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The map label for this gene is upp [H]

Identifier: 239617831

GI number: 239617831

Start: 1555837

End: 1556463

Strand: Direct

Name: upp [H]

Synonym: Kole_1457

Alternate gene names: 239617831

Gene position: 1555837-1556463 (Clockwise)

Preceding gene: 239617830

Following gene: 239617832

Centisome position: 67.58

GC content: 42.42

Gene sequence:

>627_bases
ATGAGAAACCTTATGGTTGTTAATCATCCTTTGATTCAGCATAAACTTTCTATTCTAAGGAACAAGGATACAGGACCGAA
GGAGTTTAGAGAACTCACCAGGGAGATAACCTTACTTCTTACCTACGAAGCTACAAGACATTTACCAACTTACGAAACCA
AAATTGAAACGCCCCTTTGTGCAACAACAGGAAAAATGATAGAGGATAAGAAAGTGACAGTTGTTCCCATCCTACGAGCA
GGTCTCGGAATGGTTGAAGGAGTGCTTTCGTTGATGCCCAATGCTTCCGTGGGGTTCGTAGGGCTTTATAGAGATCCTCA
AACCATCAGGCCGGTGGAATATTACTGCAAGCTTCCAAAACTCAATGACAACGAGATTTTCGTTTTGGATCCTATGTTAG
CAACAGGTTTTTCGTCTGCGGTGGCTATCGATATGGTAAAAAAAGCTGGAGGTAAAAGAATAAGCCTGATGTGTCTGATT
GCAGCTCCTGAAGGGGTTAAAGAGATTGTCAATACACATCCCGATGTTAGAATATTCACAGCATCCCTTGATGAACGATT
GAACGATCACGCTTATATACTTCCGGGACTTGGAGACGCTGGAGATCGACTCTATCGTACAAAGTAA

Upstream 100 bases:

>100_bases
CAATACCGGAAGAAATAAGAGAAGAGGTAAAAAAAGCTGTCCATGAACTCACTGAAAAGTTCCCGTTGTACAAAGATCTT
ACGTGAATTGAGGCGAGAGT

Downstream 100 bases:

>100_bases
ATATATATGTGTGTTTTTAACAAGGAGGGGAAAGTATGAAAAAATTTTTGTGGGTAGGTTTGTTGATTTTTATTCTTGTA
CTCAGTGCATGTTCCGTACA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MRNLMVVNHPLIQHKLSILRNKDTGPKEFRELTREITLLLTYEATRHLPTYETKIETPLCATTGKMIEDKKVTVVPILRA
GLGMVEGVLSLMPNASVGFVGLYRDPQTIRPVEYYCKLPKLNDNEIFVLDPMLATGFSSAVAIDMVKKAGGKRISLMCLI
AAPEGVKEIVNTHPDVRIFTASLDERLNDHAYILPGLGDAGDRLYRTK

Sequences:

>Translated_208_residues
MRNLMVVNHPLIQHKLSILRNKDTGPKEFRELTREITLLLTYEATRHLPTYETKIETPLCATTGKMIEDKKVTVVPILRA
GLGMVEGVLSLMPNASVGFVGLYRDPQTIRPVEYYCKLPKLNDNEIFVLDPMLATGFSSAVAIDMVKKAGGKRISLMCLI
AAPEGVKEIVNTHPDVRIFTASLDERLNDHAYILPGLGDAGDRLYRTK
>Mature_208_residues
MRNLMVVNHPLIQHKLSILRNKDTGPKEFRELTREITLLLTYEATRHLPTYETKIETPLCATTGKMIEDKKVTVVPILRA
GLGMVEGVLSLMPNASVGFVGLYRDPQTIRPVEYYCKLPKLNDNEIFVLDPMLATGFSSAVAIDMVKKAGGKRISLMCLI
AAPEGVKEIVNTHPDVRIFTASLDERLNDHAYILPGLGDAGDRLYRTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=211, Percent_Identity=29.8578199052133, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI57863312, Length=211, Percent_Identity=29.8578199052133, Blast_Score=94, Evalue=8e-20,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=49.2610837438424, Blast_Score=206, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17539892, Length=209, Percent_Identity=22.9665071770335, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=209, Percent_Identity=22.9665071770335, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=36.4583333333333, Blast_Score=115, Evalue=5e-27,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=30.5418719211823, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=30.5418719211823, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=30.5418719211823, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=30.5418719211823, Blast_Score=94, Evalue=8e-20,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23205; Mature: 23205

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNLMVVNHPLIQHKLSILRNKDTGPKEFRELTREITLLLTYEATRHLPTYETKIETPLC
CCCCEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEEEEHHHHCCCCCHHCCCCCEE
ATTGKMIEDKKVTVVPILRAGLGMVEGVLSLMPNASVGFVGLYRDPQTIRPVEYYCKLPK
CCCCCEECCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHEEECCC
LNDNEIFVLDPMLATGFSSAVAIDMVKKAGGKRISLMCLIAAPEGVKEIVNTHPDVRIFT
CCCCCEEEECCHHHCCCCHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHCCCCEEEEE
ASLDERLNDHAYILPGLGDAGDRLYRTK
ECHHHCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MRNLMVVNHPLIQHKLSILRNKDTGPKEFRELTREITLLLTYEATRHLPTYETKIETPLC
CCCCEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEEEEHHHHCCCCCHHCCCCCEE
ATTGKMIEDKKVTVVPILRAGLGMVEGVLSLMPNASVGFVGLYRDPQTIRPVEYYCKLPK
CCCCCEECCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHEEECCC
LNDNEIFVLDPMLATGFSSAVAIDMVKKAGGKRISLMCLIAAPEGVKEIVNTHPDVRIFT
CCCCCEEEECCHHHCCCCHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHCCCCEEEEE
ASLDERLNDHAYILPGLGDAGDRLYRTK
ECHHHCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA