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The map label for this gene is fucO [H]

Identifier: 238923471

GI number: 238923471

Start: 999702

End: 1000847

Strand: Direct

Name: fucO [H]

Synonym: EUBREC_1091

Alternate gene names: 238923471

Gene position: 999702-1000847 (Clockwise)

Preceding gene: 238923470

Following gene: 238923475

Centisome position: 28.98

GC content: 44.42

Gene sequence:

>1146_bases
ATGGCTAACAGAATCATGTTAAACGAGACATCTTATCACGGATCAGGTGCAATCCAGGAGATTGCAACAGAGGCAAAAGC
GCATGGCTTTAAAAAAGCACTGGTATGCTCTGACCCTGACTTAATCAAATTTGGAGTTACAGCAAAGGTAACAGATATCC
TTGATAAGAACGGATTGGAATATGAGATTTATTCGGAGATTAAGCCAAATCCAACAATCGACAACGTAAAGCATGGCGTA
GAGACATTTAAGAAATCAGGAGCTGATTACCTCATTGCAATCGGAGGCGGCTCTTCTATGGATACATCAAAGGCAATCGG
TATCATCATCGCAAACCCGGAGTTTGAGGATGTAAGAAGCTTAGAGGGTGTTGCATCTACAAAGAAGCCTTGTGTTCCTA
TCATCGCAGTACCTACAACAGCAGGAACAGCAGCAGAGGTTACAATCAACTATGTTATCACAGATGTAGAGAGAAAGAGA
AAGTTTGTATGTGTGGACCCACATGACATGCCAATCATCGCAATCGTAGACCCAGACATGATGTCATCAATGCCAAAGGG
ACTTACAGCATCAACAGGTATGGACGCACTCACACATGCTATCGAGGGCTATACAACAAAGGCTGCCTGGGAGATGACAG
ACATGTTCCATCTCAAAGCAATAGAGATTATTGCAAGATCCTTAAGAAGTGCAGTTGCCAATGAAAAAGAGGGACGTGAG
GGCATGGCACTTGGAGAGTACATTGCCGGAATGGGATTCTCAAATGTAGGACTTGGAATCGCTCATTCAATGGCTCATAC
ACTCGGAGCTGTTTATGATACACCACACGGAGTAGCATGTGCTATGATGCTTCCAATTGTAATGGAGTACAATGCAGACT
GCACAGGCGAAAAATATCGTGAAATCGCCCGCGCAATGGGAGTAAAGGGCGTAGATGATATGTCTGTAGAGGAGTACAGA
AAGGCTGCAATCGATGCTGTAGCGCAGCTCTCTGTAGATGTAGGAATCCCAACAAAGCTTGAAGCTATTAAGGAGGATGA
CTTAGACTTCCTCGCAGAGTCTGCTCACGCGGATGCATGTGCACCTGGAAATCCAAAGGATGCAAGTGTTGAGGATTTGA
AGGCTCTTTTCCGTAAGATTATGTAA

Upstream 100 bases:

>100_bases
TAATACTTTGTTAAAATATAGTCAGGCAGATAAGTTATAAGAATTTATCGGCAGAGTTTTTTAGGAGTATTTTTTTAAAA
TTGGAAGGAGATTTTACACT

Downstream 100 bases:

>100_bases
TTCTGCAACAGCTTACAGGGATGTAAAAATCCGGGAACTGTCAATTGACAGCATTCCCGGATTTTTAACGCTGATATAAC
TATTCTGACCAACGTGCAAA

Product: L-1,2-propanediol oxidoreductase

Products: NA

Alternate protein names: Propanediol oxidoreductase [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MANRIMLNETSYHGSGAIQEIATEAKAHGFKKALVCSDPDLIKFGVTAKVTDILDKNGLEYEIYSEIKPNPTIDNVKHGV
ETFKKSGADYLIAIGGGSSMDTSKAIGIIIANPEFEDVRSLEGVASTKKPCVPIIAVPTTAGTAAEVTINYVITDVERKR
KFVCVDPHDMPIIAIVDPDMMSSMPKGLTASTGMDALTHAIEGYTTKAAWEMTDMFHLKAIEIIARSLRSAVANEKEGRE
GMALGEYIAGMGFSNVGLGIAHSMAHTLGAVYDTPHGVACAMMLPIVMEYNADCTGEKYREIARAMGVKGVDDMSVEEYR
KAAIDAVAQLSVDVGIPTKLEAIKEDDLDFLAESAHADACAPGNPKDASVEDLKALFRKIM

Sequences:

>Translated_381_residues
MANRIMLNETSYHGSGAIQEIATEAKAHGFKKALVCSDPDLIKFGVTAKVTDILDKNGLEYEIYSEIKPNPTIDNVKHGV
ETFKKSGADYLIAIGGGSSMDTSKAIGIIIANPEFEDVRSLEGVASTKKPCVPIIAVPTTAGTAAEVTINYVITDVERKR
KFVCVDPHDMPIIAIVDPDMMSSMPKGLTASTGMDALTHAIEGYTTKAAWEMTDMFHLKAIEIIARSLRSAVANEKEGRE
GMALGEYIAGMGFSNVGLGIAHSMAHTLGAVYDTPHGVACAMMLPIVMEYNADCTGEKYREIARAMGVKGVDDMSVEEYR
KAAIDAVAQLSVDVGIPTKLEAIKEDDLDFLAESAHADACAPGNPKDASVEDLKALFRKIM
>Mature_380_residues
ANRIMLNETSYHGSGAIQEIATEAKAHGFKKALVCSDPDLIKFGVTAKVTDILDKNGLEYEIYSEIKPNPTIDNVKHGVE
TFKKSGADYLIAIGGGSSMDTSKAIGIIIANPEFEDVRSLEGVASTKKPCVPIIAVPTTAGTAAEVTINYVITDVERKRK
FVCVDPHDMPIIAIVDPDMMSSMPKGLTASTGMDALTHAIEGYTTKAAWEMTDMFHLKAIEIIARSLRSAVANEKEGREG
MALGEYIAGMGFSNVGLGIAHSMAHTLGAVYDTPHGVACAMMLPIVMEYNADCTGEKYREIARAMGVKGVDDMSVEEYRK
AAIDAVAQLSVDVGIPTKLEAIKEDDLDFLAESAHADACAPGNPKDASVEDLKALFRKIM

Specific function: Fucose metabolism; fourth step. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=413, Percent_Identity=26.3922518159806, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1789163, Length=379, Percent_Identity=60.9498680738786, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI48994951, Length=358, Percent_Identity=41.340782122905, Blast_Score=263, Evalue=1e-71,
Organism=Escherichia coli, GI87082107, Length=368, Percent_Identity=37.2282608695652, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1787493, Length=404, Percent_Identity=30.6930693069307, Blast_Score=181, Evalue=6e-47,
Organism=Escherichia coli, GI1789386, Length=338, Percent_Identity=25.1479289940828, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17537053, Length=423, Percent_Identity=25.2955082742317, Blast_Score=137, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6321181, Length=375, Percent_Identity=37.8666666666667, Blast_Score=250, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24657991, Length=420, Percent_Identity=26.6666666666667, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR013460 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.77 [H]

Molecular weight: Translated: 40838; Mature: 40707

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANRIMLNETSYHGSGAIQEIATEAKAHGFKKALVCSDPDLIKFGVTAKVTDILDKNGLE
CCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEEECCHHHHHHHHCCCCCC
YEIYSEIKPNPTIDNVKHGVETFKKSGADYLIAIGGGSSMDTSKAIGIIIANPEFEDVRS
EEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCCHHHHHH
LEGVASTKKPCVPIIAVPTTAGTAAEVTINYVITDVERKRKFVCVDPHDMPIIAIVDPDM
HHHHHCCCCCCEEEEEECCCCCCEEEEEEEEEEEEHHHCCCEEEECCCCCCEEEEECCHH
MSSMPKGLTASTGMDALTHAIEGYTTKAAWEMTDMFHLKAIEIIARSLRSAVANEKEGRE
HHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GMALGEYIAGMGFSNVGLGIAHSMAHTLGAVYDTPHGVACAMMLPIVMEYNADCTGEKYR
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHH
EIARAMGVKGVDDMSVEEYRKAAIDAVAQLSVDVGIPTKLEAIKEDDLDFLAESAHADAC
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCHHHHHHHCCCCCC
APGNPKDASVEDLKALFRKIM
CCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ANRIMLNETSYHGSGAIQEIATEAKAHGFKKALVCSDPDLIKFGVTAKVTDILDKNGLE
CCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEEECCHHHHHHHHCCCCCC
YEIYSEIKPNPTIDNVKHGVETFKKSGADYLIAIGGGSSMDTSKAIGIIIANPEFEDVRS
EEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCCHHHHHH
LEGVASTKKPCVPIIAVPTTAGTAAEVTINYVITDVERKRKFVCVDPHDMPIIAIVDPDM
HHHHHCCCCCCEEEEEECCCCCCEEEEEEEEEEEEHHHCCCEEEECCCCCCEEEEECCHH
MSSMPKGLTASTGMDALTHAIEGYTTKAAWEMTDMFHLKAIEIIARSLRSAVANEKEGRE
HHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GMALGEYIAGMGFSNVGLGIAHSMAHTLGAVYDTPHGVACAMMLPIVMEYNADCTGEKYR
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHH
EIARAMGVKGVDDMSVEEYRKAAIDAVAQLSVDVGIPTKLEAIKEDDLDFLAESAHADAC
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCHHHHHHHCCCCCC
APGNPKDASVEDLKALFRKIM
CCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]