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The map label for this gene is hbd [H]

Identifier: 238923141

GI number: 238923141

Start: 678687

End: 679559

Strand: Direct

Name: hbd [H]

Synonym: EUBREC_0734

Alternate gene names: 238923141

Gene position: 678687-679559 (Clockwise)

Preceding gene: 238923140

Following gene: 238923142

Centisome position: 19.67

GC content: 46.05

Gene sequence:

>873_bases
ATGAAGGTTGGAATTATCGGTGCTGGTACAATGGGCCAGGGAATCGCAAAAGCATTCGCACAGGTAGATGGATACGAGGT
AGCACTCTGCGATATCAAGCAGGAGTGGGCTGAAGGCGGAAAAGACAAGATTGCAAAAGGATATGCAAGACTTGTAGCAA
AAGAGAAAATGACACAGGAGAAGGTTGACGGCATTCTTGCAAGCATCACTCCTGGTTTAAAAGAAGATCTCTGCAAGGAT
TGTGACCTCATCGTTGAGGCTGCTTTCGAGGATATGCAGGTTAAGAAAACTACATTCGCTGAGTTAGACAAGATTGCTAA
GCCAGAGTGTATTTTCGCTTCAAATACATCATCACTTTCAATCACAGAGATTGGAAACGGACTTACACGTCCATTAATCG
GTATGCACTTCTTCAACCCTGCTGACCGTATGAAGTTAGTAGAGGTTATCGCAGGTGTTAACACACCTGTTGAGACAGTT
GATGCAATTAAGAAGATTGCAGAGGAGATCGGCAAGACACCTGTACAGGTTAACGAGGCTGCCGGTTTCGTAGTAAACCG
TATCCTTATCCCAATGATCAACGAGGCTGCTTTCATCAAGATGGAGGGCGTTTCAGATATCGCCGGAATCGATGCAGCTA
TGAAGCTTGGTGCTAACCATCCAATGGGACCATTAGAGCTTGGAGATTTCATCGGACTTGATATCTGCCTTGCAATCATG
GACGTTCTTTACAATGAGACAGGTGACAGCAAGTATCGTGCATGCCCACTCATTCGCAAGATGGTAAGAGGCGGAAACCT
TGGATGCAAGAGCGGCAAGGGATTCTACGTTTACAACGCAGACCGCACAAAGACACCTGTAGACGCACAGTAG

Upstream 100 bases:

>100_bases
ATTAGTTTATTCACATCAGTTTATATATATGATTAAGTTATGCTGCAGAGGCTTAGCACTTAAAGCTTTTGCACCATAAT
ATATTTTAGGAGGAATTAAA

Downstream 100 bases:

>100_bases
GAGCAATAAAGCCTGGTCTCAAAGCGTATAAATGATGCAAGCTTGCTTGCAAAAATTTGTACGCTTTAGAGACGCTAATG
GACATGAGCAAGAAGCACGG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKVGIIGAGTMGQGIAKAFAQVDGYEVALCDIKQEWAEGGKDKIAKGYARLVAKEKMTQEKVDGILASITPGLKEDLCKD
CDLIVEAAFEDMQVKKTTFAELDKIAKPECIFASNTSSLSITEIGNGLTRPLIGMHFFNPADRMKLVEVIAGVNTPVETV
DAIKKIAEEIGKTPVQVNEAAGFVVNRILIPMINEAAFIKMEGVSDIAGIDAAMKLGANHPMGPLELGDFIGLDICLAIM
DVLYNETGDSKYRACPLIRKMVRGGNLGCKSGKGFYVYNADRTKTPVDAQ

Sequences:

>Translated_290_residues
MKVGIIGAGTMGQGIAKAFAQVDGYEVALCDIKQEWAEGGKDKIAKGYARLVAKEKMTQEKVDGILASITPGLKEDLCKD
CDLIVEAAFEDMQVKKTTFAELDKIAKPECIFASNTSSLSITEIGNGLTRPLIGMHFFNPADRMKLVEVIAGVNTPVETV
DAIKKIAEEIGKTPVQVNEAAGFVVNRILIPMINEAAFIKMEGVSDIAGIDAAMKLGANHPMGPLELGDFIGLDICLAIM
DVLYNETGDSKYRACPLIRKMVRGGNLGCKSGKGFYVYNADRTKTPVDAQ
>Mature_290_residues
MKVGIIGAGTMGQGIAKAFAQVDGYEVALCDIKQEWAEGGKDKIAKGYARLVAKEKMTQEKVDGILASITPGLKEDLCKD
CDLIVEAAFEDMQVKKTTFAELDKIAKPECIFASNTSSLSITEIGNGLTRPLIGMHFFNPADRMKLVEVIAGVNTPVETV
DAIKKIAEEIGKTPVQVNEAAGFVVNRILIPMINEAAFIKMEGVSDIAGIDAAMKLGANHPMGPLELGDFIGLDICLAIM
DVLYNETGDSKYRACPLIRKMVRGGNLGCKSGKGFYVYNADRTKTPVDAQ

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=286, Percent_Identity=39.5104895104895, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI296179427, Length=303, Percent_Identity=37.2937293729373, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI20127408, Length=281, Percent_Identity=34.8754448398576, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI261878539, Length=292, Percent_Identity=33.2191780821918, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI68989263, Length=292, Percent_Identity=33.2191780821918, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=31.9148936170213, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=38.86925795053, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1788682, Length=212, Percent_Identity=40.0943396226415, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1790281, Length=268, Percent_Identity=33.5820895522388, Blast_Score=144, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=39.7212543554007, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17549919, Length=286, Percent_Identity=38.1118881118881, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71985923, Length=290, Percent_Identity=35.8620689655172, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17563036, Length=290, Percent_Identity=33.7931034482759, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71985930, Length=284, Percent_Identity=34.5070422535211, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI25144276, Length=282, Percent_Identity=32.9787234042553, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17508951, Length=282, Percent_Identity=32.9787234042553, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17508953, Length=282, Percent_Identity=32.9787234042553, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17558304, Length=280, Percent_Identity=31.0714285714286, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI193203623, Length=161, Percent_Identity=31.6770186335404, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533614, Length=161, Percent_Identity=31.6770186335404, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583077, Length=292, Percent_Identity=34.2465753424658, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24583079, Length=292, Percent_Identity=34.2465753424658, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI19921000, Length=292, Percent_Identity=34.2465753424658, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI45549573, Length=235, Percent_Identity=31.4893617021277, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI20129993, Length=222, Percent_Identity=26.5765765765766, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31168; Mature: 31168

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGIIGAGTMGQGIAKAFAQVDGYEVALCDIKQEWAEGGKDKIAKGYARLVAKEKMTQE
CEEEEEECCCHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
KVDGILASITPGLKEDLCKDCDLIVEAAFEDMQVKKTTFAELDKIAKPECIFASNTSSLS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEE
ITEIGNGLTRPLIGMHFFNPADRMKLVEVIAGVNTPVETVDAIKKIAEEIGKTPVQVNEA
HHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEHHH
AGFVVNRILIPMINEAAFIKMEGVSDIAGIDAAMKLGANHPMGPLELGDFIGLDICLAIM
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
DVLYNETGDSKYRACPLIRKMVRGGNLGCKSGKGFYVYNADRTKTPVDAQ
HHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKVGIIGAGTMGQGIAKAFAQVDGYEVALCDIKQEWAEGGKDKIAKGYARLVAKEKMTQE
CEEEEEECCCHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
KVDGILASITPGLKEDLCKDCDLIVEAAFEDMQVKKTTFAELDKIAKPECIFASNTSSLS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEE
ITEIGNGLTRPLIGMHFFNPADRMKLVEVIAGVNTPVETVDAIKKIAEEIGKTPVQVNEA
HHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEHHH
AGFVVNRILIPMINEAAFIKMEGVSDIAGIDAAMKLGANHPMGPLELGDFIGLDICLAIM
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
DVLYNETGDSKYRACPLIRKMVRGGNLGCKSGKGFYVYNADRTKTPVDAQ
HHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]