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The map label for this gene is trxB [H]

Identifier: 239616713

GI number: 239616713

Start: 332400

End: 333365

Strand: Reverse

Name: trxB [H]

Synonym: Kole_0306

Alternate gene names: 239616713

Gene position: 333365-332400 (Counterclockwise)

Preceding gene: 239616714

Following gene: 239616710

Centisome position: 14.48

GC content: 43.27

Gene sequence:

>966_bases
GTGGCCTTCTTCGATCTTGGAAGTGCTAAACAAAAGAGCGAAGTAAAGGATTACTACGATATACTCATCATTGGAGGAGG
TCCGGGAGGAATTACTGCTGGAATTTATGCGGTTCAGGCCGGACTGGATCCTCTGATCATAGAGCGTGCTCTGGAAGGTG
GACAAATTAACAACACCGAAAAAGTCGAGAATTGGACGGGTTTTCCTTCTATAAGTGGAATGGATCTTGCTGAAAAAATG
GCTGAACATGCACGTGCTTTCGATGTATCTTTCCTGAATGCGGAGGTTGTTGAACTCGAGGTCGAAGGTGAAAAGAAAAC
CGTCATACTTGACAACGGTAAGAAGATCCAGAGCCGTGTTTTGATCATTGCTACGGGTTCCAATCCAAGAAAATTGAATG
TACCAGGAGAAGCTGAATTTGCCGGTAAAGGAGTTTCTTATTGTGCAACCTGTGATGGACATTTCTTTGCCGGGAAGCAT
ATAGCTGTTATTGGTGGAGGTAACAGCGCGCTGGATGAAGCACTTTTTCTCTCCAAGATCGTTGATAAGATAACGATAGT
TCAAAATCTCCCTAAATTGACGGCAGACAAGCTTCTTCAAGAAAGAATAAAAGCTACCGGAAAGGTAGACTTTATTTTCA
ACACAGTGGTTGATAGAATCGAAGGAAGTGACAAGGTTGAAAGATTGATCCTTAAGAACGTTGAGACTGGTGAACTTTCT
ACGCTTGAAGTTGAAGGCGTGTTCGTTTTCATCGGGTTGGTACCCAATACCGGTTTTTTGAAAGGGAAAGTTAAAACCAA
CGATTGGGGATATATAATGACTGACGAGCATATGGAAACTAACGTTCCAGGAGTATATGCGATCGGAGACGTTCGTGAGA
AGGAAGTAAGACAAATTGTCACCGCCGCTGCCGACGGTGCAATAGCTGTAAGCCATGCATCAAGAACCTACTTTGATGAA
GAATAA

Upstream 100 bases:

>100_bases
TCAGATAGTTATCAACGATGAGGTCATTTTTGTTGGAGCTTATCCAGAAAAACAGTTTATAGACGAAGTCTTTAAGGCGG
TTTGATAAGGAGGGATTCCT

Downstream 100 bases:

>100_bases
AGAACTAAGTAAAAAAAGAGGGAACTCACTGTTGGGTTCCCTCTTTTTTTATCTCTCTGGTTCAGGACCATTCAAAATCT
TTATATAGTGATTCTCGAGA

Product: FAD-dependent pyridine nucleotide-disulphide oxidoreductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MAFFDLGSAKQKSEVKDYYDILIIGGGPGGITAGIYAVQAGLDPLIIERALEGGQINNTEKVENWTGFPSISGMDLAEKM
AEHARAFDVSFLNAEVVELEVEGEKKTVILDNGKKIQSRVLIIATGSNPRKLNVPGEAEFAGKGVSYCATCDGHFFAGKH
IAVIGGGNSALDEALFLSKIVDKITIVQNLPKLTADKLLQERIKATGKVDFIFNTVVDRIEGSDKVERLILKNVETGELS
TLEVEGVFVFIGLVPNTGFLKGKVKTNDWGYIMTDEHMETNVPGVYAIGDVREKEVRQIVTAAADGAIAVSHASRTYFDE
E

Sequences:

>Translated_321_residues
MAFFDLGSAKQKSEVKDYYDILIIGGGPGGITAGIYAVQAGLDPLIIERALEGGQINNTEKVENWTGFPSISGMDLAEKM
AEHARAFDVSFLNAEVVELEVEGEKKTVILDNGKKIQSRVLIIATGSNPRKLNVPGEAEFAGKGVSYCATCDGHFFAGKH
IAVIGGGNSALDEALFLSKIVDKITIVQNLPKLTADKLLQERIKATGKVDFIFNTVVDRIEGSDKVERLILKNVETGELS
TLEVEGVFVFIGLVPNTGFLKGKVKTNDWGYIMTDEHMETNVPGVYAIGDVREKEVRQIVTAAADGAIAVSHASRTYFDE
E
>Mature_320_residues
AFFDLGSAKQKSEVKDYYDILIIGGGPGGITAGIYAVQAGLDPLIIERALEGGQINNTEKVENWTGFPSISGMDLAEKMA
EHARAFDVSFLNAEVVELEVEGEKKTVILDNGKKIQSRVLIIATGSNPRKLNVPGEAEFAGKGVSYCATCDGHFFAGKHI
AVIGGGNSALDEALFLSKIVDKITIVQNLPKLTADKLLQERIKATGKVDFIFNTVVDRIEGSDKVERLILKNVETGELST
LEVEGVFVFIGLVPNTGFLKGKVKTNDWGYIMTDEHMETNVPGVYAIGDVREKEVRQIVTAAADGAIAVSHASRTYFDEE

Specific function: Serves To Protect The Cell Against DNA Damage By Alkyl Hydroperoxides. It Can Use Either NADH Or NADPH As Electron Donor For Direct Reduction Of Redox Dyes Or Of Alkyl Hydroperoxides When Combined With The Ahpc Protein. [C]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=291, Percent_Identity=25.4295532646048, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI65787454, Length=291, Percent_Identity=25.4295532646048, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI226437568, Length=291, Percent_Identity=25.4295532646048, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87081763, Length=328, Percent_Identity=37.5, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1787114, Length=313, Percent_Identity=35.7827476038339, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17559934, Length=217, Percent_Identity=30.4147465437788, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321898, Length=317, Percent_Identity=34.0694006309148, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6320560, Length=308, Percent_Identity=33.4415584415584, Blast_Score=177, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 34714; Mature: 34583

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFFDLGSAKQKSEVKDYYDILIIGGGPGGITAGIYAVQAGLDPLIIERALEGGQINNTE
CCEECCCCCCHHHHCCCEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCH
KVENWTGFPSISGMDLAEKMAEHARAFDVSFLNAEVVELEVEGEKKTVILDNGKKIQSRV
HCCCCCCCCCCCCCHHHHHHHHHHHEEEEEEECEEEEEEEECCCEEEEEEECCCEEEEEE
LIIATGSNPRKLNVPGEAEFAGKGVSYCATCDGHFFAGKHIAVIGGGNSALDEALFLSKI
EEEEECCCCEEEECCCCCCCCCCCCEEEEECCCCEECCCEEEEEECCCHHHHHHHHHHHH
VDKITIVQNLPKLTADKLLQERIKATGKVDFIFNTVVDRIEGSDKVERLILKNVETGELS
HHHHHHHHHCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHCCHHHHHHHHHCCCCCCCEE
TLEVEGVFVFIGLVPNTGFLKGKVKTNDWGYIMTDEHMETNVPGVYAIGDVREKEVRQIV
EEEEEEEEEEEEECCCCCEEEEEEEECCCCEEEECCCCCCCCCCEEEECCCCHHHHHHHH
TAAADGAIAVSHASRTYFDEE
HHHCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
AFFDLGSAKQKSEVKDYYDILIIGGGPGGITAGIYAVQAGLDPLIIERALEGGQINNTE
CEECCCCCCHHHHCCCEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCH
KVENWTGFPSISGMDLAEKMAEHARAFDVSFLNAEVVELEVEGEKKTVILDNGKKIQSRV
HCCCCCCCCCCCCCHHHHHHHHHHHEEEEEEECEEEEEEEECCCEEEEEEECCCEEEEEE
LIIATGSNPRKLNVPGEAEFAGKGVSYCATCDGHFFAGKHIAVIGGGNSALDEALFLSKI
EEEEECCCCEEEECCCCCCCCCCCCEEEEECCCCEECCCEEEEEECCCHHHHHHHHHHHH
VDKITIVQNLPKLTADKLLQERIKATGKVDFIFNTVVDRIEGSDKVERLILKNVETGELS
HHHHHHHHHCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHCCHHHHHHHHHCCCCCCCEE
TLEVEGVFVFIGLVPNTGFLKGKVKTNDWGYIMTDEHMETNVPGVYAIGDVREKEVRQIV
EEEEEEEEEEEEECCCCCEEEEEEEECCCCEEEECCCCCCCCCCEEEECCCCHHHHHHHH
TAAADGAIAVSHASRTYFDEE
HHHCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA