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The map label for this gene is licA [H]

Identifier: 238924958

GI number: 238924958

Start: 2485171

End: 2486940

Strand: Reverse

Name: licA [H]

Synonym: EUBREC_2609

Alternate gene names: 238924958

Gene position: 2486940-2485171 (Counterclockwise)

Preceding gene: 238924959

Following gene: 238924957

Centisome position: 72.09

GC content: 37.91

Gene sequence:

>1770_bases
ATGAACAAGCAGGAGAAAGATATACTGAACACGTTATATCATCAATCAGTTAACAATCAAAGAGAGATATCAGAGTTATC
CGGTCATTCTCTGGGAGTTGTAAACAAATCAATAAAAGAATTGATGAATGAAGGTTATATAAATGAAAAATGTGCTGTTA
CACCTAAGGCTCTTAAAGAATTCAAAGAAAAAGCGCCAAAGAATGCAGTGATTCTTGCAGCAGGTTATGGCATGCGAATG
GTGCCAATAAATACTGAGACTCCAAAGGGCCTTTTAGAGGTAAATGGGGAAGTTCTTATAGAGCGGACAATCAGACAGCT
TCATGAAGTGGGAATCTATGAGATATATGTAGTAGTCGGCTTCATGAAGGAGAGATATGAGTATCTCATCGATGATTTTG
GAGTGGAGCTCGTTGTCAATGAAGAGTATACGACTAAGAATAATCTATATTCAGTAAAGAAGGTTCTGAATCATTTATCA
AATACATATATCATACCGTGTGATATATGGTGCGACAAGAATCCGTACCATCACCATGAATTATATTCCTGGTATATGGT
CAGTGATTTGATTGATGATGACAGCACGGTGCGTGTTAACAGAAAAATGGAGTTGGTTACCATTCCGAAGGCTGCCGGCG
GCAATGCTATGATAGGAATTAGCTATCTGCTTGACGATGATGCACAAATTGTCAAAGGCAGAATTGAAAAATTGTGTAGT
AATTCGGCTAATGATGGTGCCTTCTGGGAGACTGCACTGTATGATAAGGACAGAATGTTTATTACCGCCAGGGTAGTACA
TTCGTGGGATGTGGTTGAAATTAACACATATGAGCAGCTCAGAGAGATGGACAGCGATTCAAATCATCTGAAAACTGATG
CAATACAGGTTATCTGCGATGCCTTATCTGTATCAGCAGACGATATTGTAGATATTACGGTATTGAAAAAGGGCATGACA
AACCGCTCGTTCCTGTTCTCATGTAAAGGGAAAAAATATATCATGAGAATTCCGGGAGAGGGAACGGATCAGCTGATAAA
CAGACGTAATGAAGCAATGGTTTATAATACTATTGATGGCAGACATATATGTGATGATATCGCTTATATAAATCCGGATA
ATGGATATAAAATCACTGCGTTTTTAGAAAATGCGAGAGTATGTGATCCGGAAAATAATGATGATGTTTGTAAATGCATG
AAGCGTCTCAGAGAATTTCATGATATGAAGCTTAAAGTAAATCATGAATTTGATATATTCGGTCAGCTTGAGTTTTATGA
GAGCCTGTGGGATGGTTCGCCTTCTGCATACAGACATTACAGGCAGACTAAGGAAAATGTCCTTTCACTCAGACCGTATA
TAGAAGCTCATGTAAATGAAAAGGTTCTTACGCATATTGATGCTGTTCCGGATAATTTCCTTTTTGTTAAGGATGAAAAT
GGAAATGAGGACATCAGACTTATTGACTGGGAATATGCAGGAATGCAGGATCCGCACGTAGATATAGCCATGTTCTGCAT
ATATTCCATGTATGACAGGGAGCATGTGGATAAGTTAATTGATGCATATTTCACAGAAGGGTGTTCAGCAGAAATCCGAA
TAAAGATTTATTGTTATATTGCAGTATGCGGACTTTTATGGAGTAACTGGTGTGAGTATAAGAGAAATCTGGGTGTTGAT
TTTGGTGAATATTCACTCAGACAGTACAGATATGCAAAGGATTATTACAAAGTAGTACAGGATGAAATGCAGAAATTGGA
GGATAATTAA

Upstream 100 bases:

>100_bases
TGGCGCGTTTTTTGTTATGAAAAATATAGTTAAGGGTTGATTTTTTAAATAAAAAGGTGTAGTATTATGAATGTTCATAA
AAACATAAGGAGAGACGAAC

Downstream 100 bases:

>100_bases
AAATGCATGAAGTAAAACGCGCGATTATCATGGCAGCAGGACTTGGTAATCGTATGAGACCGGTAACGCTTACTACTCCG
AAGCCATTGGTAAGGGTGAA

Product: choline kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MNKQEKDILNTLYHQSVNNQREISELSGHSLGVVNKSIKELMNEGYINEKCAVTPKALKEFKEKAPKNAVILAAGYGMRM
VPINTETPKGLLEVNGEVLIERTIRQLHEVGIYEIYVVVGFMKERYEYLIDDFGVELVVNEEYTTKNNLYSVKKVLNHLS
NTYIIPCDIWCDKNPYHHHELYSWYMVSDLIDDDSTVRVNRKMELVTIPKAAGGNAMIGISYLLDDDAQIVKGRIEKLCS
NSANDGAFWETALYDKDRMFITARVVHSWDVVEINTYEQLREMDSDSNHLKTDAIQVICDALSVSADDIVDITVLKKGMT
NRSFLFSCKGKKYIMRIPGEGTDQLINRRNEAMVYNTIDGRHICDDIAYINPDNGYKITAFLENARVCDPENNDDVCKCM
KRLREFHDMKLKVNHEFDIFGQLEFYESLWDGSPSAYRHYRQTKENVLSLRPYIEAHVNEKVLTHIDAVPDNFLFVKDEN
GNEDIRLIDWEYAGMQDPHVDIAMFCIYSMYDREHVDKLIDAYFTEGCSAEIRIKIYCYIAVCGLLWSNWCEYKRNLGVD
FGEYSLRQYRYAKDYYKVVQDEMQKLEDN

Sequences:

>Translated_589_residues
MNKQEKDILNTLYHQSVNNQREISELSGHSLGVVNKSIKELMNEGYINEKCAVTPKALKEFKEKAPKNAVILAAGYGMRM
VPINTETPKGLLEVNGEVLIERTIRQLHEVGIYEIYVVVGFMKERYEYLIDDFGVELVVNEEYTTKNNLYSVKKVLNHLS
NTYIIPCDIWCDKNPYHHHELYSWYMVSDLIDDDSTVRVNRKMELVTIPKAAGGNAMIGISYLLDDDAQIVKGRIEKLCS
NSANDGAFWETALYDKDRMFITARVVHSWDVVEINTYEQLREMDSDSNHLKTDAIQVICDALSVSADDIVDITVLKKGMT
NRSFLFSCKGKKYIMRIPGEGTDQLINRRNEAMVYNTIDGRHICDDIAYINPDNGYKITAFLENARVCDPENNDDVCKCM
KRLREFHDMKLKVNHEFDIFGQLEFYESLWDGSPSAYRHYRQTKENVLSLRPYIEAHVNEKVLTHIDAVPDNFLFVKDEN
GNEDIRLIDWEYAGMQDPHVDIAMFCIYSMYDREHVDKLIDAYFTEGCSAEIRIKIYCYIAVCGLLWSNWCEYKRNLGVD
FGEYSLRQYRYAKDYYKVVQDEMQKLEDN
>Mature_589_residues
MNKQEKDILNTLYHQSVNNQREISELSGHSLGVVNKSIKELMNEGYINEKCAVTPKALKEFKEKAPKNAVILAAGYGMRM
VPINTETPKGLLEVNGEVLIERTIRQLHEVGIYEIYVVVGFMKERYEYLIDDFGVELVVNEEYTTKNNLYSVKKVLNHLS
NTYIIPCDIWCDKNPYHHHELYSWYMVSDLIDDDSTVRVNRKMELVTIPKAAGGNAMIGISYLLDDDAQIVKGRIEKLCS
NSANDGAFWETALYDKDRMFITARVVHSWDVVEINTYEQLREMDSDSNHLKTDAIQVICDALSVSADDIVDITVLKKGMT
NRSFLFSCKGKKYIMRIPGEGTDQLINRRNEAMVYNTIDGRHICDDIAYINPDNGYKITAFLENARVCDPENNDDVCKCM
KRLREFHDMKLKVNHEFDIFGQLEFYESLWDGSPSAYRHYRQTKENVLSLRPYIEAHVNEKVLTHIDAVPDNFLFVKDEN
GNEDIRLIDWEYAGMQDPHVDIAMFCIYSMYDREHVDKLIDAYFTEGCSAEIRIKIYCYIAVCGLLWSNWCEYKRNLGVD
FGEYSLRQYRYAKDYYKVVQDEMQKLEDN

Specific function: Mediates phase variation of the LOS 6A2 and 12D9 epitopes. Phase variation of H.influenza LOS epitopes expressed by licA is determined by a translational switch [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002573
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01633 Choline_kinase [H]

EC number: NA

Molecular weight: Translated: 68402; Mature: 68402

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQEKDILNTLYHQSVNNQREISELSGHSLGVVNKSIKELMNEGYINEKCAVTPKALKE
CCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
FKEKAPKNAVILAAGYGMRMVPINTETPKGLLEVNGEVLIERTIRQLHEVGIYEIYVVVG
HHHHCCCCEEEEEECCCEEEEEECCCCCCCCEECCCHHHHHHHHHHHHHCCHHEEHHHHH
FMKERYEYLIDDFGVELVVNEEYTTKNNLYSVKKVLNHLSNTYIIPCDIWCDKNPYHHHE
HHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHH
LYSWYMVSDLIDDDSTVRVNRKMELVTIPKAAGGNAMIGISYLLDDDAQIVKGRIEKLCS
HHHHHHHHHHCCCCCEEEEECEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHC
NSANDGAFWETALYDKDRMFITARVVHSWDVVEINTYEQLREMDSDSNHLKTDAIQVICD
CCCCCCCEEEHEEECCCCEEEEEEEEECCCEEEECCHHHHHHCCCCCCCHHHHHHHHHHH
ALSVSADDIVDITVLKKGMTNRSFLFSCKGKKYIMRIPGEGTDQLINRRNEAMVYNTIDG
HHCCCCCCEEEEEEHHCCCCCCEEEEEECCCEEEEECCCCCHHHHHCCCCCEEEEECCCC
RHICDDIAYINPDNGYKITAFLENARVCDPENNDDVCKCMKRLREFHDMKLKVNHEFDIF
CHHHCCCCEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCEEEE
GQLEFYESLWDGSPSAYRHYRQTKENVLSLRPYIEAHVNEKVLTHIDAVPDNFLFVKDEN
EHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHCCCCCEEEEECCC
GNEDIRLIDWEYAGMQDPHVDIAMFCIYSMYDREHVDKLIDAYFTEGCSAEIRIKIYCYI
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEHH
AVCGLLWSNWCEYKRNLGVDFGEYSLRQYRYAKDYYKVVQDEMQKLEDN
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKQEKDILNTLYHQSVNNQREISELSGHSLGVVNKSIKELMNEGYINEKCAVTPKALKE
CCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
FKEKAPKNAVILAAGYGMRMVPINTETPKGLLEVNGEVLIERTIRQLHEVGIYEIYVVVG
HHHHCCCCEEEEEECCCEEEEEECCCCCCCCEECCCHHHHHHHHHHHHHCCHHEEHHHHH
FMKERYEYLIDDFGVELVVNEEYTTKNNLYSVKKVLNHLSNTYIIPCDIWCDKNPYHHHE
HHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHH
LYSWYMVSDLIDDDSTVRVNRKMELVTIPKAAGGNAMIGISYLLDDDAQIVKGRIEKLCS
HHHHHHHHHHCCCCCEEEEECEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHC
NSANDGAFWETALYDKDRMFITARVVHSWDVVEINTYEQLREMDSDSNHLKTDAIQVICD
CCCCCCCEEEHEEECCCCEEEEEEEEECCCEEEECCHHHHHHCCCCCCCHHHHHHHHHHH
ALSVSADDIVDITVLKKGMTNRSFLFSCKGKKYIMRIPGEGTDQLINRRNEAMVYNTIDG
HHCCCCCCEEEEEEHHCCCCCCEEEEEECCCEEEEECCCCCHHHHHCCCCCEEEEECCCC
RHICDDIAYINPDNGYKITAFLENARVCDPENNDDVCKCMKRLREFHDMKLKVNHEFDIF
CHHHCCCCEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCEEEE
GQLEFYESLWDGSPSAYRHYRQTKENVLSLRPYIEAHVNEKVLTHIDAVPDNFLFVKDEN
EHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHCCCCCEEEEECCC
GNEDIRLIDWEYAGMQDPHVDIAMFCIYSMYDREHVDKLIDAYFTEGCSAEIRIKIYCYI
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEHH
AVCGLLWSNWCEYKRNLGVDFGEYSLRQYRYAKDYYKVVQDEMQKLEDN
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2479481; 8861214 [H]