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The map label for this gene is atpA

Identifier: 239616627

GI number: 239616627

Start: 249309

End: 250817

Strand: Reverse

Name: atpA

Synonym: Kole_0220

Alternate gene names: 239616627

Gene position: 250817-249309 (Counterclockwise)

Preceding gene: 239616628

Following gene: 239616626

Centisome position: 10.9

GC content: 50.3

Gene sequence:

>1509_bases
GTGAAGATCAGTCCTTCAGAGATAACGAAGATAATTGAAGAGCAATTGAAGCGTTCCGACCGGGAAATAGATTATTTTGA
GGCCGGGCGGATTATCCAGGTTGGAGATGGTATTGCGCGTGCCTACGGCCTTAAAGGAGTAATGTCCAACGAACTTGTCC
AGTTCGAAAACGGTGAGTACGGCCTCGCGTTGAACCTGGAAGAGGATAACGTTGGTATCGTTGTTCTTGGAGATTACCGC
GAGATAAAGGAAGGCGATCTGGTGAAGCGCACCGGAAGAATCATCGAGGTTCCCGCCGGTGAAGCGCTTCTCGGCAGGGT
CGTCAATCCACTCGGGATTCCTCTCGATGGGAAGGGTCCCATTGAGGCTTCAGAACACCGGCCGGTAGAAATCAAAGCGC
CCGGTGTCGTTATGAGAAAACCCGTTGATACGCCTTTGCAAACGGGTATTAAAGCCATCGATGCGATGATTCCTATTGGT
AGGGGTCAGCGTGAGCTGATCATCGGAGATAGGCAGACAGGAAAAACGGCAATAGCCATCGATACAATCATAAACCAGAA
AGATCAGGGTGTTTATTGTATTTACGTTGCGATAGGACAGAAAACGGCAGTCCTGGCCAGGATAATAGATAAACTCGAAG
AGACCGGCGCAATGGAATACACCACAATCGTTGCAGCCACGGCTAATGATCCTGCAACATTGGCTTACCTCGCCCCTTAC
GCCGGAGCCGCTATGGGTGAGTATTTCATGTACAGCGGGAAAGATGCCCTTGTTATTTACGACGACCTTTCAAAACACGC
GGCGGCGTATCGTGAACTATCGCTTCTCCTAAGAAGGCCGCCAGGACGTGAAGCGTATCCTGGAGATGTTTTCTATCTCC
ATTCGAGACTTTTGGAGAGAGCGGCAAGGCTCAACGAGGAACACGGTGGCGGATCGTTAACGGCGTTGCCGATTATTGAG
ACCCTGGCAAACGACGTTAGTGCCTATATCCCGACAAACGTTATTTCCATCACCGACGGTCAGATTTATCTGGACCCGAA
CCTCTTCTATGCCGGTAACAGACCTGCTATAAACGTAGGGCTTTCAGTATCCCGTGTCGGCGGTTCCGCTCAGATAAAGG
CCATGAAAAAGATAGCCGGTAGCTTGAGGCTTGACCTTGCCCAGTACCGTGAGCTCCTCGCCTTTGCCCAGTTCTCAACT
GAATTGGACAAAGCCACGCAGGCGCAGCTCATACGTGGTGAAAAACTCACGGAGCTCTTGAAGCAGGAACAGTATTCCCC
AATGCCGGTTGAAGAACAGATAGCGGTTCTTTATGCAGGTACAAGGGGATACCTGGATGATCTGCCAACCGATAAGATCA
GGCAGTTCGAGAAACAACTGTTGCAAACCATGAGGCAAAAATATGCCGACGTGCTCAAAGCCATCAGAGAGAAAAAGGAT
ATGACCGAAGAGATAGAAGCAGGATTGAAAAAGGCGGTAGAAGACGTGCGTCAGGCGTTCGTCTCGTGA

Upstream 100 bases:

>100_bases
TTTTCAGGATAGAGTCCTTGATTTGAGTGCTTCTGGAAGGCTAAAACGTTTAGAGTATGGGCTTAAATAAGAATGGCAGC
CACTTTTTGGAGGTGGTTAA

Downstream 100 bases:

>100_bases
AGGTGGTATCATGAGCAAAGGTAAACTCCGTGCCATAAAAAAGAGAATAGATGCTACCGAATCAACGATGCAAATCACCA
GGGCGATGGAGATGGTCGCC

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MKISPSEITKIIEEQLKRSDREIDYFEAGRIIQVGDGIARAYGLKGVMSNELVQFENGEYGLALNLEEDNVGIVVLGDYR
EIKEGDLVKRTGRIIEVPAGEALLGRVVNPLGIPLDGKGPIEASEHRPVEIKAPGVVMRKPVDTPLQTGIKAIDAMIPIG
RGQRELIIGDRQTGKTAIAIDTIINQKDQGVYCIYVAIGQKTAVLARIIDKLEETGAMEYTTIVAATANDPATLAYLAPY
AGAAMGEYFMYSGKDALVIYDDLSKHAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAARLNEEHGGGSLTALPIIE
TLANDVSAYIPTNVISITDGQIYLDPNLFYAGNRPAINVGLSVSRVGGSAQIKAMKKIAGSLRLDLAQYRELLAFAQFST
ELDKATQAQLIRGEKLTELLKQEQYSPMPVEEQIAVLYAGTRGYLDDLPTDKIRQFEKQLLQTMRQKYADVLKAIREKKD
MTEEIEAGLKKAVEDVRQAFVS

Sequences:

>Translated_502_residues
MKISPSEITKIIEEQLKRSDREIDYFEAGRIIQVGDGIARAYGLKGVMSNELVQFENGEYGLALNLEEDNVGIVVLGDYR
EIKEGDLVKRTGRIIEVPAGEALLGRVVNPLGIPLDGKGPIEASEHRPVEIKAPGVVMRKPVDTPLQTGIKAIDAMIPIG
RGQRELIIGDRQTGKTAIAIDTIINQKDQGVYCIYVAIGQKTAVLARIIDKLEETGAMEYTTIVAATANDPATLAYLAPY
AGAAMGEYFMYSGKDALVIYDDLSKHAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAARLNEEHGGGSLTALPIIE
TLANDVSAYIPTNVISITDGQIYLDPNLFYAGNRPAINVGLSVSRVGGSAQIKAMKKIAGSLRLDLAQYRELLAFAQFST
ELDKATQAQLIRGEKLTELLKQEQYSPMPVEEQIAVLYAGTRGYLDDLPTDKIRQFEKQLLQTMRQKYADVLKAIREKKD
MTEEIEAGLKKAVEDVRQAFVS
>Mature_502_residues
MKISPSEITKIIEEQLKRSDREIDYFEAGRIIQVGDGIARAYGLKGVMSNELVQFENGEYGLALNLEEDNVGIVVLGDYR
EIKEGDLVKRTGRIIEVPAGEALLGRVVNPLGIPLDGKGPIEASEHRPVEIKAPGVVMRKPVDTPLQTGIKAIDAMIPIG
RGQRELIIGDRQTGKTAIAIDTIINQKDQGVYCIYVAIGQKTAVLARIIDKLEETGAMEYTTIVAATANDPATLAYLAPY
AGAAMGEYFMYSGKDALVIYDDLSKHAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAARLNEEHGGGSLTALPIIE
TLANDVSAYIPTNVISITDGQIYLDPNLFYAGNRPAINVGLSVSRVGGSAQIKAMKKIAGSLRLDLAQYRELLAFAQFST
ELDKATQAQLIRGEKLTELLKQEQYSPMPVEEQIAVLYAGTRGYLDDLPTDKIRQFEKQLLQTMRQKYADVLKAIREKKD
MTEEIEAGLKKAVEDVRQAFVS

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=507, Percent_Identity=60.1577909270217, Blast_Score=625, Evalue=1e-179,
Organism=Homo sapiens, GI4757810, Length=507, Percent_Identity=60.1577909270217, Blast_Score=625, Evalue=1e-179,
Organism=Homo sapiens, GI19913428, Length=307, Percent_Identity=30.9446254071661, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI19913426, Length=306, Percent_Identity=30.718954248366, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI32189394, Length=412, Percent_Identity=24.7572815533981, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI19913424, Length=408, Percent_Identity=24.2647058823529, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790172, Length=508, Percent_Identity=56.6929133858268, Blast_Score=579, Evalue=1e-166,
Organism=Escherichia coli, GI1790170, Length=353, Percent_Identity=26.0623229461756, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788251, Length=325, Percent_Identity=28, Blast_Score=99, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71988063, Length=505, Percent_Identity=59.8019801980198, Blast_Score=622, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI71988080, Length=505, Percent_Identity=59.8019801980198, Blast_Score=621, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI71988074, Length=505, Percent_Identity=55.8415841584158, Blast_Score=565, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI17510931, Length=357, Percent_Identity=28.5714285714286, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17570191, Length=303, Percent_Identity=31.023102310231, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI25144756, Length=404, Percent_Identity=25.7425742574257, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71988068, Length=75, Percent_Identity=46.6666666666667, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17565854, Length=250, Percent_Identity=27.2, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17509265, Length=51, Percent_Identity=60.7843137254902, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6319370, Length=507, Percent_Identity=57.7909270216962, Blast_Score=614, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6319603, Length=304, Percent_Identity=29.6052631578947, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322581, Length=413, Percent_Identity=25.4237288135593, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24658560, Length=503, Percent_Identity=60.0397614314115, Blast_Score=609, Evalue=1e-174,
Organism=Drosophila melanogaster, GI281361666, Length=305, Percent_Identity=30.8196721311475, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24646341, Length=305, Percent_Identity=30.8196721311475, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI17136796, Length=305, Percent_Identity=30.8196721311475, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24638766, Length=399, Percent_Identity=25.8145363408521, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28574560, Length=413, Percent_Identity=25.6658595641646, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583992, Length=513, Percent_Identity=25.1461988304094, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24583988, Length=251, Percent_Identity=27.0916334661355, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583986, Length=251, Percent_Identity=27.0916334661355, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24583984, Length=251, Percent_Identity=27.0916334661355, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20129479, Length=254, Percent_Identity=28.3464566929134, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_KOSOT (C5CIV6)

Other databases:

- EMBL:   CP001634
- RefSeq:   YP_002939949.1
- GeneID:   7968372
- GenomeReviews:   CP001634_GR
- KEGG:   kol:Kole_0220
- ProtClustDB:   PRK09281
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55243; Mature: 55243

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISPSEITKIIEEQLKRSDREIDYFEAGRIIQVGDGIARAYGLKGVMSNELVQFENGEY
CCCCHHHHHHHHHHHHHHCCCCCCHHHCCCEEEECCCHHHHHCCCCHHHCCEEEECCCCE
GLALNLEEDNVGIVVLGDYREIKEGDLVKRTGRIIEVPAGEALLGRVVNPLGIPLDGKGP
EEEEEECCCCEEEEEECCCHHCCCCCHHHHCCCEEEECCCHHHHHHHCCCCCCCCCCCCC
IEASEHRPVEIKAPGVVMRKPVDTPLQTGIKAIDAMIPIGRGQRELIIGDRQTGKTAIAI
CCCCCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEE
DTIINQKDQGVYCIYVAIGQKTAVLARIIDKLEETGAMEYTTIVAATANDPATLAYLAPY
EHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCEEEEECCH
AGAAMGEYFMYSGKDALVIYDDLSKHAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLER
HHHHHHHHHEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AARLNEEHGGGSLTALPIIETLANDVSAYIPTNVISITDGQIYLDPNLFYAGNRPAINVG
HHHCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCEEEECCCEEECCCCCEEEEC
LSVSRVGGSAQIKAMKKIAGSLRLDLAQYRELLAFAQFSTELDKATQAQLIRGEKLTELL
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQEQYSPMPVEEQIAVLYAGTRGYLDDLPTDKIRQFEKQLLQTMRQKYADVLKAIREKKD
HHHCCCCCCHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MTEEIEAGLKKAVEDVRQAFVS
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKISPSEITKIIEEQLKRSDREIDYFEAGRIIQVGDGIARAYGLKGVMSNELVQFENGEY
CCCCHHHHHHHHHHHHHHCCCCCCHHHCCCEEEECCCHHHHHCCCCHHHCCEEEECCCCE
GLALNLEEDNVGIVVLGDYREIKEGDLVKRTGRIIEVPAGEALLGRVVNPLGIPLDGKGP
EEEEEECCCCEEEEEECCCHHCCCCCHHHHCCCEEEECCCHHHHHHHCCCCCCCCCCCCC
IEASEHRPVEIKAPGVVMRKPVDTPLQTGIKAIDAMIPIGRGQRELIIGDRQTGKTAIAI
CCCCCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEE
DTIINQKDQGVYCIYVAIGQKTAVLARIIDKLEETGAMEYTTIVAATANDPATLAYLAPY
EHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCEEEEECCH
AGAAMGEYFMYSGKDALVIYDDLSKHAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLER
HHHHHHHHHEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AARLNEEHGGGSLTALPIIETLANDVSAYIPTNVISITDGQIYLDPNLFYAGNRPAINVG
HHHCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCEEEECCCEEECCCCCEEEEC
LSVSRVGGSAQIKAMKKIAGSLRLDLAQYRELLAFAQFSTELDKATQAQLIRGEKLTELL
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQEQYSPMPVEEQIAVLYAGTRGYLDDLPTDKIRQFEKQLLQTMRQKYADVLKAIREKKD
HHHCCCCCCHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MTEEIEAGLKKAVEDVRQAFVS
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA