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The map label for this gene is hisG [H]

Identifier: 238924048

GI number: 238924048

Start: 1569127

End: 1569774

Strand: Direct

Name: hisG [H]

Synonym: EUBREC_1686

Alternate gene names: 238924048

Gene position: 1569127-1569774 (Clockwise)

Preceding gene: 238924047

Following gene: 238924049

Centisome position: 45.49

GC content: 44.6

Gene sequence:

>648_bases
ATGAGTGATGACAGATATTTAACCTTTGCCCTGGGAAAGGGCAGACTTGCAAAAAAGACACTGCAGCTTTTTGAGCAGAT
AGGCATCACCTGTGAGGAGATGAAGGATCCGGATACCAGAAAGCTGATTTTCGTAAATGAGGAGCTTAAGCTTAGATTTT
TCCTGGCAAAGGGACCTGATGTGCCTACTTACGTGGAGTATGGCGCTGCCGATATCGGTGTGGTAGGAAAGGATACCATC
CTCGAGGAGGGCAGAAATATATACGAGGTGCTTGATTTAGGTTTTGGAAAATGCCGCATGTGTATATGCGGACCGGAGAG
TGCAAGGGAGCTTTTACAGCATCATGAGCAGATAAGAGTTGCCACCAAGTATCCTCATATCGCAAAGGATTATTTCTACA
ATAAAAAGCATCAGACGGTAGAGATTATAAAGCTAAACGGCTCAATAGAGCTTGCTCCGATTGTTGGACTTTCAGAGGTG
ATTTGTGATATAGTAGAGACCGGAACTACACTTAAGGAGAACGGACTTACCGTACTTGAGGAGGTCTGTCCGCTGTCTGC
GAGGGTTGTGGTAAACCAGGTCAGCATGAAGATGGACAATGAGCGTATCACAAAGCTCATAAGTGATTTGAAGACTGTTA
TCAAATAG

Upstream 100 bases:

>100_bases
ACAGATGGTGCTTAAGGACAAAAATAAAACGAAAGAGGACTATGCTTCATATGCGGTAGACAACCGTATAAACAGAGTTG
AGTTTATAGAGGAATAAAAG

Downstream 100 bases:

>100_bases
CGTATAATTTATATCAATACATGATTTTAGACGGAGGCTGTAATGAGAACTTTAAAACTTACAAAGGATTCACAGAAGAA
CATATTGGAGAGCCTGCTTA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MSDDRYLTFALGKGRLAKKTLQLFEQIGITCEEMKDPDTRKLIFVNEELKLRFFLAKGPDVPTYVEYGAADIGVVGKDTI
LEEGRNIYEVLDLGFGKCRMCICGPESARELLQHHEQIRVATKYPHIAKDYFYNKKHQTVEIIKLNGSIELAPIVGLSEV
ICDIVETGTTLKENGLTVLEEVCPLSARVVVNQVSMKMDNERITKLISDLKTVIK

Sequences:

>Translated_215_residues
MSDDRYLTFALGKGRLAKKTLQLFEQIGITCEEMKDPDTRKLIFVNEELKLRFFLAKGPDVPTYVEYGAADIGVVGKDTI
LEEGRNIYEVLDLGFGKCRMCICGPESARELLQHHEQIRVATKYPHIAKDYFYNKKHQTVEIIKLNGSIELAPIVGLSEV
ICDIVETGTTLKENGLTVLEEVCPLSARVVVNQVSMKMDNERITKLISDLKTVIK
>Mature_214_residues
SDDRYLTFALGKGRLAKKTLQLFEQIGITCEEMKDPDTRKLIFVNEELKLRFFLAKGPDVPTYVEYGAADIGVVGKDTIL
EEGRNIYEVLDLGFGKCRMCICGPESARELLQHHEQIRVATKYPHIAKDYFYNKKHQTVEIIKLNGSIELAPIVGLSEVI
CDIVETGTTLKENGLTVLEEVCPLSARVVVNQVSMKMDNERITKLISDLKTVIK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=227, Percent_Identity=30.3964757709251, Blast_Score=98, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320896, Length=219, Percent_Identity=26.9406392694064, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 24238; Mature: 24106

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDRYLTFALGKGRLAKKTLQLFEQIGITCEEMKDPDTRKLIFVNEELKLRFFLAKGPD
CCCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEECCCEEEEEEEECCCC
VPTYVEYGAADIGVVGKDTILEEGRNIYEVLDLGFGKCRMCICGPESARELLQHHEQIRV
CCCHHHCCCCCCCCCCCHHHHHCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHEEE
ATKYPHIAKDYFYNKKHQTVEIIKLNGSIELAPIVGLSEVICDIVETGTTLKENGLTVLE
HHCCCCHHHHHHCCCCCCEEEEEEECCCEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHH
EVCPLSARVVVNQVSMKMDNERITKLISDLKTVIK
HHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SDDRYLTFALGKGRLAKKTLQLFEQIGITCEEMKDPDTRKLIFVNEELKLRFFLAKGPD
CCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEECCCEEEEEEEECCCC
VPTYVEYGAADIGVVGKDTILEEGRNIYEVLDLGFGKCRMCICGPESARELLQHHEQIRV
CCCHHHCCCCCCCCCCCHHHHHCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHEEE
ATKYPHIAKDYFYNKKHQTVEIIKLNGSIELAPIVGLSEVICDIVETGTTLKENGLTVLE
HHCCCCHHHHHHCCCCCCEEEEEEECCCEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHH
EVCPLSARVVVNQVSMKMDNERITKLISDLKTVIK
HHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA