Click here to switch to the map view.

The map label for this gene is gltA [H]

Identifier: 239617609

GI number: 239617609

Start: 1306476

End: 1307615

Strand: Reverse

Name: gltA [H]

Synonym: Kole_1230

Alternate gene names: 239617609

Gene position: 1307615-1306476 (Counterclockwise)

Preceding gene: 239617618

Following gene: 239617608

Centisome position: 56.8

GC content: 42.54

Gene sequence:

>1140_bases
ATGACTTCTTTTGAAGGCGTAAAAATTTTCAAAGGTCTGGAAAATGTAGCAATTGCTGAAACATCCTTGAGCTACATAAA
TGGCGAAAAGGGAAGATTAGTCTACAGGGGAATCCCTGTGGAAGTTCTTGCGGAAAAAGCTTCATTTGAAGAAGTTGCTT
TTCTCCTGTGGTTTGGGTATCTGCCGAATAGAAAAGAGTTGGATGACCTTATAAGATTCATGGCAGATAGCCGGGACATA
CATCCCGAAATAGAAGATCATATTGCCAGATTACCGAATAAGGCTCATCCAATGGATGTTTTGAGGAGCTGCGTCTCGCT
GTTCGGCGTTTTCGAGGATCTTCAAGCTTCACACGACGAACTTCAAAGAGCAGCGAGAATAACAGCCAAGCTGCCAACAA
TAGTTTCTTACCACTACAGGCTATCAAGAGGGATGAAGCCTGTACCACCTGATAAAACCCTGGATCACGCGTCTAATTTT
TATTACATGATAACCGGAGAAAAGCCTGATGAAGAAATCTCAAAACTCATGAATTCGATATTAATACTGCATGCAGAGCA
AGGGCTGAACGCTTCCACTTTCACAGCCATGGTAATCGCCTCAACATTATCTGATATGTACTCTTCGATCACGGGGGCGA
TCGGAGCCCTAAAAGGTCCTCTGCATGGAGGAGCCAATGAGAAAGTGATAGACATGATAGAAGAGATAGGCACTCCAGAG
AATGTGGAGAGCTATGTTGAAAAGGCTTTGAAAGAAAAAAGGAAAATTCCCGGGTTTGGTCACAGGGTGTACAAAACTTA
TGACCCAAGATCAAAAGTTCTAAAGGAATACGCGAGAAAGCTTTCGTTGAAAATGAACGACGCCAAATATTTCCCGATAG
CCGAAAAACTCGAGAAGGTCGTTGTGGAGAAACTTGCACATAAGAAAATATTCCCGAATGTTGACCTTTATTCCGGGATA
GTTTACAAACTGCTTGGTTTCCCAAAAGAGATCTATACAGCTATATTCGCTATAGCACGTGTAGTAGGCTGGACAGCTCA
TGTTATCGAATATACCAAATCAAATAAGATAATAAGACCGTGCGGCGTCTATGTTGGACCTATGAACGCTGAATACATAC
CTTTGGAAGCGAGGGAGTGA

Upstream 100 bases:

>100_bases
GTGAAATTTTGGTGTCATTTTGCTTCATTTTTGAGTGTTCTTAGTATTTTAAAGCCGATAATTAATGAAATAATCATATG
TGGGGAAAGTGAGGAGTTGC

Downstream 100 bases:

>100_bases
AAAATGGGGAAAACCATCGCCGAAAAAATAATATCCGAACATGTTGGAAGAGACGTGAATTCTGGAGATATCGTTGTTGC
TAAGGTAGATATAGCCATGG

Product: 2-methylcitrate synthase/citrate synthase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MTSFEGVKIFKGLENVAIAETSLSYINGEKGRLVYRGIPVEVLAEKASFEEVAFLLWFGYLPNRKELDDLIRFMADSRDI
HPEIEDHIARLPNKAHPMDVLRSCVSLFGVFEDLQASHDELQRAARITAKLPTIVSYHYRLSRGMKPVPPDKTLDHASNF
YYMITGEKPDEEISKLMNSILILHAEQGLNASTFTAMVIASTLSDMYSSITGAIGALKGPLHGGANEKVIDMIEEIGTPE
NVESYVEKALKEKRKIPGFGHRVYKTYDPRSKVLKEYARKLSLKMNDAKYFPIAEKLEKVVVEKLAHKKIFPNVDLYSGI
VYKLLGFPKEIYTAIFAIARVVGWTAHVIEYTKSNKIIRPCGVYVGPMNAEYIPLEARE

Sequences:

>Translated_379_residues
MTSFEGVKIFKGLENVAIAETSLSYINGEKGRLVYRGIPVEVLAEKASFEEVAFLLWFGYLPNRKELDDLIRFMADSRDI
HPEIEDHIARLPNKAHPMDVLRSCVSLFGVFEDLQASHDELQRAARITAKLPTIVSYHYRLSRGMKPVPPDKTLDHASNF
YYMITGEKPDEEISKLMNSILILHAEQGLNASTFTAMVIASTLSDMYSSITGAIGALKGPLHGGANEKVIDMIEEIGTPE
NVESYVEKALKEKRKIPGFGHRVYKTYDPRSKVLKEYARKLSLKMNDAKYFPIAEKLEKVVVEKLAHKKIFPNVDLYSGI
VYKLLGFPKEIYTAIFAIARVVGWTAHVIEYTKSNKIIRPCGVYVGPMNAEYIPLEARE
>Mature_378_residues
TSFEGVKIFKGLENVAIAETSLSYINGEKGRLVYRGIPVEVLAEKASFEEVAFLLWFGYLPNRKELDDLIRFMADSRDIH
PEIEDHIARLPNKAHPMDVLRSCVSLFGVFEDLQASHDELQRAARITAKLPTIVSYHYRLSRGMKPVPPDKTLDHASNFY
YMITGEKPDEEISKLMNSILILHAEQGLNASTFTAMVIASTLSDMYSSITGAIGALKGPLHGGANEKVIDMIEEIGTPEN
VESYVEKALKEKRKIPGFGHRVYKTYDPRSKVLKEYARKLSLKMNDAKYFPIAEKLEKVVVEKLAHKKIFPNVDLYSGIV
YKLLGFPKEIYTAIFAIARVVGWTAHVIEYTKSNKIIRPCGVYVGPMNAEYIPLEARE

Specific function: Catalyzes The Synthesis Of 2-Methylcitrate From Propionyl-CoA And Oxaloacetate. Also Catalyzes The Condensation Of Oxaloacetate With Acetyl-CoA But With A Lower Specificity. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=326, Percent_Identity=26.6871165644172, Blast_Score=118, Evalue=9e-27,
Organism=Escherichia coli, GI1786527, Length=371, Percent_Identity=39.622641509434, Blast_Score=257, Evalue=8e-70,
Organism=Escherichia coli, GI1786939, Length=380, Percent_Identity=34.2105263157895, Blast_Score=212, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17555174, Length=376, Percent_Identity=27.1276595744681, Blast_Score=120, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6319850, Length=325, Percent_Identity=26.1538461538462, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324328, Length=319, Percent_Identity=26.6457680250784, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325257, Length=335, Percent_Identity=26.865671641791, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24640126, Length=379, Percent_Identity=25.5936675461741, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24640124, Length=379, Percent_Identity=25.5936675461741, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21356863, Length=381, Percent_Identity=24.6719160104987, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 42749; Mature: 42618

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSFEGVKIFKGLENVAIAETSLSYINGEKGRLVYRGIPVEVLAEKASFEEVAFLLWFGY
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHC
LPNRKELDDLIRFMADSRDIHPEIEDHIARLPNKAHPMDVLRSCVSLFGVFEDLQASHDE
CCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHH
LQRAARITAKLPTIVSYHYRLSRGMKPVPPDKTLDHASNFYYMITGEKPDEEISKLMNSI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEEEEECCCCHHHHHHHHHHH
LILHAEQGLNASTFTAMVIASTLSDMYSSITGAIGALKGPLHGGANEKVIDMIEEIGTPE
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCC
NVESYVEKALKEKRKIPGFGHRVYKTYDPRSKVLKEYARKLSLKMNDAKYFPIAEKLEKV
HHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHH
VVEKLAHKKIFPNVDLYSGIVYKLLGFPKEIYTAIFAIARVVGWTAHVIEYTKSNKIIRP
HHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
CGVYVGPMNAEYIPLEARE
CCCEECCCCCCEECCCCCC
>Mature Secondary Structure 
TSFEGVKIFKGLENVAIAETSLSYINGEKGRLVYRGIPVEVLAEKASFEEVAFLLWFGY
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHC
LPNRKELDDLIRFMADSRDIHPEIEDHIARLPNKAHPMDVLRSCVSLFGVFEDLQASHDE
CCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHH
LQRAARITAKLPTIVSYHYRLSRGMKPVPPDKTLDHASNFYYMITGEKPDEEISKLMNSI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEEEEECCCCHHHHHHHHHHH
LILHAEQGLNASTFTAMVIASTLSDMYSSITGAIGALKGPLHGGANEKVIDMIEEIGTPE
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCC
NVESYVEKALKEKRKIPGFGHRVYKTYDPRSKVLKEYARKLSLKMNDAKYFPIAEKLEKV
HHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHH
VVEKLAHKKIFPNVDLYSGIVYKLLGFPKEIYTAIFAIARVVGWTAHVIEYTKSNKIIRP
HHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
CGVYVGPMNAEYIPLEARE
CCCEECCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8532683; 9254593 [H]