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The map label for this gene is pepD [H]

Identifier: 238923278

GI number: 238923278

Start: 793328

End: 794767

Strand: Direct

Name: pepD [H]

Synonym: EUBREC_0889

Alternate gene names: 238923278

Gene position: 793328-794767 (Clockwise)

Preceding gene: 238923277

Following gene: 238923280

Centisome position: 23.0

GC content: 47.71

Gene sequence:

>1440_bases
ATGAGAGTATTAACAGATTTAGAGCCAAAGAACGTTTTTTCGTTTTTCGAGGATATATGCAGTATTCCTCATCCATCATA
CAAGGAAGAGAAAATCAGTAATTATCTGGTGGAGTTTGCAAAGGCAAGAGGCCTTGAGCATTACCAGGATGAGCTTCACA
ATGTGATAATCATAAAGGAAGCATCAGAAGGATATGAGGATGTGGAGCCAATCATACTGCAGGGGCACATGGATATGGTT
TGCGAGAAGGCACCTGACTGTGATAAGGATATGGATGAGGAAGGCCTGGACCTTTTGATAGATGGTGATTTTATCTCGGC
AAAGGGCACTACACTCGGTGGAGATGACGGTATCGCGGTGGCATATGCGCTTGCTATTTTGGACGATGACAGCCTGTCAC
ATCCACGCCTTGAGTTTGTATGCACTGTATGCGAGGAGGTCGGCATGGAGGGTGCTACAGGCATCGATGTGTCTATGCTT
AAGGGAAAGAAGCTTCTTAATATGGACAGCGAGGAGGAGGGAGTGATGCTCGCAAGCTGCGCCGGCGGATGCAGAGCCGA
TGTGAAGCTGCCTGTAGAGAGAGAGACAGTGAGCGGAACAAAGCTTACTGTGAGCTTATCAGGTCTCACCGGCGGACACT
CAGGCTCAGAGATTGATAAGGGAAGGGGCAATGCCAATACTCTTATGTCCAGACTGCTTCGCGACGCATCGGCACCTGTA
GCTATAGCTTCTATAGATGGCGGCAGAAAGGATAATGCCATTCCAAGAGAGTGTACTGCACAGATTATTGTAGCACCTGA
TGAGGCTGCGGCAGTGAAGGCTTCGATAGAACAGGCAGCAGCTGAGATTGCACAGGAGTTTAAGGCATCTGATCCTGACC
TTAAGCTTACTGTGTCAGAGGAGACTGACTGTAGTGAGTCAGCTATAAGTGCAAAGGACAGCGCAAGGGTTATCGCACTT
ATCGAGGCACTGCCAAACGGCATCATCAGAATGAGCCGGGAAATCGATAAGCTTGTTGAGACCTCACTTAATCTGGGAGT
TTTAAAATCAGACGATGCTGCTGTCACTTTAAGATACGCAGTCAGAAGCTCGGTCGGTGTGGCTAAAAAAAGCCTTAAGA
ACCAGCTTGTCTGCATAGCAGGCGCTTTTGCGGCAGAGGTTACATTTGAGGGCGATTATCCTGCATGGGAGTACAAGAAG
GATTCAAAGCTCCGCGAGGATATGGTACGGATTTTTGAGGAGATGTATGGCAAAAAGCCTACAGTTGAGGCTATTCATGC
CGGTGTCGAGTGCGGACTTTTAAGCGGCAAGATTGAAGGACTCGACTGCATATCAATGGGACCGGACATGTATGATATCC
ATACGACTGAGGAGAGGCTTTCCATATCCTCTGCAAAGAGGTCATATGAGTATATACTCAGAGTGATTGCGTGCAAATAA

Upstream 100 bases:

>100_bases
ATTTCACAACACTTATAATACATATACAATTAAATACCGGATTGTGTTATAATATGTCTGTCGGCGGATTCGTCGGCAGA
CTTTTTTTAAGGAGAGTAAA

Downstream 100 bases:

>100_bases
ATATTTATTCAAGGCTTTTGATAAAGGAAAGAGGTGTCATATGATACCTCTTTTTAAATGCCCTGTGAAAATAGCTCAGA
TTGTGAAATCCGACAGACAG

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MRVLTDLEPKNVFSFFEDICSIPHPSYKEEKISNYLVEFAKARGLEHYQDELHNVIIIKEASEGYEDVEPIILQGHMDMV
CEKAPDCDKDMDEEGLDLLIDGDFISAKGTTLGGDDGIAVAYALAILDDDSLSHPRLEFVCTVCEEVGMEGATGIDVSML
KGKKLLNMDSEEEGVMLASCAGGCRADVKLPVERETVSGTKLTVSLSGLTGGHSGSEIDKGRGNANTLMSRLLRDASAPV
AIASIDGGRKDNAIPRECTAQIIVAPDEAAAVKASIEQAAAEIAQEFKASDPDLKLTVSEETDCSESAISAKDSARVIAL
IEALPNGIIRMSREIDKLVETSLNLGVLKSDDAAVTLRYAVRSSVGVAKKSLKNQLVCIAGAFAAEVTFEGDYPAWEYKK
DSKLREDMVRIFEEMYGKKPTVEAIHAGVECGLLSGKIEGLDCISMGPDMYDIHTTEERLSISSAKRSYEYILRVIACK

Sequences:

