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The map label for this gene is aroK [H]

Identifier: 238922872

GI number: 238922872

Start: 416515

End: 417021

Strand: Direct

Name: aroK [H]

Synonym: EUBREC_0460

Alternate gene names: 238922872

Gene position: 416515-417021 (Clockwise)

Preceding gene: 238922871

Following gene: 238922873

Centisome position: 12.07

GC content: 45.76

Gene sequence:

>507_bases
ATGGAACAGAGAACTAATATCGTACTTATAGGCATGCCGGGAGTTGGAAAGAGTACCATAGGCGTAATACTTGCAAAGGT
GCTGGGATACAGCTTCCTGGATGCGGATTTACTGATACAGGAGCAGGAGGGAAAGCTTCTGCGTGAGATAATTGAGGAAA
AGGGCACGGACGGTTTTATAGAGGTAGAGAACCGTGTCAATGCTTCTATCAGGGCTGATAGGGCCATTATAGCTACAGGC
GGTTCGGTGGTATACGGAAAAGAGGCCATGGAGCATCTTAAGGAGATAGGCAGAGTTGTGTATCTCAAGGTTTCTTATGC
CATTTTGGAAAAACGACTTGCAGACATAAAGGGTAGAGGTGTAGTATTAAAGAAAGGGCAGACTTTAGAAACCCTTTTTG
AAGAGCGCTCAAAATTGTATGAGCAGTATGCAGACATCGAGGTTTCCGAGGAGGGGCTTGATGTGGAGCAGACAGTAGAG
AAGCTGGTGGAGGCACTTGAATTATAG

Upstream 100 bases:

>100_bases
ACCAAGAAGGACAAAAAGGCAGCAGACACAAGCGCTACAGAGAGCACACAGCAGTCAGAAAGCACCAATAGTACAGATAC
AGAGAATACTGAGGCAGTAG

Downstream 100 bases:

>100_bases
TGCTTATTTATCGTGATATGATTAGATAATAGTAGCTGCTGCGTCATTTATTAAAAGCAGCACCGGCACAAATGGCGGCT
TAAATACGTCGTCATAAATG

Product: shikimate kinase

Products: NA

Alternate protein names: SK [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MEQRTNIVLIGMPGVGKSTIGVILAKVLGYSFLDADLLIQEQEGKLLREIIEEKGTDGFIEVENRVNASIRADRAIIATG
GSVVYGKEAMEHLKEIGRVVYLKVSYAILEKRLADIKGRGVVLKKGQTLETLFEERSKLYEQYADIEVSEEGLDVEQTVE
KLVEALEL

Sequences:

>Translated_168_residues
MEQRTNIVLIGMPGVGKSTIGVILAKVLGYSFLDADLLIQEQEGKLLREIIEEKGTDGFIEVENRVNASIRADRAIIATG
GSVVYGKEAMEHLKEIGRVVYLKVSYAILEKRLADIKGRGVVLKKGQTLETLFEERSKLYEQYADIEVSEEGLDVEQTVE
KLVEALEL
>Mature_168_residues
MEQRTNIVLIGMPGVGKSTIGVILAKVLGYSFLDADLLIQEQEGKLLREIIEEKGTDGFIEVENRVNASIRADRAIIATG
GSVVYGKEAMEHLKEIGRVVYLKVSYAILEKRLADIKGRGVVLKKGQTLETLFEERSKLYEQYADIEVSEEGLDVEQTVE
KLVEALEL

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate [H]

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=165, Percent_Identity=31.5151515151515, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI87082255, Length=174, Percent_Identity=32.183908045977, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1786587, Length=145, Percent_Identity=30.3448275862069, Blast_Score=67, Evalue=6e-13,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000623
- InterPro:   IPR023000 [H]

Pfam domain/function: PF01202 SKI [H]

EC number: =2.7.1.71 [H]

Molecular weight: Translated: 18683; Mature: 18683

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQRTNIVLIGMPGVGKSTIGVILAKVLGYSFLDADLLIQEQEGKLLREIIEEKGTDGFI
CCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHCCHHHEEECCCCHHHHHHHHHCCCCCEE
EVENRVNASIRADRAIIATGGSVVYGKEAMEHLKEIGRVVYLKVSYAILEKRLADIKGRG
EECCCCCCHHCCCEEEEEECCCEEECHHHHHHHHHHHHEEEEHHHHHHHHHHHHHCCCCC
VVLKKGQTLETLFEERSKLYEQYADIEVSEEGLDVEQTVEKLVEALEL
EEEECCCHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MEQRTNIVLIGMPGVGKSTIGVILAKVLGYSFLDADLLIQEQEGKLLREIIEEKGTDGFI
CCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHCCHHHEEECCCCHHHHHHHHHCCCCCEE
EVENRVNASIRADRAIIATGGSVVYGKEAMEHLKEIGRVVYLKVSYAILEKRLADIKGRG
EECCCCCCHHCCCEEEEEECCCEEECHHHHHHHHHHHHEEEEHHHHHHHHHHHHHCCCCC
VVLKKGQTLETLFEERSKLYEQYADIEVSEEGLDVEQTVEKLVEALEL
EEEECCCHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA