Click here to switch to the map view.

The map label for this gene is galK [H]

Identifier: 238923765

GI number: 238923765

Start: 1264232

End: 1265401

Strand: Direct

Name: galK [H]

Synonym: EUBREC_1387

Alternate gene names: 238923765

Gene position: 1264232-1265401 (Clockwise)

Preceding gene: 238923764

Following gene: 238923766

Centisome position: 36.65

GC content: 44.19

Gene sequence:

>1170_bases
ATGATACAGCAGAACGTATTAGACAAATTCAAGGAGCTTTTTGGAGCAGATGGGGATATCAGAGTATATTTTGCTCCGGG
ACGTGTAAATCTGATCGGTGAGCATACTGACTACAATGGAGGACATGTGTTCCCTTGTGCACTGACCATCGGTACATATA
TGGCAGCAAGAAAGCGCGACGACAGGAAGCTTCGTTTCTACTCTATGAATTTTGACAATCTGGGGGTGGTTGAGTCATCA
CTTGATGAGTTTACACCTGATCCGGACGGACTTTGGATAAACTATCCAATGGGCGTTATGTGGGCTTTCGAGGGACGCGG
AATGAAGCTTGAAAGCGGTCTTGATATTGTTTTATTCGGAAATATTCCAAACGGCTCAGGACTTTCTTCATCAGCATCTC
TTGAGGTGGTTACAGGATATATGTTAAAGGATATTTACGGCTTTGACGTGACAAATCAGGATATTGCACTTATCGGTCAG
TATTCAGAGAACAACTACAACGGCTGTAACTGCGGTATCATGGATCAGTTTGCATCTGCAATGGGCAAAAAGGACAATGC
AATTTTCCTTGACTGCAATACTCTTGATTTTGAGTATGCACCAATCGTTTTGGACGGTGCAAAGATCGTGGTTACAAACA
GCATGGTTAAGCACAGCCTTGTAACAAGTGCTTACAATGACAGAAGAAATGAGAGTGCACAGGCTCTTAAGGATTTACAG
ACAGTATGTGACATCAAGACTCTCGGTGACCTGACAGATGAAGAGTTCGAGGCTCATAAGGATGCGATTAAGGATGAGGT
TGCACGTAAGAGAGGCAAGCATGCGGTTTATGAGAACCAGCGTACCATCAAGGCTGTTAAGGCACTGAAGGAAAATGATA
TCGAGACATTTGGAAAGCTTATGAATGCTTCACATGTATCACTTCGTGATGATTATGAGACATCATGTCCTGAGGTTGAC
GTACTTGTTGATGAGGCATGGAAGATTCCGGGTGTTATCGGATCACGAATCACAGGCGGCGGCTTTGGAGGCTGCACAGT
CAGCATAGTAAAGGACGAGGCTATTGATCAGTTTAAGGCAAACCTGACAAAGGCCTATGAAGAGAAGGTTGGAAAGACAC
CTGAGTTTTATGTTGTTTCAATCGGAGACGGACCTAGCCGTCTGGCATAA

Upstream 100 bases:

>100_bases
GCAATGTAAAAATGTGCAGTTATAATAGAGTTATAAAGAAAAAACGAATTATTTTAACTATCAATTTAACGCAAATACAA
TCAGCAAAGGAGAAGAAAAA

Downstream 100 bases:

>100_bases
AATTAGCAATATGAAATAACAGTAACGGATAAACAGGTTTTTCCCGACAATGATTAAGGAGCATGACATGATTCAGGAGA
GAATATTAGAATTAGTAAAA

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MIQQNVLDKFKELFGADGDIRVYFAPGRVNLIGEHTDYNGGHVFPCALTIGTYMAARKRDDRKLRFYSMNFDNLGVVESS
LDEFTPDPDGLWINYPMGVMWAFEGRGMKLESGLDIVLFGNIPNGSGLSSSASLEVVTGYMLKDIYGFDVTNQDIALIGQ
YSENNYNGCNCGIMDQFASAMGKKDNAIFLDCNTLDFEYAPIVLDGAKIVVTNSMVKHSLVTSAYNDRRNESAQALKDLQ
TVCDIKTLGDLTDEEFEAHKDAIKDEVARKRGKHAVYENQRTIKAVKALKENDIETFGKLMNASHVSLRDDYETSCPEVD
VLVDEAWKIPGVIGSRITGGGFGGCTVSIVKDEAIDQFKANLTKAYEEKVGKTPEFYVVSIGDGPSRLA

Sequences:

