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The map label for this gene is toxA [H]

Identifier: 238924985

GI number: 238924985

Start: 2516379

End: 2518037

Strand: Reverse

Name: toxA [H]

Synonym: EUBREC_2636

Alternate gene names: 238924985

Gene position: 2518037-2516379 (Counterclockwise)

Preceding gene: 238924986

Following gene: 238924984

Centisome position: 72.99

GC content: 34.72

Gene sequence:

>1659_bases
ATGAAATTTTTTGAAAGAGGCAAAGTGTTCATTGGAATGATAATGGGAATGGGATTATTATTTTGCGGACATAATTCGGT
TAAAGCAGTTCAAGAAGAATATACTGCTGGATCTTCTATTAAAACAGAATATGAAGGTGAGGTGAATTATGATGAGGACA
TTCAGACATATTCCAGTGGTGAAATCTTAGCCCAATCTGCAAGTGGATGGAGAAAAGATAATAATGGCTGGTGGTACCAA
TATTCTGATGGTTCGTATCCAGCCGGTAAATGGATGCAGAATGGAGGAAAATGGTATTATTTTAATCAGTATGGGTATAT
GGTAATCGGATCACAATATATTGATGGCAGTTGGTACTATTTTGATGGGAAAGGTGAAATGCTTACAGGGTGGCAACAAT
ATAGCGGTGGTTGGTGGTATCATAATGCGAATGGAGTTTGGATATCATCAGATTATGCTAATAACACCATAAAAGGAATT
GATGTATCATATTATCAGGGAAATATTGATTGGAATGCTGTAAAAAATGATGGTATACAATTTGCTATATTAAGAGTATC
TGCAAGTTACTATTCGGATTCATATCATCATTTTACTGACAAGAGATTTAAGGAGTATGCTGCAAACGCTAATTCTGTAG
GCATGCCTATAGGGGCATATATATATAGTAAAGCAAGGACAACAGAAAATGCAGTATCTGATGCAAAGTATGTGATAAAT
GAATTGAAGGGATACACAATTTCATATCCGGTAGCTATTGATTTGGAGGATTCATCACAGACCGATTTATCAAGGCAACA
GTTGGGGGCAATAGCAAAAACTTTTTGTAATGAAATTAGAAAAGCAGGCTATACTCCTATGGTGTATTGTAATGAAAATT
GGTATAAAAATTATATAGATGTAAGCCAGATTTCTAATGAAGAAATGTGGGTTGCGAGATATAATTATCACTATAATACA
GATATTCATAGAACTATTTGGCAGAGTGGTTCAACATGCAGAGTCTCAGGAATATCGGGGAATGTTGATATAGACTTTGC
AAATAAAGCTTTTAGTAGTTGGAGATATAATAATGGTAGGTGGAGTTATATTGGTACTAGTGGAGAAATGTTTACAGGGT
GGCATAGTATAGGCGGAAAGTGGTATCTGTTTAATTCGAATGGAATAATGCTAACTGGATGGCAGAAACAAGGAAAAAAG
TGGTATTATTTAGATGAAGACGGTGCTATGAGAACGGGATGGCTTTTGTTAAAATCAAATTGGTATTATTTGAATAGAAG
CGGAGAAATGTTTACAGGATGGCATAGTATAGGAGGAAAATGGTATTTATTTAACACTAATGGAATAATGCTTGGAGGTT
GGCAGAAACAAGGGGTAAATTGGTACTATTTAAGCAATAATGGTCAAATGCTTACAGGATGGCATAGTATAAGAGGAAAT
TGGTATCTATTTAATTCTAATGGGGTGATGCTTACTGGGTGGCAAAAAGTAGAAGGAAAATGGTATCTAATGAATAAGAG
TGGTGAAATGCTAATAGGTTGGCAGAAGATTGGAAAAAATTGGTATTATATGAATTCTAGTGGAAAAATGCTAACAGGTT
GGCAAAAAATTGGAAATAAAATGTATTATATGAATTCTAGCGGAGTTTGGCTATATTAG

Upstream 100 bases:

>100_bases
TACTAATTATGAGGTGAATTTGTAGCTTTTTGTATTATTATTAGTACTGGTGTGCTATAATACAGATGATATTATATGAA
AGGATGAAATAAAATTGAGT

Downstream 100 bases:

>100_bases
CGGATTTGAAATGTAATATTAAAACGAATAGGAGATGGAAAATATGAGAAAAATAATCAAATGGGCATTATGTATATGCT
TGTGTATATGTTTTGTATGC

Product: glycoside hydrolase family 25

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MKFFERGKVFIGMIMGMGLLFCGHNSVKAVQEEYTAGSSIKTEYEGEVNYDEDIQTYSSGEILAQSASGWRKDNNGWWYQ
YSDGSYPAGKWMQNGGKWYYFNQYGYMVIGSQYIDGSWYYFDGKGEMLTGWQQYSGGWWYHNANGVWISSDYANNTIKGI
DVSYYQGNIDWNAVKNDGIQFAILRVSASYYSDSYHHFTDKRFKEYAANANSVGMPIGAYIYSKARTTENAVSDAKYVIN
ELKGYTISYPVAIDLEDSSQTDLSRQQLGAIAKTFCNEIRKAGYTPMVYCNENWYKNYIDVSQISNEEMWVARYNYHYNT
DIHRTIWQSGSTCRVSGISGNVDIDFANKAFSSWRYNNGRWSYIGTSGEMFTGWHSIGGKWYLFNSNGIMLTGWQKQGKK
WYYLDEDGAMRTGWLLLKSNWYYLNRSGEMFTGWHSIGGKWYLFNTNGIMLGGWQKQGVNWYYLSNNGQMLTGWHSIRGN
WYLFNSNGVMLTGWQKVEGKWYLMNKSGEMLIGWQKIGKNWYYMNSSGKMLTGWQKIGNKMYYMNSSGVWLY

Sequences:

>Translated_552_residues
MKFFERGKVFIGMIMGMGLLFCGHNSVKAVQEEYTAGSSIKTEYEGEVNYDEDIQTYSSGEILAQSASGWRKDNNGWWYQ
YSDGSYPAGKWMQNGGKWYYFNQYGYMVIGSQYIDGSWYYFDGKGEMLTGWQQYSGGWWYHNANGVWISSDYANNTIKGI
DVSYYQGNIDWNAVKNDGIQFAILRVSASYYSDSYHHFTDKRFKEYAANANSVGMPIGAYIYSKARTTENAVSDAKYVIN
ELKGYTISYPVAIDLEDSSQTDLSRQQLGAIAKTFCNEIRKAGYTPMVYCNENWYKNYIDVSQISNEEMWVARYNYHYNT
DIHRTIWQSGSTCRVSGISGNVDIDFANKAFSSWRYNNGRWSYIGTSGEMFTGWHSIGGKWYLFNSNGIMLTGWQKQGKK
WYYLDEDGAMRTGWLLLKSNWYYLNRSGEMFTGWHSIGGKWYLFNTNGIMLGGWQKQGVNWYYLSNNGQMLTGWHSIRGN
WYLFNSNGVMLTGWQKVEGKWYLMNKSGEMLIGWQKIGKNWYYMNSSGKMLTGWQKIGNKMYYMNSSGVWLY
>Mature_552_residues
MKFFERGKVFIGMIMGMGLLFCGHNSVKAVQEEYTAGSSIKTEYEGEVNYDEDIQTYSSGEILAQSASGWRKDNNGWWYQ
YSDGSYPAGKWMQNGGKWYYFNQYGYMVIGSQYIDGSWYYFDGKGEMLTGWQQYSGGWWYHNANGVWISSDYANNTIKGI
DVSYYQGNIDWNAVKNDGIQFAILRVSASYYSDSYHHFTDKRFKEYAANANSVGMPIGAYIYSKARTTENAVSDAKYVIN
ELKGYTISYPVAIDLEDSSQTDLSRQQLGAIAKTFCNEIRKAGYTPMVYCNENWYKNYIDVSQISNEEMWVARYNYHYNT
DIHRTIWQSGSTCRVSGISGNVDIDFANKAFSSWRYNNGRWSYIGTSGEMFTGWHSIGGKWYLFNSNGIMLTGWQKQGKK
WYYLDEDGAMRTGWLLLKSNWYYLNRSGEMFTGWHSIGGKWYLFNTNGIMLGGWQKQGVNWYYLSNNGQMLTGWHSIRGN
WYLFNSNGVMLTGWQKVEGKWYLMNKSGEMLIGWQKIGKNWYYMNSSGKMLTGWQKIGNKMYYMNSSGVWLY

Specific function: Only after the enteral delivery of the enterotoxin A may the characteristic disease called pseudomembranous colitis be induced [H]

COG id: COG5263

COG function: function code R; FOG: Glucan-binding domain (YG repeat)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 32 cell wall-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018337
- InterPro:   IPR007577
- InterPro:   IPR020974 [H]

Pfam domain/function: PF01473 CW_binding_1; PF04488 Gly_transf_sug; PF11713 Peptidase_C80 [H]

EC number: NA

Molecular weight: Translated: 63992; Mature: 63992

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFFERGKVFIGMIMGMGLLFCGHNSVKAVQEEYTAGSSIKTEYEGEVNYDEDIQTYSSG
CCHHHCCCEEEHHHHHHHEEEECCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCEECCCC
EILAQSASGWRKDNNGWWYQYSDGSYPAGKWMQNGGKWYYFNQYGYMVIGSQYIDGSWYY
CEEEECCCCCEECCCCEEEEECCCCCCCCHHHHCCCEEEEECCCCEEEEEEEEECCEEEE
FDGKGEMLTGWQQYSGGWWYHNANGVWISSDYANNTIKGIDVSYYQGNIDWNAVKNDGIQ
ECCCCCEEECEECCCCEEEEECCCEEEEECCCCCCEEEEEEEEEEECCEEEEEEECCCEE
FAILRVSASYYSDSYHHFTDKRFKEYAANANSVGMPIGAYIYSKARTTENAVSDAKYVIN
EEEEEEEEHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHEEEECCCCCHHHHHHHHHHHH
ELKGYTISYPVAIDLEDSSQTDLSRQQLGAIAKTFCNEIRKAGYTPMVYCNENWYKNYID
HHCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEE
VSQISNEEMWVARYNYHYNTDIHRTIWQSGSTCRVSGISGNVDIDFANKAFSSWRYNNGR
HHHCCCCCEEEEEEEEEECCCHHHHHHCCCCEEEEEECCCCEEEEECCHHHHCCCCCCCE
WSYIGTSGEMFTGWHSIGGKWYLFNSNGIMLTGWQKQGKKWYYLDEDGAMRTGWLLLKSN
EEEEECCCCEEEEEECCCCEEEEECCCCEEEEEEHHCCCEEEEECCCCCEEEEEEEEECC
WYYLNRSGEMFTGWHSIGGKWYLFNTNGIMLGGWQKQGVNWYYLSNNGQMLTGWHSIRGN
EEEEECCCCEEEEEECCCCEEEEEECCEEEEECEECCCCEEEEECCCCEEEEEEEEECCC
WYLFNSNGVMLTGWQKVEGKWYLMNKSGEMLIGWQKIGKNWYYMNSSGKMLTGWQKIGNK
EEEECCCCEEEEEEEEECCEEEEECCCCCEEEEEEHHCCEEEEECCCCCEEECHHHHCCE
MYYMNSSGVWLY
EEEECCCCEEEC
>Mature Secondary Structure
MKFFERGKVFIGMIMGMGLLFCGHNSVKAVQEEYTAGSSIKTEYEGEVNYDEDIQTYSSG
CCHHHCCCEEEHHHHHHHEEEECCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCEECCCC
EILAQSASGWRKDNNGWWYQYSDGSYPAGKWMQNGGKWYYFNQYGYMVIGSQYIDGSWYY
CEEEECCCCCEECCCCEEEEECCCCCCCCHHHHCCCEEEEECCCCEEEEEEEEECCEEEE
FDGKGEMLTGWQQYSGGWWYHNANGVWISSDYANNTIKGIDVSYYQGNIDWNAVKNDGIQ
ECCCCCEEECEECCCCEEEEECCCEEEEECCCCCCEEEEEEEEEEECCEEEEEEECCCEE
FAILRVSASYYSDSYHHFTDKRFKEYAANANSVGMPIGAYIYSKARTTENAVSDAKYVIN
EEEEEEEEHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHEEEECCCCCHHHHHHHHHHHH
ELKGYTISYPVAIDLEDSSQTDLSRQQLGAIAKTFCNEIRKAGYTPMVYCNENWYKNYID
HHCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEE
VSQISNEEMWVARYNYHYNTDIHRTIWQSGSTCRVSGISGNVDIDFANKAFSSWRYNNGR
HHHCCCCCEEEEEEEEEECCCHHHHHHCCCCEEEEEECCCCEEEEECCHHHHCCCCCCCE
WSYIGTSGEMFTGWHSIGGKWYLFNSNGIMLTGWQKQGKKWYYLDEDGAMRTGWLLLKSN
EEEEECCCCEEEEEECCCCEEEEECCCCEEEEEEHHCCCEEEEECCCCCEEEEEEEEECC
WYYLNRSGEMFTGWHSIGGKWYLFNTNGIMLGGWQKQGVNWYYLSNNGQMLTGWHSIRGN
EEEEECCCCEEEEEECCCCEEEEEECCEEEEECEECCCCEEEEECCCCEEEEEEEEECCC
WYLFNSNGVMLTGWQKVEGKWYLMNKSGEMLIGWQKIGKNWYYMNSSGKMLTGWQKIGNK
EEEECCCCEEEEEEEEECCEEEEECCCCCEEEEEEHHCCEEEEECCCCCEEECHHHHCCE
MYYMNSSGVWLY
EEEECCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2109310; 2105276 [H]