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The map label for this gene is pbpA [H]

Identifier: 238924023

GI number: 238924023

Start: 1546905

End: 1548251

Strand: Direct

Name: pbpA [H]

Synonym: EUBREC_1661

Alternate gene names: 238924023

Gene position: 1546905-1548251 (Clockwise)

Preceding gene: 238924022

Following gene: 238924024

Centisome position: 44.84

GC content: 44.77

Gene sequence:

>1347_bases
TTGATAGGTTATTTCTTATATTTCCAGTTTGTAAAAAGCGACGAATTCATCAACAGTCCATACAATTCGCTGCAGGATCT
TTTCTCTAAGAATGTAGTGAGGGGCGAGATACAGACTAAGGATGGACATGTCATAGCACGGACAAAGGTAGGTTCAGATG
CGTCTGAGACAAGGGAATACCCTGACGGCAGAGTGTTTGCGCATGTAGCGGGCTTTGCCGTAAACGGTAAGGCAGGGCTT
GAAAAGCAGGAAAATTTCTCATTGCTTCGCTCACATGAGTTTTTCCTTGACCAGATAGTAAATGATATAAGCGGCAAGAA
AAATACCGGTGATAATGTCATAACCACACTGGATTACGAAGCACAGGCGGCTGCATACAATGCACTTGGCGACTATGAAG
GTGCTGTCATTGCAATTGAGCCGAAAACAGGAAAGATTGCAGTTATGGTGTCAAAGCCTGATTATGACCCAAATACCATC
GCAAGTGACTGGGAGAGCGTAAACGGTGATGGCAGCACTTCTCTTTACAACAGGGCAACACAGGGACAGTATGCTCCGGG
CTCAGTGTTTAAGATTTTTACAGCACTTGAGTATTATAACGAAAATCCGTCTACATACAACGACTACAGCTTTGATTGTG
ACGGCAGTATTACAAAGGACGGCTTTACAATCCACTGCGCCGGCAATAAATCACACGGACAGGAGGATTTAACAAAGTCG
TTTGCAAAGTCATGCAACTCGTCCTTTTCCAATATAGGTCTTTTGGTGGACAACAATAAGCTTAATACCTTGTGTGACGA
TATGCTTTTCAATAAGAATCTGCCCATAGCCTTTGATTCAAAAAAGAGTAAATTTGCACTGGATAACAATGCTTCGTCAG
CTCTGACCATGCAGACCACGATAGGTCAGGGAAACACGCTTGTTTCACCGCTTCACATGTGCATGATTGCCGGTGCAATC
TGCAATGATGGAAATCTGATGAGGCCATATCTGGTAGACCATACGGAAAATGCGAGCGGGGCGCTTGTGGAGCAGAATAA
ACCGGCTTCATACAAGCAGATTATGTCAAAGGATCAGGCAGCTTTTCTCCAGAATCTTATGGCAGCAGTGGTATCTGATG
GAACAGGCGCAAAGCTAAGAGACCAGAGCTATGAGGCCTTTGGAAAGACCGGAACTGCCCAGGTATCAGATTCTACAGAT
CAGACCAATGCCTGGTTTGTGGGCTATGGAAAAAAGGACGGCTACAATGATCTGGCAATCGCAGTAGTTGTGGAGGATTC
GGGTGCCGGAAGCACATATGCTGTGCCGGTGGCAAAAAAGGTATTTGATAAATATTTCAATGAATAG

Upstream 100 bases:

>100_bases
AGAAGGAGAAAACCGGCAGCAGGCAGCAAAAACAGCACGAAGACACAGAAATAGAGAGTATGCGGTTGTTACATATTTTT
TCCTTATAGTTTTTGTTGGA

Downstream 100 bases:

>100_bases
GCTTGTTGCACTTTTTTTAGAAGTAGGTTATACTTAAGTGTAATGACAGACGTTATCGTTCATATTTCGCTTGAACTGAC
AGATAGCGTTTAAACCACAC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MIGYFLYFQFVKSDEFINSPYNSLQDLFSKNVVRGEIQTKDGHVIARTKVGSDASETREYPDGRVFAHVAGFAVNGKAGL
EKQENFSLLRSHEFFLDQIVNDISGKKNTGDNVITTLDYEAQAAAYNALGDYEGAVIAIEPKTGKIAVMVSKPDYDPNTI
ASDWESVNGDGSTSLYNRATQGQYAPGSVFKIFTALEYYNENPSTYNDYSFDCDGSITKDGFTIHCAGNKSHGQEDLTKS
FAKSCNSSFSNIGLLVDNNKLNTLCDDMLFNKNLPIAFDSKKSKFALDNNASSALTMQTTIGQGNTLVSPLHMCMIAGAI
CNDGNLMRPYLVDHTENASGALVEQNKPASYKQIMSKDQAAFLQNLMAAVVSDGTGAKLRDQSYEAFGKTGTAQVSDSTD
QTNAWFVGYGKKDGYNDLAIAVVVEDSGAGSTYAVPVAKKVFDKYFNE

Sequences:

>Translated_448_residues
MIGYFLYFQFVKSDEFINSPYNSLQDLFSKNVVRGEIQTKDGHVIARTKVGSDASETREYPDGRVFAHVAGFAVNGKAGL
EKQENFSLLRSHEFFLDQIVNDISGKKNTGDNVITTLDYEAQAAAYNALGDYEGAVIAIEPKTGKIAVMVSKPDYDPNTI
ASDWESVNGDGSTSLYNRATQGQYAPGSVFKIFTALEYYNENPSTYNDYSFDCDGSITKDGFTIHCAGNKSHGQEDLTKS
FAKSCNSSFSNIGLLVDNNKLNTLCDDMLFNKNLPIAFDSKKSKFALDNNASSALTMQTTIGQGNTLVSPLHMCMIAGAI
CNDGNLMRPYLVDHTENASGALVEQNKPASYKQIMSKDQAAFLQNLMAAVVSDGTGAKLRDQSYEAFGKTGTAQVSDSTD
QTNAWFVGYGKKDGYNDLAIAVVVEDSGAGSTYAVPVAKKVFDKYFNE
>Mature_448_residues
MIGYFLYFQFVKSDEFINSPYNSLQDLFSKNVVRGEIQTKDGHVIARTKVGSDASETREYPDGRVFAHVAGFAVNGKAGL
EKQENFSLLRSHEFFLDQIVNDISGKKNTGDNVITTLDYEAQAAAYNALGDYEGAVIAIEPKTGKIAVMVSKPDYDPNTI
ASDWESVNGDGSTSLYNRATQGQYAPGSVFKIFTALEYYNENPSTYNDYSFDCDGSITKDGFTIHCAGNKSHGQEDLTKS
FAKSCNSSFSNIGLLVDNNKLNTLCDDMLFNKNLPIAFDSKKSKFALDNNASSALTMQTTIGQGNTLVSPLHMCMIAGAI
CNDGNLMRPYLVDHTENASGALVEQNKPASYKQIMSKDQAAFLQNLMAAVVSDGTGAKLRDQSYEAFGKTGTAQVSDSTD
QTNAWFVGYGKKDGYNDLAIAVVVEDSGAGSTYAVPVAKKVFDKYFNE

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=374, Percent_Identity=24.5989304812834, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786272, Length=414, Percent_Identity=22.463768115942, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 48775; Mature: 48775

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGYFLYFQFVKSDEFINSPYNSLQDLFSKNVVRGEIQTKDGHVIARTKVGSDASETREY
CEEEEEEEEEHHCCHHHCCCHHHHHHHHHCCEEECEEECCCCCEEEEEECCCCHHHHHCC
PDGRVFAHVAGFAVNGKAGLEKQENFSLLRSHEFFLDQIVNDISGKKNTGDNVITTLDYE
CCCEEEEEEEEEEECCCCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
AQAAAYNALGDYEGAVIAIEPKTGKIAVMVSKPDYDPNTIASDWESVNGDGSTSLYNRAT
HHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHCCCCCCHHHHHHCC
QGQYAPGSVFKIFTALEYYNENPSTYNDYSFDCDGSITKDGFTIHCAGNKSHGQEDLTKS
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHH
FAKSCNSSFSNIGLLVDNNKLNTLCDDMLFNKNLPIAFDSKKSKFALDNNASSALTMQTT
HHHHHCCCCHHEEEEEECCCHHHHHHHHHHCCCCCEEECCCCCEEEECCCCCCEEEEEEE
IGQGNTLVSPLHMCMIAGAICNDGNLMRPYLVDHTENASGALVEQNKPASYKQIMSKDQA
CCCCCCHHHHHHHHHHHHHHCCCCCEECCEEEECCCCCCCCEEECCCCCHHHHHHCCHHH
AFLQNLMAAVVSDGTGAKLRDQSYEAFGKTGTAQVSDSTDQTNAWFVGYGKKDGYNDLAI
HHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEECCCCCCCCEEEEEECCCCCCCCEEE
AVVVEDSGAGSTYAVPVAKKVFDKYFNE
EEEEECCCCCCEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MIGYFLYFQFVKSDEFINSPYNSLQDLFSKNVVRGEIQTKDGHVIARTKVGSDASETREY
CEEEEEEEEEHHCCHHHCCCHHHHHHHHHCCEEECEEECCCCCEEEEEECCCCHHHHHCC
PDGRVFAHVAGFAVNGKAGLEKQENFSLLRSHEFFLDQIVNDISGKKNTGDNVITTLDYE
CCCEEEEEEEEEEECCCCCCCCHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
AQAAAYNALGDYEGAVIAIEPKTGKIAVMVSKPDYDPNTIASDWESVNGDGSTSLYNRAT
HHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHCCCCCCHHHHHHCC
QGQYAPGSVFKIFTALEYYNENPSTYNDYSFDCDGSITKDGFTIHCAGNKSHGQEDLTKS
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHH
FAKSCNSSFSNIGLLVDNNKLNTLCDDMLFNKNLPIAFDSKKSKFALDNNASSALTMQTT
HHHHHCCCCHHEEEEEECCCHHHHHHHHHHCCCCCEEECCCCCEEEECCCCCCEEEEEEE
IGQGNTLVSPLHMCMIAGAICNDGNLMRPYLVDHTENASGALVEQNKPASYKQIMSKDQA
CCCCCCHHHHHHHHHHHHHHCCCCCEECCEEEECCCCCCCCEEECCCCCHHHHHHCCHHH
AFLQNLMAAVVSDGTGAKLRDQSYEAFGKTGTAQVSDSTDQTNAWFVGYGKKDGYNDLAI
HHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEECCCCCCCCEEEEEECCCCCCCCEEE
AVVVEDSGAGSTYAVPVAKKVFDKYFNE
EEEEECCCCCCEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA