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The map label for this gene is fusA [H]

Identifier: 238922794

GI number: 238922794

Start: 349050

End: 351119

Strand: Direct

Name: fusA [H]

Synonym: EUBREC_0382

Alternate gene names: 238922794

Gene position: 349050-351119 (Clockwise)

Preceding gene: 238922793

Following gene: 238922795

Centisome position: 10.12

GC content: 44.83

Gene sequence:

>2070_bases
ATGGCTCATATCGATGCTGGTAAAACAACACTGACAGAGCGTATTCTTTATTATACTGGTATTAACTATAAAATCGGTGA
TACTCATGAAGGTACTGCTACCATGGACTGGATGGAGCAGGAGCAGGAAAGAGGTATTACAATTACTTCTGCCGCTACAA
CATGTCACTGGACACTTGAAGAGTTCACTAAACCAAAGCCAGGAGCACTTGAGCATCGTATCAACATCATCGATACACCG
GGCCACGTTGACTTCACAGTAGAAGTTGAGCGTTCACTCCGTGTACTTGATGGCGCAGTTGGTGTGTTCTGTGCAAAGGG
TGGTGTTGAGCCTCAGTCAGAGAACGTTTGGCGTCAGGCTGACACATACAATGTACCTCGTATGGCATTCATCAATAAGA
TGGATATCTTAGGTGCAAACTTCTACGGAGCTGTTGACCAGATCCGTACAAGATTAGGAAAAAATGCTATCGTACTTCAG
TTACCAATCGGTAAAGAGGACGATTTCAAAGGAATTATCGACCTTTTCGAGATGAAGGCTTATATCTACAATGATGAGAA
GGGTGACGATATCACAGTTACTGATGATCTTGGAGATATGGCTGATCAGGCTGCAGAGTACCGTACAGAGCTCATTGAGA
AAATCTGTGAGTTAGATGACGATCTCATGATGCAGTATCTTGAGGGTGAGGAGCCATCTGTAGAGGATATGAAGAAGGTT
CTTCGTAAAGCAACATGTGAGTGTACAGCAGTACCTGTATGTTGTGGTTCTGCATACCGTAACAAGGGTGTACAGAAGTT
ACTTGACGCTATTGTTGAGTACATGCCAGCTCCTACAGATATCCCTTCAATCAAGGGAACAGATCTTGAGGGAAATGAGA
TTGAGAGACATTCATCAGATGATGAGCCATTCTCAGCACTTGCATTCAAGATCATGGCAGATCCATTCGTAGGAAAGCTT
GCATTCTTCCGTGTTTACTCAGGAAAATGTAAGGCAGGTTCTTATGTATTAAATGCAACAAAGGATAAGAAAGAGCGTAT
CGGACGTATTCTTCAGATGCATGCAAATAAGAGACAGGAATTGGATGAGGTTTACTCAGGTGATATCGCTGCTGCTGTTG
GATTTAAATTCACAACAACAGGTGATACAATCTGTGATGAGCAGCATCCGGTTATCCTTGAGTCTATGGAGTTCCCAGAG
CCAGTTATCGAGCTCGCTATCGAGCCAAAGACAAAAGCTGGACAGGGTAAGTTAGGTGAGGCTCTTGCAAAGCTTGCAGA
GGAGGATCCTACATTCCGTGCTCATACTGATCAGGAAACAGGTCAGACAATCATCGCTGGTATGGGTGAGCTTCACCTTG
AGATCATCGTTGACCGTCTTCTCCGTGAGTTCAAGGTTGAGGCAAACGTTGGTGCACCTCAGGTTGCTTACAAGGAGACA
TTTACAAAGGCTGTTGATCAGGAATACAAATATGCTAAGCAGTCAGGTGGACGTGGACAGTACGGACACTGTAAGGTACG
TTTCGAGCCAATGGATGCCAATGGAGAAGAACTTTTCAAGTTCGATTCAGAGGTTGTCGGTGGTGCTATTCCTAAGGAAT
ACATTCCATCAATTGGCGAAGGTATCGAGGAGGCTACAAAGGCCGGCTCTCTTGGTGGATTCCCAGTAGTTGGTATCCAT
GCAACAGTATACGATGGATCTTACCATGAGGTCGATTCATCAGAGATGGCATTCCACATTGCCGGATCTATGTGTTTCAA
AGAGGCTATGGCAAAGGCTGCACCTGTATTACTTGAGCCTATCATGAAGGTAGAGGTTACAATGCCTGAGGAGTACATGG
GAGACGTTATCGGTGATGTTAACTCTCGTCGTGGACGTATCGAGGGTATGGACGATCTCGGCGGTGGAAAGATTGTACAT
GCATATGTACCACTTGCAGAGATGTTCGGTTACTCTACAGACCTTCGTTCTAAGACACAGGGACGTGGAAACTACTCAAT
GTTCTTCGACAGATATGAGCCGGTTCCAAAGAATGTACAGGACAAGGTTCTTGCTAACCACGCAAAATAA

Upstream 100 bases:

>100_bases
TTGTAACAGAGTCCGGTTGTGCATAGGACACTAAATATAGGAGGAAAAAACCTTGGCTGGAAGAGAATATCCACTTGAGA
GAACCAGAAATATTGGAATC

Downstream 100 bases:

>100_bases
TTGCAAATTAGCAAACAATTTATAGTACAAATGATGAAATATATACTATATATGGTATAAAAATCAAAAATAAAGGCATT
TCCCCTTGAAAAAGGGGGAT

Product: elongation factor G

Products: GDP; phosphate

Alternate protein names: EF-G [H]

Number of amino acids: Translated: 689; Mature: 688

Protein sequence:

>689_residues
MAHIDAGKTTLTERILYYTGINYKIGDTHEGTATMDWMEQEQERGITITSAATTCHWTLEEFTKPKPGALEHRINIIDTP
GHVDFTVEVERSLRVLDGAVGVFCAKGGVEPQSENVWRQADTYNVPRMAFINKMDILGANFYGAVDQIRTRLGKNAIVLQ
LPIGKEDDFKGIIDLFEMKAYIYNDEKGDDITVTDDLGDMADQAAEYRTELIEKICELDDDLMMQYLEGEEPSVEDMKKV
LRKATCECTAVPVCCGSAYRNKGVQKLLDAIVEYMPAPTDIPSIKGTDLEGNEIERHSSDDEPFSALAFKIMADPFVGKL
AFFRVYSGKCKAGSYVLNATKDKKERIGRILQMHANKRQELDEVYSGDIAAAVGFKFTTTGDTICDEQHPVILESMEFPE
PVIELAIEPKTKAGQGKLGEALAKLAEEDPTFRAHTDQETGQTIIAGMGELHLEIIVDRLLREFKVEANVGAPQVAYKET
FTKAVDQEYKYAKQSGGRGQYGHCKVRFEPMDANGEELFKFDSEVVGGAIPKEYIPSIGEGIEEATKAGSLGGFPVVGIH
ATVYDGSYHEVDSSEMAFHIAGSMCFKEAMAKAAPVLLEPIMKVEVTMPEEYMGDVIGDVNSRRGRIEGMDDLGGGKIVH
AYVPLAEMFGYSTDLRSKTQGRGNYSMFFDRYEPVPKNVQDKVLANHAK

Sequences:

