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The map label for this gene is hisH [H]

Identifier: 238923839

GI number: 238923839

Start: 1345838

End: 1346452

Strand: Direct

Name: hisH [H]

Synonym: EUBREC_1467

Alternate gene names: 238923839

Gene position: 1345838-1346452 (Clockwise)

Preceding gene: 238923838

Following gene: 238923840

Centisome position: 39.01

GC content: 44.39

Gene sequence:

>615_bases
ATGATTGCAATCATCGATTATGGAGCAGGCAACCTGCGAAGTGTGGAAAAGGCTCTTACAGCTATAGGCGAGGAGAGTAT
TGTGACCAGAGACAGGCATGAGATTTTAAATGCCGATAAGGTAATACTTCCCGGAGTAGGAGCTTTTGGAGATGCAATGA
ATTCGCTTAAAAAATACGAGCTGGACAAGGTGATTCACGAGGTTTGTGACATGGACAAGCCATTTCTTGGCATATGCCTG
GGACTTCAGCTATTATTTGAGGGAAGCGATGAGAGTCAGGGCGTTGAGGGGCTTCATGTGCTTGACGGACAGATACTTCG
CATACCAGATAAGGAAGGACTTAAAATACCTCACATAGGCTGGAATTCACTTGATTTACAGAACAATGGAAGGCTGTTTA
AAGGTCTTTCAGAGCATCCGTATGTATATTTTGTGCATTCGTACTATCTGAAAGCCGCTGATGAAGCAATTGTCACAGCA
ACGACAGAGTACAGCACACACATTCATGCGTCTGTAGAGAAAAACAATGTGTTCGCCTGCCAGTTCCATCCGGAAAAGAG
CAGCACAGTCGGACTTTCGATACTTAAAAATTTTGCAGGGATAGGGGAGGCATAA

Upstream 100 bases:

>100_bases
GATGCCATTGCTCTATATAATATAGATGATAGAGATGACTATACACTGGCACTGACACAGAAATTAAATGAATTAGGCAT
TAAAGAGGAGACAAAATGAT

Downstream 100 bases:

>100_bases
TATGTTTACGAAGAGAATAATCCCATGTCTGGATGTGAATAACGGACGTGTTGTTAAGGGCATAAACTTTGTCAATTTAA
GAGATGCAGGTGACCCGGTT

Product: imidazole glycerol phosphate synthase subunit HisH

Products: NA

Alternate protein names: IGP synthase glutamine amidotransferase subunit; IGP synthase subunit hisH; ImGP synthase subunit hisH; IGPS subunit hisH [H]

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MIAIIDYGAGNLRSVEKALTAIGEESIVTRDRHEILNADKVILPGVGAFGDAMNSLKKYELDKVIHEVCDMDKPFLGICL
GLQLLFEGSDESQGVEGLHVLDGQILRIPDKEGLKIPHIGWNSLDLQNNGRLFKGLSEHPYVYFVHSYYLKAADEAIVTA
TTEYSTHIHASVEKNNVFACQFHPEKSSTVGLSILKNFAGIGEA

Sequences:

>Translated_204_residues
MIAIIDYGAGNLRSVEKALTAIGEESIVTRDRHEILNADKVILPGVGAFGDAMNSLKKYELDKVIHEVCDMDKPFLGICL
GLQLLFEGSDESQGVEGLHVLDGQILRIPDKEGLKIPHIGWNSLDLQNNGRLFKGLSEHPYVYFVHSYYLKAADEAIVTA
TTEYSTHIHASVEKNNVFACQFHPEKSSTVGLSILKNFAGIGEA
>Mature_204_residues
MIAIIDYGAGNLRSVEKALTAIGEESIVTRDRHEILNADKVILPGVGAFGDAMNSLKKYELDKVIHEVCDMDKPFLGICL
GLQLLFEGSDESQGVEGLHVLDGQILRIPDKEGLKIPHIGWNSLDLQNNGRLFKGLSEHPYVYFVHSYYLKAADEAIVTA
TTEYSTHIHASVEKNNVFACQFHPEKSSTVGLSILKNFAGIGEA

Specific function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR [H]

COG id: COG0118

COG function: function code E; Glutamine amidotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788334, Length=197, Percent_Identity=42.1319796954315, Blast_Score=151, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6319725, Length=209, Percent_Identity=37.3205741626794, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010139
- InterPro:   IPR016226 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 22397; Mature: 22397

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAIIDYGAGNLRSVEKALTAIGEESIVTRDRHEILNADKVILPGVGAFGDAMNSLKKYE
CEEEEECCCCCHHHHHHHHHHCCCCHHHCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHH
LDKVIHEVCDMDKPFLGICLGLQLLFEGSDESQGVEGLHVLDGQILRIPDKEGLKIPHIG
HHHHHHHHHCCCCCHHHHHHHHHHEECCCCCCCCCCEEEEECCEEEECCCCCCCCCCCCC
WNSLDLQNNGRLFKGLSEHPYVYFVHSYYLKAADEAIVTATTEYSTHIHASVEKNNVFAC
CCCEEECCCCCEECCCCCCCEEEEEEHHHHHHCCCEEEEEEECCCEEEEEEEECCCEEEE
QFHPEKSSTVGLSILKNFAGIGEA
EECCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIAIIDYGAGNLRSVEKALTAIGEESIVTRDRHEILNADKVILPGVGAFGDAMNSLKKYE
CEEEEECCCCCHHHHHHHHHHCCCCHHHCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHH
LDKVIHEVCDMDKPFLGICLGLQLLFEGSDESQGVEGLHVLDGQILRIPDKEGLKIPHIG
HHHHHHHHHCCCCCHHHHHHHHHHEECCCCCCCCCCEEEEECCEEEECCCCCCCCCCCCC
WNSLDLQNNGRLFKGLSEHPYVYFVHSYYLKAADEAIVTATTEYSTHIHASVEKNNVFAC
CCCEEECCCCCEECCCCCCCEEEEEEHHHHHHCCCEEEEEEECCCEEEEEEEECCCEEEE
QFHPEKSSTVGLSILKNFAGIGEA
EECCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Glycosyltransferases; Pentosyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA