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The map label for this gene is nadC [H]

Identifier: 238923415

GI number: 238923415

Start: 930306

End: 931160

Strand: Direct

Name: nadC [H]

Synonym: EUBREC_1035

Alternate gene names: 238923415

Gene position: 930306-931160 (Clockwise)

Preceding gene: 238923414

Following gene: 238923416

Centisome position: 26.97

GC content: 45.5

Gene sequence:

>855_bases
ATGTACGATCAGGTAACACTGGGCCTCAACGTAGACCCATTCATATTAAGCGCATTAAAGGAGGACATCACAAGCGAGGA
CGTGTCCACAAACAGCGTGATGCCACATCCACAGGCAGGAGAGGTGGATTTAATCTGCAAACAGGACGGAATCATCTGTG
GACTGCAGGTTTTTGAGAGAGTTTTCACACTGCTTGATGCAGATACAAAGGTAGAGTTTTACGTAAAGGATGGCGATAGG
GTAGAAAATAAGCAGCTTATCGGCAAGGTTTACGGAGATATCAGAGTACTCTTGTGCGGTGAGAGAACTGCGCTCAATTA
TTTACAGCGCATGAGTGGAATTGCCACATATACCAGTCAGGTTGCAGCGCTCTTAGAGGGCACCGGTATCAAGCTTTTGG
ATACCAGAAAGACAACCCCAAACAATAGAATTTTTGAAAAATACTCGGTCAGAGTCGGTGGTGGAAACAACCACAGATAC
AATCTCTCGGATGGAGTGCTTCTTAAGGATAACCACATCGGAGCAGCTGGCGGCGTAAAAGAGGCAATCGCCATGGCAAA
GGCCTATGCTCCGTTTGTCAGAAAGATTGAGGTTGAGGTAGAGAGCTTTGATATGGTGAAGGATGCGGTTGAAGCCGGTG
CCGACATTATCATGCTCGACAACATGTCCACAGAGCTTTTAAAGCAGTGCATCGACTACATTGACGGCAGAGCCGAAATT
GAGGTTTCGGGAAATGTTACCAAAGAAAATATTGCAAGAATAAAGGGTCTTGGTGTAGACTATGTATCAAGTGGTGCGCT
CACACATTCAGCGCCTATTATGGATTTATCACTTAAAAATCTACACGCAGTATAG

Upstream 100 bases:

>100_bases
CTACATTCAGGCATAAAAGCAAGTATCACCCCGGCACCACACAGCATAAAAAGTGCGAAACCGTAATAAATAATAATTTG
AACGAAAGGAATTTAAATAT

Downstream 100 bases:

>100_bases
ATTTTAGATTGCCGGTCGCACTATGCTGTGACAGTAATGTTTTACAGAAAGGAACGAAAATGAACGGTGATGAGAGAAGA
AAAAAAATAATAAATATTCT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MYDQVTLGLNVDPFILSALKEDITSEDVSTNSVMPHPQAGEVDLICKQDGIICGLQVFERVFTLLDADTKVEFYVKDGDR
VENKQLIGKVYGDIRVLLCGERTALNYLQRMSGIATYTSQVAALLEGTGIKLLDTRKTTPNNRIFEKYSVRVGGGNNHRY
NLSDGVLLKDNHIGAAGGVKEAIAMAKAYAPFVRKIEVEVESFDMVKDAVEAGADIIMLDNMSTELLKQCIDYIDGRAEI
EVSGNVTKENIARIKGLGVDYVSSGALTHSAPIMDLSLKNLHAV

Sequences:

>Translated_284_residues
MYDQVTLGLNVDPFILSALKEDITSEDVSTNSVMPHPQAGEVDLICKQDGIICGLQVFERVFTLLDADTKVEFYVKDGDR
VENKQLIGKVYGDIRVLLCGERTALNYLQRMSGIATYTSQVAALLEGTGIKLLDTRKTTPNNRIFEKYSVRVGGGNNHRY
NLSDGVLLKDNHIGAAGGVKEAIAMAKAYAPFVRKIEVEVESFDMVKDAVEAGADIIMLDNMSTELLKQCIDYIDGRAEI
EVSGNVTKENIARIKGLGVDYVSSGALTHSAPIMDLSLKNLHAV
>Mature_284_residues
MYDQVTLGLNVDPFILSALKEDITSEDVSTNSVMPHPQAGEVDLICKQDGIICGLQVFERVFTLLDADTKVEFYVKDGDR
VENKQLIGKVYGDIRVLLCGERTALNYLQRMSGIATYTSQVAALLEGTGIKLLDTRKTTPNNRIFEKYSVRVGGGNNHRY
NLSDGVLLKDNHIGAAGGVKEAIAMAKAYAPFVRKIEVEVESFDMVKDAVEAGADIIMLDNMSTELLKQCIDYIDGRAEI
EVSGNVTKENIARIKGLGVDYVSSGALTHSAPIMDLSLKNLHAV

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=285, Percent_Identity=35.4385964912281, Blast_Score=166, Evalue=2e-41,
Organism=Escherichia coli, GI1786299, Length=279, Percent_Identity=40.5017921146953, Blast_Score=191, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6321162, Length=285, Percent_Identity=38.2456140350877, Blast_Score=177, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31048; Mature: 31048

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDQVTLGLNVDPFILSALKEDITSEDVSTNSVMPHPQAGEVDLICKQDGIICGLQVFER
CCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHH
VFTLLDADTKVEFYVKDGDRVENKQLIGKVYGDIRVLLCGERTALNYLQRMSGIATYTSQ
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHH
VAALLEGTGIKLLDTRKTTPNNRIFEKYSVRVGGGNNHRYNLSDGVLLKDNHIGAAGGVK
HHHHHCCCCEEEEECCCCCCCCCEEEEEEEEECCCCCCEEECCCCEEEECCCCCCCCCHH
EAIAMAKAYAPFVRKIEVEVESFDMVKDAVEAGADIIMLDNMSTELLKQCIDYIDGRAEI
HHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCEEE
EVSGNVTKENIARIKGLGVDYVSSGALTHSAPIMDLSLKNLHAV
EECCCCCHHHHHHHHCCCCHHHCCCCCCCCCCEEEEEHHHHCCC
>Mature Secondary Structure
MYDQVTLGLNVDPFILSALKEDITSEDVSTNSVMPHPQAGEVDLICKQDGIICGLQVFER
CCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHH
VFTLLDADTKVEFYVKDGDRVENKQLIGKVYGDIRVLLCGERTALNYLQRMSGIATYTSQ
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHH
VAALLEGTGIKLLDTRKTTPNNRIFEKYSVRVGGGNNHRYNLSDGVLLKDNHIGAAGGVK
HHHHHCCCCEEEEECCCCCCCCCEEEEEEEEECCCCCCEEECCCCEEEECCCCCCCCCHH
EAIAMAKAYAPFVRKIEVEVESFDMVKDAVEAGADIIMLDNMSTELLKQCIDYIDGRAEI
HHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCEEE
EVSGNVTKENIARIKGLGVDYVSSGALTHSAPIMDLSLKNLHAV
EECCCCCHHHHHHHHCCCCHHHCCCCCCCCCCEEEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419294; 11677609; 9016724 [H]