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The map label for this gene is ffh [H]

Identifier: 238923877

GI number: 238923877

Start: 1386330

End: 1387706

Strand: Direct

Name: ffh [H]

Synonym: EUBREC_1505

Alternate gene names: 238923877

Gene position: 1386330-1387706 (Clockwise)

Preceding gene: 238923876

Following gene: 238923878

Centisome position: 40.19

GC content: 47.2

Gene sequence:

>1377_bases
ATGGCATTTGACAGTTTATCAGAAAAACTGCAGAACGTTTTTAAGAATCTCCGCAGCAAGGGAAAGCTTACTGAGGATGA
TGTAAAGGCTGCTCTTAAAGAGGTTAAGATGGCACTCCTTGAGGCCGATGTTAACTTCAAGGTTGTTAAGCAGTTCACAA
AGAGTGTTCAGGAGAGAGCAATCGGACAGGATGTCATGAATGGTCTCAATCCCGGCCAGATGGTCATCAAAATCGTAAAC
GAAGAGATGATTAAGCTTATGGGCTCTGAGACAACAGAGATTGCTTTCAGGCCGGGCAAGGAGCTTACCGTTATCATGAT
GGTAGGTCTTCAGGGAGCCGGTAAGACAACCACCACAGCAAAAATTGCCGGAAAGCTTAAGAGCAAGGGCAAGAAATCAC
TGCTTGTAGCCTGTGATGTATATCGTCCGGCTGCGATTGAGCAGTTAAAGATAAATGGTGAGAAGCAGGGCGTTGAGGTT
TTCTCAATGGGTGACAAAAACAAGCCTGCCGACATCGCAAAGGCTGCTGTGGAGCACGCTAAGAAAAACGATTTCAATGT
TGTTATCATCGATACTGCCGGACGTCTTCATATTGATGAGGATATGATGGCAGAGCTTATTGAGATAAAAGAAGCTACTG
ATGTTTTCCAGACCATCCTCGTGGTAGATGCCATGACAGGTCAGGATGCGGTAAATGTAGCAGGTACCTTTGATGAAAAG
ATAGGAATTGACGGAGTTGTCATCACAAAGCTTGATGGTGACACCAGAGGTGGAGCGGCACTTTCAATCAGAGCCGTTAC
AGGAAAGCCGATACTATACGCAGGTATGGGCGAGAAGCTTTCAGACCTTGAGCAGTTCTATCCGGAGCGTATGGCTTCAA
GAATCCTCGGCATGGGCGATGTGCTTTCCATGATTGAGAAGGCGCAGGAGAACATTGATGAGGAACAGGCCAAGAAGCTT
GAGCAGAAGATGCGCAAAAATGAGTTTGATTTTGAGATGTACCTTGATTCGATGAGTCAGATGAAGAAGATGGGCGGTCT
TTCAAGCGTGATGGGCATGATGCCGGGCATGGGTATCGGTGGAGGCAAGATGCCGGATATTGATACAGATGAAGCTGAAA
AGGGCATGGCCCGCACAGAGGCAATCATCTATTCCATGACACCTGAGGAAAGACGAAATCCAAAGCTTCTTAATCCAAGC
CGCAAGGCTCGTATTGCAAGAGGAGCAGGCGTGGATGTATCAGAGGTCAACAGACTTGTAAAGCAGTTTGAGCAGACAAA
GAAGTTCATGAAGCAGATGCCCGGTATGATGGGCGGCAAGAAGGGACGCCGTGGAGGCGGTGGTCTTGGAGGCTTATTCA
AAGGACTTCCGTTTTAA

Upstream 100 bases:

>100_bases
AGGATTCATGAGCTGACAAATGATTTTAAGAAATCACATAATGAGCTATTAATGAATGAAATCGAAGCTATTTCGAATCA
GATACTAGAGGAGCTGTAAT

Downstream 100 bases:

>100_bases
TGGATTTCATTAAAGGAATTTCATTAAAGAATTTCATGTTTTGTTAACAAAAGTATTTATTTTACTTTTGATATATATTA
TTCAATAAACCTATGAGGAG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MAFDSLSEKLQNVFKNLRSKGKLTEDDVKAALKEVKMALLEADVNFKVVKQFTKSVQERAIGQDVMNGLNPGQMVIKIVN
EEMIKLMGSETTEIAFRPGKELTVIMMVGLQGAGKTTTTAKIAGKLKSKGKKSLLVACDVYRPAAIEQLKINGEKQGVEV
FSMGDKNKPADIAKAAVEHAKKNDFNVVIIDTAGRLHIDEDMMAELIEIKEATDVFQTILVVDAMTGQDAVNVAGTFDEK
IGIDGVVITKLDGDTRGGAALSIRAVTGKPILYAGMGEKLSDLEQFYPERMASRILGMGDVLSMIEKAQENIDEEQAKKL
EQKMRKNEFDFEMYLDSMSQMKKMGGLSSVMGMMPGMGIGGGKMPDIDTDEAEKGMARTEAIIYSMTPEERRNPKLLNPS
RKARIARGAGVDVSEVNRLVKQFEQTKKFMKQMPGMMGGKKGRRGGGGLGGLFKGLPF

Sequences:

>Translated_458_residues
MAFDSLSEKLQNVFKNLRSKGKLTEDDVKAALKEVKMALLEADVNFKVVKQFTKSVQERAIGQDVMNGLNPGQMVIKIVN
EEMIKLMGSETTEIAFRPGKELTVIMMVGLQGAGKTTTTAKIAGKLKSKGKKSLLVACDVYRPAAIEQLKINGEKQGVEV
FSMGDKNKPADIAKAAVEHAKKNDFNVVIIDTAGRLHIDEDMMAELIEIKEATDVFQTILVVDAMTGQDAVNVAGTFDEK
IGIDGVVITKLDGDTRGGAALSIRAVTGKPILYAGMGEKLSDLEQFYPERMASRILGMGDVLSMIEKAQENIDEEQAKKL
EQKMRKNEFDFEMYLDSMSQMKKMGGLSSVMGMMPGMGIGGGKMPDIDTDEAEKGMARTEAIIYSMTPEERRNPKLLNPS
RKARIARGAGVDVSEVNRLVKQFEQTKKFMKQMPGMMGGKKGRRGGGGLGGLFKGLPF
>Mature_457_residues
AFDSLSEKLQNVFKNLRSKGKLTEDDVKAALKEVKMALLEADVNFKVVKQFTKSVQERAIGQDVMNGLNPGQMVIKIVNE
EMIKLMGSETTEIAFRPGKELTVIMMVGLQGAGKTTTTAKIAGKLKSKGKKSLLVACDVYRPAAIEQLKINGEKQGVEVF
SMGDKNKPADIAKAAVEHAKKNDFNVVIIDTAGRLHIDEDMMAELIEIKEATDVFQTILVVDAMTGQDAVNVAGTFDEKI
GIDGVVITKLDGDTRGGAALSIRAVTGKPILYAGMGEKLSDLEQFYPERMASRILGMGDVLSMIEKAQENIDEEQAKKLE
QKMRKNEFDFEMYLDSMSQMKKMGGLSSVMGMMPGMGIGGGKMPDIDTDEAEKGMARTEAIIYSMTPEERRNPKLLNPSR
KARIARGAGVDVSEVNRLVKQFEQTKKFMKQMPGMMGGKKGRRGGGGLGGLFKGLPF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=469, Percent_Identity=33.6886993603412, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI226371618, Length=407, Percent_Identity=33.1695331695332, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI295424842, Length=305, Percent_Identity=27.2131147540984, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI23308697, Length=305, Percent_Identity=27.2131147540984, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI89061728, Length=150, Percent_Identity=36, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1788963, Length=431, Percent_Identity=48.9559164733179, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1789874, Length=194, Percent_Identity=39.1752577319588, Blast_Score=138, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17539958, Length=451, Percent_Identity=31.4855875831486, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI193206261, Length=300, Percent_Identity=30, Blast_Score=115, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6325345, Length=476, Percent_Identity=31.9327731092437, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6320498, Length=304, Percent_Identity=26.6447368421053, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI17647949, Length=464, Percent_Identity=32.5431034482759, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24641198, Length=306, Percent_Identity=25.8169934640523, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50010; Mature: 49879

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
7.0 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.8 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFDSLSEKLQNVFKNLRSKGKLTEDDVKAALKEVKMALLEADVNFKVVKQFTKSVQERA
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IGQDVMNGLNPGQMVIKIVNEEMIKLMGSETTEIAFRPGKELTVIMMVGLQGAGKTTTTA
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCCCCCHHH
KIAGKLKSKGKKSLLVACDVYRPAAIEQLKINGEKQGVEVFSMGDKNKPADIAKAAVEHA
HHHHHHHCCCCCEEEEEEECCCCHHHHHHEECCCCCCCEEEECCCCCCCHHHHHHHHHHH
KKNDFNVVIIDTAGRLHIDEDMMAELIEIKEATDVFQTILVVDAMTGQDAVNVAGTFDEK
CCCCCEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHH
IGIDGVVITKLDGDTRGGAALSIRAVTGKPILYAGMGEKLSDLEQFYPERMASRILGMGD
CCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHH
VLSMIEKAQENIDEEQAKKLEQKMRKNEFDFEMYLDSMSQMKKMGGLSSVMGMMPGMGIG
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCC
GGKMPDIDTDEAEKGMARTEAIIYSMTPEERRNPKLLNPSRKARIARGAGVDVSEVNRLV
CCCCCCCCCCHHHHHHHHHHHEEEECCCHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHH
KQFEQTKKFMKQMPGMMGGKKGRRGGGGLGGLFKGLPF
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCC
>Mature Secondary Structure 
AFDSLSEKLQNVFKNLRSKGKLTEDDVKAALKEVKMALLEADVNFKVVKQFTKSVQERA
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IGQDVMNGLNPGQMVIKIVNEEMIKLMGSETTEIAFRPGKELTVIMMVGLQGAGKTTTTA
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCCCCCHHH
KIAGKLKSKGKKSLLVACDVYRPAAIEQLKINGEKQGVEVFSMGDKNKPADIAKAAVEHA
HHHHHHHCCCCCEEEEEEECCCCHHHHHHEECCCCCCCEEEECCCCCCCHHHHHHHHHHH
KKNDFNVVIIDTAGRLHIDEDMMAELIEIKEATDVFQTILVVDAMTGQDAVNVAGTFDEK
CCCCCEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHH
IGIDGVVITKLDGDTRGGAALSIRAVTGKPILYAGMGEKLSDLEQFYPERMASRILGMGD
CCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHH
VLSMIEKAQENIDEEQAKKLEQKMRKNEFDFEMYLDSMSQMKKMGGLSSVMGMMPGMGIG
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCC
GGKMPDIDTDEAEKGMARTEAIIYSMTPEERRNPKLLNPSRKARIARGAGVDVSEVNRLV
CCCCCCCCCCHHHHHHHHHHHEEEECCCHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHH
KQFEQTKKFMKQMPGMMGGKKGRRGGGGLGGLFKGLPF
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]