKTYTVEALKIIAKAAKGGMRDAVNLLERALVFGEKIEEDNVKNI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
LGILPEEYLKSYLVAILNGDSDEIIALSENIERLGYSHDSVIRQSIELTKDMISRRELEF
HHCCCHHHHHHHHHHHCCCCCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ERGVKLIEKLWEVNREMRYSENKKLTFEVLSLTTLAAMNVPSVSVEPAKAVNAVVKEEVK
HHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
KSNEEKEVEPITTDIDVSKKSEKVDSKFKEFFETIYEEGHVLIWVLLNLATIKEEDDVFA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCCEEE
LSFALNDLFARELAKEHIETISELMKMRLGKPAKINDNDIVESSDILKKLNPDEKAYVKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHH
ILTLFEGLDAKDVKIEIEEEGNG
HHHHHCCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MIFMAEVLYRKYRPKKFEEIVGQDQVKIVLKKAIENQSIAHAYIFFGPRGTGKTTTARIL
CEEHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHH
AKALNCLSHDDKPCGKCESCIAVDNNSHMDVIEIDAASYRGIDEIRKIRDAASYRPTMGH
HHHHHHHCCCCCCCCCCCCEEEECCCCCCEEEEECCHHCCCHHHHHHHHHHHCCCCCCCC
YKVYIVDEFHMLTREAFNALLKTLEEPPEHIVFILATTNLEKVPETILSRCQVFTFKPLS
EEEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHCCEEEECCCC
EGQIVEYLQRILKEEKKTYTVEALKIIAKAAKGGMRDAVNLLERALVFGEKIEEDNVKNI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
LGILPEEYLKSYLVAILNGDSDEIIALSENIERLGYSHDSVIRQSIELTKDMISRRELEF
HHCCCHHHHHHHHHHHCCCCCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ERGVKLIEKLWEVNREMRYSENKKLTFEVLSLTTLAAMNVPSVSVEPAKAVNAVVKEEVK
HHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
KSNEEKEVEPITTDIDVSKKSEKVDSKFKEFFETIYEEGHVLIWVLLNLATIKEEDDVFA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHCCCCCCEEE
LSFALNDLFARELAKEHIETISELMKMRLGKPAKINDNDIVESSDILKKLNPDEKAYVKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHH
ILTLFEGLDAKDVKIEIEEEGNG
HHHHHCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]