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The map label for this gene is ttcA [H]

Identifier: 238923740

GI number: 238923740

Start: 1234363

End: 1235496

Strand: Direct

Name: ttcA [H]

Synonym: EUBREC_1362

Alternate gene names: 238923740

Gene position: 1234363-1235496 (Clockwise)

Preceding gene: 238923739

Following gene: 238923741

Centisome position: 35.78

GC content: 43.74

Gene sequence:

>1134_bases
ATGCAGCTTAGTATAGAAGAAGTTAAAAAGCTGGATAGTAACAGCTATCAGATAATAGATATAAGAAGTGAGGAAGAGGT
GGCGCACGGTGCCATAAAGGGAGCACTCAATATTCAGGCAGAGGAAATAGAGTCAGATGAGAGGGTGCCACATGATAAGA
AGCTTGTCATAGTCTGCAGCCGTGGTAAGACGAGTGTGGATGTGGCAGAGTATCTCACAGAAAAAGGTTTTGATGCGGCA
AGCTTAAAGGGAGGCTATATAAGCTGGCTGCTTGATGCCATGAAAGAGGATGAGGTGGCAGAGCGCGATATAAAGGCAGA
TGTGGAGCAAAGCATCAGAAAGAAATTTAAGAAATCCATCTGGCGCAAGTTTACAAAGGCGATAAATACCTATGAGCTTG
TAAAACCGGGGGATAAGATTGCAGTGTGTATCTCGGGAGGTAAGGATTCCATGCTCATGGCAAAGCTGTTTCAGGAGCTT
AAGCATCACAATAAGTTTGATTTTGATGTGAAGTTTCTCGTCATGGACCCGGGCTACAATGAGGCAAACAGGCATGTCAT
AGAGGAAAACTGCAGGAACCTTGGCATCCCTGCCACTATTTTTGAGTCAGATATATTTGATGCTGTATATGATATCGAAA
AATCGCCATGCTATTTATGTGCGAGGATGAGAAGAGGACATCTGTATGCATTTGCAAAGGAGCTGGGCTGCAACAAAATT
GCGCTCGGACATCACTATGATGATGTTATTGAGACGATACTCATGGGTATGCTCTACGGTGCACAGGTACAGACCATGAT
GCCTAAGCTTCACAGCACAAACTTTGAGGGCATGGAGCTTATCAGGCCTCTTTACCTGGTCAGGGAGGACGATATCAAGG
CATGGCGTGATTACAACGGTCTGCATTTCATACAGTGTGCCTGCAAGTTTACAGATACCTGTACCACCTGCAATAATGAG
GAAAACCGCTCAAAGCGTGTTGAGATAAAGCAGCTCATCGCTAATCTTAAAAAGGTGAATCCTTTTGTCGAGGCAAATAT
ATTTAAGAGCGTGGAGAATGTAAATCTGGCTACGGTTGTAGCATATAAAAAGGATGGCATAAAGCACAGCTTCCTAGATC
ACTATGATGAATAA

Upstream 100 bases:

>100_bases
CCTTATTATGATAGGGCTCATCCTTGTGGTGACGGCATATTATGAGTACAGGATATTTCAGGAAATAAAGTCATTGCGGA
AATAATATAGGAGAAATAAA

Downstream 100 bases:

>100_bases
GACAGATATATTTCAGGAGGGCATTGTATGGCAGATATCATGGATTATATTGACTGGCGTGGAGATATAGGCTTTGATGA
GGTGCATGTAAATGAGGTGG

Product: putative ATPase of the PP-loop superfamily implicated in cell cycle control

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MQLSIEEVKKLDSNSYQIIDIRSEEEVAHGAIKGALNIQAEEIESDERVPHDKKLVIVCSRGKTSVDVAEYLTEKGFDAA
SLKGGYISWLLDAMKEDEVAERDIKADVEQSIRKKFKKSIWRKFTKAINTYELVKPGDKIAVCISGGKDSMLMAKLFQEL
KHHNKFDFDVKFLVMDPGYNEANRHVIEENCRNLGIPATIFESDIFDAVYDIEKSPCYLCARMRRGHLYAFAKELGCNKI
ALGHHYDDVIETILMGMLYGAQVQTMMPKLHSTNFEGMELIRPLYLVREDDIKAWRDYNGLHFIQCACKFTDTCTTCNNE
ENRSKRVEIKQLIANLKKVNPFVEANIFKSVENVNLATVVAYKKDGIKHSFLDHYDE

Sequences:

>Translated_377_residues
MQLSIEEVKKLDSNSYQIIDIRSEEEVAHGAIKGALNIQAEEIESDERVPHDKKLVIVCSRGKTSVDVAEYLTEKGFDAA
SLKGGYISWLLDAMKEDEVAERDIKADVEQSIRKKFKKSIWRKFTKAINTYELVKPGDKIAVCISGGKDSMLMAKLFQEL
KHHNKFDFDVKFLVMDPGYNEANRHVIEENCRNLGIPATIFESDIFDAVYDIEKSPCYLCARMRRGHLYAFAKELGCNKI
ALGHHYDDVIETILMGMLYGAQVQTMMPKLHSTNFEGMELIRPLYLVREDDIKAWRDYNGLHFIQCACKFTDTCTTCNNE
ENRSKRVEIKQLIANLKKVNPFVEANIFKSVENVNLATVVAYKKDGIKHSFLDHYDE
>Mature_377_residues
MQLSIEEVKKLDSNSYQIIDIRSEEEVAHGAIKGALNIQAEEIESDERVPHDKKLVIVCSRGKTSVDVAEYLTEKGFDAA
SLKGGYISWLLDAMKEDEVAERDIKADVEQSIRKKFKKSIWRKFTKAINTYELVKPGDKIAVCISGGKDSMLMAKLFQEL
KHHNKFDFDVKFLVMDPGYNEANRHVIEENCRNLGIPATIFESDIFDAVYDIEKSPCYLCARMRRGHLYAFAKELGCNKI
ALGHHYDDVIETILMGMLYGAQVQTMMPKLHSTNFEGMELIRPLYLVREDDIKAWRDYNGLHFIQCACKFTDTCTTCNNE
ENRSKRVEIKQLIANLKKVNPFVEANIFKSVENVNLATVVAYKKDGIKHSFLDHYDE

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=271, Percent_Identity=32.8413284132841, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI193211090, Length=243, Percent_Identity=30.0411522633745, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17540090, Length=252, Percent_Identity=26.984126984127, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24651972, Length=252, Percent_Identity=25.7936507936508, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 43171; Mature: 43171

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSIEEVKKLDSNSYQIIDIRSEEEVAHGAIKGALNIQAEEIESDERVPHDKKLVIVCS
CCCCHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEEEEC
RGKTSVDVAEYLTEKGFDAASLKGGYISWLLDAMKEDEVAERDIKADVEQSIRKKFKKSI
CCCCCHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WRKFTKAINTYELVKPGDKIAVCISGGKDSMLMAKLFQELKHHNKFDFDVKFLVMDPGYN
HHHHHHHHCCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCC
EANRHVIEENCRNLGIPATIFESDIFDAVYDIEKSPCYLCARMRRGHLYAFAKELGCNKI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCEE
ALGHHYDDVIETILMGMLYGAQVQTMMPKLHSTNFEGMELIRPLYLVREDDIKAWRDYNG
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHCCCC
LHFIQCACKFTDTCTTCNNEENRSKRVEIKQLIANLKKVNPFVEANIFKSVENVNLATVV
EEEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEE
AYKKDGIKHSFLDHYDE
EECCCCCCHHHHHHCCC
>Mature Secondary Structure
MQLSIEEVKKLDSNSYQIIDIRSEEEVAHGAIKGALNIQAEEIESDERVPHDKKLVIVCS
CCCCHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEEEEC
RGKTSVDVAEYLTEKGFDAASLKGGYISWLLDAMKEDEVAERDIKADVEQSIRKKFKKSI
CCCCCHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WRKFTKAINTYELVKPGDKIAVCISGGKDSMLMAKLFQELKHHNKFDFDVKFLVMDPGYN
HHHHHHHHCCEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCC
EANRHVIEENCRNLGIPATIFESDIFDAVYDIEKSPCYLCARMRRGHLYAFAKELGCNKI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCEE
ALGHHYDDVIETILMGMLYGAQVQTMMPKLHSTNFEGMELIRPLYLVREDDIKAWRDYNG
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHCCCC
LHFIQCACKFTDTCTTCNNEENRSKRVEIKQLIANLKKVNPFVEANIFKSVENVNLATVV
EEEEEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEE
AYKKDGIKHSFLDHYDE
EECCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA