Click here to switch to the map view.

The map label for this gene is zitB [H]

Identifier: 239616831

GI number: 239616831

Start: 454065

End: 454976

Strand: Direct

Name: zitB [H]

Synonym: Kole_0424

Alternate gene names: 239616831

Gene position: 454065-454976 (Clockwise)

Preceding gene: 239616830

Following gene: 239616832

Centisome position: 19.72

GC content: 38.93

Gene sequence:

>912_bases
ATGGCATATTCCCATAGAAAAAAACACGGGCATTCACATAGTTTTGAGGATACCTCTGAAAGACGATTATTGTTTTCCAT
TGTACTGAATCTCGGGATAACCCTCGTGGAATTTATTGGTGGAATAGTATCAAACAGTCTGGCTCTGATTTCAGATTCTC
TTCACAATCTCACTGATTCAAGCTCGATGATTGTGAGCTACTCAGCAAAAAGAATTGCGCGAAAAAAACGAACACCGTTT
CATACCTACGGTTTCAAGAGAGCAGAGATCCTGGCAGCTGCACTGAACTCAATTGTTCTTCTTGCCATTGCGCTTTTCCT
TTTTGTGGAAGCATTCAAAAAAGTTTTTACCCCTTCGGAAATAAACGGTACAGTCATGTTGACAGTTGCAGTTATTGGCT
TACTCGGCAACCTCTTCACGGCCATTTTACTATTCAATGACGCAAAAAAGAGCTTGAACGTGAAATCGACTTTCATACAT
ATCGTAAGTGACACTCTCTCTTCGGTATTCGTAATAATCGCTGCCGTTCTCATAAGGAATTACGGCTGGATAATTCTTGA
TCCCCTGTTTACCGGAGTCGTTGGTGTTTTCATACTCTTTCAATCCATTTCCATATTGAAAGAATCCGTTCATATTCTCA
TGCAGGGAACTCCAAAGGATATTGAACTAGAAAAGATCTCAAAAGAAATCGAGAAATTTGATTTTGTGAAAAATGTTCAT
CATCTCCATGTATGGACAACAGATGGGCACGACAAATATCTCGAATGTCACGTGGAACTCTTTGACAATAATCTGGAAAA
AGCCGATGCCTATTTAGATGAAATAAACGATCTTCTAGAGAAACAGTTCCATATAGAGCATTCTACAATCCAATTTGAAA
GGGATCGTTGTAAGAAGAATGGAAAGCAATAA

Upstream 100 bases:

>100_bases
TAATCTCTCCAGCCCTACTCGTGCACGGCGGAAGAGGTCTCGTTGGCATCTCTACAATGGTGAGATAATATCAAAAAGGG
ATGGAAAGGACTGGATTAAA

Downstream 100 bases:

>100_bases
AAACATTTACTACAGCCCAACCAAACAAGGACTTAAGGAAATGGAAGAGAAATTATCAGTATATTTGATAAAACATCTTT
TTTGAAATTGACTGTACCGC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MAYSHRKKHGHSHSFEDTSERRLLFSIVLNLGITLVEFIGGIVSNSLALISDSLHNLTDSSSMIVSYSAKRIARKKRTPF
HTYGFKRAEILAAALNSIVLLAIALFLFVEAFKKVFTPSEINGTVMLTVAVIGLLGNLFTAILLFNDAKKSLNVKSTFIH
IVSDTLSSVFVIIAAVLIRNYGWIILDPLFTGVVGVFILFQSISILKESVHILMQGTPKDIELEKISKEIEKFDFVKNVH
HLHVWTTDGHDKYLECHVELFDNNLEKADAYLDEINDLLEKQFHIEHSTIQFERDRCKKNGKQ

Sequences:

>Translated_303_residues
MAYSHRKKHGHSHSFEDTSERRLLFSIVLNLGITLVEFIGGIVSNSLALISDSLHNLTDSSSMIVSYSAKRIARKKRTPF
HTYGFKRAEILAAALNSIVLLAIALFLFVEAFKKVFTPSEINGTVMLTVAVIGLLGNLFTAILLFNDAKKSLNVKSTFIH
IVSDTLSSVFVIIAAVLIRNYGWIILDPLFTGVVGVFILFQSISILKESVHILMQGTPKDIELEKISKEIEKFDFVKNVH
HLHVWTTDGHDKYLECHVELFDNNLEKADAYLDEINDLLEKQFHIEHSTIQFERDRCKKNGKQ
>Mature_302_residues
AYSHRKKHGHSHSFEDTSERRLLFSIVLNLGITLVEFIGGIVSNSLALISDSLHNLTDSSSMIVSYSAKRIARKKRTPFH
TYGFKRAEILAAALNSIVLLAIALFLFVEAFKKVFTPSEINGTVMLTVAVIGLLGNLFTAILLFNDAKKSLNVKSTFIHI
VSDTLSSVFVIIAAVLIRNYGWIILDPLFTGVVGVFILFQSISILKESVHILMQGTPKDIELEKISKEIEKFDFVKNVHH
LHVWTTDGHDKYLECHVELFDNNLEKADAYLDEINDLLEKQFHIEHSTIQFERDRCKKNGKQ

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=322, Percent_Identity=27.0186335403727, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI21359890, Length=302, Percent_Identity=29.1390728476821, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI52352805, Length=307, Percent_Identity=25.0814332247557, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI289803013, Length=269, Percent_Identity=27.8810408921933, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI289803009, Length=269, Percent_Identity=27.8810408921933, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI289803007, Length=269, Percent_Identity=27.8810408921933, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI289803003, Length=269, Percent_Identity=27.8810408921933, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI64762489, Length=269, Percent_Identity=27.8810408921933, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI222080086, Length=123, Percent_Identity=34.9593495934959, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI40255009, Length=123, Percent_Identity=34.9593495934959, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI52351208, Length=129, Percent_Identity=39.5348837209302, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI14210520, Length=220, Percent_Identity=25, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI52352803, Length=124, Percent_Identity=34.6774193548387, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786966, Length=284, Percent_Identity=35.9154929577465, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1790349, Length=279, Percent_Identity=22.5806451612903, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193210990, Length=314, Percent_Identity=29.2993630573248, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32564488, Length=305, Percent_Identity=31.4754098360656, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17555796, Length=319, Percent_Identity=28.5266457680251, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17555794, Length=324, Percent_Identity=27.4691358024691, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17550442, Length=137, Percent_Identity=32.8467153284672, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17550440, Length=137, Percent_Identity=32.8467153284672, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323899, Length=140, Percent_Identity=37.8571428571429, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320411, Length=177, Percent_Identity=31.0734463276836, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324892, Length=115, Percent_Identity=40.8695652173913, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583858, Length=335, Percent_Identity=26.2686567164179, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24656728, Length=335, Percent_Identity=29.2537313432836, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24656724, Length=335, Percent_Identity=29.2537313432836, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24656720, Length=335, Percent_Identity=29.2537313432836, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24656715, Length=335, Percent_Identity=29.2537313432836, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357035, Length=335, Percent_Identity=29.2537313432836, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24645863, Length=132, Percent_Identity=39.3939393939394, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24585900, Length=146, Percent_Identity=28.0821917808219, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585898, Length=146, Percent_Identity=28.0821917808219, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585896, Length=146, Percent_Identity=28.0821917808219, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921672, Length=146, Percent_Identity=28.0821917808219, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24584409, Length=146, Percent_Identity=28.7671232876712, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574430, Length=146, Percent_Identity=28.7671232876712, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34257; Mature: 34126

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSHRKKHGHSHSFEDTSERRLLFSIVLNLGITLVEFIGGIVSNSLALISDSLHNLTDS
CCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCC
SSMIVSYSAKRIARKKRTPFHTYGFKRAEILAAALNSIVLLAIALFLFVEAFKKVFTPSE
CCHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
INGTVMLTVAVIGLLGNLFTAILLFNDAKKSLNVKSTFIHIVSDTLSSVFVIIAAVLIRN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
YGWIILDPLFTGVVGVFILFQSISILKESVHILMQGTPKDIELEKISKEIEKFDFVKNVH
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCE
HLHVWTTDGHDKYLECHVELFDNNLEKADAYLDEINDLLEKQFHIEHSTIQFERDRCKKN
EEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
GKQ
CCC
>Mature Secondary Structure 
AYSHRKKHGHSHSFEDTSERRLLFSIVLNLGITLVEFIGGIVSNSLALISDSLHNLTDS
CCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCC
SSMIVSYSAKRIARKKRTPFHTYGFKRAEILAAALNSIVLLAIALFLFVEAFKKVFTPSE
CCHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
INGTVMLTVAVIGLLGNLFTAILLFNDAKKSLNVKSTFIHIVSDTLSSVFVIIAAVLIRN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
YGWIILDPLFTGVVGVFILFQSISILKESVHILMQGTPKDIELEKISKEIEKFDFVKNVH
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCE
HLHVWTTDGHDKYLECHVELFDNNLEKADAYLDEINDLLEKQFHIEHSTIQFERDRCKKN
EEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
GKQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]