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The map label for this gene is lysA [H]

Identifier: 239617262

GI number: 239617262

Start: 916338

End: 917525

Strand: Direct

Name: lysA [H]

Synonym: Kole_0871

Alternate gene names: 239617262

Gene position: 916338-917525 (Clockwise)

Preceding gene: 239617260

Following gene: 239617270

Centisome position: 39.8

GC content: 39.9

Gene sequence:

>1188_bases
ATGAAAGAATTATTGAAAAAGATTGCGAAAGTTTATGGGACACCAGTGTATGTGTATTTTGAGAAAGAGATCAAAAACCG
TATAGACAACGTTTTAGGAGTTTTTGAGGGAATAAATGTTTTTCCAACGTTTGCTGTGAAAGCAAACAACAACCCCCACT
TATTGAAGGTCATTTACAATAAAGGCTTCGGGATGGATGTAATTACCCCGGGAGAGCTTTATGCTGCAAAATTGGCAGGT
GCTTCGCCTGAAAAACTGGTATGGAACGGTAATGGAAAAACAGAAACAGACATAAAGAAGTTCATTGGAAGCGTGAAATA
TGTGAACGTAGATTCTTTTGAAGAAATGGAGATCTGGAAAAAGAAAGAAGCAAACGTTGAATTGTTTATCAGAGTGAATC
CCAATATAGATGCGCGTACACATCCTCATATCTCCACTGGTCTAAAAAAACATAAATTCGGTATCCCGTTGGATAAACTC
GATGAATTTCTGAAGAAATTCCCCGATAACCGAATCAAGGGATTACACGTTCATATAGGATCTCAGATAACCACCGTTGC
CCCTTTCGTTGAGGCGTTCGAAAAAGTCTCTGAAGTATCGAAAAAATATGGATTTGAGAAGATCAACATTGGTGGGGGAT
GGGGAATAAATTACGATGGAAAGGAGCTGGATTTATTAGAATACAGGAAAAAAGTTGTCCCGCTTTTGAAGAATTTCAAG
GAAGTTATATGCGAGATCGGCAGGTACATCATTGGCCCATCAGGGATTTTATTGTTAAAGGTTCTGAACTTAAAAAAGAC
TGATGACAAATATTTTGTTGTTGTGGACGGAGGAATGAATACTTTAATCAGGCCAGCACTTTATGGTGCGCATCATGGTA
TCAAGATTCTCGAGCCCACTGCTTTATCCGGGAAAATAGATATAGTCGGTCCCCTTTGCGAATCTGGAGATAAGCTGGCA
TGGGATATAGAAATAGAGTTACCTGAAGTCAGCAGTTTGTTGTACGTTGAAAACGCAGGAGCGTACGGATTCTCAATGTC
TAACAACTACAATTCTACCCTCAGGCCAGCGGAGGTACTGGTAAAAGAAAACGGTGAAATAGTATTGATAAGGCGAAGAG
AAACTTTAAATGATCTGTTTGGAACAGTGCAGAGAACCGAGATCCGAGAACCCGAGAATCCGAGATAG

Upstream 100 bases:

>100_bases
GTAAGTATGAATACCTCTTTGTTGGTTGTACTCGGCTTCACAACTAACATAGCCAATTTAGGCATTACATCAACCAGTTT
ACGGTGTTAGGAGTGAAAAA

Downstream 100 bases:

>100_bases
CCGCTTCGCGGCAGATAAGAACCCTTCGGGATTGTTACGACCGGCTACGCCGGTGTTGCGAACTCCTGCGGAGTTGTCGC
GAACTGCTTCGCAGTTGACA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MKELLKKIAKVYGTPVYVYFEKEIKNRIDNVLGVFEGINVFPTFAVKANNNPHLLKVIYNKGFGMDVITPGELYAAKLAG
ASPEKLVWNGNGKTETDIKKFIGSVKYVNVDSFEEMEIWKKKEANVELFIRVNPNIDARTHPHISTGLKKHKFGIPLDKL
DEFLKKFPDNRIKGLHVHIGSQITTVAPFVEAFEKVSEVSKKYGFEKINIGGGWGINYDGKELDLLEYRKKVVPLLKNFK
EVICEIGRYIIGPSGILLLKVLNLKKTDDKYFVVVDGGMNTLIRPALYGAHHGIKILEPTALSGKIDIVGPLCESGDKLA
WDIEIELPEVSSLLYVENAGAYGFSMSNNYNSTLRPAEVLVKENGEIVLIRRRETLNDLFGTVQRTEIREPENPR

Sequences:

>Translated_395_residues
MKELLKKIAKVYGTPVYVYFEKEIKNRIDNVLGVFEGINVFPTFAVKANNNPHLLKVIYNKGFGMDVITPGELYAAKLAG
ASPEKLVWNGNGKTETDIKKFIGSVKYVNVDSFEEMEIWKKKEANVELFIRVNPNIDARTHPHISTGLKKHKFGIPLDKL
DEFLKKFPDNRIKGLHVHIGSQITTVAPFVEAFEKVSEVSKKYGFEKINIGGGWGINYDGKELDLLEYRKKVVPLLKNFK
EVICEIGRYIIGPSGILLLKVLNLKKTDDKYFVVVDGGMNTLIRPALYGAHHGIKILEPTALSGKIDIVGPLCESGDKLA
WDIEIELPEVSSLLYVENAGAYGFSMSNNYNSTLRPAEVLVKENGEIVLIRRRETLNDLFGTVQRTEIREPENPR
>Mature_395_residues
MKELLKKIAKVYGTPVYVYFEKEIKNRIDNVLGVFEGINVFPTFAVKANNNPHLLKVIYNKGFGMDVITPGELYAAKLAG
ASPEKLVWNGNGKTETDIKKFIGSVKYVNVDSFEEMEIWKKKEANVELFIRVNPNIDARTHPHISTGLKKHKFGIPLDKL
DEFLKKFPDNRIKGLHVHIGSQITTVAPFVEAFEKVSEVSKKYGFEKINIGGGWGINYDGKELDLLEYRKKVVPLLKNFK
EVICEIGRYIIGPSGILLLKVLNLKKTDDKYFVVVDGGMNTLIRPALYGAHHGIKILEPTALSGKIDIVGPLCESGDKLA
WDIEIELPEVSSLLYVENAGAYGFSMSNNYNSTLRPAEVLVKENGEIVLIRRRETLNDLFGTVQRTEIREPENPR

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=349, Percent_Identity=22.9226361031519, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1789203, Length=404, Percent_Identity=29.4554455445545, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44465; Mature: 44465

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELLKKIAKVYGTPVYVYFEKEIKNRIDNVLGVFEGINVFPTFAVKANNNPHLLKVIYN
CHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEC
KGFGMDVITPGELYAAKLAGASPEKLVWNGNGKTETDIKKFIGSVKYVNVDSFEEMEIWK
CCCCCCEECCCHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHCCEEEEECCCCHHHHHHH
KKEANVELFIRVNPNIDARTHPHISTGLKKHKFGIPLDKLDEFLKKFPDNRIKGLHVHIG
HCCCCEEEEEEECCCCCCCCCCCHHHCCHHCCCCCCHHHHHHHHHHCCCCCCEEEEEEEC
SQITTVAPFVEAFEKVSEVSKKYGFEKINIGGGWGINYDGKELDLLEYRKKVVPLLKNFK
CCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
EVICEIGRYIIGPSGILLLKVLNLKKTDDKYFVVVDGGMNTLIRPALYGAHHGIKILEPT
HHHHHHHHEEECCCCEEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCEEECCC
ALSGKIDIVGPLCESGDKLAWDIEIELPEVSSLLYVENAGAYGFSMSNNYNSTLRPAEVL
CCCCCEEEEEHHCCCCCEEEEEEEEECCCCCEEEEEECCCCEEEEECCCCCCCCCHHHHH
VKENGEIVLIRRRETLNDLFGTVQRTEIREPENPR
EECCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKELLKKIAKVYGTPVYVYFEKEIKNRIDNVLGVFEGINVFPTFAVKANNNPHLLKVIYN
CHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEC
KGFGMDVITPGELYAAKLAGASPEKLVWNGNGKTETDIKKFIGSVKYVNVDSFEEMEIWK
CCCCCCEECCCHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHCCEEEEECCCCHHHHHHH
KKEANVELFIRVNPNIDARTHPHISTGLKKHKFGIPLDKLDEFLKKFPDNRIKGLHVHIG
HCCCCEEEEEEECCCCCCCCCCCHHHCCHHCCCCCCHHHHHHHHHHCCCCCCEEEEEEEC
SQITTVAPFVEAFEKVSEVSKKYGFEKINIGGGWGINYDGKELDLLEYRKKVVPLLKNFK
CCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
EVICEIGRYIIGPSGILLLKVLNLKKTDDKYFVVVDGGMNTLIRPALYGAHHGIKILEPT
HHHHHHHHEEECCCCEEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCEEECCC
ALSGKIDIVGPLCESGDKLAWDIEIELPEVSSLLYVENAGAYGFSMSNNYNSTLRPAEVL
CCCCCEEEEEHHCCCCCEEEEEEEEECCCCCEEEEEECCCCEEEEECCCCCCCCCHHHHH
VKENGEIVLIRRRETLNDLFGTVQRTEIREPENPR
EECCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]