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The map label for this gene is murA

Identifier: 239618138

GI number: 239618138

Start: 1903157

End: 1904422

Strand: Direct

Name: murA

Synonym: Kole_1771

Alternate gene names: 239618138

Gene position: 1903157-1904422 (Clockwise)

Preceding gene: 239618137

Following gene: 239618139

Centisome position: 82.67

GC content: 43.36

Gene sequence:

>1266_bases
TTGAGTGAAATTGTCGTAGAAGGTGGCAGGAAATTAATCGGCGAAGTACCAATCAGCGGCTCAAAAAATGCGGCACTTCC
CATTCTGGCAGCTGCCGTTATGATAGATGAACCGGTTGTATTGGACAATGTACCGGAACTCAAAGATGTTTTCACAATGC
TAACCATTCTCCAAAGAATCGGGAAGAAGGTGTCTTTCAGGGATAATAGGGTTGTTGTGGAACCGGGGAATGTTCTTATG
GGAGATGTCCCTTACGAATTGGTTAGGATGATGAGGGCTTCTTTCAACGTTCTTGGCCCGCTGACAATGGTATGTGGATG
GGCGAAAGTTGGGAAGCCGGGTGGCTGCAATATAGGTCAAAGACCAGTGGACTTTCACATTGAAGGTTTGAAGGCTTTAG
GATTTTTGATAAAAGAGGAACATGGTGATGTCATAGCGAAAAAACCCTCGAGTTTTAAGGAAGAACTTTATTATAAACTG
CCTTTTCCGAGTGTTGGTGCTACGGAACAGTTAATGACCGTAGCGGCACTCATGTCAGAAAGTAAGACGATAATAGAAAA
CGTCGCCAGAGAACCTGAAATACAGGACCTTCAGAATTTTCTCAACAAAGCAGGTGCGAAGATTAAAGGTGCAGGAACCG
ATAGAATAGAAATTGAGGGTGTGGAGAAACTTCATGGAATCGAGTATCACATTATACCCGACAGAATAGAAGCGGGAACT
TATTTACTTGCAGGTGTTTCAACCAGAGGCAGAGTGAAAGTCTCAAATGTGATACCGGAACATCTCGAAGCCTTGCTGAA
AGTGCTGGATGAGCTTGGAGTAAGTATAACTTGCGATAAAAATAGTATAGAGGTTTCTGTTTCTGGCGAGCTAAAGCCAA
TTCGTGTTTCCACGGCACCTTATCCTGGTTTTCCAACGGATTTGCAGCCAATGCTCACAGCTGTACTCTGTACAGTTCCG
GGAGAGTCGATAATCGAAGAGAAGGTTTTTGAAAACAGGTTTGGTTATGTAGATGAGATGAACAGAATGAGTGCAAATAT
AAAAGTCATGAACAGGGTCGCTCATATAGTAGGAGTAGAAAAACTGAGTGGAGCCCAGATATATGCACCCGATATAAGGG
CGACTGCCGGCATGCTTATTGCAGCTCTTTCAGCAGAAGGTCAAACAGTGATAAAGAATGCAGCGCATATATTTAGAGGC
TACGAAAAATTGAAAGAAAAATTTACCACGATAGGGGCACAGATAGAGGTATATCCTGAGGAGTGA

Upstream 100 bases:

>100_bases
TCATGGTATAGGGCAGCTTTTCAGTTTTCCATGTTAGAATGATATTGGATGGAATAGTGGCTTTAATCGTTCTTATCAGC
TTTGAATGGAGGGAATTAAG

Downstream 100 bases:

>100_bases
AGCGATTAGATGAAGTACCCGGTGTATTTAGAAAAGGTTGAGAACGGATATCTTGATTCGCTCATAGAAACCGTTGAAAA
AGAACTGGATGCCTGCACGC

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSEIVVEGGRKLIGEVPISGSKNAALPILAAAVMIDEPVVLDNVPELKDVFTMLTILQRIGKKVSFRDNRVVVEPGNVLM
GDVPYELVRMMRASFNVLGPLTMVCGWAKVGKPGGCNIGQRPVDFHIEGLKALGFLIKEEHGDVIAKKPSSFKEELYYKL
PFPSVGATEQLMTVAALMSESKTIIENVAREPEIQDLQNFLNKAGAKIKGAGTDRIEIEGVEKLHGIEYHIIPDRIEAGT
YLLAGVSTRGRVKVSNVIPEHLEALLKVLDELGVSITCDKNSIEVSVSGELKPIRVSTAPYPGFPTDLQPMLTAVLCTVP
GESIIEEKVFENRFGYVDEMNRMSANIKVMNRVAHIVGVEKLSGAQIYAPDIRATAGMLIAALSAEGQTVIKNAAHIFRG
YEKLKEKFTTIGAQIEVYPEE

Sequences:

>Translated_421_residues
MSEIVVEGGRKLIGEVPISGSKNAALPILAAAVMIDEPVVLDNVPELKDVFTMLTILQRIGKKVSFRDNRVVVEPGNVLM
GDVPYELVRMMRASFNVLGPLTMVCGWAKVGKPGGCNIGQRPVDFHIEGLKALGFLIKEEHGDVIAKKPSSFKEELYYKL
PFPSVGATEQLMTVAALMSESKTIIENVAREPEIQDLQNFLNKAGAKIKGAGTDRIEIEGVEKLHGIEYHIIPDRIEAGT
YLLAGVSTRGRVKVSNVIPEHLEALLKVLDELGVSITCDKNSIEVSVSGELKPIRVSTAPYPGFPTDLQPMLTAVLCTVP
GESIIEEKVFENRFGYVDEMNRMSANIKVMNRVAHIVGVEKLSGAQIYAPDIRATAGMLIAALSAEGQTVIKNAAHIFRG
YEKLKEKFTTIGAQIEVYPEE
>Mature_420_residues
SEIVVEGGRKLIGEVPISGSKNAALPILAAAVMIDEPVVLDNVPELKDVFTMLTILQRIGKKVSFRDNRVVVEPGNVLMG
DVPYELVRMMRASFNVLGPLTMVCGWAKVGKPGGCNIGQRPVDFHIEGLKALGFLIKEEHGDVIAKKPSSFKEELYYKLP
FPSVGATEQLMTVAALMSESKTIIENVAREPEIQDLQNFLNKAGAKIKGAGTDRIEIEGVEKLHGIEYHIIPDRIEAGTY
LLAGVSTRGRVKVSNVIPEHLEALLKVLDELGVSITCDKNSIEVSVSGELKPIRVSTAPYPGFPTDLQPMLTAVLCTVPG
ESIIEEKVFENRFGYVDEMNRMSANIKVMNRVAHIVGVEKLSGAQIYAPDIRATAGMLIAALSAEGQTVIKNAAHIFRGY
EKLKEKFTTIGAQIEVYPEE

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=417, Percent_Identity=47.0023980815348, Blast_Score=347, Evalue=9e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_KOSOT (C5CFW2)

Other databases:

- EMBL:   CP001634
- RefSeq:   YP_002941460.1
- GeneID:   7968259
- GenomeReviews:   CP001634_GR
- KEGG:   kol:Kole_1771
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45920; Mature: 45789

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: ACT_SITE 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIVVEGGRKLIGEVPISGSKNAALPILAAAVMIDEPVVLDNVPELKDVFTMLTILQRI
CCCEEECCCCCCEECCCCCCCCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHH
GKKVSFRDNRVVVEPGNVLMGDVPYELVRMMRASFNVLGPLTMVCGWAKVGKPGGCNIGQ
CCCCCCCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RPVDFHIEGLKALGFLIKEEHGDVIAKKPSSFKEELYYKLPFPSVGATEQLMTVAALMSE
CCCCHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHEEECCCCCCCCHHHHHHHHHHHHC
SKTIIENVAREPEIQDLQNFLNKAGAKIKGAGTDRIEIEGVEKLHGIEYHIIPDRIEAGT
CHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCEEEECCHHHHCCCEEEEECCCCCCCC
YLLAGVSTRGRVKVSNVIPEHLEALLKVLDELGVSITCDKNSIEVSVSGELKPIRVSTAP
EEEEECCCCCCEEEHHCCHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCEEEEEEECCC
YPGFPTDLQPMLTAVLCTVPGESIIEEKVFENRFGYVDEMNRMSANIKVMNRVAHIVGVE
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
KLSGAQIYAPDIRATAGMLIAALSAEGQTVIKNAAHIFRGYEKLKEKFTTIGAQIEVYPE
HCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
E
C
>Mature Secondary Structure 
SEIVVEGGRKLIGEVPISGSKNAALPILAAAVMIDEPVVLDNVPELKDVFTMLTILQRI
CCEEECCCCCCEECCCCCCCCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHH
GKKVSFRDNRVVVEPGNVLMGDVPYELVRMMRASFNVLGPLTMVCGWAKVGKPGGCNIGQ
CCCCCCCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RPVDFHIEGLKALGFLIKEEHGDVIAKKPSSFKEELYYKLPFPSVGATEQLMTVAALMSE
CCCCHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHEEECCCCCCCCHHHHHHHHHHHHC
SKTIIENVAREPEIQDLQNFLNKAGAKIKGAGTDRIEIEGVEKLHGIEYHIIPDRIEAGT
CHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCEEEECCHHHHCCCEEEEECCCCCCCC
YLLAGVSTRGRVKVSNVIPEHLEALLKVLDELGVSITCDKNSIEVSVSGELKPIRVSTAP
EEEEECCCCCCEEEHHCCHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCEEEEEEECCC
YPGFPTDLQPMLTAVLCTVPGESIIEEKVFENRFGYVDEMNRMSANIKVMNRVAHIVGVE
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
KLSGAQIYAPDIRATAGMLIAALSAEGQTVIKNAAHIFRGYEKLKEKFTTIGAQIEVYPE
HCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA