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The map label for this gene is hup2 [H]

Identifier: 239616737

GI number: 239616737

Start: 350963

End: 351235

Strand: Reverse

Name: hup2 [H]

Synonym: Kole_0330

Alternate gene names: 239616737

Gene position: 351235-350963 (Counterclockwise)

Preceding gene: 239616741

Following gene: 239616733

Centisome position: 15.26

GC content: 46.89

Gene sequence:

>273_bases
GTGAACAAAAAGGAGCTTGTGGCAGAAATTGCTGGGAGAACTGGGGTAACAAAGAAACGTGCAGCAGAAATCCTTGACTG
CTTTATCGAGATCGTCGGCGAGAAGCTTTCCAAGGGTGAGGAAGTCAAGCTCGTTGGTTTCGGTACCTTTGAGGTTGCTA
CCAGAAAGCCCAGAAAAGGCGTGAACCCAAGGACCAAGAAGCCCATCAAGATTCCTGGAGGAAAGGTTCCCAAGTTCAGA
GCCGGTAAAGAATTAAAAGAGAAAGTTAAGTAA

Upstream 100 bases:

>100_bases
ATTTTCAACAAAGACTTACAGCTCTTATATAGTTGCAAAGACTACTTGAAAAGTGTTAGAATATCGACGACAGCTCATTT
CTAGAATAGGGGGTGTTTCT

Downstream 100 bases:

>100_bases
TTTTCTTTCAAGAAAGCAGGGGTGAGAAATTGTCTCACCCCTGTTTTTTTGTCCATGCAAGTATCTGTTCAACAACTTTT
CGATTTTTTATTACCTTCAT

Product: histone family protein DNA-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 90; Mature: 90

Protein sequence:

>90_residues
MNKKELVAEIAGRTGVTKKRAAEILDCFIEIVGEKLSKGEEVKLVGFGTFEVATRKPRKGVNPRTKKPIKIPGGKVPKFR
AGKELKEKVK

Sequences:

>Translated_90_residues
MNKKELVAEIAGRTGVTKKRAAEILDCFIEIVGEKLSKGEEVKLVGFGTFEVATRKPRKGVNPRTKKPIKIPGGKVPKFR
AGKELKEKVK
>Mature_90_residues
MNKKELVAEIAGRTGVTKKRAAEILDCFIEIVGEKLSKGEEVKLVGFGTFEVATRKPRKGVNPRTKKPIKIPGGKVPKFR
AGKELKEKVK

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions [H]

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family [H]

Homologues:

Organism=Escherichia coli, GI1786644, Length=90, Percent_Identity=48.8888888888889, Blast_Score=86, Evalue=4e-19,
Organism=Escherichia coli, GI1790433, Length=90, Percent_Identity=44.4444444444444, Blast_Score=76, Evalue=4e-16,
Organism=Escherichia coli, GI1788005, Length=90, Percent_Identity=35.5555555555556, Blast_Score=64, Evalue=2e-12,
Organism=Escherichia coli, GI1787141, Length=91, Percent_Identity=31.8681318681319, Blast_Score=61, Evalue=2e-11,

Paralogues:

None

Copy number: 860 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). 2040 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992 [H]

Pfam domain/function: PF00216 Bac_DNA_binding [H]

EC number: NA

Molecular weight: Translated: 9932; Mature: 9932

Theoretical pI: Translated: 10.98; Mature: 10.98

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKELVAEIAGRTGVTKKRAAEILDCFIEIVGEKLSKGEEVKLVGFGTFEVATRKPRKG
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCCC
VNPRTKKPIKIPGGKVPKFRAGKELKEKVK
CCCCCCCCEECCCCCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MNKKELVAEIAGRTGVTKKRAAEILDCFIEIVGEKLSKGEEVKLVGFGTFEVATRKPRKG
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCCC
VNPRTKKPIKIPGGKVPKFRAGKELKEKVK
CCCCCCCCEECCCCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]