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The map label for this gene is lpd3 [H]

Identifier: 239617765

GI number: 239617765

Start: 1476913

End: 1478265

Strand: Reverse

Name: lpd3 [H]

Synonym: Kole_1390

Alternate gene names: 239617765

Gene position: 1478265-1476913 (Counterclockwise)

Preceding gene: 239617766

Following gene: 239617758

Centisome position: 64.21

GC content: 43.83

Gene sequence:

>1353_bases
TTGCCAAAGTATGATGTTATTGTTGTTGGTGGAGGCCCTGGCGGCAGTGACTGTGCGATAAGGCTGTCACAGAGAGGAAA
GAAAGTTGCGATAGTTGAAAGAAAAGAATTCGGAGGTACGTGTACGAATGTTGGCTGCATTCCAACGAAAGCCCTTCTTA
CTGTCGCAAAGCTCTATTCAGATATCAAGGAAAAAGGAAAAAGACTCGGTGTGTTAGCACAGGTTGACATAGACTTAAAG
ACCGTTATGAAACATATGAACCGTTCTATCCTCATGTCAAGGAAGGGAACAGAAACCCTCCTGAAAAAATACGGCGTGGA
AATAATAAAAGACAACGTGGTCTACAAAAACGGCAGCTTTTACCTTGAAAACGCAAATGAAATACTCGATACAGAAAAGA
TCGTCCTCGCAACAGGATCGAAGCCAAAAATCCCCAAAACCCTTGCCGTTGAAGGCATCTGGACCTCCAATGAGGTCTTT
TCCATGTCCGAATTTCCGGAAAGTATTCTCATAATAGGAGCTGGTTACATCGGAGTAGAAATGGCCACTATATTCAATGC
TTTTGGAACAAAGGTCATTCTTGTTGAACTGCAGCCACGCATAATCCCTTTCGAAGACATTGACGCTTCCATAGTACTTG
AAAAATCCCTTAAAAAACGCGGTGTGAAAGTAAAAACGGGTGTAGCGGTAGAAAAAATAGAAAAGCTCGATAATGGATTC
CTGACAGCCCTTTCTGACGGCGAACAGCTCGAAACCGAAAAGGTTCTCGTTGCCATAGGCAGGGCACCAGTCTATCCGGA
GGGATTGGAAGACACTGAACTGGTGGAAAACGGCAAAATCACTACAAATAAAGATTTTGAAACAAAATGGCCAAACGTTT
ACGCGATAGGAGACGTAAGAGGGGCCATCATGCTCGCCCACGTTGCCAGTGCTGAAGGCATCGCTCTCGCAGAAAAACTT
TCAGGAAAAGACTACGACTATTATAGTGAAACTGTTCCTGCAGTAATATTCTGTGAACCGGAAATTGGTTCCACTGGTAT
CAAAGAAACAGAAGATGGTTTGAGTGATGACTACGACAAATTCCTCTTTCCCATGAGCGCCAACCCCAGAGCTAACATAC
TGGCAGAACGCGACGGTTTCGTAAAATTGATAGCAAACAAGAGTGATCACAAAATCGTCGGAATAACTATTGTCGGTCCT
AATGCCGTTGAACTTCTTATGGAAGGTGTTGTGGTAATAAACGAACAGCTCACGGTAGAAGAATTACTGAAATCCATTCA
CCCCCATCCAACCCTGTCAGAAATTATTCGTGATGCAGCGGAGGGTCTTGAGGGAAATCCCATTCATATCTGA

Upstream 100 bases:

>100_bases
CAGGAACATTCCATGAAGGGCAGACATGGTGGATTAACGGATGACGAGATGTTCGTTCCTTTGATTTTTTTGCGAAAGTG
ATTGATGGGAGGGATAAACG

Downstream 100 bases:

>100_bases
GATTCCTTTCTGAATTTACAGTCACCTATAAAGCAGCCGGCACAGTCCGGCTGTTTTTTACAGTATTTTTTTGCATGTTC
CACTATAAGAGCGTGATATT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase 3; LPD-3 [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MPKYDVIVVGGGPGGSDCAIRLSQRGKKVAIVERKEFGGTCTNVGCIPTKALLTVAKLYSDIKEKGKRLGVLAQVDIDLK
TVMKHMNRSILMSRKGTETLLKKYGVEIIKDNVVYKNGSFYLENANEILDTEKIVLATGSKPKIPKTLAVEGIWTSNEVF
SMSEFPESILIIGAGYIGVEMATIFNAFGTKVILVELQPRIIPFEDIDASIVLEKSLKKRGVKVKTGVAVEKIEKLDNGF
LTALSDGEQLETEKVLVAIGRAPVYPEGLEDTELVENGKITTNKDFETKWPNVYAIGDVRGAIMLAHVASAEGIALAEKL
SGKDYDYYSETVPAVIFCEPEIGSTGIKETEDGLSDDYDKFLFPMSANPRANILAERDGFVKLIANKSDHKIVGITIVGP
NAVELLMEGVVVINEQLTVEELLKSIHPHPTLSEIIRDAAEGLEGNPIHI

Sequences:

>Translated_450_residues
MPKYDVIVVGGGPGGSDCAIRLSQRGKKVAIVERKEFGGTCTNVGCIPTKALLTVAKLYSDIKEKGKRLGVLAQVDIDLK
TVMKHMNRSILMSRKGTETLLKKYGVEIIKDNVVYKNGSFYLENANEILDTEKIVLATGSKPKIPKTLAVEGIWTSNEVF
SMSEFPESILIIGAGYIGVEMATIFNAFGTKVILVELQPRIIPFEDIDASIVLEKSLKKRGVKVKTGVAVEKIEKLDNGF
LTALSDGEQLETEKVLVAIGRAPVYPEGLEDTELVENGKITTNKDFETKWPNVYAIGDVRGAIMLAHVASAEGIALAEKL
SGKDYDYYSETVPAVIFCEPEIGSTGIKETEDGLSDDYDKFLFPMSANPRANILAERDGFVKLIANKSDHKIVGITIVGP
NAVELLMEGVVVINEQLTVEELLKSIHPHPTLSEIIRDAAEGLEGNPIHI
>Mature_449_residues
PKYDVIVVGGGPGGSDCAIRLSQRGKKVAIVERKEFGGTCTNVGCIPTKALLTVAKLYSDIKEKGKRLGVLAQVDIDLKT
VMKHMNRSILMSRKGTETLLKKYGVEIIKDNVVYKNGSFYLENANEILDTEKIVLATGSKPKIPKTLAVEGIWTSNEVFS
MSEFPESILIIGAGYIGVEMATIFNAFGTKVILVELQPRIIPFEDIDASIVLEKSLKKRGVKVKTGVAVEKIEKLDNGFL
TALSDGEQLETEKVLVAIGRAPVYPEGLEDTELVENGKITTNKDFETKWPNVYAIGDVRGAIMLAHVASAEGIALAEKLS
GKDYDYYSETVPAVIFCEPEIGSTGIKETEDGLSDDYDKFLFPMSANPRANILAERDGFVKLIANKSDHKIVGITIVGPN
AVELLMEGVVVINEQLTVEELLKSIHPHPTLSEIIRDAAEGLEGNPIHI

Specific function: LPD-3 may substitute for lipoamide dehydrogenase of the 2-oxoglutarate dehydrogenase and pyruvate multienzyme complexes when the latter is inactive or missing [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=464, Percent_Identity=34.2672413793103, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI50301238, Length=465, Percent_Identity=28.8172043010753, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI22035672, Length=471, Percent_Identity=28.0254777070064, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI33519430, Length=488, Percent_Identity=27.2540983606557, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI33519428, Length=488, Percent_Identity=27.2540983606557, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI33519426, Length=488, Percent_Identity=27.2540983606557, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI148277071, Length=488, Percent_Identity=27.2540983606557, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI148277065, Length=488, Percent_Identity=27.2540983606557, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI291045266, Length=489, Percent_Identity=29.2433537832311, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI291045268, Length=479, Percent_Identity=27.9749478079332, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1786307, Length=461, Percent_Identity=32.5379609544469, Blast_Score=218, Evalue=4e-58,
Organism=Escherichia coli, GI87082354, Length=472, Percent_Identity=30.0847457627119, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=26.7108167770419, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789915, Length=426, Percent_Identity=29.5774647887324, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=31.9565217391304, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=27.9661016949153, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71983429, Length=429, Percent_Identity=25.6410256410256, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71983419, Length=429, Percent_Identity=25.6410256410256, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71982272, Length=479, Percent_Identity=27.348643006263, Blast_Score=105, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6321091, Length=481, Percent_Identity=33.2640332640333, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6325240, Length=482, Percent_Identity=29.4605809128631, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6325166, Length=460, Percent_Identity=27.6086956521739, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21358499, Length=463, Percent_Identity=32.829373650108, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24640549, Length=477, Percent_Identity=28.0922431865828, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24640553, Length=477, Percent_Identity=28.0922431865828, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24640551, Length=477, Percent_Identity=28.0922431865828, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=26.7368421052632, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49019; Mature: 48888

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYDVIVVGGGPGGSDCAIRLSQRGKKVAIVERKEFGGTCTNVGCIPTKALLTVAKLYS
CCCEEEEEEECCCCCCCEEEEECCCCCEEEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHH
DIKEKGKRLGVLAQVDIDLKTVMKHMNRSILMSRKGTETLLKKYGVEIIKDNVVYKNGSF
HHHHHHHHEEEEEEECCCHHHHHHHCCCCEEECCCCHHHHHHHCCCEEEECCEEEECCCE
YLENANEILDTEKIVLATGSKPKIPKTLAVEGIWTSNEVFSMSEFPESILIIGAGYIGVE
EEECCHHHHCCCEEEEEECCCCCCCCEEEEEEEECCCCEEEHHHCCCEEEEEECCHHHHH
MATIFNAFGTKVILVELQPRIIPFEDIDASIVLEKSLKKRGVKVKTGVAVEKIEKLDNGF
HHHHHHHCCCEEEEEEECCCEECCCCCCHHEEEHHHHHHCCCEEECCHHHHHHHHHCCCE
LTALSDGEQLETEKVLVAIGRAPVYPEGLEDTELVENGKITTNKDFETKWPNVYAIGDVR
EEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCEECCCCCCCCCCCEEEECCCC
GAIMLAHVASAEGIALAEKLSGKDYDYYSETVPAVIFCEPEIGSTGIKETEDGLSDDYDK
CEEEEEECCCCCCEEHHHHHCCCCCCCHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCHH
FLFPMSANPRANILAERDGFVKLIANKSDHKIVGITIVGPNAVELLMEGVVVINEQLTVE
EEEECCCCCCCCEEECCCCEEEEEECCCCCEEEEEEEECCHHHHHHHCCEEEEECCCCHH
ELLKSIHPHPTLSEIIRDAAEGLEGNPIHI
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PKYDVIVVGGGPGGSDCAIRLSQRGKKVAIVERKEFGGTCTNVGCIPTKALLTVAKLYS
CCEEEEEEECCCCCCCEEEEECCCCCEEEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHH
DIKEKGKRLGVLAQVDIDLKTVMKHMNRSILMSRKGTETLLKKYGVEIIKDNVVYKNGSF
HHHHHHHHEEEEEEECCCHHHHHHHCCCCEEECCCCHHHHHHHCCCEEEECCEEEECCCE
YLENANEILDTEKIVLATGSKPKIPKTLAVEGIWTSNEVFSMSEFPESILIIGAGYIGVE
EEECCHHHHCCCEEEEEECCCCCCCCEEEEEEEECCCCEEEHHHCCCEEEEEECCHHHHH
MATIFNAFGTKVILVELQPRIIPFEDIDASIVLEKSLKKRGVKVKTGVAVEKIEKLDNGF
HHHHHHHCCCEEEEEEECCCEECCCCCCHHEEEHHHHHHCCCEEECCHHHHHHHHHCCCE
LTALSDGEQLETEKVLVAIGRAPVYPEGLEDTELVENGKITTNKDFETKWPNVYAIGDVR
EEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCEECCCCCCCCCCCEEEECCCC
GAIMLAHVASAEGIALAEKLSGKDYDYYSETVPAVIFCEPEIGSTGIKETEDGLSDDYDK
CEEEEEECCCCCCEEHHHHHCCCCCCCHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCHH
FLFPMSANPRANILAERDGFVKLIANKSDHKIVGITIVGPNAVELLMEGVVVINEQLTVE
EEEECCCCCCCCEEECCCCEEEEEECCCCCEEEEEEEECCHHHHHHHCCEEEEECCCCHH
ELLKSIHPHPTLSEIIRDAAEGLEGNPIHI
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]