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The map label for this gene is lytS [H]

Identifier: 239617503

GI number: 239617503

Start: 1188321

End: 1190000

Strand: Reverse

Name: lytS [H]

Synonym: Kole_1119

Alternate gene names: 239617503

Gene position: 1190000-1188321 (Counterclockwise)

Preceding gene: 239617504

Following gene: 239617502

Centisome position: 51.69

GC content: 40.42

Gene sequence:

>1680_bases
ATGTTTGAAAACATCGCTTTCATCCTGATTGAGAGAGTAGCCATAATCACCATGACCATCTATATTATTTTCACTTTTTC
TTTCTCTCAAAGACACCTAATCATACGTTCCAAACCACAATCAACCATTTTTATAGGAATTCTTGGGGGAGTTCTCGGTA
TCATAGGAACCTTTCTCGGAATAGAGTATAAAACGGCTATAACAAACTATCGAGATATGGGGGTTATAATCGCAGCAGTC
ATAGGCGGGCCGATATCCGGAACTATAAGCGGCCTTATCGCTGGACTTCACAGGATGACCCTTGGAGGAGTTACCGGGAT
ATCGTGTTCATTAGCAACCATCATGGTTGGTGTTCTAACAGGTTTTTCACGAAAACTCTTCGGGCCGAAGCTTCTACGTC
CTCAGTTTGTGGTTCCCTTGACAATTGGAATGGAATTTTTACACCTTGGCTTTGTTTATCTGGTAACCTTCCCAAAAGAC
ATTGCCGCAGACATAGTGACCACTGTTTTGCTTCCAATGGTTTTAGGAAATTCAATCGGCGTCTTATTGCTTTCACTCAT
ATTCAGAAACCTCCAAATAGAAAAAGAGAATGTAACCGAAGAAACCACTCAATCGATGTTCAAAATAGTAGAGAACACGA
TAGGTCTTATAGATAAAGGACTCAATGAGACCACAGCAAGACAGATATGTGAAACGATAAAGAAATTGACAAGTTTTGAC
GCTGTAGCGCTCACAACAAGAGAAAAAATCCTGAGTCACGTTGGCGCCGGCGAAGATCACCACACCCCGGGAAATCCAAA
TCTCACAGAATCCACAAGACTAACCATTCAAAAAGGTAAAGCTAGACTAATAAAACACCGTTCAGGTATTGGTTGCAGTC
ATAAAAACTGTCCCCTGTTCAGAGGCATTCTCATTCCCATAAAATTCACAAATGGCGAGACTATTGGAACGTTGAAGTTA
TACAAAACAAAGGAAAATGACATAGAGAAGTACGAGATAACCTTTGCAAAGGGCCTTGGACAGATACTTTCTCTTGAACT
CGAACTTTCAAAAACCAGCAAAGAAGCCAGAGACAACGCGGAAGCGCGTTACAGGCAACTTGTAGCCAAAACAGATCCTC
ATTTCCTTTTCAACATACTCAATGCTCTGGCTTACCTAACCAGGCACGATTCAGAAAAAGCCAGAGAAATGATCCTAAAA
CTCTCAGAAATGATGAGATATACACTTCGCGAAAAGAGAACCTTCGTTCCTCTGGACGACGAACTCTCTTTTGTAAGAAA
TTACCTGCAACTCATGAAAATCCGTTTTGGCGAGCTTTTGGACTTCAAAATGGAAAAGGACCTCAAAGAACCATTTTGGA
TTCCACCTTTTACAATCCAACCGATAGTAGAGAACTCGATCAAGCACGGCATGATACCAAACAAAAAGCTATTCGTAAGA
ATCAGTGTGAAAGTTAAATCAAGGAATGTCGAGATCTTGATATTCGACACAGGAAAGGGTATAGAAAATGAAAATAAGCT
TCAAACAGGTATTGGGTTAAAATTGATAAGGGAAAGATTGTCTAACCTGTACGGAGAAAAAGCCCATTTGGAAGTTAATA
GCAAACCAATGAAAGGGACGACCATAACGATAAGAATACCGGAATCACTGGCAAAGAAAAAGGTTAGTGAAATAAGCTAA

Upstream 100 bases:

>100_bases
TTTTAAAAAACTCAAAGCCTCAGGACAAAAGGTGTTTATCATAGCCAGCGACGAATTTGGATACAGAGGCATGAGTGGAG
ATCCGGTTTAGGGGGAGAGT

Downstream 100 bases:

>100_bases
GTATGCTTGAAGAAGGGAGGCATAGGCGTTTATTTCTCCGAGTTTTGAAATTGAAAATCTAAACGCCAAAAGCTTATGAA
TATAAAAGCTATCGTTGTCG

Product: signal transduction histidine kinase, LytS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MFENIAFILIERVAIITMTIYIIFTFSFSQRHLIIRSKPQSTIFIGILGGVLGIIGTFLGIEYKTAITNYRDMGVIIAAV
IGGPISGTISGLIAGLHRMTLGGVTGISCSLATIMVGVLTGFSRKLFGPKLLRPQFVVPLTIGMEFLHLGFVYLVTFPKD
IAADIVTTVLLPMVLGNSIGVLLLSLIFRNLQIEKENVTEETTQSMFKIVENTIGLIDKGLNETTARQICETIKKLTSFD
AVALTTREKILSHVGAGEDHHTPGNPNLTESTRLTIQKGKARLIKHRSGIGCSHKNCPLFRGILIPIKFTNGETIGTLKL
YKTKENDIEKYEITFAKGLGQILSLELELSKTSKEARDNAEARYRQLVAKTDPHFLFNILNALAYLTRHDSEKAREMILK
LSEMMRYTLREKRTFVPLDDELSFVRNYLQLMKIRFGELLDFKMEKDLKEPFWIPPFTIQPIVENSIKHGMIPNKKLFVR
ISVKVKSRNVEILIFDTGKGIENENKLQTGIGLKLIRERLSNLYGEKAHLEVNSKPMKGTTITIRIPESLAKKKVSEIS

Sequences:

>Translated_559_residues
MFENIAFILIERVAIITMTIYIIFTFSFSQRHLIIRSKPQSTIFIGILGGVLGIIGTFLGIEYKTAITNYRDMGVIIAAV
IGGPISGTISGLIAGLHRMTLGGVTGISCSLATIMVGVLTGFSRKLFGPKLLRPQFVVPLTIGMEFLHLGFVYLVTFPKD
IAADIVTTVLLPMVLGNSIGVLLLSLIFRNLQIEKENVTEETTQSMFKIVENTIGLIDKGLNETTARQICETIKKLTSFD
AVALTTREKILSHVGAGEDHHTPGNPNLTESTRLTIQKGKARLIKHRSGIGCSHKNCPLFRGILIPIKFTNGETIGTLKL
YKTKENDIEKYEITFAKGLGQILSLELELSKTSKEARDNAEARYRQLVAKTDPHFLFNILNALAYLTRHDSEKAREMILK
LSEMMRYTLREKRTFVPLDDELSFVRNYLQLMKIRFGELLDFKMEKDLKEPFWIPPFTIQPIVENSIKHGMIPNKKLFVR
ISVKVKSRNVEILIFDTGKGIENENKLQTGIGLKLIRERLSNLYGEKAHLEVNSKPMKGTTITIRIPESLAKKKVSEIS
>Mature_559_residues
MFENIAFILIERVAIITMTIYIIFTFSFSQRHLIIRSKPQSTIFIGILGGVLGIIGTFLGIEYKTAITNYRDMGVIIAAV
IGGPISGTISGLIAGLHRMTLGGVTGISCSLATIMVGVLTGFSRKLFGPKLLRPQFVVPLTIGMEFLHLGFVYLVTFPKD
IAADIVTTVLLPMVLGNSIGVLLLSLIFRNLQIEKENVTEETTQSMFKIVENTIGLIDKGLNETTARQICETIKKLTSFD
AVALTTREKILSHVGAGEDHHTPGNPNLTESTRLTIQKGKARLIKHRSGIGCSHKNCPLFRGILIPIKFTNGETIGTLKL
YKTKENDIEKYEITFAKGLGQILSLELELSKTSKEARDNAEARYRQLVAKTDPHFLFNILNALAYLTRHDSEKAREMILK
LSEMMRYTLREKRTFVPLDDELSFVRNYLQLMKIRFGELLDFKMEKDLKEPFWIPPFTIQPIVENSIKHGMIPNKKLFVR
ISVKVKSRNVEILIFDTGKGIENENKLQTGIGLKLIRERLSNLYGEKAHLEVNSKPMKGTTITIRIPESLAKKKVSEIS

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788446, Length=517, Percent_Identity=29.9806576402321, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1788723, Length=560, Percent_Identity=29.6428571428571, Blast_Score=224, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR005467
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF01590 GAF; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 62666; Mature: 62666

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENIAFILIERVAIITMTIYIIFTFSFSQRHLIIRSKPQSTIFIGILGGVLGIIGTFLG
CCCCHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHC
IEYKTAITNYRDMGVIIAAVIGGPISGTISGLIAGLHRMTLGGVTGISCSLATIMVGVLT
CCHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
GFSRKLFGPKLLRPQFVVPLTIGMEFLHLGFVYLVTFPKDIAADIVTTVLLPMVLGNSIG
HHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHCCCHH
VLLLSLIFRNLQIEKENVTEETTQSMFKIVENTIGLIDKGLNETTARQICETIKKLTSFD
HHHHHHHHHHCEECHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
AVALTTREKILSHVGAGEDHHTPGNPNLTESTRLTIQKGKARLIKHRSGIGCSHKNCPLF
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHCCCCCCCCCCCCEE
RGILIPIKFTNGETIGTLKLYKTKENDIEKYEITFAKGLGQILSLELELSKTSKEARDNA
EEEEEEEEECCCCEEEEEEEEECCCCCCHHEEEEHHHHCHHHHEEEEEEHHHHHHHHCCH
EARYRQLVAKTDPHFLFNILNALAYLTRHDSEKAREMILKLSEMMRYTLREKRTFVPLDD
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
ELSFVRNYLQLMKIRFGELLDFKMEKDLKEPFWIPPFTIQPIVENSIKHGMIPNKKLFVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHCCCCCCCEEEEE
ISVKVKSRNVEILIFDTGKGIENENKLQTGIGLKLIRERLSNLYGEKAHLEVNSKPMKGT
EEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
TITIRIPESLAKKKVSEIS
EEEEECCHHHHHHHHHHCC
>Mature Secondary Structure
MFENIAFILIERVAIITMTIYIIFTFSFSQRHLIIRSKPQSTIFIGILGGVLGIIGTFLG
CCCCHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHC
IEYKTAITNYRDMGVIIAAVIGGPISGTISGLIAGLHRMTLGGVTGISCSLATIMVGVLT
CCHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
GFSRKLFGPKLLRPQFVVPLTIGMEFLHLGFVYLVTFPKDIAADIVTTVLLPMVLGNSIG
HHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHCCCHH
VLLLSLIFRNLQIEKENVTEETTQSMFKIVENTIGLIDKGLNETTARQICETIKKLTSFD
HHHHHHHHHHCEECHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
AVALTTREKILSHVGAGEDHHTPGNPNLTESTRLTIQKGKARLIKHRSGIGCSHKNCPLF
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHCCCCCCCCCCCCEE
RGILIPIKFTNGETIGTLKLYKTKENDIEKYEITFAKGLGQILSLELELSKTSKEARDNA
EEEEEEEEECCCCEEEEEEEEECCCCCCHHEEEEHHHHCHHHHEEEEEEHHHHHHHHCCH
EARYRQLVAKTDPHFLFNILNALAYLTRHDSEKAREMILKLSEMMRYTLREKRTFVPLDD
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
ELSFVRNYLQLMKIRFGELLDFKMEKDLKEPFWIPPFTIQPIVENSIKHGMIPNKKLFVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHHCCCCCCCEEEEE
ISVKVKSRNVEILIFDTGKGIENENKLQTGIGLKLIRERLSNLYGEKAHLEVNSKPMKGT
EEEEEECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
TITIRIPESLAKKKVSEIS
EEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]