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The map label for this gene is gyrA [H]

Identifier: 238922438

GI number: 238922438

Start: 6021

End: 8579

Strand: Direct

Name: gyrA [H]

Synonym: EUBREC_0006

Alternate gene names: 238922438

Gene position: 6021-8579 (Clockwise)

Preceding gene: 238922437

Following gene: 238922439

Centisome position: 0.17

GC content: 44.7

Gene sequence:

>2559_bases
GTGGACGACAAAATTTTTGACCAGATACAGCAGGTCGATTTGAAAAAAACAATGGAGAGCTCCTACATAGATTACGCGAT
GAGCGTTATTGCAAGCCGTGCCCTCCCTGATGTCAGGGACGGATTAAAGCCTGTTCAGAGGCGAGTACTCTACTCTATGG
TCGAGCTCGGAAATACACCTGACAAGCCACACAGAAAATGTGCGCGTATTGTCGGTGATACAATGGGTAAATACCATCCA
CACGGAGACAGCTCAATCTATGGAGCACTCGTAAATATGGCACAGGACTGGTCTATGAGATACACACTCGTGGACGGTCA
TGGAAACTTTGGTTCAGTCGATGGAGACGGAGCCGCCGCCATGCGATACACAGAGGCAAGACTCTCAAAGATTTCTCTTG
AATTAATCAAGGATATCGGCAAAAATACAGTAGATTTTGAGCCAAACTTTGATGAGACAGAAAAAGAGCCGACAGTGCTC
CCATCAAGATATCCGAACCTTTTAGTAAACGGAACCACAGGAATCGCGGTAGGTATGGCAACCAATATCCCACCTCACAA
TCTGCGTGAAGTGGTAAATGCCGTAGTGCGCCTTATCGACAACGATATCGAGGACAAAGAAACCACAATTGATGAGCTTA
TCGATGTGGTAAAGGGACCGGATTTCCCTACAGGCGGCATAATTCTCGGAACAAGTGGCATCAAAGAGGCTTACAGAACA
GGCCGCGGCAAAATAAGAGTCCGTGCTGTCACCAATATCGAGCCTATGGAAAACGGCAAAAACAGAATTGTAGTGACAGA
GCTGCCATACAACGTAAACAAAGCTCGTCTTATTGAGAAAATAGCTGAGCTTCATAAGGACAAAAAGATAGATGGAATAA
CAGACCTCCGCGACGAGACAAGCCGTGAGGGAATGAGAATCGTGGTAGAGCTCCGCCGTGATGTGAACCCGAGTGTAGTT
TTAAATCTGCTTTTCAAGCATACACAGCTCCAGGATACGTTTGGAGTGATAAACCTTGCACTCGTAAACGGAGAGCCAAA
GGTATTAAATCTATACGATCTGCTCAATTACTATCTCATCCATCAGAAGGATGTAGTGACCAGACGTACAAAGTTTGATC
TAGACAAGGCAGAGGCCAGGGCACATATTGTAGAGGGTCTCATTATTGCCCAGGACAACATAGACGAGGTAATAAGTATT
ATCCGCTCAAGCCAGACCACACAACAGGCAAAGACCAGATTGATGGAGAGATTTGGCCTGACAGATGAGCAGTCACAGGC
AATTGTTGATATGCGTCTTAGGGCTCTGACAGGTCTGGAAAGAGAAAAGCTCGAGGCTGAGTATAAGGAGCTCATGGCTC
AGATTGCGCAGTTAAAGGCTATTCTTGCCGATGAGAAAAAGCTTCTTGGAGTAATCAGGGAGGAAATCATCGCAATTGCA
GATAAATACGGCGACGACAGAAAGACAGAGATAGGCTATGACGAGTATGATATGTCGATGGAGGATCTCATTCCTGAGAC
AAATACAGTCATAACAATGACAAAGGTAGGCTACATAAAGCGCATGAGCACTGATAATTTCAAGGCTCAGCACCGCGGTG
GCAAGGGAATAAAGGGAATGGAGACAATCGAGGATGATTATATCGTCGAGATGCTCATGACCACATCACACCACTACCTG
ATGTTTTTCACAAATACAGGAAGAGTATACAGAATCAAGGCATATGAGATACCTGAGGCAAGCCGTACATCAAGAGGCAC
AGCCATCATCAATCTCATACCTCTTCAGCCTGACGAGAAAATAACAGCCATGATTCCAATCAAAGAATACGAGGATGACA
AGTATCTGTTCATGGCTACAAGAAACGGAATAGTCAAGAAAACCCCGATAAAGGATTATGAGAATATCCGAAAGAACGGA
CTTGCAGCAATCAATCTGCGCGAGGACGACAAACTCATAGAGGTCAAGGTCACAGACAATTCAGAGGATATTTTGCTCTT
CACCAAATTCGGACAGTGTATCAGATTCAAGGAGACAGATGTGCGCTCAACAGGCCGTACAACCATGGGTGTTATCGGAA
TGAATCTTGCACCAAATGATGTAATAATCGCAATGCAGACCGCATCAATGGGTGAGGCAGTGCTTTTAGTATCATCAAAC
GGCCTTGGAAAACGTACACGAATTGACGAATTTACCACACAAAACCGTGGCGGTAAGGGAGTAAAATGCTACAAGATTAC
AGAAAAATCAGGCAATCTCGTAGGAGTCAAATCAGTTGAAAACGATGATGAGCTCATGCTCATCACAACAGAGGGAATTA
TCATCAGAATCCAGGTAAGTGATGTAACAGTGCTTGGACGAATCACAACAGGTGTCAAGCTCATCAACCTGAAAGAAGGA
GTGAGCGTAGCCAGCATCGCAAAGGTAGTAGAGGATAAGACTCTCATGCCACCTGAGGAAGCTAAGGAAGAGAATGACGA
ATCAGAAAATAGTGACGAAGACTCAGCAGAGAATAATAATTCACATGCTGAAGCTATCGAAAATAACACAGAAGCATAA

Upstream 100 bases:

>100_bases
CACACTGATGGGTGATAAGGTAGAGCCAAGAAAAGAATTTATTGAAGCTAATGCCAAGTATGTAACAAATCTTGACATCT
AGCAGGGAGGAGTAATTTAA

Downstream 100 bases:

>100_bases
CTAAATTCATAAAAGCAGGGTCATAAGATCCTGCTTTTTGCGAATGTGGTGATACTATTCGAGCCTTATTGCGAAAAAAT
GTTTACATGCAAGCACTATG

Product: DNA gyrase, A subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 852; Mature: 852

Protein sequence:

>852_residues
MDDKIFDQIQQVDLKKTMESSYIDYAMSVIASRALPDVRDGLKPVQRRVLYSMVELGNTPDKPHRKCARIVGDTMGKYHP
HGDSSIYGALVNMAQDWSMRYTLVDGHGNFGSVDGDGAAAMRYTEARLSKISLELIKDIGKNTVDFEPNFDETEKEPTVL
PSRYPNLLVNGTTGIAVGMATNIPPHNLREVVNAVVRLIDNDIEDKETTIDELIDVVKGPDFPTGGIILGTSGIKEAYRT
GRGKIRVRAVTNIEPMENGKNRIVVTELPYNVNKARLIEKIAELHKDKKIDGITDLRDETSREGMRIVVELRRDVNPSVV
LNLLFKHTQLQDTFGVINLALVNGEPKVLNLYDLLNYYLIHQKDVVTRRTKFDLDKAEARAHIVEGLIIAQDNIDEVISI
IRSSQTTQQAKTRLMERFGLTDEQSQAIVDMRLRALTGLEREKLEAEYKELMAQIAQLKAILADEKKLLGVIREEIIAIA
DKYGDDRKTEIGYDEYDMSMEDLIPETNTVITMTKVGYIKRMSTDNFKAQHRGGKGIKGMETIEDDYIVEMLMTTSHHYL
MFFTNTGRVYRIKAYEIPEASRTSRGTAIINLIPLQPDEKITAMIPIKEYEDDKYLFMATRNGIVKKTPIKDYENIRKNG
LAAINLREDDKLIEVKVTDNSEDILLFTKFGQCIRFKETDVRSTGRTTMGVIGMNLAPNDVIIAMQTASMGEAVLLVSSN
GLGKRTRIDEFTTQNRGGKGVKCYKITEKSGNLVGVKSVENDDELMLITTEGIIIRIQVSDVTVLGRITTGVKLINLKEG
VSVASIAKVVEDKTLMPPEEAKEENDESENSDEDSAENNNSHAEAIENNTEA

Sequences:

>Translated_852_residues
MDDKIFDQIQQVDLKKTMESSYIDYAMSVIASRALPDVRDGLKPVQRRVLYSMVELGNTPDKPHRKCARIVGDTMGKYHP
HGDSSIYGALVNMAQDWSMRYTLVDGHGNFGSVDGDGAAAMRYTEARLSKISLELIKDIGKNTVDFEPNFDETEKEPTVL
PSRYPNLLVNGTTGIAVGMATNIPPHNLREVVNAVVRLIDNDIEDKETTIDELIDVVKGPDFPTGGIILGTSGIKEAYRT
GRGKIRVRAVTNIEPMENGKNRIVVTELPYNVNKARLIEKIAELHKDKKIDGITDLRDETSREGMRIVVELRRDVNPSVV
LNLLFKHTQLQDTFGVINLALVNGEPKVLNLYDLLNYYLIHQKDVVTRRTKFDLDKAEARAHIVEGLIIAQDNIDEVISI
IRSSQTTQQAKTRLMERFGLTDEQSQAIVDMRLRALTGLEREKLEAEYKELMAQIAQLKAILADEKKLLGVIREEIIAIA
DKYGDDRKTEIGYDEYDMSMEDLIPETNTVITMTKVGYIKRMSTDNFKAQHRGGKGIKGMETIEDDYIVEMLMTTSHHYL
MFFTNTGRVYRIKAYEIPEASRTSRGTAIINLIPLQPDEKITAMIPIKEYEDDKYLFMATRNGIVKKTPIKDYENIRKNG
LAAINLREDDKLIEVKVTDNSEDILLFTKFGQCIRFKETDVRSTGRTTMGVIGMNLAPNDVIIAMQTASMGEAVLLVSSN
GLGKRTRIDEFTTQNRGGKGVKCYKITEKSGNLVGVKSVENDDELMLITTEGIIIRIQVSDVTVLGRITTGVKLINLKEG
VSVASIAKVVEDKTLMPPEEAKEENDESENSDEDSAENNNSHAEAIENNTEA
>Mature_852_residues
MDDKIFDQIQQVDLKKTMESSYIDYAMSVIASRALPDVRDGLKPVQRRVLYSMVELGNTPDKPHRKCARIVGDTMGKYHP
HGDSSIYGALVNMAQDWSMRYTLVDGHGNFGSVDGDGAAAMRYTEARLSKISLELIKDIGKNTVDFEPNFDETEKEPTVL
PSRYPNLLVNGTTGIAVGMATNIPPHNLREVVNAVVRLIDNDIEDKETTIDELIDVVKGPDFPTGGIILGTSGIKEAYRT
GRGKIRVRAVTNIEPMENGKNRIVVTELPYNVNKARLIEKIAELHKDKKIDGITDLRDETSREGMRIVVELRRDVNPSVV
LNLLFKHTQLQDTFGVINLALVNGEPKVLNLYDLLNYYLIHQKDVVTRRTKFDLDKAEARAHIVEGLIIAQDNIDEVISI
IRSSQTTQQAKTRLMERFGLTDEQSQAIVDMRLRALTGLEREKLEAEYKELMAQIAQLKAILADEKKLLGVIREEIIAIA
DKYGDDRKTEIGYDEYDMSMEDLIPETNTVITMTKVGYIKRMSTDNFKAQHRGGKGIKGMETIEDDYIVEMLMTTSHHYL
MFFTNTGRVYRIKAYEIPEASRTSRGTAIINLIPLQPDEKITAMIPIKEYEDDKYLFMATRNGIVKKTPIKDYENIRKNG
LAAINLREDDKLIEVKVTDNSEDILLFTKFGQCIRFKETDVRSTGRTTMGVIGMNLAPNDVIIAMQTASMGEAVLLVSSN
GLGKRTRIDEFTTQNRGGKGVKCYKITEKSGNLVGVKSVENDDELMLITTEGIIIRIQVSDVTVLGRITTGVKLINLKEG
VSVASIAKVVEDKTLMPPEEAKEENDESENSDEDSAENNNSHAEAIENNTEA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=318, Percent_Identity=27.3584905660377, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI19913408, Length=175, Percent_Identity=33.1428571428571, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1788562, Length=839, Percent_Identity=47.7949940405244, Blast_Score=798, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=683, Percent_Identity=39.5314787701318, Blast_Score=467, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17535065, Length=295, Percent_Identity=28.8135593220339, Blast_Score=93, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI212645657, Length=281, Percent_Identity=28.1138790035587, Blast_Score=91, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI115534553, Length=170, Percent_Identity=32.3529411764706, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=515, Percent_Identity=22.3300970873786, Blast_Score=75, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=183, Percent_Identity=31.6939890710383, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136538, Length=175, Percent_Identity=30.2857142857143, Blast_Score=75, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 95511; Mature: 95511

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDKIFDQIQQVDLKKTMESSYIDYAMSVIASRALPDVRDGLKPVQRRVLYSMVELGNTP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC
DKPHRKCARIVGDTMGKYHPHGDSSIYGALVNMAQDWSMRYTLVDGHGNFGSVDGDGAAA
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHH
MRYTEARLSKISLELIKDIGKNTVDFEPNFDETEKEPTVLPSRYPNLLVNGTTGIAVGMA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEE
TNIPPHNLREVVNAVVRLIDNDIEDKETTIDELIDVVKGPDFPTGGIILGTSGIKEAYRT
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHC
GRGKIRVRAVTNIEPMENGKNRIVVTELPYNVNKARLIEKIAELHKDKKIDGITDLRDET
CCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
SREGMRIVVELRRDVNPSVVLNLLFKHTQLQDTFGVINLALVNGEPKVLNLYDLLNYYLI
HHCHHEEEEEHHHCCCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCEEEHHHHHHHHHH
HQKDVVTRRTKFDLDKAEARAHIVEGLIIAQDNIDEVISIIRSSQTTQQAKTRLMERFGL
CCHHHHHHHHHCCCCHHHHHHHHHHCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCC
TDEQSQAIVDMRLRALTGLEREKLEAEYKELMAQIAQLKAILADEKKLLGVIREEIIAIA
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKYGDDRKTEIGYDEYDMSMEDLIPETNTVITMTKVGYIKRMSTDNFKAQHRGGKGIKGM
HHCCCCCCCCCCCCHHCCCHHHHCCCCCCEEEEEECCHHEECCCCCCCHHCCCCCCCCCC
ETIEDDYIVEMLMTTSHHYLMFFTNTGRVYRIKAYEIPEASRTSRGTAIINLIPLQPDEK
HHHCHHHHHHHHHHCCCEEEEEEECCCEEEEEEEEECCCCCCCCCCEEEEEEEECCCCCC
ITAMIPIKEYEDDKYLFMATRNGIVKKTPIKDYENIRKNGLAAINLREDDKLIEVKVTDN
EEEEEEEEECCCCCEEEEEECCCCEECCCCHHHHHHHHCCEEEEEECCCCCEEEEEEECC
SEDILLFTKFGQCIRFKETDVRSTGRTTMGVIGMNLAPNDVIIAMQTASMGEAVLLVSSN
CCCEEEEECCCCEEEECCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCEEEEEECC
GLGKRTRIDEFTTQNRGGKGVKCYKITEKSGNLVGVKSVENDDELMLITTEGIIIRIQVS
CCCCCCCCHHHHCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCEEEEEECCEEEEEEEC
DVTVLGRITTGVKLINLKEGVSVASIAKVVEDKTLMPPEEAKEENDESENSDEDSAENNN
CEEEEEECCCCEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCC
SHAEAIENNTEA
CHHHHHCCCCCC
>Mature Secondary Structure
MDDKIFDQIQQVDLKKTMESSYIDYAMSVIASRALPDVRDGLKPVQRRVLYSMVELGNTP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC
DKPHRKCARIVGDTMGKYHPHGDSSIYGALVNMAQDWSMRYTLVDGHGNFGSVDGDGAAA
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHH
MRYTEARLSKISLELIKDIGKNTVDFEPNFDETEKEPTVLPSRYPNLLVNGTTGIAVGMA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEE
TNIPPHNLREVVNAVVRLIDNDIEDKETTIDELIDVVKGPDFPTGGIILGTSGIKEAYRT
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHC
GRGKIRVRAVTNIEPMENGKNRIVVTELPYNVNKARLIEKIAELHKDKKIDGITDLRDET
CCCEEEEEEECCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
SREGMRIVVELRRDVNPSVVLNLLFKHTQLQDTFGVINLALVNGEPKVLNLYDLLNYYLI
HHCHHEEEEEHHHCCCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCEEEHHHHHHHHHH
HQKDVVTRRTKFDLDKAEARAHIVEGLIIAQDNIDEVISIIRSSQTTQQAKTRLMERFGL
CCHHHHHHHHHCCCCHHHHHHHHHHCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCC
TDEQSQAIVDMRLRALTGLEREKLEAEYKELMAQIAQLKAILADEKKLLGVIREEIIAIA
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKYGDDRKTEIGYDEYDMSMEDLIPETNTVITMTKVGYIKRMSTDNFKAQHRGGKGIKGM
HHCCCCCCCCCCCCHHCCCHHHHCCCCCCEEEEEECCHHEECCCCCCCHHCCCCCCCCCC
ETIEDDYIVEMLMTTSHHYLMFFTNTGRVYRIKAYEIPEASRTSRGTAIINLIPLQPDEK
HHHCHHHHHHHHHHCCCEEEEEEECCCEEEEEEEEECCCCCCCCCCEEEEEEEECCCCCC
ITAMIPIKEYEDDKYLFMATRNGIVKKTPIKDYENIRKNGLAAINLREDDKLIEVKVTDN
EEEEEEEEECCCCCEEEEEECCCCEECCCCHHHHHHHHCCEEEEEECCCCCEEEEEEECC
SEDILLFTKFGQCIRFKETDVRSTGRTTMGVIGMNLAPNDVIIAMQTASMGEAVLLVSSN
CCCEEEEECCCCEEEECCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCEEEEEECC
GLGKRTRIDEFTTQNRGGKGVKCYKITEKSGNLVGVKSVENDDELMLITTEGIIIRIQVS
CCCCCCCCHHHHCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCEEEEEECCEEEEEEEC
DVTVLGRITTGVKLINLKEGVSVASIAKVVEDKTLMPPEEAKEENDESENSDEDSAENNN
CEEEEEECCCCEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCC
SHAEAIENNTEA
CHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]