>Translated_389_residues
MIQQNVLDKFKELFGADGDIRVYFAPGRVNLIGEHTDYNGGHVFPCALTIGTYMAARKRDDRKLRFYSMNFDNLGVVESS
LDEFTPDPDGLWINYPMGVMWAFEGRGMKLESGLDIVLFGNIPNGSGLSSSASLEVVTGYMLKDIYGFDVTNQDIALIGQ
YSENNYNGCNCGIMDQFASAMGKKDNAIFLDCNTLDFEYAPIVLDGAKIVVTNSMVKHSLVTSAYNDRRNESAQALKDLQ
TVCDIKTLGDLTDEEFEAHKDAIKDEVARKRGKHAVYENQRTIKAVKALKENDIETFGKLMNASHVSLRDDYETSCPEVD
VLVDEAWKIPGVIGSRITGGGFGGCTVSIVKDEAIDQFKANLTKAYEEKVGKTPEFYVVSIGDGPSRLA
>Mature_389_residues
MIQQNVLDKFKELFGADGDIRVYFAPGRVNLIGEHTDYNGGHVFPCALTIGTYMAARKRDDRKLRFYSMNFDNLGVVESS
LDEFTPDPDGLWINYPMGVMWAFEGRGMKLESGLDIVLFGNIPNGSGLSSSASLEVVTGYMLKDIYGFDVTNQDIALIGQ
YSENNYNGCNCGIMDQFASAMGKKDNAIFLDCNTLDFEYAPIVLDGAKIVVTNSMVKHSLVTSAYNDRRNESAQALKDLQ
TVCDIKTLGDLTDEEFEAHKDAIKDEVARKRGKHAVYENQRTIKAVKALKENDIETFGKLMNASHVSLRDDYETSCPEVD
VLVDEAWKIPGVIGSRITGGGFGGCTVSIVKDEAIDQFKANLTKAYEEKVGKTPEFYVVSIGDGPSRLA

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=385, Percent_Identity=39.4805194805195, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI4503897, Length=424, Percent_Identity=30.8962264150943, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI48527957, Length=424, Percent_Identity=30.8962264150943, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1786972, Length=367, Percent_Identity=41.6893732970027, Blast_Score=280, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI71989053, Length=425, Percent_Identity=28.2352941176471, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319494, Length=88, Percent_Identity=43.1818181818182, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24661292, Length=427, Percent_Identity=27.4004683840749, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21355577, Length=427, Percent_Identity=27.4004683840749, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24661285, Length=427, Percent_Identity=27.4004683840749, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 42933; Mature: 42933

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQQNVLDKFKELFGADGDIRVYFAPGRVNLIGEHTDYNGGHVFPCALTIGTYMAARKRD
CCCHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCC
DRKLRFYSMNFDNLGVVESSLDEFTPDPDGLWINYPMGVMWAFEGRGMKLESGLDIVLFG
CCEEEEEEECCCCCCHHHHHHHHCCCCCCCEEEECCCEEEEEECCCCEEECCCCEEEEEE
NIPNGSGLSSSASLEVVTGYMLKDIYGFDVTNQDIALIGQYSENNYNGCNCGIMDQFASA
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHH
MGKKDNAIFLDCNTLDFEYAPIVLDGAKIVVTNSMVKHSLVTSAYNDRRNESAQALKDLQ
HCCCCCEEEEEECCCCCEECCEEECCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TVCDIKTLGDLTDEEFEAHKDAIKDEVARKRGKHAVYENQRTIKAVKALKENDIETFGKL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHCCHHHHHHH
MNASHVSLRDDYETSCPEVDVLVDEAWKIPGVIGSRITGGGFGGCTVSIVKDEAIDQFKA
HCCCCCEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHH
NLTKAYEEKVGKTPEFYVVSIGDGPSRLA
HHHHHHHHHHCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MIQQNVLDKFKELFGADGDIRVYFAPGRVNLIGEHTDYNGGHVFPCALTIGTYMAARKRD
CCCHHHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCCCCCEEEEHHHHHHHHHHHHCCC
DRKLRFYSMNFDNLGVVESSLDEFTPDPDGLWINYPMGVMWAFEGRGMKLESGLDIVLFG
CCEEEEEEECCCCCCHHHHHHHHCCCCCCCEEEECCCEEEEEECCCCEEECCCCEEEEEE
NIPNGSGLSSSASLEVVTGYMLKDIYGFDVTNQDIALIGQYSENNYNGCNCGIMDQFASA
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHH
MGKKDNAIFLDCNTLDFEYAPIVLDGAKIVVTNSMVKHSLVTSAYNDRRNESAQALKDLQ
HCCCCCEEEEEECCCCCEECCEEECCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHH
TVCDIKTLGDLTDEEFEAHKDAIKDEVARKRGKHAVYENQRTIKAVKALKENDIETFGKL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHCCHHHHHHH
MNASHVSLRDDYETSCPEVDVLVDEAWKIPGVIGSRITGGGFGGCTVSIVKDEAIDQFKA
HCCCCCEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHH
NLTKAYEEKVGKTPEFYVVSIGDGPSRLA
HHHHHHHHHHCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]