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The map label for this gene is tcrA [H]

Identifier: 239617803

GI number: 239617803

Start: 1523906

End: 1524592

Strand: Reverse

Name: tcrA [H]

Synonym: Kole_1429

Alternate gene names: 239617803

Gene position: 1524592-1523906 (Counterclockwise)

Preceding gene: 239617804

Following gene: 239617802

Centisome position: 66.23

GC content: 42.21

Gene sequence:

>687_bases
GTGAAAATACTGGTTGTTGAGGACAACAAAAAACTTGCAGAAAATATAAAAAAATATCTTGAACTCGAAGGTTTCATCGT
TGACCTGGCATATGACGGAAACGAAGGTCTGGATCTCGCGCTTTCCTATAACTACGACTGTATAATACTGGACATAATCT
TGCCCGGTATGTCAGGCATTGAAATTTGTCGTTTTTTGAGAGATGAAGAAAAGAGCCAGGTACCGATACTGATGCTCACG
GCACTGGGCAGTGTGGAAAATCGGGTGGAAGGACTTAATGTCGGTGCTGATGATTACATGCCAAAACCCTTTGACCTTAG
AGAACTTGTGGCAAGAGTCCGTGCACTCATCAGGAGAAATCAGGTTGTTCGTCAGGAAACTCTCAAATACGGCGACCTTG
TAATGAACCTGCAAACCAGGGAAGTCAGCTGTAAAGGGGAACCTCTGAATCTCAGCAGTAAAGAATTTTCACTCCTTGAG
CTTTTCATGCGTAATCCTGGTGTCGTATTTAGCAGAGAACAAATTCTTGATAAGTTATGGGAAAGCGGGTTCGAACCGCG
CAGTAATATCGTTGACGTTTATGTGCTCTACCTGAGAAAAAAGCTCAAACCTTTTGGTTACGACGAAAAAATAGAGACAG
TTCATAACATCGGGTATAGACTCAAGAAAGAAGATGATAAAACGTGA

Upstream 100 bases:

>100_bases
TGTAGTACCAAAACCAGATCACCCAACCAAACCGTCAGATGACCACGAAAAACCAAAACCCAAACCGCCCGGCGGGAAAA
AGGACGGTAGGTGAGACCCG

Downstream 100 bases:

>100_bases
CTTTAAAAGCAAAGATCTCTCTGCTGTACCTTATTGCGTACGGTTCATCTTTGCTTTTTTTAGCCGCCTTTCTCTACGCT
ATCGTATACGATCTGAAATA

Product: two component transcriptional regulator, winged helix family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKILVVEDNKKLAENIKKYLELEGFIVDLAYDGNEGLDLALSYNYDCIILDIILPGMSGIEICRFLRDEEKSQVPILMLT
ALGSVENRVEGLNVGADDYMPKPFDLRELVARVRALIRRNQVVRQETLKYGDLVMNLQTREVSCKGEPLNLSSKEFSLLE
LFMRNPGVVFSREQILDKLWESGFEPRSNIVDVYVLYLRKKLKPFGYDEKIETVHNIGYRLKKEDDKT

Sequences:

>Translated_228_residues
MKILVVEDNKKLAENIKKYLELEGFIVDLAYDGNEGLDLALSYNYDCIILDIILPGMSGIEICRFLRDEEKSQVPILMLT
ALGSVENRVEGLNVGADDYMPKPFDLRELVARVRALIRRNQVVRQETLKYGDLVMNLQTREVSCKGEPLNLSSKEFSLLE
LFMRNPGVVFSREQILDKLWESGFEPRSNIVDVYVLYLRKKLKPFGYDEKIETVHNIGYRLKKEDDKT
>Mature_228_residues
MKILVVEDNKKLAENIKKYLELEGFIVDLAYDGNEGLDLALSYNYDCIILDIILPGMSGIEICRFLRDEEKSQVPILMLT
ALGSVENRVEGLNVGADDYMPKPFDLRELVARVRALIRRNQVVRQETLKYGDLVMNLQTREVSCKGEPLNLSSKEFSLLE
LFMRNPGVVFSREQILDKLWESGFEPRSNIVDVYVLYLRKKLKPFGYDEKIETVHNIGYRLKKEDDKT

Specific function: Member of the three-protein two-component system HK1/HK2/tcrA [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=45.6140350877193, Blast_Score=191, Evalue=3e-50,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=44.3438914027149, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=39.0134529147982, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=40.4545454545455, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=36.322869955157, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI2367329, Length=209, Percent_Identity=39.2344497607655, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=34.5132743362832, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=34.5132743362832, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=34.3891402714932, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=35.1598173515982, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=32.8828828828829, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=32.9004329004329, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=32.6086956521739, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=32.4786324786325, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=36.1111111111111, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790299, Length=123, Percent_Identity=29.2682926829268, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790437, Length=127, Percent_Identity=29.9212598425197, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26328; Mature: 26328

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVVEDNKKLAENIKKYLELEGFIVDLAYDGNEGLDLALSYNYDCIILDIILPGMSGI
CEEEEEECCHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEECCCCEEEEEEECCCCCHH
EICRFLRDEEKSQVPILMLTALGSVENRVEGLNVGADDYMPKPFDLRELVARVRALIRRN
HHHHHHHHCCCCCCCEEEEEHHCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
QVVRQETLKYGDLVMNLQTREVSCKGEPLNLSSKEFSLLELFMRNPGVVFSREQILDKLW
HHHHHHHHHHHHEEEEEEECEEECCCCCCCCCCHHHHHHHHHHCCCCCEECHHHHHHHHH
ESGFEPRSNIVDVYVLYLRKKLKPFGYDEKIETVHNIGYRLKKEDDKT
HCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure
MKILVVEDNKKLAENIKKYLELEGFIVDLAYDGNEGLDLALSYNYDCIILDIILPGMSGI
CEEEEEECCHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEECCCCEEEEEEECCCCCHH
EICRFLRDEEKSQVPILMLTALGSVENRVEGLNVGADDYMPKPFDLRELVARVRALIRRN
HHHHHHHHCCCCCCCEEEEEHHCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
QVVRQETLKYGDLVMNLQTREVSCKGEPLNLSSKEFSLLELFMRNPGVVFSREQILDKLW
HHHHHHHHHHHHEEEEEEECEEECCCCCCCCCCHHHHHHHHHHCCCCCEECHHHHHHHHH
ESGFEPRSNIVDVYVLYLRKKLKPFGYDEKIETVHNIGYRLKKEDDKT
HCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]