>Translated_689_residues
MAHIDAGKTTLTERILYYTGINYKIGDTHEGTATMDWMEQEQERGITITSAATTCHWTLEEFTKPKPGALEHRINIIDTP
GHVDFTVEVERSLRVLDGAVGVFCAKGGVEPQSENVWRQADTYNVPRMAFINKMDILGANFYGAVDQIRTRLGKNAIVLQ
LPIGKEDDFKGIIDLFEMKAYIYNDEKGDDITVTDDLGDMADQAAEYRTELIEKICELDDDLMMQYLEGEEPSVEDMKKV
LRKATCECTAVPVCCGSAYRNKGVQKLLDAIVEYMPAPTDIPSIKGTDLEGNEIERHSSDDEPFSALAFKIMADPFVGKL
AFFRVYSGKCKAGSYVLNATKDKKERIGRILQMHANKRQELDEVYSGDIAAAVGFKFTTTGDTICDEQHPVILESMEFPE
PVIELAIEPKTKAGQGKLGEALAKLAEEDPTFRAHTDQETGQTIIAGMGELHLEIIVDRLLREFKVEANVGAPQVAYKET
FTKAVDQEYKYAKQSGGRGQYGHCKVRFEPMDANGEELFKFDSEVVGGAIPKEYIPSIGEGIEEATKAGSLGGFPVVGIH
ATVYDGSYHEVDSSEMAFHIAGSMCFKEAMAKAAPVLLEPIMKVEVTMPEEYMGDVIGDVNSRRGRIEGMDDLGGGKIVH
AYVPLAEMFGYSTDLRSKTQGRGNYSMFFDRYEPVPKNVQDKVLANHAK
>Mature_688_residues
AHIDAGKTTLTERILYYTGINYKIGDTHEGTATMDWMEQEQERGITITSAATTCHWTLEEFTKPKPGALEHRINIIDTPG
HVDFTVEVERSLRVLDGAVGVFCAKGGVEPQSENVWRQADTYNVPRMAFINKMDILGANFYGAVDQIRTRLGKNAIVLQL
PIGKEDDFKGIIDLFEMKAYIYNDEKGDDITVTDDLGDMADQAAEYRTELIEKICELDDDLMMQYLEGEEPSVEDMKKVL
RKATCECTAVPVCCGSAYRNKGVQKLLDAIVEYMPAPTDIPSIKGTDLEGNEIERHSSDDEPFSALAFKIMADPFVGKLA
FFRVYSGKCKAGSYVLNATKDKKERIGRILQMHANKRQELDEVYSGDIAAAVGFKFTTTGDTICDEQHPVILESMEFPEP
VIELAIEPKTKAGQGKLGEALAKLAEEDPTFRAHTDQETGQTIIAGMGELHLEIIVDRLLREFKVEANVGAPQVAYKETF
TKAVDQEYKYAKQSGGRGQYGHCKVRFEPMDANGEELFKFDSEVVGGAIPKEYIPSIGEGIEEATKAGSLGGFPVVGIHA
TVYDGSYHEVDSSEMAFHIAGSMCFKEAMAKAAPVLLEPIMKVEVTMPEEYMGDVIGDVNSRRGRIEGMDDLGGGKIVHA
YVPLAEMFGYSTDLRSKTQGRGNYSMFFDRYEPVPKNVQDKVLANHAK

Specific function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=700, Percent_Identity=42.2857142857143, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI19923640, Length=721, Percent_Identity=37.7253814147018, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI25306287, Length=716, Percent_Identity=34.2178770949721, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI25306283, Length=450, Percent_Identity=40.8888888888889, Blast_Score=302, Evalue=8e-82,
Organism=Homo sapiens, GI4503483, Length=416, Percent_Identity=28.8461538461538, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI94966754, Length=138, Percent_Identity=41.304347826087, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI157426893, Length=148, Percent_Identity=33.1081081081081, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI310132016, Length=119, Percent_Identity=39.4957983193277, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI310110807, Length=119, Percent_Identity=39.4957983193277, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI310123363, Length=119, Percent_Identity=39.4957983193277, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1789738, Length=694, Percent_Identity=58.35734870317, Blast_Score=821, Evalue=0.0,
Organism=Escherichia coli, GI1790835, Length=502, Percent_Identity=28.4860557768924, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI48994988, Length=148, Percent_Identity=37.8378378378378, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1788922, Length=156, Percent_Identity=35.2564102564103, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17533571, Length=698, Percent_Identity=40.2578796561605, Blast_Score=511, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17556745, Length=728, Percent_Identity=29.1208791208791, Blast_Score=304, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17506493, Length=420, Percent_Identity=28.0952380952381, Blast_Score=123, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17557151, Length=155, Percent_Identity=36.7741935483871, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323098, Length=702, Percent_Identity=39.8860398860399, Blast_Score=514, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6322359, Length=788, Percent_Identity=31.3451776649746, Blast_Score=354, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6324707, Length=474, Percent_Identity=24.8945147679325, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320593, Length=474, Percent_Identity=24.8945147679325, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323320, Length=172, Percent_Identity=34.3023255813954, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324166, Length=140, Percent_Identity=35.7142857142857, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24582462, Length=698, Percent_Identity=42.5501432664756, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI221458488, Length=726, Percent_Identity=32.2314049586777, Blast_Score=343, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24585709, Length=420, Percent_Identity=28.3333333333333, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24585711, Length=420, Percent_Identity=28.3333333333333, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24585713, Length=420, Percent_Identity=28.3333333333333, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI78706572, Length=140, Percent_Identity=37.8571428571429, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28574573, Length=206, Percent_Identity=30.5825242718447, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR004540
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 76320; Mature: 76189

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHIDAGKTTLTERILYYTGINYKIGDTHEGTATMDWMEQEQERGITITSAATTCHWTLE
CCCCCCCCHHHHHHHHEEECCCEEECCCCCCCCHHHHHHHHHHCCEEEEECCCEEEEEHH
EFTKPKPGALEHRINIIDTPGHVDFTVEVERSLRVLDGAVGVFCAKGGVEPQSENVWRQA
HHCCCCCCCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHC
DTYNVPRMAFINKMDILGANFYGAVDQIRTRLGKNAIVLQLPIGKEDDFKGIIDLFEMKA
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHH
YIYNDEKGDDITVTDDLGDMADQAAEYRTELIEKICELDDDLMMQYLEGEEPSVEDMKKV
HEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHH
LRKATCECTAVPVCCGSAYRNKGVQKLLDAIVEYMPAPTDIPSIKGTDLEGNEIERHSSD
HHHHCCCCEEECCCCCHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
DEPFSALAFKIMADPFVGKLAFFRVYSGKCKAGSYVLNATKDKKERIGRILQMHANKRQE
CCCHHHHHHHHHHCCHHHHHHHHHEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
LDEVYSGDIAAAVGFKFTTTGDTICDEQHPVILESMEFPEPVIELAIEPKTKAGQGKLGE
HHHHHCCCEEEHCCEEEECCCCCCCCCCCCEEEECCCCCCHHHHEEECCCCCCCCCHHHH
ALAKLAEEDPTFRAHTDQETGQTIIAGMGELHLEIIVDRLLREFKVEANVGAPQVAYKET
HHHHHHHCCCCEEECCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
FTKAVDQEYKYAKQSGGRGQYGHCKVRFEPMDANGEELFKFDSEVVGGAIPKEYIPSIGE
HHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHCCHHHH
GIEEATKAGSLGGFPVVGIHATVYDGSYHEVDSSEMAFHIAGSMCFKEAMAKAAPVLLEP
HHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
IMKVEVTMPEEYMGDVIGDVNSRRGRIEGMDDLGGGKIVHAYVPLAEMFGYSTDLRSKTQ
HHHEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHCCCCCCHHHHCC
GRGNYSMFFDRYEPVPKNVQDKVLANHAK
CCCCEEEEECCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
AHIDAGKTTLTERILYYTGINYKIGDTHEGTATMDWMEQEQERGITITSAATTCHWTLE
CCCCCCCHHHHHHHHEEECCCEEECCCCCCCCHHHHHHHHHHCCEEEEECCCEEEEEHH
EFTKPKPGALEHRINIIDTPGHVDFTVEVERSLRVLDGAVGVFCAKGGVEPQSENVWRQA
HHCCCCCCCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHC
DTYNVPRMAFINKMDILGANFYGAVDQIRTRLGKNAIVLQLPIGKEDDFKGIIDLFEMKA
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHH
YIYNDEKGDDITVTDDLGDMADQAAEYRTELIEKICELDDDLMMQYLEGEEPSVEDMKKV
HEECCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHH
LRKATCECTAVPVCCGSAYRNKGVQKLLDAIVEYMPAPTDIPSIKGTDLEGNEIERHSSD
HHHHCCCCEEECCCCCHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
DEPFSALAFKIMADPFVGKLAFFRVYSGKCKAGSYVLNATKDKKERIGRILQMHANKRQE
CCCHHHHHHHHHHCCHHHHHHHHHEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
LDEVYSGDIAAAVGFKFTTTGDTICDEQHPVILESMEFPEPVIELAIEPKTKAGQGKLGE
HHHHHCCCEEEHCCEEEECCCCCCCCCCCCEEEECCCCCCHHHHEEECCCCCCCCCHHHH
ALAKLAEEDPTFRAHTDQETGQTIIAGMGELHLEIIVDRLLREFKVEANVGAPQVAYKET
HHHHHHHCCCCEEECCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
FTKAVDQEYKYAKQSGGRGQYGHCKVRFEPMDANGEELFKFDSEVVGGAIPKEYIPSIGE
HHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHCCHHHH
GIEEATKAGSLGGFPVVGIHATVYDGSYHEVDSSEMAFHIAGSMCFKEAMAKAAPVLLEP
HHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
IMKVEVTMPEEYMGDVIGDVNSRRGRIEGMDDLGGGKIVHAYVPLAEMFGYSTDLRSKTQ
HHHEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHCCCCCCHHHHCC
GRGNYSMFFDRYEPVPKNVQDKVLANHAK
CCCCEEEEECCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA