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The map label for this gene is ilvA [H]

Identifier: 238923875

GI number: 238923875

Start: 1384645

End: 1385895

Strand: Direct

Name: ilvA [H]

Synonym: EUBREC_1503

Alternate gene names: 238923875

Gene position: 1384645-1385895 (Clockwise)

Preceding gene: 238923874

Following gene: 238923876

Centisome position: 40.14

GC content: 45.72

Gene sequence:

>1251_bases
ATGAATAGTTATACCGAAGAAATGAAAGGGAGAACAAATATGCTGACATTAGATAAATTTGAAGAAGCAAGTGAGAAGGT
CAAGGAGGTCACCCTTGAGACAAAGCTCATTTACAGTGACTTTTTAAGTGACCAGACAGGCAATAAGGTATATCTGAAGC
CTGAAAATATGCAGTTTACCGGAGCTTACAAGGTCAGAGGTGCGTACTACAAGATAAGCACACTCACCGATGAGGAGAGG
GCAAAGGGACTCATCACAGCATCTGCAGGAAACCATGCGCAGGGTGTTGCGTATGCTGCAAAGTGCTATGGCTGCAAGGC
TGTCATCGTAATGCCTACCACCACACCTCTTATCAAGGTAAACCGTACAAAGAGCTACGGCGCTGAGGTAGTGCTTTATG
GAGATGTGTATGATGAGGCATGTGCCAAGGCATATGAGCTTGCAGAGAAAGAGGGCTACACATTTATCCATCCGTTTGAT
GATTTAGCTGTCGCAACAGGACAGGGAACTATTGCTATGGAGATATTTAAGGAGCTTCCTCTTGTTGAGTACATCCTCGT
TCCAATCGGCGGCGGCGGGCTGGCAACAGGTGTATCCACACTTGCAAAGCTCTTAAACCCAAAGATTAAGGTTATCGGAG
TGGAGCCGGCCGGTGCCAATTGTATGCAGGAGTCATTTAAGAACGGCAAGGTGACCACTTTACCAAGTGTAAATACTATT
GCAGACGGAACAGCGGTAAAGACACCGGGCTCAAATATTTTCCCATACATAAAGAAAAATCTTGATGATATTATCACAGT
GGAGGATGACGAGCTTATCGTGGCCTTCCTTGACATGGTTGAGAATCACAAGATGATAGTCGAAAACTCAGGTCTTCTGA
CTGTAGCTGCGCTTAAGCATCTCGGAGTAAAGGACAAGAGAGTGGTTTCTATCCTAAGTGGCGGCAACATGGATGTTATT
ACCATGTCATCAGTTGTACAGCAGGGGCTTATTTTCAGAGACAGAATCTTTACTGTTTCAGTGCTTCTGCCGGATAAGCC
GGGCGAGCTTGCCAAGGTTTCACAGACTCTTGCCGATGTACAGGGCAATGTAATCAAGCTGGAGCATAACCAGTTTGTCA
CTACAAACAGAAGTGCGGCTGTCGAGCTTCGCATCACGCTTGAGTGTTTTGGTACAGAGCACAAGGAGCAGATTATTGCT
GCGCTCGAGAAGAAGGGCTATAAGCCAAGAATTGTACGCACTATGATATAA

Upstream 100 bases:

>100_bases
TTATATATATCTGTATGGAATTTTTGGTATAATATAATGAAAAATAACTATTCAGAACCACTGAGAACAATGCATTTTTG
CGAATAATGTGTGGGTGGGT

Downstream 100 bases:

>100_bases
AAATAAAAGTATCAAGTATTTTTACTTGACACCGGGCAAACTATGTGTTATTCTACCATAGGTTCGAGGGAAAAAGAGGA
TACTTGATATGGAAGAAAAA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MNSYTEEMKGRTNMLTLDKFEEASEKVKEVTLETKLIYSDFLSDQTGNKVYLKPENMQFTGAYKVRGAYYKISTLTDEER
AKGLITASAGNHAQGVAYAAKCYGCKAVIVMPTTTPLIKVNRTKSYGAEVVLYGDVYDEACAKAYELAEKEGYTFIHPFD
DLAVATGQGTIAMEIFKELPLVEYILVPIGGGGLATGVSTLAKLLNPKIKVIGVEPAGANCMQESFKNGKVTTLPSVNTI
ADGTAVKTPGSNIFPYIKKNLDDIITVEDDELIVAFLDMVENHKMIVENSGLLTVAALKHLGVKDKRVVSILSGGNMDVI
TMSSVVQQGLIFRDRIFTVSVLLPDKPGELAKVSQTLADVQGNVIKLEHNQFVTTNRSAAVELRITLECFGTEHKEQIIA
ALEKKGYKPRIVRTMI

Sequences:

>Translated_416_residues
MNSYTEEMKGRTNMLTLDKFEEASEKVKEVTLETKLIYSDFLSDQTGNKVYLKPENMQFTGAYKVRGAYYKISTLTDEER
AKGLITASAGNHAQGVAYAAKCYGCKAVIVMPTTTPLIKVNRTKSYGAEVVLYGDVYDEACAKAYELAEKEGYTFIHPFD
DLAVATGQGTIAMEIFKELPLVEYILVPIGGGGLATGVSTLAKLLNPKIKVIGVEPAGANCMQESFKNGKVTTLPSVNTI
ADGTAVKTPGSNIFPYIKKNLDDIITVEDDELIVAFLDMVENHKMIVENSGLLTVAALKHLGVKDKRVVSILSGGNMDVI
TMSSVVQQGLIFRDRIFTVSVLLPDKPGELAKVSQTLADVQGNVIKLEHNQFVTTNRSAAVELRITLECFGTEHKEQIIA
ALEKKGYKPRIVRTMI
>Mature_416_residues
MNSYTEEMKGRTNMLTLDKFEEASEKVKEVTLETKLIYSDFLSDQTGNKVYLKPENMQFTGAYKVRGAYYKISTLTDEER
AKGLITASAGNHAQGVAYAAKCYGCKAVIVMPTTTPLIKVNRTKSYGAEVVLYGDVYDEACAKAYELAEKEGYTFIHPFD
DLAVATGQGTIAMEIFKELPLVEYILVPIGGGGLATGVSTLAKLLNPKIKVIGVEPAGANCMQESFKNGKVTTLPSVNTI
ADGTAVKTPGSNIFPYIKKNLDDIITVEDDELIVAFLDMVENHKMIVENSGLLTVAALKHLGVKDKRVVSILSGGNMDVI
TMSSVVQQGLIFRDRIFTVSVLLPDKPGELAKVSQTLADVQGNVIKLEHNQFVTTNRSAAVELRITLECFGTEHKEQIIA
ALEKKGYKPRIVRTMI

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=325, Percent_Identity=34.1538461538462, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI19923959, Length=299, Percent_Identity=32.7759197324415, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI33469958, Length=271, Percent_Identity=29.1512915129151, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI1790207, Length=385, Percent_Identity=37.4025974025974, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1789505, Length=315, Percent_Identity=39.3650793650794, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI1789235, Length=284, Percent_Identity=27.8169014084507, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=393, Percent_Identity=33.0788804071247, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17537387, Length=390, Percent_Identity=33.5897435897436, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17508781, Length=312, Percent_Identity=30.4487179487179, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320930, Length=327, Percent_Identity=39.7553516819572, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6322631, Length=307, Percent_Identity=38.7622149837134, Blast_Score=203, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6319788, Length=286, Percent_Identity=24.8251748251748, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322024, Length=143, Percent_Identity=28.6713286713287, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21355833, Length=365, Percent_Identity=32.3287671232877, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24645328, Length=297, Percent_Identity=30.3030303030303, Blast_Score=121, Evalue=8e-28,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 45469; Mature: 45469

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSYTEEMKGRTNMLTLDKFEEASEKVKEVTLETKLIYSDFLSDQTGNKVYLKPENMQFT
CCCHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEE
GAYKVRGAYYKISTLTDEERAKGLITASAGNHAQGVAYAAKCYGCKAVIVMPTTTPLIKV
EEEEEEEEEEEEEECCCHHHHCEEEEECCCCCCCCCEEEHHHCCCEEEEEECCCCCEEEE
NRTKSYGAEVVLYGDVYDEACAKAYELAEKEGYTFIHPFDDLAVATGQGTIAMEIFKELP
ECCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCCCHHHHHHHCC
LVEYILVPIGGGGLATGVSTLAKLLNPKIKVIGVEPAGANCMQESFKNGKVTTLPSVNTI
CEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCEEECCCCCCC
ADGTAVKTPGSNIFPYIKKNLDDIITVEDDELIVAFLDMVENHKMIVENSGLLTVAALKH
CCCCEEECCCCCCCHHHHCCCCCEEEECCCCHHHHHHHHHCCCEEEEECCCEEEEEHHHH
LGVKDKRVVSILSGGNMDVITMSSVVQQGLIFRDRIFTVSVLLPDKPGELAKVSQTLADV
CCCCCHHEEEEECCCCEEEEEHHHHHHHCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHC
QGNVIKLEHNQFVTTNRSAAVELRITLECFGTEHKEQIIAALEKKGYKPRIVRTMI
CCCEEEEECCEEEEECCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MNSYTEEMKGRTNMLTLDKFEEASEKVKEVTLETKLIYSDFLSDQTGNKVYLKPENMQFT
CCCHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEE
GAYKVRGAYYKISTLTDEERAKGLITASAGNHAQGVAYAAKCYGCKAVIVMPTTTPLIKV
EEEEEEEEEEEEEECCCHHHHCEEEEECCCCCCCCCEEEHHHCCCEEEEEECCCCCEEEE
NRTKSYGAEVVLYGDVYDEACAKAYELAEKEGYTFIHPFDDLAVATGQGTIAMEIFKELP
ECCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCCCCHHHHHHHCC
LVEYILVPIGGGGLATGVSTLAKLLNPKIKVIGVEPAGANCMQESFKNGKVTTLPSVNTI
CEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCEEECCCCCCC
ADGTAVKTPGSNIFPYIKKNLDDIITVEDDELIVAFLDMVENHKMIVENSGLLTVAALKH
CCCCEEECCCCCCCHHHHCCCCCEEEECCCCHHHHHHHHHCCCEEEEECCCEEEEEHHHH
LGVKDKRVVSILSGGNMDVITMSSVVQQGLIFRDRIFTVSVLLPDKPGELAKVSQTLADV
CCCCCHHEEEEECCCCEEEEEHHHHHHHCCEEEEEEEEEEEEECCCCCHHHHHHHHHHHC
QGNVIKLEHNQFVTTNRSAAVELRITLECFGTEHKEQIIAALEKKGYKPRIVRTMI
CCCEEEEECCEEEEECCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]