Click here to switch to the map view.

The map label for this gene is aroE [H]

Identifier: 238925189

GI number: 238925189

Start: 2725030

End: 2725908

Strand: Reverse

Name: aroE [H]

Synonym: EUBREC_2843

Alternate gene names: 238925189

Gene position: 2725908-2725030 (Counterclockwise)

Preceding gene: 238925191

Following gene: 238925188

Centisome position: 79.02

GC content: 45.16

Gene sequence:

>879_bases
ATGGCAGAGAGAATCACAGGACACACAGAACTCATCGGACTTATGGCTTACCCAATCAGACATTCAAGCTCACCGGCAAT
GCACAATGAGGCATTTGCATATCTTGGACTTGACTACGCTTATCTGGCATTTGAGGTTGATAACAACACTCTCGAGGATG
CGGTTAAGGGAATCAGAGCATTAAAGCTTGTAGGCTCTAATGTATCAATGCCAAACAAGACAGTTGTAGGACAGTACTTA
GACAAGCTTTCACCTGCAGCAGAGCTTTGCGGAGCTGTAAATACAATAGTAAACGAGAACGGAGTACTCACAGGACACAT
CACAGACGGTATCGGCTTCATGCAGGCGCTCAAGGATAACGACATCGATGTTATCGGAAAGAAGATGACAATCGCAGGAG
CAGGCGGAGCTGCTACAGCTATCGAGATTCAGGCAGCACTTGACGGTGTCAAGGAAATCTCAATCTTCAATATCCATGAC
AAGTTCTGGGCAAACGCTGAAGAGACAGTTAGAAAGATCAACGAGAAGACAGACTGCAAGGCTACTCTTTACGACCTTGA
TGACAAGGAGAAGTTAAGAGAAGAGATGGCTGATTCCTACATCTTCGTAAACGGAACAGGTGTTGGCATGAAGCCACTCG
AGGGAATGTCTGTAGTACCTGACAAATCATTCTTCCGTCCTGAGCTTATCGTAATTGACGTACCTTACTCTCCACTTGAG
ACAAAGATGCGTTCTATGGCAAAAGAGGTGGGCTGCAAGACAATGAACGGTCTTGGAATGATGCTTTTCCAGGGAGCAGC
AGCCTTCAAGCTCTGGACAGGAAAAGATATGCCAATCGAGCATATGAAGGAAGTATTAAACATCAGATATGATGATTAA

Upstream 100 bases:

>100_bases
GGTTGTTAAGTTTTTAACGAAGTGGGCATCGTTGAAAACATAGCTAAGTAAAATACGAATAATCAATATTATCACATTTA
AAAATGAAGGAGATTTAATC

Downstream 100 bases:

>100_bases
TCAGACACAGAAATTAAATCACATTGAATTATTTTGACAGAAATTAAGGAGAACACTGATGAATAAAAAATATTTACCTA
GCGCATTAATCCTTTACTTA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MAERITGHTELIGLMAYPIRHSSSPAMHNEAFAYLGLDYAYLAFEVDNNTLEDAVKGIRALKLVGSNVSMPNKTVVGQYL
DKLSPAAELCGAVNTIVNENGVLTGHITDGIGFMQALKDNDIDVIGKKMTIAGAGGAATAIEIQAALDGVKEISIFNIHD
KFWANAEETVRKINEKTDCKATLYDLDDKEKLREEMADSYIFVNGTGVGMKPLEGMSVVPDKSFFRPELIVIDVPYSPLE
TKMRSMAKEVGCKTMNGLGMMLFQGAAAFKLWTGKDMPIEHMKEVLNIRYDD

Sequences:

>Translated_292_residues
MAERITGHTELIGLMAYPIRHSSSPAMHNEAFAYLGLDYAYLAFEVDNNTLEDAVKGIRALKLVGSNVSMPNKTVVGQYL
DKLSPAAELCGAVNTIVNENGVLTGHITDGIGFMQALKDNDIDVIGKKMTIAGAGGAATAIEIQAALDGVKEISIFNIHD
KFWANAEETVRKINEKTDCKATLYDLDDKEKLREEMADSYIFVNGTGVGMKPLEGMSVVPDKSFFRPELIVIDVPYSPLE
TKMRSMAKEVGCKTMNGLGMMLFQGAAAFKLWTGKDMPIEHMKEVLNIRYDD
>Mature_291_residues
AERITGHTELIGLMAYPIRHSSSPAMHNEAFAYLGLDYAYLAFEVDNNTLEDAVKGIRALKLVGSNVSMPNKTVVGQYLD
KLSPAAELCGAVNTIVNENGVLTGHITDGIGFMQALKDNDIDVIGKKMTIAGAGGAATAIEIQAALDGVKEISIFNIHDK
FWANAEETVRKINEKTDCKATLYDLDDKEKLREEMADSYIFVNGTGVGMKPLEGMSVVPDKSFFRPELIVIDVPYSPLET
KMRSMAKEVGCKTMNGLGMMLFQGAAAFKLWTGKDMPIEHMKEVLNIRYDD

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=282, Percent_Identity=50.354609929078, Blast_Score=302, Evalue=1e-83,
Organism=Escherichia coli, GI1789675, Length=268, Percent_Identity=26.4925373134328, Blast_Score=78, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320332, Length=283, Percent_Identity=27.208480565371, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 31994; Mature: 31863

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERITGHTELIGLMAYPIRHSSSPAMHNEAFAYLGLDYAYLAFEVDNNTLEDAVKGIRA
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEEEEEECCCHHHHHHHHHHH
LKLVGSNVSMPNKTVVGQYLDKLSPAAELCGAVNTIVNENGVLTGHITDGIGFMQALKDN
HHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCC
DIDVIGKKMTIAGAGGAATAIEIQAALDGVKEISIFNIHDKFWANAEETVRKINEKTDCK
CCEEECCEEEEEECCCCCEEEEEHHHHCCHHEEEEEEEHHHHHCCHHHHHHHHCCCCCCE
ATLYDLDDKEKLREEMADSYIFVNGTGVGMKPLEGMSVVPDKSFFRPELIVIDVPYSPLE
EEEECCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCEECCCCCCCCCEEEEEECCCCHHH
TKMRSMAKEVGCKTMNGLGMMLFQGAAAFKLWTGKDMPIEHMKEVLNIRYDD
HHHHHHHHHHCCCHHCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
AERITGHTELIGLMAYPIRHSSSPAMHNEAFAYLGLDYAYLAFEVDNNTLEDAVKGIRA
CCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCEEEEEEEECCCHHHHHHHHHHH
LKLVGSNVSMPNKTVVGQYLDKLSPAAELCGAVNTIVNENGVLTGHITDGIGFMQALKDN
HHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCC
DIDVIGKKMTIAGAGGAATAIEIQAALDGVKEISIFNIHDKFWANAEETVRKINEKTDCK
CCEEECCEEEEEECCCCCEEEEEHHHHCCHHEEEEEEEHHHHHCCHHHHHHHHCCCCCCE
ATLYDLDDKEKLREEMADSYIFVNGTGVGMKPLEGMSVVPDKSFFRPELIVIDVPYSPLE
EEEECCCCHHHHHHHHCCCEEEEECCCCCCCCCCCCEECCCCCCCCCEEEEEECCCCHHH
TKMRSMAKEVGCKTMNGLGMMLFQGAAAFKLWTGKDMPIEHMKEVLNIRYDD
HHHHHHHHHHCCCHHCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]