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The map label for this gene is gmk [H]

Identifier: 238924035

GI number: 238924035

Start: 1558014

End: 1558673

Strand: Direct

Name: gmk [H]

Synonym: EUBREC_1673

Alternate gene names: 238924035

Gene position: 1558014-1558673 (Clockwise)

Preceding gene: 238924034

Following gene: 238924036

Centisome position: 45.16

GC content: 40.45

Gene sequence:

>660_bases
ATGAGTAACACAGGAAAATTAGTTGTTTTTTCAGGCTTTTCGGGTTCCGGAAAGGGTACTATCATGAAGGAGCTTATGGC
AAAGCATGGTGATGATTATGCACTGAGCGTATCAGCCACGACCAGAGGTCCAAGGCCGGGTGAGGAGCATGGCAGAGAGT
ATTTTTTTATCTCAGAGGAAGAATTTGAACAGATGATAAAGGCAGACGGACTGCTTGAGTATGCCAAGTATGTAGATCAT
TACTACGGCACACCAAAGTCATATGTAAATGAGCAGCTTAGCGCAGGAAAGAATGTGATTCTTGAGATAGAAATCCAGGG
AGCTTTAAAGATAAAGAAGCAGTTTCCTGATACGGTGCTTATGTTTGTGTCAGCGCCGAGTGCAGATGAGCTTAAGGACC
GGCTTGTAGGAAGAGGCACAGAGACAAAAGAGGTCTGTGCACAGAGACTTTCAAGAGCATATGAGGAGTCTTTAGGCATA
GAGAAATATGATTATTTAGTGGTAAATGATAAGCTTGACGATTGTGTAGAGCTTGTGAATGATATCATCCACAGCTCTGA
CGACACAAAAAAGAATCAGGATTATCTGGTATCATCAAATATAGATTTTATAAATAAAATGAGAAAAGAGCTTTTAAGCT
TTTCGAAAGGAGATAAATAA

Upstream 100 bases:

>100_bases
CAATGATCTTAAGATTTCTGACACAGGCATCAGTCTTAAAACTGATATAGAAAAGGTCAGGGAACAGATTCAAAATATTG
AGTAATTTTAGGAGATTGTG

Downstream 100 bases:

>100_bases
TATGATACATCCATCGTATGTAGAGTTAATGAAGGTAGTAAACAACAATGTAGAGATAGGTGAAGAGCCGGTAGTAAACA
GCCGTTATTCTATCGTTATT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MSNTGKLVVFSGFSGSGKGTIMKELMAKHGDDYALSVSATTRGPRPGEEHGREYFFISEEEFEQMIKADGLLEYAKYVDH
YYGTPKSYVNEQLSAGKNVILEIEIQGALKIKKQFPDTVLMFVSAPSADELKDRLVGRGTETKEVCAQRLSRAYEESLGI
EKYDYLVVNDKLDDCVELVNDIIHSSDDTKKNQDYLVSSNIDFINKMRKELLSFSKGDK

Sequences:

>Translated_219_residues
MSNTGKLVVFSGFSGSGKGTIMKELMAKHGDDYALSVSATTRGPRPGEEHGREYFFISEEEFEQMIKADGLLEYAKYVDH
YYGTPKSYVNEQLSAGKNVILEIEIQGALKIKKQFPDTVLMFVSAPSADELKDRLVGRGTETKEVCAQRLSRAYEESLGI
EKYDYLVVNDKLDDCVELVNDIIHSSDDTKKNQDYLVSSNIDFINKMRKELLSFSKGDK
>Mature_218_residues
SNTGKLVVFSGFSGSGKGTIMKELMAKHGDDYALSVSATTRGPRPGEEHGREYFFISEEEFEQMIKADGLLEYAKYVDHY
YGTPKSYVNEQLSAGKNVILEIEIQGALKIKKQFPDTVLMFVSAPSADELKDRLVGRGTETKEVCAQRLSRAYEESLGIE
KYDYLVVNDKLDDCVELVNDIIHSSDDTKKNQDYLVSSNIDFINKMRKELLSFSKGDK

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=191, Percent_Identity=35.0785340314136, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI226874833, Length=191, Percent_Identity=35.0785340314136, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI4504221, Length=191, Percent_Identity=35.0785340314136, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI21361598, Length=182, Percent_Identity=29.6703296703297, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI38570142, Length=190, Percent_Identity=25.7894736842105, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI14780902, Length=213, Percent_Identity=25.8215962441315, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI186972120, Length=186, Percent_Identity=29.5698924731183, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI186700627, Length=186, Percent_Identity=29.5698924731183, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI186700629, Length=186, Percent_Identity=29.5698924731183, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI262118255, Length=174, Percent_Identity=31.0344827586207, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI262118263, Length=174, Percent_Identity=31.0344827586207, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI4505237, Length=174, Percent_Identity=31.0344827586207, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI262118259, Length=174, Percent_Identity=31.0344827586207, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI52630447, Length=178, Percent_Identity=28.0898876404494, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1790080, Length=199, Percent_Identity=38.6934673366834, Blast_Score=147, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17508835, Length=189, Percent_Identity=40.7407407407407, Blast_Score=139, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI193203132, Length=188, Percent_Identity=40.9574468085106, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71988041, Length=178, Percent_Identity=24.7191011235955, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71988048, Length=178, Percent_Identity=24.7191011235955, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=41.2087912087912, Blast_Score=139, Evalue=4e-34,
Organism=Drosophila melanogaster, GI21356141, Length=200, Percent_Identity=35.5, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI281362230, Length=187, Percent_Identity=31.0160427807487, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24648808, Length=187, Percent_Identity=31.0160427807487, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI161078487, Length=129, Percent_Identity=37.2093023255814, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161078485, Length=129, Percent_Identity=37.2093023255814, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24648810, Length=129, Percent_Identity=37.2093023255814, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281362232, Length=129, Percent_Identity=37.2093023255814, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45551002, Length=129, Percent_Identity=31.0077519379845, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI85816281, Length=129, Percent_Identity=31.0077519379845, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI85816106, Length=129, Percent_Identity=31.0077519379845, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221330166, Length=127, Percent_Identity=29.9212598425197, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330162, Length=127, Percent_Identity=29.9212598425197, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330164, Length=127, Percent_Identity=29.9212598425197, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 24638; Mature: 24507

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTGKLVVFSGFSGSGKGTIMKELMAKHGDDYALSVSATTRGPRPGEEHGREYFFISEE
CCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCCEEEEECHH
EFEQMIKADGLLEYAKYVDHYYGTPKSYVNEQLSAGKNVILEIEIQGALKIKKQFPDTVL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHCCCEEE
MFVSAPSADELKDRLVGRGTETKEVCAQRLSRAYEESLGIEKYDYLVVNDKLDDCVELVN
EEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHH
DIIHSSDDTKKNQDYLVSSNIDFINKMRKELLSFSKGDK
HHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SNTGKLVVFSGFSGSGKGTIMKELMAKHGDDYALSVSATTRGPRPGEEHGREYFFISEE
CCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCCEEEEECHH
EFEQMIKADGLLEYAKYVDHYYGTPKSYVNEQLSAGKNVILEIEIQGALKIKKQFPDTVL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHCCCEEE
MFVSAPSADELKDRLVGRGTETKEVCAQRLSRAYEESLGIEKYDYLVVNDKLDDCVELVN
EEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHH
DIIHSSDDTKKNQDYLVSSNIDFINKMRKELLSFSKGDK
HHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA