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The map label for this gene is epsC [H]

Identifier: 239618126

GI number: 239618126

Start: 1889682

End: 1891577

Strand: Direct

Name: epsC [H]

Synonym: Kole_1759

Alternate gene names: 239618126

Gene position: 1889682-1891577 (Clockwise)

Preceding gene: 239618125

Following gene: 239618127

Centisome position: 82.08

GC content: 41.19

Gene sequence:

>1896_bases
TTGGAGAGGGAAAAAATCAGAAATTTCACAAGGTTTATCATTCTTACCGGCGTTGATTTTTTGCTTATCTACGCCTCTTA
TGCCCTTGGTATGTATTTTAGATACGGTTTGTTTTCTTTGAACGAACCTCATTTCTTTCAAAATGGTCTTTTTTTCAGCT
TCTTTATCTTGCTCTCGATGATATTCAACGGTGTTTATTCCATCGCGTGGAGTTATTCCTCCTTTCGTGATTACTGGGTG
ATTCTACGGGGAGCTTTTATTGGTTATGCTGCGGGGTTTGCTTTTGGAAGATTAATGCTTCTTGCTGGCATGGATGTGTT
CACCGTTCCTTTCACGGTAGCGACGATGACGTTTATTGGGGCAACTTTTTTGATAATCTGGTCCAGAATATTCTGGTTGA
CGTATCTGTTCCTGAAGATAGAGCGTTCCGGGAAGTCTCTGGATAGAATTCTCATTGTGGGTGCCGGAGATGCTGGAACA
ACGCTGGTTGATGAAATAACACGGCATCCCGAATACGGGAGAGTCGTAGGATTTGTGGATGATTCACCGAGAAAGCAAAA
GAAAAGAATACGTGGAATTCCTGTTCTTGGTACAACGGAAGAGATAATGCAAATAGTCGATAAATACCAGATAAACAGGG
TTATAATTGCTATTCCTTCGGCTACATCCGATCAAATGAGAAGGATAATGTACAGAATCGATAGGAATAAAGTTCGGGTT
CAAACGCTTCCCGGGCTAACCGAGATCATAGATAGGAAAGCGCGATTGGGGTATCTCAGGGACATAAATATAGAGGATTT
ACTTGGACGTGAACCTGTTGAAATAGATAAGAAATCTTTGAGAGGCTATATAACCGGAAAACGTGTTCTTGTAACTGGTG
CAGGGGGAAGTATAGGCAGCGAGCTTTGCCGCCAAATAGCGTATTTGGAACCGAAAGCTCTCATCATTCTCGGAAAAGGT
GAAAACAGCATTCACAATATAGAGGAAGAATTAAAGGAAAAATATCCAGATCTAAAGGTTCATAGAGTAATAGGAGACGT
TCAGGATAAAGACAGGATGGAATTTATAATAGCCACCTTTAAGCCCGAGATTATTTTTCATGCCGCTGCTCATAAACATG
TACCGATAATGGAGGAAAATCCGACAGAAGCCTTCAGGGTAAATACACTTGGAACTTATATCCTGGCATCCATAGCTGAA
AAATATGGATGTGAAAGGTTCGTGATGATTTCCACCGATAAGGCTGTCAGGCCATCTTCAATAATGGGTGTTTCGAAAAG
ACTTGCCGAGCAGATTTTGAAGTCAATAGCGCGTTATTCGAAGATGCGCATCGGCATTGTACGATTTGGAAATGTCCTTG
GAAGCAGGGGGAGCGTTGTTCCGAAGTTCAAAAAGCAAATAGAAAATGGTGGTCCTGTTACGGTAACAGATCCAAGAATG
ACGCGATATTTCATGACCATCCCCGAAGCAGTCTCTCTCGTTATGCAGGCCGGGGCATACGCAAAAAACGGTGATGTCTT
TGTCCTGGATATGGGAAAACCTGTGAAGATATCTGATTTAGCAAGAGATATGATAACCCTTGCTGGTTATGTTCCGGATC
AGGAGATAAAAATAGAATATATAGGTGCAAGACCGGGAGAGAAGCTTTTTGAGGAATTATCACTGGATTCTGAAAAATTT
GATAAAACACCCCATCCAAAGATCTTCAGGCTCAAAGATGACAGGGAATTCATGGAAGGAGAGGAATTGAAGGCTTTTAT
AGATAAAATGAGTATAACAATAAAAGAGCACGATATATCTGAAATCAACAAAATAATTCAGCAATATGTACCAGACGCGA
TAGCCAGGGTGAAAGTTGAAATACCGGAACTCGGTTTGAGAAAAGAGAAAAAGTAG

Upstream 100 bases:

>100_bases
TAATAAATTTCTTCATTTGAAGAAAGATGTCCCCATGAAAAATACATGAATACATGATAGTTGGAGATGTTAAAATATAA
CCAGAAAAGGAGTGGAGATT

Downstream 100 bases:

>100_bases
TGAGTAGGTTCTGTAAAAAGTTTTTTGAAAGGAGCAGATTATATGTTTGTTCCCCTTGCCAGACCCGATATAACCCAGAA
AGAAATTGATGCTGTAACAG

Product: polysaccharide biosynthesis protein CapD

Products: UDPglucoseal [C]

Alternate protein names: NA

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MEREKIRNFTRFIILTGVDFLLIYASYALGMYFRYGLFSLNEPHFFQNGLFFSFFILLSMIFNGVYSIAWSYSSFRDYWV
ILRGAFIGYAAGFAFGRLMLLAGMDVFTVPFTVATMTFIGATFLIIWSRIFWLTYLFLKIERSGKSLDRILIVGAGDAGT
TLVDEITRHPEYGRVVGFVDDSPRKQKKRIRGIPVLGTTEEIMQIVDKYQINRVIIAIPSATSDQMRRIMYRIDRNKVRV
QTLPGLTEIIDRKARLGYLRDINIEDLLGREPVEIDKKSLRGYITGKRVLVTGAGGSIGSELCRQIAYLEPKALIILGKG
ENSIHNIEEELKEKYPDLKVHRVIGDVQDKDRMEFIIATFKPEIIFHAAAHKHVPIMEENPTEAFRVNTLGTYILASIAE
KYGCERFVMISTDKAVRPSSIMGVSKRLAEQILKSIARYSKMRIGIVRFGNVLGSRGSVVPKFKKQIENGGPVTVTDPRM
TRYFMTIPEAVSLVMQAGAYAKNGDVFVLDMGKPVKISDLARDMITLAGYVPDQEIKIEYIGARPGEKLFEELSLDSEKF
DKTPHPKIFRLKDDREFMEGEELKAFIDKMSITIKEHDISEINKIIQQYVPDAIARVKVEIPELGLRKEKK

Sequences:

>Translated_631_residues
MEREKIRNFTRFIILTGVDFLLIYASYALGMYFRYGLFSLNEPHFFQNGLFFSFFILLSMIFNGVYSIAWSYSSFRDYWV
ILRGAFIGYAAGFAFGRLMLLAGMDVFTVPFTVATMTFIGATFLIIWSRIFWLTYLFLKIERSGKSLDRILIVGAGDAGT
TLVDEITRHPEYGRVVGFVDDSPRKQKKRIRGIPVLGTTEEIMQIVDKYQINRVIIAIPSATSDQMRRIMYRIDRNKVRV
QTLPGLTEIIDRKARLGYLRDINIEDLLGREPVEIDKKSLRGYITGKRVLVTGAGGSIGSELCRQIAYLEPKALIILGKG
ENSIHNIEEELKEKYPDLKVHRVIGDVQDKDRMEFIIATFKPEIIFHAAAHKHVPIMEENPTEAFRVNTLGTYILASIAE
KYGCERFVMISTDKAVRPSSIMGVSKRLAEQILKSIARYSKMRIGIVRFGNVLGSRGSVVPKFKKQIENGGPVTVTDPRM
TRYFMTIPEAVSLVMQAGAYAKNGDVFVLDMGKPVKISDLARDMITLAGYVPDQEIKIEYIGARPGEKLFEELSLDSEKF
DKTPHPKIFRLKDDREFMEGEELKAFIDKMSITIKEHDISEINKIIQQYVPDAIARVKVEIPELGLRKEKK
>Mature_631_residues
MEREKIRNFTRFIILTGVDFLLIYASYALGMYFRYGLFSLNEPHFFQNGLFFSFFILLSMIFNGVYSIAWSYSSFRDYWV
ILRGAFIGYAAGFAFGRLMLLAGMDVFTVPFTVATMTFIGATFLIIWSRIFWLTYLFLKIERSGKSLDRILIVGAGDAGT
TLVDEITRHPEYGRVVGFVDDSPRKQKKRIRGIPVLGTTEEIMQIVDKYQINRVIIAIPSATSDQMRRIMYRIDRNKVRV
QTLPGLTEIIDRKARLGYLRDINIEDLLGREPVEIDKKSLRGYITGKRVLVTGAGGSIGSELCRQIAYLEPKALIILGKG
ENSIHNIEEELKEKYPDLKVHRVIGDVQDKDRMEFIIATFKPEIIFHAAAHKHVPIMEENPTEAFRVNTLGTYILASIAE
KYGCERFVMISTDKAVRPSSIMGVSKRLAEQILKSIARYSKMRIGIVRFGNVLGSRGSVVPKFKKQIENGGPVTVTDPRM
TRYFMTIPEAVSLVMQAGAYAKNGDVFVLDMGKPVKISDLARDMITLAGYVPDQEIKIEYIGARPGEKLFEELSLDSEKF
DKTPHPKIFRLKDDREFMEGEELKAFIDKMSITIKEHDISEINKIIQQYVPDAIARVKVEIPELGLRKEKK

Specific function: Involved in biofilm formation [H]

COG id: COG1086

COG function: function code MG; Predicted nucleoside-diphosphate sugar epimerases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide synthase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=285, Percent_Identity=25.9649122807018, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR003869 [H]

Pfam domain/function: PF02719 Polysacc_synt_2 [H]

EC number: 5.1.3.2 [C]

Molecular weight: Translated: 71888; Mature: 71888

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEREKIRNFTRFIILTGVDFLLIYASYALGMYFRYGLFSLNEPHFFQNGLFFSFFILLSM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHH
IFNGVYSIAWSYSSFRDYWVILRGAFIGYAAGFAFGRLMLLAGMDVFTVPFTVATMTFIG
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ATFLIIWSRIFWLTYLFLKIERSGKSLDRILIVGAGDAGTTLVDEITRHPEYGRVVGFVD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCEEEEEC
DSPRKQKKRIRGIPVLGTTEEIMQIVDKYQINRVIIAIPSATSDQMRRIMYRIDRNKVRV
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCEEE
QTLPGLTEIIDRKARLGYLRDINIEDLLGREPVEIDKKSLRGYITGKRVLVTGAGGSIGS
EECCCHHHHHHHHHHCCCEECCCHHHHCCCCCCCCCHHHHCEEECCCEEEEEECCCCHHH
ELCRQIAYLEPKALIILGKGENSIHNIEEELKEKYPDLKVHRVIGDVQDKDRMEFIIATF
HHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEHHHHCCCCCCCCCEEEEEEC
KPEIIFHAAAHKHVPIMEENPTEAFRVNTLGTYILASIAEKYGCERFVMISTDKAVRPSS
CCCEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
IMGVSKRLAEQILKSIARYSKMRIGIVRFGNVLGSRGSVVPKFKKQIENGGPVTVTDPRM
HHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEECCHH
TRYFMTIPEAVSLVMQAGAYAKNGDVFVLDMGKPVKISDLARDMITLAGYVPDQEIKIEY
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEE
IGARPGEKLFEELSLDSEKFDKTPHPKIFRLKDDREFMEGEELKAFIDKMSITIKEHDIS
ECCCCHHHHHHHHCCCHHHCCCCCCCCEEEEECCHHHHCHHHHHHHHHHHEEEEECCCHH
EINKIIQQYVPDAIARVKVEIPELGLRKEKK
HHHHHHHHHCCHHHHEEEEECCCCCCCCCCC
>Mature Secondary Structure
MEREKIRNFTRFIILTGVDFLLIYASYALGMYFRYGLFSLNEPHFFQNGLFFSFFILLSM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHH
IFNGVYSIAWSYSSFRDYWVILRGAFIGYAAGFAFGRLMLLAGMDVFTVPFTVATMTFIG
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ATFLIIWSRIFWLTYLFLKIERSGKSLDRILIVGAGDAGTTLVDEITRHPEYGRVVGFVD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCEEEEEC
DSPRKQKKRIRGIPVLGTTEEIMQIVDKYQINRVIIAIPSATSDQMRRIMYRIDRNKVRV
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCEEE
QTLPGLTEIIDRKARLGYLRDINIEDLLGREPVEIDKKSLRGYITGKRVLVTGAGGSIGS
EECCCHHHHHHHHHHCCCEECCCHHHHCCCCCCCCCHHHHCEEECCCEEEEEECCCCHHH
ELCRQIAYLEPKALIILGKGENSIHNIEEELKEKYPDLKVHRVIGDVQDKDRMEFIIATF
HHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEHHHHCCCCCCCCCEEEEEEC
KPEIIFHAAAHKHVPIMEENPTEAFRVNTLGTYILASIAEKYGCERFVMISTDKAVRPSS
CCCEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
IMGVSKRLAEQILKSIARYSKMRIGIVRFGNVLGSRGSVVPKFKKQIENGGPVTVTDPRM
HHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEECCHH
TRYFMTIPEAVSLVMQAGAYAKNGDVFVLDMGKPVKISDLARDMITLAGYVPDQEIKIEY
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEE
IGARPGEKLFEELSLDSEKFDKTPHPKIFRLKDDREFMEGEELKAFIDKMSITIKEHDIS
ECCCCHHHHHHHHCCCHHHCCCCCCCCEEEEECCHHHHCHHHHHHHHHHHEEEEECCCHH
EINKIIQQYVPDAIARVKVEIPELGLRKEKK
HHHHHHHHHCCHHHHEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): 57600 [C]

Specific activity: 233.3

Km value (mM): 0.256 {UDPgalactose}} 0.225 {UDPgalactose}} 0.2 {UDPgalactose}} 0.18 {UDPgalactose}} 0.16 {UDPgalactose}} 0.14 {UDPgalactose}} 0.048 {UDPgalactose}} 0.026 {UDPgalactose}} [C]

Substrates: UDPglucose [C]

Specific reaction: UDPglucose <==> UDPglucoseal [C]

General reaction: Epimerization (specificity for carbon forming a hexosulose) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969506; 9384377 [H]