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The map label for this gene is phoR [H]

Identifier: 239617944

GI number: 239617944

Start: 1684700

End: 1685953

Strand: Direct

Name: phoR [H]

Synonym: Kole_1572

Alternate gene names: 239617944

Gene position: 1684700-1685953 (Clockwise)

Preceding gene: 239617943

Following gene: 239617945

Centisome position: 73.18

GC content: 41.55

Gene sequence:

>1254_bases
TTGTTGACGGTATTTGTTATAATTCTGGCAGCGCTTTCCGCGCTGCTAGTTTATCTTCTGTACCGGACTAAAGTGGTGTA
TGTCAGGTATGAAAAAACTATAAAGCGTTTCGCGGAGCTCGCGAATATTTCCGGCTCCCGTTCTCCTGTTGCAATTTACA
ATGCAGTCAGGACACTTATTAGAGATAAAACAGAAGAGATTAAGCGTGTTTCAGAAAAATTAAAGTATATGGAAAACGTG
CTCGATAATCTCGGTGATGCTCTTTTCATAACAGACGCTGAAGGTAGAGTTGAATTTATAAACAAATCGGCCAAGGAACT
AGTGAAATCCCAGGACCTTCTCGGAAAGAAGATGAACGAGATAATCGACAATTATTACATCGTTGATCTACTTGAAGATG
CCGTGAAGAGTGGTTCGGTTCAGCAGACGAATCTTACGATTTTTCATCCCAAACGACGTTTTTATGAATGCAAAGCTATT
CCGGTTAGCTATGGTGAAAAGATTCATTGTTTGCTCATTCTCAGAGATATTACGATGGAGAGAAACCTGGAACTCATGAG
GCGCGAGTTTGTTTCTAACGTTTCTCACGAATTGAGAACACCATTAACCTCGATACATGGTTACGCCGAAACCCTGCTTG
AGTACGATTTGAGCGATGAAGAAACTGTCAGAAAATTTCTGAGAATAATCGAGGGTGAATCTGCTCGTATGACGCGCCTG
ATAAACGATCTGCTGGACCTTGAAAAACTCGAGGCCGGTGATATTCAACTCGTTCTGGAAGACGTTGAACTTTCTGAGGT
GGGAGAGTACGTTATAAAAATTGTGTCACCTCTCGCTGAAGAACTCGGAGTATCAATTTATGAAGACATGGAACGTGGAG
TCTTCGTTGAGGGGGATTTTGACAGGCTTGTGCAGCTGACGCTTAATCTTGTTGATAATGCCGTTAAATATACTTCTGTA
AAAGAGCACGGACCAAAAGAAGTCTGGATACGTGTTTATACAGCGAATAATTATGCAGTGCTGGAAGTTGAGGATACTGG
TATTGGTATTCCCGAAGAAGCTCGAAAACACATATTTGAGAGGTTTTACAGGGTTGATAAAGCACGGTCAAGGAAAATGG
GAGGTACGGGTTTAGGGCTTGCAATAGTTAAATTGATCGCTGAAAAACACGGTGGAACGGTTTCACTGGACAGTGAATTT
GGAAATGGGACAACGTTTAAAGTTAGATTACCACTTAAGAAGGTGATAGAATGA

Upstream 100 bases:

>100_bases
GAGAACGAAGATCGAAGAGGATCCTTCCAATCCTAAATATATCATAACAGTGAGGGGTAAAGGATACAAATTCAGAGACC
CTGGAAAGGAAGACTGATTT

Downstream 100 bases:

>100_bases
GAGCTTATGATGTTATTTTGAAGAAGAGAAATGGATTACCAAATTCACATGAGGAATTGAAGTTTCTTATTGAAGGTTAT
GTTAAAGGGGAAGTGCCGGA

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MLTVFVIILAALSALLVYLLYRTKVVYVRYEKTIKRFAELANISGSRSPVAIYNAVRTLIRDKTEEIKRVSEKLKYMENV
LDNLGDALFITDAEGRVEFINKSAKELVKSQDLLGKKMNEIIDNYYIVDLLEDAVKSGSVQQTNLTIFHPKRRFYECKAI
PVSYGEKIHCLLILRDITMERNLELMRREFVSNVSHELRTPLTSIHGYAETLLEYDLSDEETVRKFLRIIEGESARMTRL
INDLLDLEKLEAGDIQLVLEDVELSEVGEYVIKIVSPLAEELGVSIYEDMERGVFVEGDFDRLVQLTLNLVDNAVKYTSV
KEHGPKEVWIRVYTANNYAVLEVEDTGIGIPEEARKHIFERFYRVDKARSRKMGGTGLGLAIVKLIAEKHGGTVSLDSEF
GNGTTFKVRLPLKKVIE

Sequences:

>Translated_417_residues
MLTVFVIILAALSALLVYLLYRTKVVYVRYEKTIKRFAELANISGSRSPVAIYNAVRTLIRDKTEEIKRVSEKLKYMENV
LDNLGDALFITDAEGRVEFINKSAKELVKSQDLLGKKMNEIIDNYYIVDLLEDAVKSGSVQQTNLTIFHPKRRFYECKAI
PVSYGEKIHCLLILRDITMERNLELMRREFVSNVSHELRTPLTSIHGYAETLLEYDLSDEETVRKFLRIIEGESARMTRL
INDLLDLEKLEAGDIQLVLEDVELSEVGEYVIKIVSPLAEELGVSIYEDMERGVFVEGDFDRLVQLTLNLVDNAVKYTSV
KEHGPKEVWIRVYTANNYAVLEVEDTGIGIPEEARKHIFERFYRVDKARSRKMGGTGLGLAIVKLIAEKHGGTVSLDSEF
GNGTTFKVRLPLKKVIE
>Mature_417_residues
MLTVFVIILAALSALLVYLLYRTKVVYVRYEKTIKRFAELANISGSRSPVAIYNAVRTLIRDKTEEIKRVSEKLKYMENV
LDNLGDALFITDAEGRVEFINKSAKELVKSQDLLGKKMNEIIDNYYIVDLLEDAVKSGSVQQTNLTIFHPKRRFYECKAI
PVSYGEKIHCLLILRDITMERNLELMRREFVSNVSHELRTPLTSIHGYAETLLEYDLSDEETVRKFLRIIEGESARMTRL
INDLLDLEKLEAGDIQLVLEDVELSEVGEYVIKIVSPLAEELGVSIYEDMERGVFVEGDFDRLVQLTLNLVDNAVKYTSV
KEHGPKEVWIRVYTANNYAVLEVEDTGIGIPEEARKHIFERFYRVDKARSRKMGGTGLGLAIVKLIAEKHGGTVSLDSEF
GNGTTFKVRLPLKKVIE

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=412, Percent_Identity=31.5533980582524, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789149, Length=231, Percent_Identity=36.3636363636364, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI48994928, Length=281, Percent_Identity=30.6049822064057, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI145693157, Length=225, Percent_Identity=32.4444444444444, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788393, Length=245, Percent_Identity=31.4285714285714, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=32.2314049586777, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788549, Length=354, Percent_Identity=26.271186440678, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=34.6491228070175, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790436, Length=341, Percent_Identity=28.4457478005865, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790346, Length=287, Percent_Identity=31.7073170731707, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1788713, Length=237, Percent_Identity=29.1139240506329, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=32.7586206896552, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787894, Length=235, Percent_Identity=31.9148936170213, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1789808, Length=299, Percent_Identity=29.4314381270903, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=29.957805907173, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790861, Length=222, Percent_Identity=31.981981981982, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788279, Length=229, Percent_Identity=26.2008733624454, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1790300, Length=363, Percent_Identity=24.5179063360882, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=218, Percent_Identity=31.1926605504587, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790551, Length=232, Percent_Identity=29.7413793103448, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790567, Length=361, Percent_Identity=27.1468144044321, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=77, Percent_Identity=42.8571428571429, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47595; Mature: 47595

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVFVIILAALSALLVYLLYRTKVVYVRYEKTIKRFAELANISGSRSPVAIYNAVRTLI
CHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
RDKTEEIKRVSEKLKYMENVLDNLGDALFITDAEGRVEFINKSAKELVKSQDLLGKKMNE
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IIDNYYIVDLLEDAVKSGSVQQTNLTIFHPKRRFYECKAIPVSYGEKIHCLLILRDITME
HHHHHHHHHHHHHHHHCCCCEECEEEEECCCCCCEEEEECCCCCCCCEEEEEEEEHHHHH
RNLELMRREFVSNVSHELRTPLTSIHGYAETLLEYDLSDEETVRKFLRIIEGESARMTRL
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHH
INDLLDLEKLEAGDIQLVLEDVELSEVGEYVIKIVSPLAEELGVSIYEDMERGVFVEGDF
HHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCEEEECCH
DRLVQLTLNLVDNAVKYTSVKEHGPKEVWIRVYTANNYAVLEVEDTGIGIPEEARKHIFE
HHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEEECCEEEEEEECCCCCCCHHHHHHHHH
RFYRVDKARSRKMGGTGLGLAIVKLIAEKHGGTVSLDSEFGNGTTFKVRLPLKKVIE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCHHHHCC
>Mature Secondary Structure
MLTVFVIILAALSALLVYLLYRTKVVYVRYEKTIKRFAELANISGSRSPVAIYNAVRTLI
CHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
RDKTEEIKRVSEKLKYMENVLDNLGDALFITDAEGRVEFINKSAKELVKSQDLLGKKMNE
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IIDNYYIVDLLEDAVKSGSVQQTNLTIFHPKRRFYECKAIPVSYGEKIHCLLILRDITME
HHHHHHHHHHHHHHHHCCCCEECEEEEECCCCCCEEEEECCCCCCCCEEEEEEEEHHHHH
RNLELMRREFVSNVSHELRTPLTSIHGYAETLLEYDLSDEETVRKFLRIIEGESARMTRL
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHH
INDLLDLEKLEAGDIQLVLEDVELSEVGEYVIKIVSPLAEELGVSIYEDMERGVFVEGDF
HHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCEEEECCH
DRLVQLTLNLVDNAVKYTSVKEHGPKEVWIRVYTANNYAVLEVEDTGIGIPEEARKHIFE
HHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEEECCEEEEEEECCCCCCCHHHHHHHHH
RFYRVDKARSRKMGGTGLGLAIVKLIAEKHGGTVSLDSEFGNGTTFKVRLPLKKVIE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]