>Translated_479_residues
MRVLTDLEPKNVFSFFEDICSIPHPSYKEEKISNYLVEFAKARGLEHYQDELHNVIIIKEASEGYEDVEPIILQGHMDMV
CEKAPDCDKDMDEEGLDLLIDGDFISAKGTTLGGDDGIAVAYALAILDDDSLSHPRLEFVCTVCEEVGMEGATGIDVSML
KGKKLLNMDSEEEGVMLASCAGGCRADVKLPVERETVSGTKLTVSLSGLTGGHSGSEIDKGRGNANTLMSRLLRDASAPV
AIASIDGGRKDNAIPRECTAQIIVAPDEAAAVKASIEQAAAEIAQEFKASDPDLKLTVSEETDCSESAISAKDSARVIAL
IEALPNGIIRMSREIDKLVETSLNLGVLKSDDAAVTLRYAVRSSVGVAKKSLKNQLVCIAGAFAAEVTFEGDYPAWEYKK
DSKLREDMVRIFEEMYGKKPTVEAIHAGVECGLLSGKIEGLDCISMGPDMYDIHTTEERLSISSAKRSYEYILRVIACK
>Mature_479_residues
MRVLTDLEPKNVFSFFEDICSIPHPSYKEEKISNYLVEFAKARGLEHYQDELHNVIIIKEASEGYEDVEPIILQGHMDMV
CEKAPDCDKDMDEEGLDLLIDGDFISAKGTTLGGDDGIAVAYALAILDDDSLSHPRLEFVCTVCEEVGMEGATGIDVSML
KGKKLLNMDSEEEGVMLASCAGGCRADVKLPVERETVSGTKLTVSLSGLTGGHSGSEIDKGRGNANTLMSRLLRDASAPV
AIASIDGGRKDNAIPRECTAQIIVAPDEAAAVKASIEQAAAEIAQEFKASDPDLKLTVSEETDCSESAISAKDSARVIAL
IEALPNGIIRMSREIDKLVETSLNLGVLKSDDAAVTLRYAVRSSVGVAKKSLKNQLVCIAGAFAAEVTFEGDYPAWEYKK
DSKLREDMVRIFEEMYGKKPTVEAIHAGVECGLLSGKIEGLDCISMGPDMYDIHTTEERLSISSAKRSYEYILRVIACK

Specific function: Dipeptidase with broad substrate specificity [H]

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=480, Percent_Identity=35.625, Blast_Score=313, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 51823; Mature: 51823

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLTDLEPKNVFSFFEDICSIPHPSYKEEKISNYLVEFAKARGLEHYQDELHNVIIIKE
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCEEEEEE
ASEGYEDVEPIILQGHMDMVCEKAPDCDKDMDEEGLDLLIDGDFISAKGTTLGGDDGIAV
CCCCCCCCCCEEEECCHHHHHHCCCCCCCCCCCCCCEEEEECCEEECCCCCCCCCCCCEE
AYALAILDDDSLSHPRLEFVCTVCEEVGMEGATGIDVSMLKGKKLLNMDSEEEGVMLASC
HEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHCCCCCCCCCEEEEEC
AGGCRADVKLPVERETVSGTKLTVSLSGLTGGHSGSEIDKGRGNANTLMSRLLRDASAPV
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
AIASIDGGRKDNAIPRECTAQIIVAPDEAAAVKASIEQAAAEIAQEFKASDPDLKLTVSE
EEEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
ETDCSESAISAKDSARVIALIEALPNGIIRMSREIDKLVETSLNLGVLKSDDAAVTLRYA
CCCCCHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEHHH
VRSSVGVAKKSLKNQLVCIAGAFAAEVTFEGDYPAWEYKKDSKLREDMVRIFEEMYGKKP
HHHHHHHHHHHHHCCEEEEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
TVEAIHAGVECGLLSGKIEGLDCISMGPDMYDIHTTEERLSISSAKRSYEYILRVIACK
CHHHHHCCCCEEEECCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVLTDLEPKNVFSFFEDICSIPHPSYKEEKISNYLVEFAKARGLEHYQDELHNVIIIKE
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCEEEEEE
ASEGYEDVEPIILQGHMDMVCEKAPDCDKDMDEEGLDLLIDGDFISAKGTTLGGDDGIAV
CCCCCCCCCCEEEECCHHHHHHCCCCCCCCCCCCCCEEEEECCEEECCCCCCCCCCCCEE
AYALAILDDDSLSHPRLEFVCTVCEEVGMEGATGIDVSMLKGKKLLNMDSEEEGVMLASC
HEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHCCCCCCCCCEEEEEC
AGGCRADVKLPVERETVSGTKLTVSLSGLTGGHSGSEIDKGRGNANTLMSRLLRDASAPV
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
AIASIDGGRKDNAIPRECTAQIIVAPDEAAAVKASIEQAAAEIAQEFKASDPDLKLTVSE
EEEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
ETDCSESAISAKDSARVIALIEALPNGIIRMSREIDKLVETSLNLGVLKSDDAAVTLRYA
CCCCCHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEHHH
VRSSVGVAKKSLKNQLVCIAGAFAAEVTFEGDYPAWEYKKDSKLREDMVRIFEEMYGKKP
HHHHHHHHHHHHHCCEEEEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
TVEAIHAGVECGLLSGKIEGLDCISMGPDMYDIHTTEERLSISSAKRSYEYILRVIACK
CHHHHHCCCCEEEECCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]