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The map label for this gene is clpB2 [H]

Identifier: 238924911

GI number: 238924911

Start: 2435910

End: 2438540

Strand: Reverse

Name: clpB2 [H]

Synonym: EUBREC_2562

Alternate gene names: 238924911

Gene position: 2438540-2435910 (Counterclockwise)

Preceding gene: 238924912

Following gene: 238924909

Centisome position: 70.69

GC content: 47.55

Gene sequence:

>2631_bases
ATGGATAACATAGTAGAAGGGAGTGAGACTATGAACATTCAAAAATTTACACAGAAATCAATAGAGGCAGTCAATGACTG
CGAGAAGCTTGCATATGATTATGGCAATCAGGAGATAGAACAGGAGCACCTGCTTGTGGCATTACTTTCACAGGAGGACG
GACTGATACCGAAGCTGATTGACAAGATGGAGATAAACGTAGAGCATTTCACAGAGAATGCAAAGCGCCATCTGGCAGCG
CGTACAAAAGTAAGCGGCAGCAGTGCACAGGTCTATGTGGGCAATGATTTAAACAAGGTTCTTATCCATGCTGAGGACGA
GGCAAAGGCAATGGGAGATGAGTATGTTTCGGTAGAGCATCTTTTCCTGTGTCTGCTGAAGTATCCAAACAAGGCAATGA
AGGAGCTGATAAAGGAGTATGGTCTCACAAGAGACAGATTCCTCACAGCACTTTCTACGGTCAGGGGCAATCAGAAGGTC
ACATCCGATAACCCTGAGGCCACATATGATACACTTGAGAAATATGGCTACGACATGGTGGAGCGTGCAAGACAGCAGAA
GCTTGATCCTGTTATCGGCCGTGATGATGAGATACGAAATGTAGTGCGTATTCTCTCACGTAAGACTAAAAATAACCCGG
TACTTATCGGTGAGCCGGGTGTTGGTAAAACGGCAGTCGTTGAGGGACTGGCGCAGCGTATCGTAAAGGGCGATGTGCCT
GAGGGCTTAAAGGACAAAAAACTGTTTGCACTCGATATGGGCTCTCTGATTGCAGGAGCTAAGTACAGGGGCGAGTTTGA
GGAGAGACTTAAGGCAGTGCTTGAGGAGGTAAAAGCCTCTGACGGACAGATAATTCTCTTTATCGATGAGCTTCACACAA
TAGTAGGAGCCGGAAAGACAGACGGAGCTATGGATGCAGGACAGCTTCTTAAGCCAATGCTTGCAAGAGGTGAGCTGCAC
TGCGTGGGCGCCACCACACTTGATGAGTACCGTGAGTACATTGAGAAGGATGCAGCTCTTGAGAGACGTTTCCAGCCTGT
TATGGTAGACGAGCCGACAGTAGAGGACACTATCTCAATACTTCGTGGTCTTAAGGACAGATACGAGGTATTCCATGGCG
TTAAAATCACAGATTCGGCACTTGTCACAGCGGCAGTGCTTTCAAACAGATACATCACAGACAGATTTTTGCCTGATAAG
GCAATAGACCTTGTGGATGAGGCATGCGCCATGATAAAGACGGAGCTTGATTCAATGCCGGCAGAGCTTGATGAGCAGAA
TCGTAAGATTATGCAGCTTGAGATAGAGGAGACAGCTCTAAAGAAAGAGACAGACCACTTAAGTCAGGACAGGCTCGCAG
CACTACAAAAGGAGCTTGCAGAGCTGCGTGATGACTTCAATGCGAAAAAGGCTCAGTGGCAGAACGAGAAGGGCGCTGTT
GACAAGGTCAGCAAGCTTCGTGAAAAGATTGAGTCCACAAAGAATGAAATCAAGACAGCGCAGCAGAACTATGACCTGGA
AAAGGCGGCAGAGCTGCAGTACGGCGTTCTTCCAAATTTGCAGAAGGAGCTGGAATCAGAGGAAGCACTGCTTAAGGACA
GGGATTTATCGCTTGTACGTGAGAACGTGGGCGATGAGGAGATTGCACTCATTATCTCGCGCTGGACAGGAATACCTGTT
GCAAAGCTTACGGAGAGTGAGCGTAATAAGACACTTCACCTCGATGAGGAGCTGCACAAGAGGGTAATAGGACAGGATGA
CGGAGTCACAAAGGTGACAGAGGCTATCATCCGATCAAAGGCAGGCATCAAGGATCCTACAAAGCCGATAGGTTCGTTTA
TGTTCCTCGGACCTACAGGTGTAGGTAAGACAGAGCTTGCAAAGGCACTTGCGGCAAGTCTTTTTGATGATGAGAACAAC
ATGGTCAGACTCGATATGAGTGAGTACATGGAGAAGTACTCAGTGTCACGACTCATCGGAGCGCCTCCTGGATATGTAGG
CTATGATGAGGGTGGACAGCTCACAGAGGCTGTAAGGCGTAAGCCATACTCAGTAGTACTCTTTGATGAGGTGGAAAAAG
CCCATCCGGATGTATTCAATGTGCTGCTTCAGGTGCTTGATGACGGACGAATTACTGACTCACAGGGACGTACCGTGGAT
TTCAAAAACACTATCATCATTATGACAAGCAACCTCGGCTCACAGGAGCTTCTTGAGGGTATAGAGGCAGACGGCAGCAT
CAGCACAGAGTGTGAGAACCGCGTCATGGATGAGCTTAAGGGTCATTTCAGACCGGAGTTTTTAAACAGACTTGATGAGA
TCATCATGTTCAAGCCTCTCACAAAGGATAACATTGGTCATATCATCACCTTGCTCATGGCAGACTTAAACAAGCGTCTT
GTCGACAAGGAAATCACAGTCGAGCTGACAGACACTGCAAAGCAGTTTATCACCGACAATGGCTACGATCCGGTATACGG
AGCAAGACCGCTCAAGAGATATCTGCAGAAGCATGTCGAGACACTCGCTGCAAAGCTGATTCTGGCAGATGGTGTGAGAG
CAGGAGATACCATTCTTATAGATGTGAAGGATGGCAAGCTTAGTGCATCGGCAGTTCAGAAAAATGCATAA

Upstream 100 bases:

>100_bases
TGCTATAACATAGTCACAAGGAAATATTGAAGAATTATTTAAAGGATTATTTAGAGATAAAATTTTGATATTACCTGTAT
AACACATAAGAATCATATTT

Downstream 100 bases:

>100_bases
GCAAATGTATAGAAATTAACAGCTCTTTCTCTTTACAATTTCTGTACTTATTTCAATTTTTACATGGCTTGCAGAGGTAG
AATTTATTATCTCTGCAAGC

Product: heat shock protein ClpB-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 876; Mature: 876

Protein sequence:

>876_residues
MDNIVEGSETMNIQKFTQKSIEAVNDCEKLAYDYGNQEIEQEHLLVALLSQEDGLIPKLIDKMEINVEHFTENAKRHLAA
RTKVSGSSAQVYVGNDLNKVLIHAEDEAKAMGDEYVSVEHLFLCLLKYPNKAMKELIKEYGLTRDRFLTALSTVRGNQKV
TSDNPEATYDTLEKYGYDMVERARQQKLDPVIGRDDEIRNVVRILSRKTKNNPVLIGEPGVGKTAVVEGLAQRIVKGDVP
EGLKDKKLFALDMGSLIAGAKYRGEFEERLKAVLEEVKASDGQIILFIDELHTIVGAGKTDGAMDAGQLLKPMLARGELH
CVGATTLDEYREYIEKDAALERRFQPVMVDEPTVEDTISILRGLKDRYEVFHGVKITDSALVTAAVLSNRYITDRFLPDK
AIDLVDEACAMIKTELDSMPAELDEQNRKIMQLEIEETALKKETDHLSQDRLAALQKELAELRDDFNAKKAQWQNEKGAV
DKVSKLREKIESTKNEIKTAQQNYDLEKAAELQYGVLPNLQKELESEEALLKDRDLSLVRENVGDEEIALIISRWTGIPV
AKLTESERNKTLHLDEELHKRVIGQDDGVTKVTEAIIRSKAGIKDPTKPIGSFMFLGPTGVGKTELAKALAASLFDDENN
MVRLDMSEYMEKYSVSRLIGAPPGYVGYDEGGQLTEAVRRKPYSVVLFDEVEKAHPDVFNVLLQVLDDGRITDSQGRTVD
FKNTIIIMTSNLGSQELLEGIEADGSISTECENRVMDELKGHFRPEFLNRLDEIIMFKPLTKDNIGHIITLLMADLNKRL
VDKEITVELTDTAKQFITDNGYDPVYGARPLKRYLQKHVETLAAKLILADGVRAGDTILIDVKDGKLSASAVQKNA

Sequences:

>Translated_876_residues
MDNIVEGSETMNIQKFTQKSIEAVNDCEKLAYDYGNQEIEQEHLLVALLSQEDGLIPKLIDKMEINVEHFTENAKRHLAA
RTKVSGSSAQVYVGNDLNKVLIHAEDEAKAMGDEYVSVEHLFLCLLKYPNKAMKELIKEYGLTRDRFLTALSTVRGNQKV
TSDNPEATYDTLEKYGYDMVERARQQKLDPVIGRDDEIRNVVRILSRKTKNNPVLIGEPGVGKTAVVEGLAQRIVKGDVP
EGLKDKKLFALDMGSLIAGAKYRGEFEERLKAVLEEVKASDGQIILFIDELHTIVGAGKTDGAMDAGQLLKPMLARGELH
CVGATTLDEYREYIEKDAALERRFQPVMVDEPTVEDTISILRGLKDRYEVFHGVKITDSALVTAAVLSNRYITDRFLPDK
AIDLVDEACAMIKTELDSMPAELDEQNRKIMQLEIEETALKKETDHLSQDRLAALQKELAELRDDFNAKKAQWQNEKGAV
DKVSKLREKIESTKNEIKTAQQNYDLEKAAELQYGVLPNLQKELESEEALLKDRDLSLVRENVGDEEIALIISRWTGIPV
AKLTESERNKTLHLDEELHKRVIGQDDGVTKVTEAIIRSKAGIKDPTKPIGSFMFLGPTGVGKTELAKALAASLFDDENN
MVRLDMSEYMEKYSVSRLIGAPPGYVGYDEGGQLTEAVRRKPYSVVLFDEVEKAHPDVFNVLLQVLDDGRITDSQGRTVD
FKNTIIIMTSNLGSQELLEGIEADGSISTECENRVMDELKGHFRPEFLNRLDEIIMFKPLTKDNIGHIITLLMADLNKRL
VDKEITVELTDTAKQFITDNGYDPVYGARPLKRYLQKHVETLAAKLILADGVRAGDTILIDVKDGKLSASAVQKNA
>Mature_876_residues
MDNIVEGSETMNIQKFTQKSIEAVNDCEKLAYDYGNQEIEQEHLLVALLSQEDGLIPKLIDKMEINVEHFTENAKRHLAA
RTKVSGSSAQVYVGNDLNKVLIHAEDEAKAMGDEYVSVEHLFLCLLKYPNKAMKELIKEYGLTRDRFLTALSTVRGNQKV
TSDNPEATYDTLEKYGYDMVERARQQKLDPVIGRDDEIRNVVRILSRKTKNNPVLIGEPGVGKTAVVEGLAQRIVKGDVP
EGLKDKKLFALDMGSLIAGAKYRGEFEERLKAVLEEVKASDGQIILFIDELHTIVGAGKTDGAMDAGQLLKPMLARGELH
CVGATTLDEYREYIEKDAALERRFQPVMVDEPTVEDTISILRGLKDRYEVFHGVKITDSALVTAAVLSNRYITDRFLPDK
AIDLVDEACAMIKTELDSMPAELDEQNRKIMQLEIEETALKKETDHLSQDRLAALQKELAELRDDFNAKKAQWQNEKGAV
DKVSKLREKIESTKNEIKTAQQNYDLEKAAELQYGVLPNLQKELESEEALLKDRDLSLVRENVGDEEIALIISRWTGIPV
AKLTESERNKTLHLDEELHKRVIGQDDGVTKVTEAIIRSKAGIKDPTKPIGSFMFLGPTGVGKTELAKALAASLFDDENN
MVRLDMSEYMEKYSVSRLIGAPPGYVGYDEGGQLTEAVRRKPYSVVLFDEVEKAHPDVFNVLLQVLDDGRITDSQGRTVD
FKNTIIIMTSNLGSQELLEGIEADGSISTECENRVMDELKGHFRPEFLNRLDEIIMFKPLTKDNIGHIITLLMADLNKRL
VDKEITVELTDTAKQFITDNGYDPVYGARPLKRYLQKHVETLAAKLILADGVRAGDTILIDVKDGKLSASAVQKNA

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=318, Percent_Identity=37.7358490566038, Blast_Score=204, Evalue=3e-52,
Organism=Escherichia coli, GI1788943, Length=860, Percent_Identity=52.6744186046512, Blast_Score=904, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=329, Percent_Identity=42.2492401215805, Blast_Score=269, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6320464, Length=706, Percent_Identity=52.2662889518414, Blast_Score=761, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=872, Percent_Identity=41.1697247706422, Blast_Score=671, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 98084; Mature: 98084

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNIVEGSETMNIQKFTQKSIEAVNDCEKLAYDYGNQEIEQEHLLVALLSQEDGLIPKLI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHH
DKMEINVEHFTENAKRHLAARTKVSGSSAQVYVGNDLNKVLIHAEDEAKAMGDEYVSVEH
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEECHHHHHHCCHHHHHHH
LFLCLLKYPNKAMKELIKEYGLTRDRFLTALSTVRGNQKVTSDNPEATYDTLEKYGYDMV
HHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHH
ERARQQKLDPVIGRDDEIRNVVRILSRKTKNNPVLIGEPGVGKTAVVEGLAQRIVKGDVP
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCC
EGLKDKKLFALDMGSLIAGAKYRGEFEERLKAVLEEVKASDGQIILFIDELHTIVGAGKT
CCCCCCEEEEEEHHHHHHCCHHCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCC
DGAMDAGQLLKPMLARGELHCVGATTLDEYREYIEKDAALERRFQPVMVDEPTVEDTISI
CCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LRGLKDRYEVFHGVKITDSALVTAAVLSNRYITDRFLPDKAIDLVDEACAMIKTELDSMP
HHHHHHHHHHHCCCEECHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
AELDEQNRKIMQLEIEETALKKETDHLSQDRLAALQKELAELRDDFNAKKAQWQNEKGAV
CHHHHCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHH
DKVSKLREKIESTKNEIKTAQQNYDLEKAAELQYGVLPNLQKELESEEALLKDRDLSLVR
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHH
ENVGDEEIALIISRWTGIPVAKLTESERNKTLHLDEELHKRVIGQDDGVTKVTEAIIRSK
HCCCCHHHHHHHHHCCCCCHHHHCHHHCCCEEECCHHHHHHHCCCCCCHHHHHHHHHHHC
AGIKDPTKPIGSFMFLGPTGVGKTELAKALAASLFDDENNMVRLDMSEYMEKYSVSRLIG
CCCCCCCHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHC
APPGYVGYDEGGQLTEAVRRKPYSVVLFDEVEKAHPDVFNVLLQVLDDGRITDSQGRTVD
CCCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCEECCCCCEEE
FKNTIIIMTSNLGSQELLEGIEADGSISTECENRVMDELKGHFRPEFLNRLDEIIMFKPL
ECCEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCC
TKDNIGHIITLLMADLNKRLVDKEITVELTDTAKQFITDNGYDPVYGARPLKRYLQKHVE
CCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
TLAAKLILADGVRAGDTILIDVKDGKLSASAVQKNA
HHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHCCCC
>Mature Secondary Structure
MDNIVEGSETMNIQKFTQKSIEAVNDCEKLAYDYGNQEIEQEHLLVALLSQEDGLIPKLI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHH
DKMEINVEHFTENAKRHLAARTKVSGSSAQVYVGNDLNKVLIHAEDEAKAMGDEYVSVEH
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEECHHHHHHCCHHHHHHH
LFLCLLKYPNKAMKELIKEYGLTRDRFLTALSTVRGNQKVTSDNPEATYDTLEKYGYDMV
HHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHH
ERARQQKLDPVIGRDDEIRNVVRILSRKTKNNPVLIGEPGVGKTAVVEGLAQRIVKGDVP
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCC
EGLKDKKLFALDMGSLIAGAKYRGEFEERLKAVLEEVKASDGQIILFIDELHTIVGAGKT
CCCCCCEEEEEEHHHHHHCCHHCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCC
DGAMDAGQLLKPMLARGELHCVGATTLDEYREYIEKDAALERRFQPVMVDEPTVEDTISI
CCCCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
LRGLKDRYEVFHGVKITDSALVTAAVLSNRYITDRFLPDKAIDLVDEACAMIKTELDSMP
HHHHHHHHHHHCCCEECHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
AELDEQNRKIMQLEIEETALKKETDHLSQDRLAALQKELAELRDDFNAKKAQWQNEKGAV
CHHHHCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHH
DKVSKLREKIESTKNEIKTAQQNYDLEKAAELQYGVLPNLQKELESEEALLKDRDLSLVR
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHH
ENVGDEEIALIISRWTGIPVAKLTESERNKTLHLDEELHKRVIGQDDGVTKVTEAIIRSK
HCCCCHHHHHHHHHCCCCCHHHHCHHHCCCEEECCHHHHHHHCCCCCCHHHHHHHHHHHC
AGIKDPTKPIGSFMFLGPTGVGKTELAKALAASLFDDENNMVRLDMSEYMEKYSVSRLIG
CCCCCCCHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHC
APPGYVGYDEGGQLTEAVRRKPYSVVLFDEVEKAHPDVFNVLLQVLDDGRITDSQGRTVD
CCCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHCCCCEECCCCCEEE
FKNTIIIMTSNLGSQELLEGIEADGSISTECENRVMDELKGHFRPEFLNRLDEIIMFKPL
ECCEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCC
TKDNIGHIITLLMADLNKRLVDKEITVELTDTAKQFITDNGYDPVYGARPLKRYLQKHVE
CCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
TLAAKLILADGVRAGDTILIDVKDGKLSASAVQKNA
HHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]