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The map label for this gene is suhB [H]

Identifier: 239617810

GI number: 239617810

Start: 1532261

End: 1533037

Strand: Reverse

Name: suhB [H]

Synonym: Kole_1436

Alternate gene names: 239617810

Gene position: 1533037-1532261 (Counterclockwise)

Preceding gene: 239617815

Following gene: 239617807

Centisome position: 66.59

GC content: 41.57

Gene sequence:

>777_bases
GTGATTCAAACGGATCGTCTGGAATTAGCTCTTAAAATAATTGAAAAAGCCGGCATTGAACTAAACGAAAACTTCACAAA
AGTTAGAAAGATTGCTCATAAAAGTGATCAATTCGATCTGGTAACTCAGTTTGACCTTAGCATTCAAAAAATGCTAACAA
ACGAGATCCAAAAACAATTTCCTGAAGATAAAATACTGGCAGAAGAAGGCGAAGCCTCGCAAAACACATTTCAGGAGAAC
CAGTGGATAATAGATCCAATAGATGGAACCGTCAATTTCATTCATCGATTCCCTATCTTTTGCATCTCTCTAGCCTTTTA
CGGAAAAGAAGAAAAGTTTGGCCTCATTTATGAACCCCGCAACAACACTCTTTTCCATGCACTTGAAGGCAAAGGAGCTT
TTCTAAACGGGGAAAGAATACACGTATCGAACACCATGAACCTCAATGAATCTCTCGTTACGCTCGGCACTTCCGTACTT
GGTGCCTCAGAACTTTTAAAGCACCTGCATCGAAAGGTCAGACGCGTCAGACTCCTTGGAAGCGCGGCCATTCAAGGAGC
ATACGTTGGTTGGGGAGTATCCGAAGCCTTTATAGGATACAAAATGAAAATCTGGGATATTGCGGCCGCTTACTTGATAG
TAAAAGAGGCCGGTGGAAGGGTAACAAACTGGTATGGTGAAGACGTAGAAGTCCACCAGACAAATGAAATGCTCTTCACC
AACGGTAAAATCCTTGAGCCACTGTCAAAAATACTTTCAAGTATCAAACTCGATTGA

Upstream 100 bases:

>100_bases
AAAGAGCTATACTGTGACTGACATTTCACCAAATTCTTGAAGGAAGTGCTTTTTCGCATGAGGTTGAGGTTTTATAATAA
CATCGAAAATATCTCTGGGG

Downstream 100 bases:

>100_bases
AGATTGCTACAACCTCAACGTGGTGAGTATCTGGAAACATATCGAACGCTCTCAGAGCCTTGAGAGAAAAGCCTTTGTTG
CTCAAGTATCTGGAATCTCT

Product: inositol monophosphatase

Products: NA

Alternate protein names: I-1-Pase; IMPase; Inositol-1-phosphatase [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MIQTDRLELALKIIEKAGIELNENFTKVRKIAHKSDQFDLVTQFDLSIQKMLTNEIQKQFPEDKILAEEGEASQNTFQEN
QWIIDPIDGTVNFIHRFPIFCISLAFYGKEEKFGLIYEPRNNTLFHALEGKGAFLNGERIHVSNTMNLNESLVTLGTSVL
GASELLKHLHRKVRRVRLLGSAAIQGAYVGWGVSEAFIGYKMKIWDIAAAYLIVKEAGGRVTNWYGEDVEVHQTNEMLFT
NGKILEPLSKILSSIKLD

Sequences:

>Translated_258_residues
MIQTDRLELALKIIEKAGIELNENFTKVRKIAHKSDQFDLVTQFDLSIQKMLTNEIQKQFPEDKILAEEGEASQNTFQEN
QWIIDPIDGTVNFIHRFPIFCISLAFYGKEEKFGLIYEPRNNTLFHALEGKGAFLNGERIHVSNTMNLNESLVTLGTSVL
GASELLKHLHRKVRRVRLLGSAAIQGAYVGWGVSEAFIGYKMKIWDIAAAYLIVKEAGGRVTNWYGEDVEVHQTNEMLFT
NGKILEPLSKILSSIKLD
>Mature_258_residues
MIQTDRLELALKIIEKAGIELNENFTKVRKIAHKSDQFDLVTQFDLSIQKMLTNEIQKQFPEDKILAEEGEASQNTFQEN
QWIIDPIDGTVNFIHRFPIFCISLAFYGKEEKFGLIYEPRNNTLFHALEGKGAFLNGERIHVSNTMNLNESLVTLGTSVL
GASELLKHLHRKVRRVRLLGSAAIQGAYVGWGVSEAFIGYKMKIWDIAAAYLIVKEAGGRVTNWYGEDVEVHQTNEMLFT
NGKILEPLSKILSSIKLD

Specific function: Displays a 20-fold higher rate of hydrolysis of the D isoform of inositol 1-phosphate than of the L isoform [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI7657236, Length=232, Percent_Identity=33.1896551724138, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI5031789, Length=264, Percent_Identity=31.8181818181818, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI221625487, Length=264, Percent_Identity=31.8181818181818, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI221625507, Length=144, Percent_Identity=35.4166666666667, Blast_Score=101, Evalue=8e-22,
Organism=Escherichia coli, GI1788882, Length=228, Percent_Identity=32.8947368421053, Blast_Score=130, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI193202572, Length=267, Percent_Identity=30.7116104868914, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI193202570, Length=270, Percent_Identity=30.3703703703704, Blast_Score=127, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6321836, Length=207, Percent_Identity=32.8502415458937, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6320493, Length=205, Percent_Identity=35.1219512195122, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21357329, Length=259, Percent_Identity=35.1351351351351, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24664922, Length=241, Percent_Identity=37.344398340249, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24664926, Length=241, Percent_Identity=35.6846473029046, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21357303, Length=237, Percent_Identity=36.7088607594937, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI21357957, Length=251, Percent_Identity=32.2709163346614, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24664918, Length=235, Percent_Identity=33.1914893617021, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.25 [H]

Molecular weight: Translated: 29257; Mature: 29257

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00629 IMP_1 ; PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQTDRLELALKIIEKAGIELNENFTKVRKIAHKSDQFDLVTQFDLSIQKMLTNEIQKQF
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHC
PEDKILAEEGEASQNTFQENQWIIDPIDGTVNFIHRFPIFCISLAFYGKEEKFGLIYEPR
CCCCEECCCCCCCCCHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
NNTLFHALEGKGAFLNGERIHVSNTMNLNESLVTLGTSVLGASELLKHLHRKVRRVRLLG
CCEEEEEECCCCEEECCCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
SAAIQGAYVGWGVSEAFIGYKMKIWDIAAAYLIVKEAGGRVTNWYGEDVEVHQTNEMLFT
HHHHCCCEECCCHHHHHHCEEEHHHHHHHHHHHEECCCCCEEECCCCCEEEEECCCEEEE
NGKILEPLSKILSSIKLD
CCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIQTDRLELALKIIEKAGIELNENFTKVRKIAHKSDQFDLVTQFDLSIQKMLTNEIQKQF
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHC
PEDKILAEEGEASQNTFQENQWIIDPIDGTVNFIHRFPIFCISLAFYGKEEKFGLIYEPR
CCCCEECCCCCCCCCHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
NNTLFHALEGKGAFLNGERIHVSNTMNLNESLVTLGTSVLGASELLKHLHRKVRRVRLLG
CCEEEEEECCCCEEECCCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
SAAIQGAYVGWGVSEAFIGYKMKIWDIAAAYLIVKEAGGRVTNWYGEDVEVHQTNEMLFT
HHHHCCCEECCCHHHHHHCEEEHHHHHHHHHHHEECCCCCEEECCCCCEEEEECCCEEEE
NGKILEPLSKILSSIKLD
CCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9720201; 10360571; 10508089 [H]