Click here to switch to the map view.

The map label for this gene is degP [H]

Identifier: 239617971

GI number: 239617971

Start: 1714859

End: 1716247

Strand: Direct

Name: degP [H]

Synonym: Kole_1599

Alternate gene names: 239617971

Gene position: 1714859-1716247 (Clockwise)

Preceding gene: 239617968

Following gene: 239617982

Centisome position: 74.49

GC content: 45.21

Gene sequence:

>1389_bases
ATGAAAAGACTTTTTGTTGTTTCTCTCGTGATCCTTCTTGCAACCCTGGGTCTGGCATATGTGAATCCAGATTATGAAAG
TCCCATTGTGAAGGTTGTGGAAGTAGCAGCACCCGCAGTCGTAAAGATCGATGTGGTAACCACTCAGCGTTATAGTCCCT
TCGATCCTTTCACTGATGAGTTTTTTAGAAAATTCTTCGGTGAGATTCCCTTTGGAGAGCGAAAAGCAGAAGCACTTGGT
TCTGGATTCATATTTGATAAAGAGGGTTACATTCTTACCAACGAACATGTTGTCCATAACGCTGACAAGATAATGGTTAC
TTTGCTGGATGGTAGCAAATACCCGGCGAAGTATATCGGTGGGGATGAAGAACTCGATATCGCGGTTATCAAGATAGATC
CTGACGGAAAGGATCTCCCTGTTCTTGAAATAGGCGATTCTGATAAGCTTCAGATAGGCGAATGGGCGATAGCTATTGGG
AATCCTCTTGGATTCCAGCATACGGTGACGGTAGGTGTTGTGAGTGCGGTAGGAAGGCAGATCCCGAAACCGGAAGGAAA
TGGTTATTATTCCAATCTCATTCAAACGGACGCGGCGATTAATCCTGGAAACTCTGGTGGACCGCTTTTGAACATTCACG
GTCAGGTTATCGGGATCAATACAGCCATCGTTTCTCCCCAGTATGGGACAACGCTTGGCTTTGCGATCCCGATCAATATG
GCCATGAGGTTTGTGGATTCTATAATCAAAACAGGGACTGTTCAAAAAGCTTTCCTTGGCGTTTATGTCACAACGGTTAC
CGAAAGCACAGCTAAATCGCTGGGCCTAAAGGTTGATGAAGGTGCGTTGGTCACCGATGTTTTCAAGGATTCTCCTGCGG
AAAAAGCCGGTATAAAACCTCAAGACGTCATTATAAAACTGAATGGCCTTGATATTCGCAGCTCTTCAGAGCTTGTAGCG
GCGGTACACAACTATCCCGCGGGAGCCAGAGTTACGATAACGGTTGACAGGTTCGGCAAGAGGATCACTTTCGATGTTGT
CCTTGGTTATCAGGATAACGCTTCCGGCGAATCGAATGCACAGTACTCAGATGACAAATTAGGATTGGTTTTGGGAAACC
TGCTACCCGGGGACAGGGAAAGGCTTTCAATTCCGGAGGAGATCAATGGTGTAATTGTGCGTGATGTTAAAGCTAAAGCC
TATGCAGCGCAGCTTGGAATCAAGAAGGACGATGTCATTATTCGAATCAGCATCAACGGTAAGCAGAAAGAAATATCCAG
TCTGGAGGATTACGAAAAGGTAATAAAATCCCTTGAAAGAGGGGACTATGTAGCACTCTTCATATTGCATGAGGGTGTAC
GGTTTGTAGCTTCATTCAGATATTACTGA

Upstream 100 bases:

>100_bases
TAAGTATAACACTTTTGAACCATCAGAATAATCGCAAAGTCTCAAAAAATGAACCCAATTTTTTGCCACACAGTTGATGA
AGAGGAGGGAGGTAGAAAAT

Downstream 100 bases:

>100_bases
TATCGATATAAACTGCATAAAAAAGCGCCGCGTCACCAGTAACGGTGTGCTCGCGGCGCTCCCCCCTTTTCCCCTGTTAC
GGGTACACAAGGGATTATAG

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MKRLFVVSLVILLATLGLAYVNPDYESPIVKVVEVAAPAVVKIDVVTTQRYSPFDPFTDEFFRKFFGEIPFGERKAEALG
SGFIFDKEGYILTNEHVVHNADKIMVTLLDGSKYPAKYIGGDEELDIAVIKIDPDGKDLPVLEIGDSDKLQIGEWAIAIG
NPLGFQHTVTVGVVSAVGRQIPKPEGNGYYSNLIQTDAAINPGNSGGPLLNIHGQVIGINTAIVSPQYGTTLGFAIPINM
AMRFVDSIIKTGTVQKAFLGVYVTTVTESTAKSLGLKVDEGALVTDVFKDSPAEKAGIKPQDVIIKLNGLDIRSSSELVA
AVHNYPAGARVTITVDRFGKRITFDVVLGYQDNASGESNAQYSDDKLGLVLGNLLPGDRERLSIPEEINGVIVRDVKAKA
YAAQLGIKKDDVIIRISINGKQKEISSLEDYEKVIKSLERGDYVALFILHEGVRFVASFRYY

Sequences:

>Translated_462_residues
MKRLFVVSLVILLATLGLAYVNPDYESPIVKVVEVAAPAVVKIDVVTTQRYSPFDPFTDEFFRKFFGEIPFGERKAEALG
SGFIFDKEGYILTNEHVVHNADKIMVTLLDGSKYPAKYIGGDEELDIAVIKIDPDGKDLPVLEIGDSDKLQIGEWAIAIG
NPLGFQHTVTVGVVSAVGRQIPKPEGNGYYSNLIQTDAAINPGNSGGPLLNIHGQVIGINTAIVSPQYGTTLGFAIPINM
AMRFVDSIIKTGTVQKAFLGVYVTTVTESTAKSLGLKVDEGALVTDVFKDSPAEKAGIKPQDVIIKLNGLDIRSSSELVA
AVHNYPAGARVTITVDRFGKRITFDVVLGYQDNASGESNAQYSDDKLGLVLGNLLPGDRERLSIPEEINGVIVRDVKAKA
YAAQLGIKKDDVIIRISINGKQKEISSLEDYEKVIKSLERGDYVALFILHEGVRFVASFRYY
>Mature_462_residues
MKRLFVVSLVILLATLGLAYVNPDYESPIVKVVEVAAPAVVKIDVVTTQRYSPFDPFTDEFFRKFFGEIPFGERKAEALG
SGFIFDKEGYILTNEHVVHNADKIMVTLLDGSKYPAKYIGGDEELDIAVIKIDPDGKDLPVLEIGDSDKLQIGEWAIAIG
NPLGFQHTVTVGVVSAVGRQIPKPEGNGYYSNLIQTDAAINPGNSGGPLLNIHGQVIGINTAIVSPQYGTTLGFAIPINM
AMRFVDSIIKTGTVQKAFLGVYVTTVTESTAKSLGLKVDEGALVTDVFKDSPAEKAGIKPQDVIIKLNGLDIRSSSELVA
AVHNYPAGARVTITVDRFGKRITFDVVLGYQDNASGESNAQYSDDKLGLVLGNLLPGDRERLSIPEEINGVIVRDVKAKA
YAAQLGIKKDDVIIRISINGKQKEISSLEDYEKVIKSLERGDYVALFILHEGVRFVASFRYY

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=302, Percent_Identity=40.7284768211921, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI22129776, Length=313, Percent_Identity=38.6581469648562, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI24308541, Length=309, Percent_Identity=33.3333333333333, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI7019477, Length=311, Percent_Identity=34.0836012861736, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI1786356, Length=457, Percent_Identity=36.3238512035011, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1789629, Length=426, Percent_Identity=37.0892018779343, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1789630, Length=358, Percent_Identity=32.9608938547486, Blast_Score=167, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24646839, Length=312, Percent_Identity=33.974358974359, Blast_Score=152, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 50214; Mature: 50214

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLFVVSLVILLATLGLAYVNPDYESPIVKVVEVAAPAVVKIDVVTTQRYSPFDPFTDE
CCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHCCCEEEEEEEEEECCCCCCCCCHHH
FFRKFFGEIPFGERKAEALGSGFIFDKEGYILTNEHVVHNADKIMVTLLDGSKYPAKYIG
HHHHHHCCCCCCCHHHHHHCCCEEECCCCCEEECCCEEECCCEEEEEEECCCCCCHHHCC
GDEELDIAVIKIDPDGKDLPVLEIGDSDKLQIGEWAIAIGNPLGFQHTVTVGVVSAVGRQ
CCCCEEEEEEEECCCCCCCCEEEECCCCCEEECEEEEEECCCCCCCEEHHHHHHHHHHHH
IPKPEGNGYYSNLIQTDAAINPGNSGGPLLNIHGQVIGINTAIVSPQYGTTLGFAIPINM
CCCCCCCCHHHHHHHCCCCCCCCCCCCCEEEECCEEEEEEEEEECCCCCCEEEEEEHHHH
AMRFVDSIIKTGTVQKAFLGVYVTTVTESTAKSLGLKVDEGALVTDVFKDSPAEKAGIKP
HHHHHHHHHHCCCHHHHHEEEEEEEECHHHHHHCCCEECCCCEEEHHHCCCCCHHCCCCC
QDVIIKLNGLDIRSSSELVAAVHNYPAGARVTITVDRFGKRITFDVVLGYQDNASGESNA
CCEEEEEECCEECCCCHHEEEECCCCCCCEEEEEHHHCCCEEEEEEEEEECCCCCCCCCC
QYSDDKLGLVLGNLLPGDRERLSIPEEINGVIVRDVKAKAYAAQLGIKKDDVIIRISING
CCCCCCEEEEEECCCCCCHHHCCCCHHHCCEEEEECCHHHHHHHCCCCCCCEEEEEEECC
KQKEISSLEDYEKVIKSLERGDYVALFILHEGVRFVASFRYY
CHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCHHHHHHCCCC
>Mature Secondary Structure
MKRLFVVSLVILLATLGLAYVNPDYESPIVKVVEVAAPAVVKIDVVTTQRYSPFDPFTDE
CCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHCCCEEEEEEEEEECCCCCCCCCHHH
FFRKFFGEIPFGERKAEALGSGFIFDKEGYILTNEHVVHNADKIMVTLLDGSKYPAKYIG
HHHHHHCCCCCCCHHHHHHCCCEEECCCCCEEECCCEEECCCEEEEEEECCCCCCHHHCC
GDEELDIAVIKIDPDGKDLPVLEIGDSDKLQIGEWAIAIGNPLGFQHTVTVGVVSAVGRQ
CCCCEEEEEEEECCCCCCCCEEEECCCCCEEECEEEEEECCCCCCCEEHHHHHHHHHHHH
IPKPEGNGYYSNLIQTDAAINPGNSGGPLLNIHGQVIGINTAIVSPQYGTTLGFAIPINM
CCCCCCCCHHHHHHHCCCCCCCCCCCCCEEEECCEEEEEEEEEECCCCCCEEEEEEHHHH
AMRFVDSIIKTGTVQKAFLGVYVTTVTESTAKSLGLKVDEGALVTDVFKDSPAEKAGIKP
HHHHHHHHHHCCCHHHHHEEEEEEEECHHHHHHCCCEECCCCEEEHHHCCCCCHHCCCCC
QDVIIKLNGLDIRSSSELVAAVHNYPAGARVTITVDRFGKRITFDVVLGYQDNASGESNA
CCEEEEEECCEECCCCHHEEEECCCCCCCEEEEEHHHCCCEEEEEEEEEECCCCCCCCCC
QYSDDKLGLVLGNLLPGDRERLSIPEEINGVIVRDVKAKAYAAQLGIKKDDVIIRISING
CCCCCCEEEEEECCCCCCHHHCCCCHHHCCEEEEECCHHHHHHHCCCCCCCEEEEEEECC
KQKEISSLEDYEKVIKSLERGDYVALFILHEGVRFVASFRYY
CHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]