Click here to switch to the map view.

The map label for this gene is thiD [H]

Identifier: 238924877

GI number: 238924877

Start: 2401551

End: 2402342

Strand: Reverse

Name: thiD [H]

Synonym: EUBREC_2528

Alternate gene names: 238924877

Gene position: 2402342-2401551 (Counterclockwise)

Preceding gene: 238924878

Following gene: 238924876

Centisome position: 69.64

GC content: 48.36

Gene sequence:

>792_bases
ATGCATACAGCACTTACAATTGCGGGAAGCGATTCAAGCGGTGGCGCAGGCGTGCAGGCCGATTTAAAGACCATGCTTGC
AAACGGTGTGTTTGGCGAGAGTGTCATCACGGCACTCACGGCACAAAACACCATGGGAGTTGACGCGGTGATGAATGTAC
CGGCTGATTTTATCGAGGCACAGATGAAGGCTGTTTTTTCGGATATTTTTCCGGATGCGGTGAAAATCGGTATGACATCA
TCGGTAGATACGATTGAGGCGATTGCCGCAGGTCTTGTAAAATATAAGGCAAAAAACATAGTTCTGGACCCGGTGATGGT
CGCTACAAGCGGAAGCAGGCTGCTTGAGGAAAATGCAGCAAACACTCTGATGGAGAAGCTGTTTCCACTGGCTGACATCA
TCACGCCAAATATCCCTGAGCTTGAGGTGATATCAGGCAGACAGATTGAAAGCACAGATGACATCATAGAGGCATCAAAG
GCTGTTTATGATAAATACGGCTGTCCGGTTTTAAGCAAGGGAGGTCATTTCACAGACACAGCATGTGTGTGTGACTATTT
GTGGGATGGAAAGCAAATCATCACATTTGAGACCAAAAGAGTGGATAATCCAAACTCACACGGCACAGGCTGCACGCTTT
CATCAGCGATAGCCAGCGGTCTGGCAAAGGGTCAGTCGCTCGAGCAGGCTGTGGATAACGGCAAGAGATATGTCACAGCA
TGTTTAAAAGCCATGCTTGACCTGGGACACGGCAGCGGTCCTATGAATCATGGAGCGTTGTTCATACAATGA

Upstream 100 bases:

>100_bases
ACAGTATGACATACTGCTATAACTACAGTAATTAAACAATATTTTGAAGATACTGAACAGTTACGAGAAATCACAACATT
CAGTAGAAAGGAGCGTAAAT

Downstream 100 bases:

>100_bases
AATAAGCACATGTTAAATAATTAATAGCAGTAATAATAAGAATAGTAATAACTACTAATTAACAGTAATAAAATAAAGAA
CAGGAGAGTACAATGAGTAA

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MHTALTIAGSDSSGGAGVQADLKTMLANGVFGESVITALTAQNTMGVDAVMNVPADFIEAQMKAVFSDIFPDAVKIGMTS
SVDTIEAIAAGLVKYKAKNIVLDPVMVATSGSRLLEENAANTLMEKLFPLADIITPNIPELEVISGRQIESTDDIIEASK
AVYDKYGCPVLSKGGHFTDTACVCDYLWDGKQIITFETKRVDNPNSHGTGCTLSSAIASGLAKGQSLEQAVDNGKRYVTA
CLKAMLDLGHGSGPMNHGALFIQ

Sequences:

>Translated_263_residues
MHTALTIAGSDSSGGAGVQADLKTMLANGVFGESVITALTAQNTMGVDAVMNVPADFIEAQMKAVFSDIFPDAVKIGMTS
SVDTIEAIAAGLVKYKAKNIVLDPVMVATSGSRLLEENAANTLMEKLFPLADIITPNIPELEVISGRQIESTDDIIEASK
AVYDKYGCPVLSKGGHFTDTACVCDYLWDGKQIITFETKRVDNPNSHGTGCTLSSAIASGLAKGQSLEQAVDNGKRYVTA
CLKAMLDLGHGSGPMNHGALFIQ
>Mature_263_residues
MHTALTIAGSDSSGGAGVQADLKTMLANGVFGESVITALTAQNTMGVDAVMNVPADFIEAQMKAVFSDIFPDAVKIGMTS
SVDTIEAIAAGLVKYKAKNIVLDPVMVATSGSRLLEENAANTLMEKLFPLADIITPNIPELEVISGRQIESTDDIIEASK
AVYDKYGCPVLSKGGHFTDTACVCDYLWDGKQIITFETKRVDNPNSHGTGCTLSSAIASGLAKGQSLEQAVDNGKRYVTA
CLKAMLDLGHGSGPMNHGALFIQ

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=258, Percent_Identity=42.6356589147287, Blast_Score=199, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6325378, Length=276, Percent_Identity=35.5072463768116, Blast_Score=153, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324997, Length=272, Percent_Identity=38.9705882352941, Blast_Score=145, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6324517, Length=272, Percent_Identity=36.3970588235294, Blast_Score=135, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 27620; Mature: 27620

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTALTIAGSDSSGGAGVQADLKTMLANGVFGESVITALTAQNTMGVDAVMNVPADFIEA
CCCEEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHCCHHHHHH
QMKAVFSDIFPDAVKIGMTSSVDTIEAIAAGLVKYKAKNIVLDPVMVATSGSRLLEENAA
HHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCEEECCEEEECCCHHHHHHHHH
NTLMEKLFPLADIITPNIPELEVISGRQIESTDDIIEASKAVYDKYGCPVLSKGGHFTDT
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCHH
ACVCDYLWDGKQIITFETKRVDNPNSHGTGCTLSSAIASGLAKGQSLEQAVDNGKRYVTA
HHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCHHHHHH
CLKAMLDLGHGSGPMNHGALFIQ
HHHHHHHCCCCCCCCCCCEEEEC
>Mature Secondary Structure
MHTALTIAGSDSSGGAGVQADLKTMLANGVFGESVITALTAQNTMGVDAVMNVPADFIEA
CCCEEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHCCHHHHHH
QMKAVFSDIFPDAVKIGMTSSVDTIEAIAAGLVKYKAKNIVLDPVMVATSGSRLLEENAA
HHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCEEECCEEEECCCHHHHHHHHH
NTLMEKLFPLADIITPNIPELEVISGRQIESTDDIIEASKAVYDKYGCPVLSKGGHFTDT
HHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCHH
ACVCDYLWDGKQIITFETKRVDNPNSHGTGCTLSSAIASGLAKGQSLEQAVDNGKRYVTA
HHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCHHHHHH
CLKAMLDLGHGSGPMNHGALFIQ
HHHHHHHCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]