Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 238923597

GI number: 238923597

Start: 1121529

End: 1121834

Strand: Direct

Name: trxA [H]

Synonym: EUBREC_1219

Alternate gene names: 238923597

Gene position: 1121529-1121834 (Clockwise)

Preceding gene: 238923596

Following gene: 238923598

Centisome position: 32.51

GC content: 37.91

Gene sequence:

>306_bases
ATGTCAGCTATTAATATCAATAAAAATAATTTTGAGAACGAAGTACTGAATTCCGATAAAACCGTTCTTTTAGATTTTTG
GGCATCTTGGTGTGCGCCTTGCCGTAGGGTAGTACCTATTGTAGAGGAGATTGCAGATGAGCGTATGGATATTAAAGTTG
GAAAGATTAATGTAGATGAAGAGCCTGAACTGGCAAATAAGTTCAGTATTATGAGCATTCCGACTTTAGTGGTTATGAAG
AATGGGAAGATTGTACAGCAGGTTTCAGGGGCGAGACCTAAGAATGCGATTTTAGAAATGCTTTAG

Upstream 100 bases:

>100_bases
GAAGTTAATTTAATGTGGTATGGTGATGTAATCACGGAAAACAAATGAATTTAAGACTATAACAAAGCTACAAAAAGAAA
AAGATAAGGAGGACTGTAAA

Downstream 100 bases:

>100_bases
GGAGGTGTGCTAATGGGATTTTTTGATTTCTTTAAACAGTCGAATATTAATCAAGGCATAGAAGAATATAAAATGACTGC
TGGTGCAGTTCTGCTGGATG

Product: thiol-disulfide isomerase and thioredoxin

Products: NA

Alternate protein names: Trx; MPT46 [H]

Number of amino acids: Translated: 101; Mature: 100

Protein sequence:

>101_residues
MSAININKNNFENEVLNSDKTVLLDFWASWCAPCRRVVPIVEEIADERMDIKVGKINVDEEPELANKFSIMSIPTLVVMK
NGKIVQQVSGARPKNAILEML

Sequences:

>Translated_101_residues
MSAININKNNFENEVLNSDKTVLLDFWASWCAPCRRVVPIVEEIADERMDIKVGKINVDEEPELANKFSIMSIPTLVVMK
NGKIVQQVSGARPKNAILEML
>Mature_100_residues
SAININKNNFENEVLNSDKTVLLDFWASWCAPCRRVVPIVEEIADERMDIKVGKINVDEEPELANKFSIMSIPTLVVMKN
GKIVQQVSGARPKNAILEML

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=103, Percent_Identity=29.126213592233, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87082331, Length=99, Percent_Identity=41.4141414141414, Blast_Score=97, Evalue=2e-22,
Organism=Escherichia coli, GI1788936, Length=83, Percent_Identity=44.578313253012, Blast_Score=86, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71980562, Length=98, Percent_Identity=31.6326530612245, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=86, Percent_Identity=31.3953488372093, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17569137, Length=104, Percent_Identity=32.6923076923077, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=82, Percent_Identity=37.8048780487805, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193209454, Length=104, Percent_Identity=32.6923076923077, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=104, Percent_Identity=32.6923076923077, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=85, Percent_Identity=31.7647058823529, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=89, Percent_Identity=35.9550561797753, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=87, Percent_Identity=36.7816091954023, Blast_Score=81, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323072, Length=81, Percent_Identity=37.037037037037, Blast_Score=75, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=87, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321022, Length=88, Percent_Identity=32.9545454545455, Blast_Score=64, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28573567, Length=85, Percent_Identity=38.8235294117647, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24639826, Length=86, Percent_Identity=34.8837209302326, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=41.025641025641, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=41.025641025641, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21358065, Length=89, Percent_Identity=39.3258426966292, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11372; Mature: 11241

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAININKNNFENEVLNSDKTVLLDFWASWCAPCRRVVPIVEEIADERMDIKVGKINVDE
CCEECCCCCCCCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
EPELANKFSIMSIPTLVVMKNGKIVQQVSGARPKNAILEML
CCCCHHHCCCCCCCEEEEEECCCCEEHHCCCCCCHHHHHCC
>Mature Secondary Structure 
SAININKNNFENEVLNSDKTVLLDFWASWCAPCRRVVPIVEEIADERMDIKVGKINVDE
CEECCCCCCCCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
EPELANKFSIMSIPTLVVMKNGKIVQQVSGARPKNAILEML
CCCCHHHCCCCCCCEEEEEECCCCEEHHCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]