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The map label for this gene is lon [H]

Identifier: 239616938

GI number: 239616938

Start: 587247

End: 589622

Strand: Direct

Name: lon [H]

Synonym: Kole_0536

Alternate gene names: 239616938

Gene position: 587247-589622 (Clockwise)

Preceding gene: 239616937

Following gene: 239616939

Centisome position: 25.51

GC content: 43.1

Gene sequence:

>2376_bases
ATGGCGCAGAAGTTCCAGCTACTGGAAAAGGCAGCGGTGAACCCTGAAAAGAAAGCGCAGATTCCGGATGTTCTCCCTGC
AATCGCCACACGAACGAACATGCTTATCTACCCTTCACTGGTAATGCCGTTATATGTCGGTAGAGATAAATCATTGACAG
CTCTTGAAGAGTCGATAGCAAAATACGACCAGCTCATATTTTTAATTTCACAAAAAGACGTAACCACTGAGAACCCAACT
GTGGAAGATCTCTATAAAGTCGGAACCGTTGCACGTATCGTGCAGTTGATGAAAATGCCTGATGGCAATTACAAGATCCT
CGTTGAAGGTCTCGCGCGTGCAAAGATAGTTGACGTTGTTGAAAAAGATAATCTTTTCGTTTTTAAGATAGAGGTTTTGA
AAGCTAAATATCGAAGGACGAAAGTTCTTGAAGCCCTCATCCGAAAAGTAAAAGAACTGGCGATGAAGTATGTCAACATG
AGCCGTCGATATCCGGATGAATCCATAGTCGCGCTTGAAGATACCGCTAATCCTGATAAATTCGCAGATTTTGTCTCGTC
TCTCCTGCCGTTGCCACTTGAAGAAAAGCAAAAACTCCTGGATGCTGTATCGCCCAAGGAGAGATTAGAGCTGCTTCTCG
AGATTTTAACCCGGGAAGTAGAAATACTCAATCTTGAGGAAGAACTTGATAGAAGAGTAAAAGAGAAAATCGAGCAAAGC
CAGAAAGAATACTATCTCCGTGAAAAAATGAAGGCTATACAGGAAGAGCTCGAAGGTGAAGAAGACATCGAAATAAAGGA
ACTAAAAGAAAAGCTCGAAAAAGGGAATTATCCAAAAGAGGTTAGGGACAAAGCCGAACAGGAGATATCAAGGCTTGAAA
AGATGTCACCATACTCCGCTGAAGCTACGGTGATCAGAACCTATCTTGATTGGTTGCTAAATCTACCATGGACAGAGGAA
ACAGAAGATCACATCGATATAAAGGCTGTTAGAAAAACTCTCGACGCAAATCATTATGGTCTTGAGGATGTCAAGGAAAG
GGTGCTTGAGTTCCTAGCCGCAAGGAATTTTTCCAAGAACCTTCGCGCACCAATTCTATGCCTGGTGGGACCACCGGGAG
TTGGAAAAACATCTCTTGGTAGATCCATTGCAGAGGCTATGGGGCGAAAATTTGGAAGGATCTCCCTAGGTGGTATGAGG
GATGAGGCCGAAATTAGAGGTCATCGCCGTACTTACGTTGGAGCCCTTCCGGGTAGAATCATTCAGATGATAAGAAAATT
GAATTCTAAGAATCCTGTGATCGTTCTGGACGAGATCGACAAACTGGGTGTGAGTTTCCAGGGAGATCCAGCTTCAGCTT
TGCTGGAGGTTCTCGATCCTGAACAGAACAACACCTTTACAGATCATTATCTTGAGGTTCCTTTTGATCTGTCAAAGGTT
CTTTTCATAACAACTGCAAATGTGCTCTATACTATTCCACCGGCACTCAGAGATCGTATGGAGATCATCGAGATACCGGG
ATATACCGATACTGAGAAACTTCATATCGCTAAGGATTACATACTCCCGAAACTCTATGAAGAGTATTCTATAACGAAGC
GAAAAGTGAATATCACCGAGGGTGCTATAAAAAAGATAATAACTGAGTACACCAGAGAAGCTGGTGTGAGAAACCTCGAT
AGAAATCTTTCTAAGATTATCAGGAGAGCAATCTTGAAACTTTCTGAAGGTCAGAAGAGCGTGAAGGTAACCAAAAATAA
TATCGAGGAGTACCTTGGAATACCGAAGTATAAAGAAAGCGATTTAAGAAAGCGTCCGGAAATTGGGGTTTGTACAGGTC
TGGCATGGACGGCTGTTGGCGGTGAAATAATGCACATTGAGGTGCTTCCTATCCCCGGAAAAGGGAAATTCATCACCACA
GGACAGCTCGGTGATGTTATGAAGGAATCGGCACAGATAGCGCTCAGCCTTGCCAAAAAACTGTGCGACGGCAAAAAATA
CGTTAAGGTATTTGAAACGAACGATTTTCATATTCATGTCCCGGAAGGTGCGGTTCCGAAAGATGGTCCCTCCGCCGGAG
TAACACTGTTGACAGCTATCATTTCTGCCGTAACAGGAACCCCAATAAAGCATGATGTTGCTATGACCGGTGAAATAACG
CTGAGAGGGCGCGTTTTACCAATCGGCGGATTAAAAGAAAAGCTTATGGCAGCTTATCGTGCGGGAATCAAAACAGTTAT
ACTTCCAGAAACTAACAAAAGAGATCTCGAGAAAGTTCCAGATGAAATAAAAGACAAGCTAAAATTTGTCTTCGTGGAAA
CAGTTAAAGAGGTCATTGAGGAGGCTCTGGTAAAGGATGTTGATAAAAAAGGTTGA

Upstream 100 bases:

>100_bases
AAAAAACAAGAAGATTGAAATTGAGCGGATCCTATAAATGGATAGAGAGAATGGTGAAAGACTTTTTCAAAAAGGAAAGA
CAAACCAAGGAGGTGAAATA

Downstream 100 bases:

>100_bases
ACTCGTCAAAACCGCATTCAAACCCGGAGATTACCCTGAGCCTGTTAAAAGAGAAGTTGCTTTTGCCGGAAGGTCGAACG
TCGGGAAATCTACATTGCTA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 791; Mature: 790

Protein sequence:

>791_residues
MAQKFQLLEKAAVNPEKKAQIPDVLPAIATRTNMLIYPSLVMPLYVGRDKSLTALEESIAKYDQLIFLISQKDVTTENPT
VEDLYKVGTVARIVQLMKMPDGNYKILVEGLARAKIVDVVEKDNLFVFKIEVLKAKYRRTKVLEALIRKVKELAMKYVNM
SRRYPDESIVALEDTANPDKFADFVSSLLPLPLEEKQKLLDAVSPKERLELLLEILTREVEILNLEEELDRRVKEKIEQS
QKEYYLREKMKAIQEELEGEEDIEIKELKEKLEKGNYPKEVRDKAEQEISRLEKMSPYSAEATVIRTYLDWLLNLPWTEE
TEDHIDIKAVRKTLDANHYGLEDVKERVLEFLAARNFSKNLRAPILCLVGPPGVGKTSLGRSIAEAMGRKFGRISLGGMR
DEAEIRGHRRTYVGALPGRIIQMIRKLNSKNPVIVLDEIDKLGVSFQGDPASALLEVLDPEQNNTFTDHYLEVPFDLSKV
LFITTANVLYTIPPALRDRMEIIEIPGYTDTEKLHIAKDYILPKLYEEYSITKRKVNITEGAIKKIITEYTREAGVRNLD
RNLSKIIRRAILKLSEGQKSVKVTKNNIEEYLGIPKYKESDLRKRPEIGVCTGLAWTAVGGEIMHIEVLPIPGKGKFITT
GQLGDVMKESAQIALSLAKKLCDGKKYVKVFETNDFHIHVPEGAVPKDGPSAGVTLLTAIISAVTGTPIKHDVAMTGEIT
LRGRVLPIGGLKEKLMAAYRAGIKTVILPETNKRDLEKVPDEIKDKLKFVFVETVKEVIEEALVKDVDKKG

Sequences:

>Translated_791_residues
MAQKFQLLEKAAVNPEKKAQIPDVLPAIATRTNMLIYPSLVMPLYVGRDKSLTALEESIAKYDQLIFLISQKDVTTENPT
VEDLYKVGTVARIVQLMKMPDGNYKILVEGLARAKIVDVVEKDNLFVFKIEVLKAKYRRTKVLEALIRKVKELAMKYVNM
SRRYPDESIVALEDTANPDKFADFVSSLLPLPLEEKQKLLDAVSPKERLELLLEILTREVEILNLEEELDRRVKEKIEQS
QKEYYLREKMKAIQEELEGEEDIEIKELKEKLEKGNYPKEVRDKAEQEISRLEKMSPYSAEATVIRTYLDWLLNLPWTEE
TEDHIDIKAVRKTLDANHYGLEDVKERVLEFLAARNFSKNLRAPILCLVGPPGVGKTSLGRSIAEAMGRKFGRISLGGMR
DEAEIRGHRRTYVGALPGRIIQMIRKLNSKNPVIVLDEIDKLGVSFQGDPASALLEVLDPEQNNTFTDHYLEVPFDLSKV
LFITTANVLYTIPPALRDRMEIIEIPGYTDTEKLHIAKDYILPKLYEEYSITKRKVNITEGAIKKIITEYTREAGVRNLD
RNLSKIIRRAILKLSEGQKSVKVTKNNIEEYLGIPKYKESDLRKRPEIGVCTGLAWTAVGGEIMHIEVLPIPGKGKFITT
GQLGDVMKESAQIALSLAKKLCDGKKYVKVFETNDFHIHVPEGAVPKDGPSAGVTLLTAIISAVTGTPIKHDVAMTGEIT
LRGRVLPIGGLKEKLMAAYRAGIKTVILPETNKRDLEKVPDEIKDKLKFVFVETVKEVIEEALVKDVDKKG
>Mature_790_residues
AQKFQLLEKAAVNPEKKAQIPDVLPAIATRTNMLIYPSLVMPLYVGRDKSLTALEESIAKYDQLIFLISQKDVTTENPTV
EDLYKVGTVARIVQLMKMPDGNYKILVEGLARAKIVDVVEKDNLFVFKIEVLKAKYRRTKVLEALIRKVKELAMKYVNMS
RRYPDESIVALEDTANPDKFADFVSSLLPLPLEEKQKLLDAVSPKERLELLLEILTREVEILNLEEELDRRVKEKIEQSQ
KEYYLREKMKAIQEELEGEEDIEIKELKEKLEKGNYPKEVRDKAEQEISRLEKMSPYSAEATVIRTYLDWLLNLPWTEET
EDHIDIKAVRKTLDANHYGLEDVKERVLEFLAARNFSKNLRAPILCLVGPPGVGKTSLGRSIAEAMGRKFGRISLGGMRD
EAEIRGHRRTYVGALPGRIIQMIRKLNSKNPVIVLDEIDKLGVSFQGDPASALLEVLDPEQNNTFTDHYLEVPFDLSKVL
FITTANVLYTIPPALRDRMEIIEIPGYTDTEKLHIAKDYILPKLYEEYSITKRKVNITEGAIKKIITEYTREAGVRNLDR
NLSKIIRRAILKLSEGQKSVKVTKNNIEEYLGIPKYKESDLRKRPEIGVCTGLAWTAVGGEIMHIEVLPIPGKGKFITTG
QLGDVMKESAQIALSLAKKLCDGKKYVKVFETNDFHIHVPEGAVPKDGPSAGVTLLTAIISAVTGTPIKHDVAMTGEITL
RGRVLPIGGLKEKLMAAYRAGIKTVILPETNKRDLEKVPDEIKDKLKFVFVETVKEVIEEALVKDVDKKG

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=834, Percent_Identity=39.9280575539568, Blast_Score=572, Evalue=1e-163,
Organism=Homo sapiens, GI21396489, Length=622, Percent_Identity=43.8906752411576, Blast_Score=533, Evalue=1e-151,
Organism=Escherichia coli, GI1786643, Length=779, Percent_Identity=47.4967907573813, Blast_Score=727, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=667, Percent_Identity=39.5802098950525, Blast_Score=501, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17556486, Length=775, Percent_Identity=36.1290322580645, Blast_Score=474, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6319449, Length=678, Percent_Identity=40.8554572271386, Blast_Score=502, Evalue=1e-142,
Organism=Drosophila melanogaster, GI221513036, Length=669, Percent_Identity=42.0029895366218, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24666867, Length=669, Percent_Identity=42.0029895366218, Blast_Score=541, Evalue=1e-154,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89451; Mature: 89320

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQKFQLLEKAAVNPEKKAQIPDVLPAIATRTNMLIYPSLVMPLYVGRDKSLTALEESIA
CCHHHHHHHHHHCCCHHHCCCHHHHHHHHHHCCEEEEHHHHHHHHCCCCCCHHHHHHHHH
KYDQLIFLISQKDVTTENPTVEDLYKVGTVARIVQLMKMPDGNYKILVEGLARAKIVDVV
HHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHH
EKDNLFVFKIEVLKAKYRRTKVLEALIRKVKELAMKYVNMSRRYPDESIVALEDTANPDK
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
FADFVSSLLPLPLEEKQKLLDAVSPKERLELLLEILTREVEILNLEEELDRRVKEKIEQS
HHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QKEYYLREKMKAIQEELEGEEDIEIKELKEKLEKGNYPKEVRDKAEQEISRLEKMSPYSA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
EATVIRTYLDWLLNLPWTEETEDHIDIKAVRKTLDANHYGLEDVKERVLEFLAARNFSKN
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
LRAPILCLVGPPGVGKTSLGRSIAEAMGRKFGRISLGGMRDEAEIRGHRRTYVGALPGRI
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCHHHHCCCHHHHHHCCHHHH
IQMIRKLNSKNPVIVLDEIDKLGVSFQGDPASALLEVLDPEQNNTFTDHYLEVPFDLSKV
HHHHHHHCCCCCEEEEECHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCHHHH
LFITTANVLYTIPPALRDRMEIIEIPGYTDTEKLHIAKDYILPKLYEEYSITKRKVNITE
HHHEECHHHEECCHHHHCCHHEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHEEECHH
GAIKKIITEYTREAGVRNLDRNLSKIIRRAILKLSEGQKSVKVTKNNIEEYLGIPKYKES
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCH
DLRKRPEIGVCTGLAWTAVGGEIMHIEVLPIPGKGKFITTGQLGDVMKESAQIALSLAKK
HHHCCCCCCEECCCHHHHCCCEEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHH
LCDGKKYVKVFETNDFHIHVPEGAVPKDGPSAGVTLLTAIISAVTGTPIKHDVAMTGEIT
HHCCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECEEE
LRGRVLPIGGLKEKLMAAYRAGIKTVILPETNKRDLEKVPDEIKDKLKFVFVETVKEVIE
EEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHH
EALVKDVDKKG
HHHHHHHCCCC
>Mature Secondary Structure 
AQKFQLLEKAAVNPEKKAQIPDVLPAIATRTNMLIYPSLVMPLYVGRDKSLTALEESIA
CHHHHHHHHHHCCCHHHCCCHHHHHHHHHHCCEEEEHHHHHHHHCCCCCCHHHHHHHHH
KYDQLIFLISQKDVTTENPTVEDLYKVGTVARIVQLMKMPDGNYKILVEGLARAKIVDVV
HHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHH
EKDNLFVFKIEVLKAKYRRTKVLEALIRKVKELAMKYVNMSRRYPDESIVALEDTANPDK
CCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
FADFVSSLLPLPLEEKQKLLDAVSPKERLELLLEILTREVEILNLEEELDRRVKEKIEQS
HHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QKEYYLREKMKAIQEELEGEEDIEIKELKEKLEKGNYPKEVRDKAEQEISRLEKMSPYSA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
EATVIRTYLDWLLNLPWTEETEDHIDIKAVRKTLDANHYGLEDVKERVLEFLAARNFSKN
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
LRAPILCLVGPPGVGKTSLGRSIAEAMGRKFGRISLGGMRDEAEIRGHRRTYVGALPGRI
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCHHHHCCCHHHHHHCCHHHH
IQMIRKLNSKNPVIVLDEIDKLGVSFQGDPASALLEVLDPEQNNTFTDHYLEVPFDLSKV
HHHHHHHCCCCCEEEEECHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCHHHH
LFITTANVLYTIPPALRDRMEIIEIPGYTDTEKLHIAKDYILPKLYEEYSITKRKVNITE
HHHEECHHHEECCHHHHCCHHEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHEEECHH
GAIKKIITEYTREAGVRNLDRNLSKIIRRAILKLSEGQKSVKVTKNNIEEYLGIPKYKES
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCH
DLRKRPEIGVCTGLAWTAVGGEIMHIEVLPIPGKGKFITTGQLGDVMKESAQIALSLAKK
HHHCCCCCCEECCCHHHHCCCEEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHH
LCDGKKYVKVFETNDFHIHVPEGAVPKDGPSAGVTLLTAIISAVTGTPIKHDVAMTGEIT
HHCCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECEEE
LRGRVLPIGGLKEKLMAAYRAGIKTVILPETNKRDLEKVPDEIKDKLKFVFVETVKEVIE
EEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHH
EALVKDVDKKG
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA