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The map label for this gene is ymxG [H]

Identifier: 239618018

GI number: 239618018

Start: 1769044

End: 1770321

Strand: Direct

Name: ymxG [H]

Synonym: Kole_1647

Alternate gene names: 239618018

Gene position: 1769044-1770321 (Clockwise)

Preceding gene: 239618017

Following gene: 239618019

Centisome position: 76.84

GC content: 42.25

Gene sequence:

>1278_bases
ATGAGAAGCACTGCAAATGTTAAACTCGTGAAATTAGATAACGGATCCACAATCATCTTTGAAAAGAAGAGTGACACCAG
AACGGTGTCACTTGCTTTTGCGGCTAAAGTCGGTTCGGCTTACGAAGATAGTCAATTGAGTGGAATTTCCCATTTTATAG
AACATGCTCTTTTTAAGGGCACTAAAAAGAGGAGCGCTTACGAGATCAAAGAACCCATCGAAAGAGTTGGCGGTACTTTG
AATGCCTATACCGGCAGAATCTCAACAGTTTTTTACGCTCACGTTCCGGATACCCATGCAAAAGAGGCTCTTGAAATTCT
CTATGATATGGTGAAAAACCCGGCTTTTTCGAAAGAGGCTGTCGAGATAGAAAAGGAGGTTATTCTAGAAGAGATCGCTG
CAACCCACGATGACCCCTTCGACATGATCTACGATCACACCATTCGTGAGATATGGGATCCAAATTACGGGAGGTCAATA
CTCGGTAGTCTTGAAACAGTTAGAAAGATCACCCCGGAAGCTTTGCGAAAGTTTCACAACAGATATTATAGTGCCGAACA
TATGGTTTTTGCGATCTCCGGGAATTTTAATGAATCTATAATCGAAAGGGCAGAAGAACTCCTGCGCTCTTTTTCACGAA
ACGGTAGTACTCCAACACGTATTGAAGGCTACATGAAACCTAAAAGGCTCGTGTCTCTTGAAACAAAGAAAGACCTCAAT
CAGGTGCACTTACTTTTGTCCAAACCCGCACCTTCCAGGCTTTCAAAGGATTTTGTGGCCTTTCGCATATTCAATGTTCT
TTTTGGGAGTGGCATGAGCTCCGTACTCTTTCACAACATAAGGGAAAAATTGGGCATGGTTTACCACATAGATTCCGAAT
ATGTTGCCTATCATGATTTCGGAACCTTCTTTATCAGTGCTTCAACCAATGAACGGCATATTCAGCGCCTGGTTGATAGT
GTCCGGTTTGAATTGGAGCGTCTTGCGAAAGAGGGTGTGTCCGAAAACGAGTACCTGTATGGGAAGGAAAGGCTTAAAGG
AAAAATCATGCTCGCTACCGAGAGTACATTGAACTCTTTGAGTTTGTACCTTGATGAGGTTATAATCAATGGTAAGCCTA
AAACGGTGGAAGAAATCATAAGCGAGATAAATTATTTAAGTCTCGGTAAGCTCAACGAAGTAATTGAGCGCTACCTTTCA
GGCGATTGGAACATTTCTTTGTTAGTACCTGAAGATCTCCAGGAAATAGATCCTGTTAAGCTTAGCTTCAGCATTTGA

Upstream 100 bases:

>100_bases
CAGACGAGCAGAAAAAGTCGCGTGGAAGGAGCTCCGGCAGACCTTCACACTACGGCAATAGAAGACCAAACGGGCACAAA
AAAGAGGGCGGAAGAAATCA

Downstream 100 bases:

>100_bases
GCAGGTTTTAGACTTAGTTTTTTTGTAAAATTAGATTCACCAGCGCTAAGCTTATGTTTCTTGTTGGGAAAATCCCGAAA
AAATTCTTTCAGAGGGTTGA

Product: peptidase M16 domain protein

Products: NA

Alternate protein names: ORFP [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MRSTANVKLVKLDNGSTIIFEKKSDTRTVSLAFAAKVGSAYEDSQLSGISHFIEHALFKGTKKRSAYEIKEPIERVGGTL
NAYTGRISTVFYAHVPDTHAKEALEILYDMVKNPAFSKEAVEIEKEVILEEIAATHDDPFDMIYDHTIREIWDPNYGRSI
LGSLETVRKITPEALRKFHNRYYSAEHMVFAISGNFNESIIERAEELLRSFSRNGSTPTRIEGYMKPKRLVSLETKKDLN
QVHLLLSKPAPSRLSKDFVAFRIFNVLFGSGMSSVLFHNIREKLGMVYHIDSEYVAYHDFGTFFISASTNERHIQRLVDS
VRFELERLAKEGVSENEYLYGKERLKGKIMLATESTLNSLSLYLDEVIINGKPKTVEEIISEINYLSLGKLNEVIERYLS
GDWNISLLVPEDLQEIDPVKLSFSI

Sequences:

>Translated_425_residues
MRSTANVKLVKLDNGSTIIFEKKSDTRTVSLAFAAKVGSAYEDSQLSGISHFIEHALFKGTKKRSAYEIKEPIERVGGTL
NAYTGRISTVFYAHVPDTHAKEALEILYDMVKNPAFSKEAVEIEKEVILEEIAATHDDPFDMIYDHTIREIWDPNYGRSI
LGSLETVRKITPEALRKFHNRYYSAEHMVFAISGNFNESIIERAEELLRSFSRNGSTPTRIEGYMKPKRLVSLETKKDLN
QVHLLLSKPAPSRLSKDFVAFRIFNVLFGSGMSSVLFHNIREKLGMVYHIDSEYVAYHDFGTFFISASTNERHIQRLVDS
VRFELERLAKEGVSENEYLYGKERLKGKIMLATESTLNSLSLYLDEVIINGKPKTVEEIISEINYLSLGKLNEVIERYLS
GDWNISLLVPEDLQEIDPVKLSFSI
>Mature_425_residues
MRSTANVKLVKLDNGSTIIFEKKSDTRTVSLAFAAKVGSAYEDSQLSGISHFIEHALFKGTKKRSAYEIKEPIERVGGTL
NAYTGRISTVFYAHVPDTHAKEALEILYDMVKNPAFSKEAVEIEKEVILEEIAATHDDPFDMIYDHTIREIWDPNYGRSI
LGSLETVRKITPEALRKFHNRYYSAEHMVFAISGNFNESIIERAEELLRSFSRNGSTPTRIEGYMKPKRLVSLETKKDLN
QVHLLLSKPAPSRLSKDFVAFRIFNVLFGSGMSSVLFHNIREKLGMVYHIDSEYVAYHDFGTFFISASTNERHIQRLVDS
VRFELERLAKEGVSENEYLYGKERLKGKIMLATESTLNSLSLYLDEVIINGKPKTVEEIISEINYLSLGKLNEVIERYLS
GDWNISLLVPEDLQEIDPVKLSFSI

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=420, Percent_Identity=23.5714285714286, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI46593007, Length=267, Percent_Identity=27.7153558052434, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI24308013, Length=427, Percent_Identity=25.5269320843091, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1787770, Length=204, Percent_Identity=28.921568627451, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI2367164, Length=217, Percent_Identity=30.4147465437788, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71999683, Length=410, Percent_Identity=23.6585365853659, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17553678, Length=417, Percent_Identity=19.9040767386091, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6323192, Length=400, Percent_Identity=26.25, Blast_Score=126, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6323421, Length=247, Percent_Identity=25.5060728744939, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357875, Length=404, Percent_Identity=24.009900990099, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24646943, Length=404, Percent_Identity=24.009900990099, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI19921772, Length=438, Percent_Identity=22.1461187214612, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221513245, Length=239, Percent_Identity=25.9414225941423, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 48426; Mature: 48426

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSTANVKLVKLDNGSTIIFEKKSDTRTVSLAFAAKVGSAYEDSQLSGISHFIEHALFKG
CCCCCCEEEEEECCCCEEEEECCCCCEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHCC
TKKRSAYEIKEPIERVGGTLNAYTGRISTVFYAHVPDTHAKEALEILYDMVKNPAFSKEA
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHH
VEIEKEVILEEIAATHDDPFDMIYDHTIREIWDPNYGRSILGSLETVRKITPEALRKFHN
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHH
RYYSAEHMVFAISGNFNESIIERAEELLRSFSRNGSTPTRIEGYMKPKRLVSLETKKDLN
HHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHEEEHHHHHHH
QVHLLLSKPAPSRLSKDFVAFRIFNVLFGSGMSSVLFHNIREKLGMVYHIDSEYVAYHDF
HHHHEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEECCCEEEEEEC
GTFFISASTNERHIQRLVDSVRFELERLAKEGVSENEYLYGKERLKGKIMLATESTLNSL
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHCCCEEEEEEHHHHHHH
SLYLDEVIINGKPKTVEEIISEINYLSLGKLNEVIERYLSGDWNISLLVPEDLQEIDPVK
HHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECHHHHHCCCEE
LSFSI
EEECC
>Mature Secondary Structure
MRSTANVKLVKLDNGSTIIFEKKSDTRTVSLAFAAKVGSAYEDSQLSGISHFIEHALFKG
CCCCCCEEEEEECCCCEEEEECCCCCEEEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHCC
TKKRSAYEIKEPIERVGGTLNAYTGRISTVFYAHVPDTHAKEALEILYDMVKNPAFSKEA
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCHHH
VEIEKEVILEEIAATHDDPFDMIYDHTIREIWDPNYGRSILGSLETVRKITPEALRKFHN
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHH
RYYSAEHMVFAISGNFNESIIERAEELLRSFSRNGSTPTRIEGYMKPKRLVSLETKKDLN
HHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHEEEHHHHHHH
QVHLLLSKPAPSRLSKDFVAFRIFNVLFGSGMSSVLFHNIREKLGMVYHIDSEYVAYHDF
HHHHEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEECCCEEEEEEC
GTFFISASTNERHIQRLVDSVRFELERLAKEGVSENEYLYGKERLKGKIMLATESTLNSL
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHCCCEEEEEEHHHHHHH
SLYLDEVIINGKPKTVEEIISEINYLSLGKLNEVIERYLSGDWNISLLVPEDLQEIDPVK
HHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECHHHHHCCCEE
LSFSI
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 8098035 [H]